Cellular substrate of abnormal network maturation in neuropsychiatric disorders

Project Information

PSYCHOCELL

Grant agreement ID: 681577

DOI 10.3030/681577

Project closed

EC signature date 25 February 2016

Start date 1 June 2016

End date 30 November 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 000 000,00

EU contribution € 2 000 000,00

Coordinated by

UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Germany

Publications

Peer reviewed articles (24)

An increase of inhibition drives the developmental decorrelation of neural activity

Author(s): Chini, Mattia; Pfeffer, Thomas; Hanganu-Opatz, Ileana
Published in: eLife, Issue 5, 2022, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.5281/zenodo.7277502

Anesthetics fragment hippocampal network activity, alter spine dynamics, and affect memory consolidation

Author(s): Wei Yang 1, Mattia Chini , Jastyn A Pöpplau , Andrey Formozov , Alexander Dieter , Patrick Piechocinski , Cynthia Rais , Fabio Morellini , Olaf Sporns , Ileana L Hanganu-Opatz , J Simon Wiegert
Published in: PLOS Biology, 2021, ISSN 1544-9173
Publisher: Public Library of Science
DOI: 10.1371/journal.pbio.3001146

Sparser and Less Efficient Hippocampal-Prefrontal Projections account for Developmental Network Dysfunction in a Model of Psychiatric Risk Mediated by Gene-Environment Interaction.

Author(s): Lingzhen Song; Xiaxia Xu; Peggy Putthoff; David Fleck; Marc Spehr; Ileana L. Hanganu-Opatz
Published in: The Journal of Neuroscience, Issue 2, 2022, ISSN 0270-6474
Publisher: Society for Neuroscience
DOI: 10.18154/rwth-2022-00994

Prefrontal Cortex Development in Health and Disease: Lessons from Rodents and Humans

Author(s): Mattia Chini, Ileana L. Hanganu-Opatz
Published in: Trends in Neurosciences, 2020, ISSN 0166-2236
Publisher: Elsevier BV
DOI: 10.1016/j.tins.2020.10.017

Calcium Imaging and Electrophysiology of hippocampal Activity under Anesthesia and natural Sleep in Mice

Author(s): Andrey Formozov , Mattia Chini , Alexander Dieter , Wei Yang , Jastyn A Pöpplau , Ileana L Hanganu-Opatz , J Simon Wiegert
Published in: Sci Data, 2022, ISSN 2052-4463
Publisher: Springer Nature
DOI: 10.1038/s41597-022-01244-2

Cross-Talk of Low-Level Sensory and High-Level Cognitive Processing: Development, Mechanisms, and Relevance for Cross-Modal Abilities of the Brain

Author(s): Xiaxia Xu, Ileana L. Hanganu-Opatz, Malte Bieler
Published in: Frontiers in Neurorobotics, Issue 14, 2020, ISSN 1662-5218
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnbot.2020.00007

Prenatal Immune and Endocrine Modulators of Offspring's Brain Development and Cognitive Functions Later in Life

Author(s): Schepanski S, Busse C, Hanganu-Opatz IL, Arck P
Published in: Frontiers in Immunology, 2018, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2018.02186

Pregnancy-induced maternal microchimerism shapes neurodevelopment and behavior in mice

Author(s): Steven Schepanski 1 2 , Mattia Chini 2 , Veronika Sternemann 1 2 , Christopher Urbschat 1 , Kristin Thiele 1 , Ting Sun 3 4 , Yu Zhao 3 , Mareike Poburski 1 2 , Anna Woestemeier 5 , Marie-Theres Thieme 1 , Dimitra E Zazara 1 , Malik Alawi 6 , Nicole Fischer 7 , Joerg Heeren 8 , Nikita Vladimirov 9 , Andrew Woehler 9 , Victor G Puelles 10 , Stefan Bonn 3 , Nicola Gagliani
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-32230-2

Layer-specific optogenetic activation of pyramidal neurons causes beta–gamma entrainment of neonatal networks

Author(s): Sebastian H Bitzenhofer, Joachim Ahlbeck, Amy Wolff, J. Simon Wiegert, Christine E. Gee, Thomas G. Oertner, Ileana L. Hanganu-Opatz
Published in: Nature Communications, Issue 8, 2017, Page(s) 14563, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms14563

From Shortage to Surge: A Developmental Switch in Hippocampal–Prefrontal Coupling in a Gene–Environment Model of Neuropsychiatric Disorders

Author(s): Henrike Hartung, Nicole Cichon, Vito De Feo, Stephanie Riemann, Sandra Schildt, Christoph Lindemann, Christoph Mulert, Joseph A. Gogos, Ileana L. Hanganu-Opatz
Published in: Cerebral Cortex, Issue 26/11, 2016, Page(s) 4265-4281, ISSN 1047-3211
Publisher: Oxford University Press
DOI: 10.1093/cercor/bhw274

Methodological Approach for Optogenetic Manipulation of Neonatal Neuronal Networks

Author(s): Sebastian H. Bitzenhofer, Joachim Ahlbeck, Ileana L. Hanganu-Opatz
Published in: Frontiers in Cellular Neuroscience, Issue 11, 2017, ISSN 1662-5102
Publisher: Frontiers Research Foundation
DOI: 10.3389/fncel.2017.00239

Rate and Temporal Coding Convey Multisensory Information in Primary Sensory Cortices

