Cellular substrate of abnormal network maturation in neuropsychiatric disorders

Project Information

PSYCHOCELL

Grant agreement ID: 681577

DOI 10.3030/681577

Project closed

EC signature date 25 February 2016

Start date 1 June 2016

End date 30 November 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 000 000,00

EU contribution € 2 000 000,00

Coordinated by

UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (27)

An increase of inhibition drives the developmental decorrelation of neural activity

Author(s): Chini, Mattia; Pfeffer, Thomas; Hanganu-Opatz, Ileana
Published in: eLife, Issue 5, 2022, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.5281/zenodo.7277502

Anesthetics fragment hippocampal network activity, alter spine dynamics, and affect memory consolidation

Author(s): Wei Yang 1, Mattia Chini , Jastyn A Pöpplau , Andrey Formozov , Alexander Dieter , Patrick Piechocinski , Cynthia Rais , Fabio Morellini , Olaf Sporns , Ileana L Hanganu-Opatz , J Simon Wiegert
Published in: PLOS Biology, 2021, ISSN 1544-9173
Publisher: Public Library of Science
DOI: 10.1371/journal.pbio.3001146

Sparser and Less Efficient Hippocampal-Prefrontal Projections account for Developmental Network Dysfunction in a Model of Psychiatric Risk Mediated by Gene-Environment Interaction.

Author(s): Lingzhen Song; Xiaxia Xu; Peggy Putthoff; David Fleck; Marc Spehr; Ileana L. Hanganu-Opatz
Published in: The Journal of Neuroscience, Issue 2, 2022, ISSN 0270-6474
Publisher: Society for Neuroscience
DOI: 10.18154/rwth-2022-00994

Prefrontal Cortex Development in Health and Disease: Lessons from Rodents and Humans

Author(s): Mattia Chini, Ileana L. Hanganu-Opatz
Published in: Trends in Neurosciences, 2020, ISSN 0166-2236
Publisher: Elsevier BV
DOI: 10.1016/j.tins.2020.10.017

Calcium Imaging and Electrophysiology of hippocampal Activity under Anesthesia and natural Sleep in Mice

Author(s): Andrey Formozov , Mattia Chini , Alexander Dieter , Wei Yang , Jastyn A Pöpplau , Ileana L Hanganu-Opatz , J Simon Wiegert
Published in: Sci Data, 2022, ISSN 2052-4463
Publisher: Springer Nature
DOI: 10.1038/s41597-022-01244-2

Cross-Talk of Low-Level Sensory and High-Level Cognitive Processing: Development, Mechanisms, and Relevance for Cross-Modal Abilities of the Brain

Author(s): Xiaxia Xu, Ileana L. Hanganu-Opatz, Malte Bieler
Published in: Frontiers in Neurorobotics, Issue 14, 2020, ISSN 1662-5218
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnbot.2020.00007

Prenatal Immune and Endocrine Modulators of Offspring's Brain Development and Cognitive Functions Later in Life

Author(s): Schepanski S, Busse C, Hanganu-Opatz IL, Arck P
Published in: Frontiers in Immunology, 2018, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2018.02186

Pregnancy-induced maternal microchimerism shapes neurodevelopment and behavior in mice

Author(s): Steven Schepanski 1 2 , Mattia Chini 2 , Veronika Sternemann 1 2 , Christopher Urbschat 1 , Kristin Thiele 1 , Ting Sun 3 4 , Yu Zhao 3 , Mareike Poburski 1 2 , Anna Woestemeier 5 , Marie-Theres Thieme 1 , Dimitra E Zazara 1 , Malik Alawi 6 , Nicole Fischer 7 , Joerg Heeren 8 , Nikita Vladimirov 9 , Andrew Woehler 9 , Victor G Puelles 10 , Stefan Bonn 3 , Nicola Gagliani
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-32230-2

Layer-specific optogenetic activation of pyramidal neurons causes beta–gamma entrainment of neonatal networks

Author(s): Sebastian H Bitzenhofer, Joachim Ahlbeck, Amy Wolff, J. Simon Wiegert, Christine E. Gee, Thomas G. Oertner, Ileana L. Hanganu-Opatz
Published in: Nature Communications, Issue 8, 2017, Page(s) 14563, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms14563

From Shortage to Surge: A Developmental Switch in Hippocampal–Prefrontal Coupling in a Gene–Environment Model of Neuropsychiatric Disorders

Author(s): Henrike Hartung, Nicole Cichon, Vito De Feo, Stephanie Riemann, Sandra Schildt, Christoph Lindemann, Christoph Mulert, Joseph A. Gogos, Ileana L. Hanganu-Opatz
Published in: Cerebral Cortex, Issue 26/11, 2016, Page(s) 4265-4281, ISSN 1047-3211
Publisher: Oxford University Press
DOI: 10.1093/cercor/bhw274

Methodological Approach for Optogenetic Manipulation of Neonatal Neuronal Networks

Author(s): Sebastian H. Bitzenhofer, Joachim Ahlbeck, Ileana L. Hanganu-Opatz
Published in: Frontiers in Cellular Neuroscience, Issue 11, 2017, ISSN 1662-5102
Publisher: Frontiers Research Foundation
DOI: 10.3389/fncel.2017.00239

Rate and Temporal Coding Convey Multisensory Information in Primary Sensory Cortices

Author(s): Malte Bieler, Kay Sieben, Nicole Cichon, Sandra Schildt, Brigitte Röder, Ileana L. Hanganu-Opatz
Published in: eneuro, Issue 4/2, 2017, Page(s) ENEURO.0037-17.2017, ISSN 2373-2822
Publisher: Society for Neuroscience
DOI: 10.1523/ENEURO.0037-17.2017

Tapered Fibers Combined With a Multi-Electrode Array for Optogenetics in Mouse Medial Prefrontal Cortex

Author(s): Leonardo Sileo, Sebastian H. Bitzenhofer, Barbara Spagnolo, Jastyn A. Pöpplau, Tobias Holzhammer, Marco Pisanello, Filippo Pisano, Elisa Bellistri, Emanuela Maglie, Massimo De Vittorio, Patrick Ruther, Ileana L. Hanganu-Opatz, Ferruccio Pisanello
Published in: Frontiers in Neuroscience, Issue 12, 2018, ISSN 1662-453X
Publisher: Frontiers
DOI: 10.3389/fnins.2018.00771

Glutamatergic drive along the septo-temporal axis of hippocampus boosts prelimbic oscillations in the neonatal mouse

Author(s): Joachim Ahlbeck, Lingzhen Song, Mattia Chini, Sebastian H Bitzenhofer, Ileana L Hanganu-Opatz
Published in: eLife, Issue 7, 2018, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/eLife.33158

Transient knock-down of prefrontal DISC1 in immune-challenged mice causes abnormal long-range coupling and cognitive dysfunction throughout development

Author(s): Xiaxia Xu, Mattia Chini, Sebastian H. Bitzenhofer, Ileana L. Hanganu-Opatz
Published in: The Journal of Neuroscience, 2019, Page(s) 2170-18, ISSN 0270-6474
Publisher: Society for Neuroscience
DOI: 10.1523/jneurosci.2170-18.2018

Multisensory integration in rodent tactile but not visual thalamus

Author(s): Malte Bieler, Xiaxia Xu, Annette Marquardt, Ileana L. Hanganu-Opatz
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-33815-y

Developmental dysfunction of prefrontal–hippocampal networks in mouse models of mental illness

Author(s): Victoria C. Oberlander, Xiaxia Xu, Mattia Chini, Ileana L. Hanganu‐Opatz
Published in: European Journal of Neuroscience, 2019, ISSN 0953-816X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/ejn.14436