Author(s): Malte Bieler, Kay Sieben, Nicole Cichon, Sandra Schildt, Brigitte Röder, Ileana L. Hanganu-Opatz
Published in: eneuro, Issue 4/2, 2017, Page(s) ENEURO.0037-17.2017, ISSN 2373-2822
Publisher: Society for Neuroscience
DOI: 10.1523/ENEURO.0037-17.2017

Tapered Fibers Combined With a Multi-Electrode Array for Optogenetics in Mouse Medial Prefrontal Cortex

Author(s): Leonardo Sileo, Sebastian H. Bitzenhofer, Barbara Spagnolo, Jastyn A. Pöpplau, Tobias Holzhammer, Marco Pisanello, Filippo Pisano, Elisa Bellistri, Emanuela Maglie, Massimo De Vittorio, Patrick Ruther, Ileana L. Hanganu-Opatz, Ferruccio Pisanello
Published in: Frontiers in Neuroscience, Issue 12, 2018, ISSN 1662-453X
Publisher: Frontiers
DOI: 10.3389/fnins.2018.00771

Glutamatergic drive along the septo-temporal axis of hippocampus boosts prelimbic oscillations in the neonatal mouse

Author(s): Joachim Ahlbeck, Lingzhen Song, Mattia Chini, Sebastian H Bitzenhofer, Ileana L Hanganu-Opatz
Published in: eLife, Issue 7, 2018, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/eLife.33158

Transient knock-down of prefrontal DISC1 in immune-challenged mice causes abnormal long-range coupling and cognitive dysfunction throughout development

Author(s): Xiaxia Xu, Mattia Chini, Sebastian H. Bitzenhofer, Ileana L. Hanganu-Opatz
Published in: The Journal of Neuroscience, 2019, Page(s) 2170-18, ISSN 0270-6474
Publisher: Society for Neuroscience
DOI: 10.1523/jneurosci.2170-18.2018

Multisensory integration in rodent tactile but not visual thalamus

Author(s): Malte Bieler, Xiaxia Xu, Annette Marquardt, Ileana L. Hanganu-Opatz
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-33815-y

Developmental dysfunction of prefrontal–hippocampal networks in mouse models of mental illness

Author(s): Victoria C. Oberlander, Xiaxia Xu, Mattia Chini, Ileana L. Hanganu‐Opatz
Published in: European Journal of Neuroscience, 2019, ISSN 0953-816X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/ejn.14436

Neural Correlates of Anesthesia in Newborn Mice and Humans

Author(s): Mattia Chini, Sabine Gretenkord, Johanna K. Kostka, Jastyn A. Pöpplau, Laura Cornelissen, Charles B. Berde, Ileana L. Hanganu-Opatz, Sebastian H. Bitzenhofer
Published in: Frontiers in Neural Circuits, Issue 13, 2019, ISSN 1662-5110
Publisher: Frontiers Research Foundation
DOI: 10.3389/fncir.2019.00038

Coordinated electrical activity in the olfactory bulb gates the oscillatory entrainment of entorhinal networks in neonatal mice

Author(s): Sabine Gretenkord, Johanna K. Kostka, Henrike Hartung, Katja Watznauer, David Fleck, Angélica Minier-Toribio, Marc Spehr, Ileana L. Hanganu-Opatz
Published in: PLOS Biology, Issue 17/1, 2019, Page(s) e2006994, ISSN 1545-7885
Publisher: PLOS
DOI: 10.1371/journal.pbio.2006994

A transient developmental increase in prefrontal activity alters network maturation and causes cognitive dysfunction in adult mice

Author(s): Sebastian H Bitzenhofer , Jastyn A Pöpplau , Mattia Chini , Annette Marquardt , Ileana L Hanganu-Opatz
Published in: Neuron, 2021, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2021.02.011

Resolving and Rescuing Developmental Miswiring in a Mouse Model of Cognitive Impairment

Author(s): Mattia Chini, Jastyn A. Pöpplau, Christoph Lindemann, Laura Carol-Perdiguer, Marilena Hnida, Victoria Oberländer, Xiaxia Xu, Joachim Ahlbeck, Sebastian H. Bitzenhofer, Christoph Mulert, Ileana L. Hanganu-Opatz
Published in: Neuron, Issue 105/1, 2020, Page(s) 60-74.e7, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2019.09.042

Gamma activity accelerates during prefrontal development

Author(s): Sebastian H Bitzenhofer, Jastyn A Pöpplau, Ileana Hanganu-Opatz
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.56795

Developmental decrease of entorhinal-hippocampal communication in immune-challenged DISC1 knockdown mice

Author(s): Xiaxia Xu , Lingzhen Song , Rebecca Kringel , Ileana L Hanganu-Opatz
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-27114-w

Knock-Down of Hippocampal DISC1 in Immune-Challenged Mice Impairs the Prefrontal–Hippocampal Coupling and the Cognitive Performance Throughout Development

Author(s): Xiaxia Xu, Lingzhen Song, Ileana L Hanganu-Opatz
Published in: Cerebral Cortex, Issue 31/2, 2020, Page(s) 1240-1258, ISSN 1047-3211
Publisher: Oxford University Press
DOI: 10.1093/cercor/bhaa291

Other (1)

Reorganization of Adolescent Prefrontal Circuitry Is Required for Cognitive Maturation

Author(s): Pöpplau J-A, Schwarze T, Marquart A, Hanganu-Opatz IL
Published in: Cell Press Sneak Peak, 2022
Publisher: Cell Press
DOI: 10.2139/ssrn.4323725