Neural Correlates of Anesthesia in Newborn Mice and Humans

Author(s): Mattia Chini, Sabine Gretenkord, Johanna K. Kostka, Jastyn A. Pöpplau, Laura Cornelissen, Charles B. Berde, Ileana L. Hanganu-Opatz, Sebastian H. Bitzenhofer
Published in: Frontiers in Neural Circuits, Issue 13, 2019, ISSN 1662-5110
Publisher: Frontiers Research Foundation
DOI: 10.3389/fncir.2019.00038

Coordinated electrical activity in the olfactory bulb gates the oscillatory entrainment of entorhinal networks in neonatal mice

Author(s): Sabine Gretenkord, Johanna K. Kostka, Henrike Hartung, Katja Watznauer, David Fleck, Angélica Minier-Toribio, Marc Spehr, Ileana L. Hanganu-Opatz
Published in: PLOS Biology, Issue 17/1, 2019, Page(s) e2006994, ISSN 1545-7885
Publisher: PLOS
DOI: 10.1371/journal.pbio.2006994

A transient developmental increase in prefrontal activity alters network maturation and causes cognitive dysfunction in adult mice

Author(s): Sebastian H Bitzenhofer , Jastyn A Pöpplau , Mattia Chini , Annette Marquardt , Ileana L Hanganu-Opatz
Published in: Neuron, 2021, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2021.02.011

Resolving and Rescuing Developmental Miswiring in a Mouse Model of Cognitive Impairment

Author(s): Mattia Chini, Jastyn A. Pöpplau, Christoph Lindemann, Laura Carol-Perdiguer, Marilena Hnida, Victoria Oberländer, Xiaxia Xu, Joachim Ahlbeck, Sebastian H. Bitzenhofer, Christoph Mulert, Ileana L. Hanganu-Opatz
Published in: Neuron, Issue 105/1, 2020, Page(s) 60-74.e7, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2019.09.042

Neuronal oscillations: early biomarkers of psychiatric disease?

Author(s): Gnther A, Hanganu-Opatz IL
Published in: Frintiers in Behavioral Neuroscience, 2022, ISSN 1662-5153
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnbeh.2022.1038981

The Logic of Developing Neocortical Circuits in Health and Disease.

Author(s): Hanganu-Opatz IL, Butt SJB, Hippenmeyer S, De Marco Garca NV, Cardin JA, Voytek B, Muotri AR.
Published in: Journal of Neuroscience, 2020, ISSN 0270-6474
Publisher: Society for Neuroscience
DOI: 10.1523/jneurosci.1655-20.2020

Balancing family with a successful career in neuroscience

Author(s): Poirazi P, Belin D, Grff J, Hanganu-Opatz, Lopez-Bendito G
Published in: European Journal of Neuroscience, 2016, ISSN 0953-816X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/ejn.13280

Gamma activity accelerates during prefrontal development

Author(s): Sebastian H Bitzenhofer, Jastyn A Pöpplau, Ileana Hanganu-Opatz
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.56795

Developmental decrease of entorhinal-hippocampal communication in immune-challenged DISC1 knockdown mice

Author(s): Xiaxia Xu , Lingzhen Song , Rebecca Kringel , Ileana L Hanganu-Opatz
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-27114-w

Knock-Down of Hippocampal DISC1 in Immune-Challenged Mice Impairs the Prefrontal–Hippocampal Coupling and the Cognitive Performance Throughout Development

Author(s): Xiaxia Xu, Lingzhen Song, Ileana L Hanganu-Opatz
Published in: Cerebral Cortex, Issue 31/2, 2020, Page(s) 1240-1258, ISSN 1047-3211
Publisher: Oxford University Press
DOI: 10.1093/cercor/bhaa291

Other (1)

Reorganization of Adolescent Prefrontal Circuitry Is Required for Cognitive Maturation

Author(s): Pöpplau J-A, Schwarze T, Marquart A, Hanganu-Opatz IL
Published in: Cell Press Sneak Peak, 2022
Publisher: Cell Press
DOI: 10.2139/ssrn.4323725