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Engineering of hybrid cells using lab-on-chip technology

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Publications

Microfluidic platform enables tailored translocation and reaction cascades in nanoliter droplet networks

Author(s): Simon Bachler; Dominik Haidas; Marion Ort; Todd A. Duncombe; Petra S. Dittrich
Published in: Communications Biology, 3 (1), 6, 2020, Page(s) 769, ISSN 2399-3642
Publisher: Springer Nature
DOI: 10.3929/ethz-b-000458790

Microfluidic platform enables tailored translocation and reaction cascades in nanoliter droplet networks

Author(s): Simon Bachler, Dominik Haidas, Marion Ort, Todd A. Duncombe, Petra S. Dittrich
Published in: Communications Biology, 3/1, 2020, ISSN 2399-3642
Publisher: NPG
DOI: 10.1038/s42003-​020-01489-w

Permeation Studies across Symmetric and Asymmetric Membranes in Microdroplet Arrays

Author(s): Simon Bachler, Marion Ort, Stefanie D. Krämer, Petra S. Dittrich
Published in: Analytical Chemistry, 2, 2021, Page(s) 5137-5144, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.0c04939

“Basicles”: Microbial Growth and Production Monitoring in Giant Lipid Vesicles

Author(s): Jusková, Petra; Schmid, Yannick R. F.; Stucki, Ariane; Schmitt, Steven; Held, Martin; Dittrich, Petra S.
Published in: ACS Applied Materials & Interfaces, 11 (38), 11, 2019, Page(s) 34698–34706, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.9b12169

Membrane deformation and layer-by-layer peeling of giant vesicles induced by the pore-forming toxin pneumolysin

Author(s): Patrick Drücker, Ioan Iacovache, Simon Bachler, Benoît Zuber, Eduard B. Babiychuk, Petra S. Dittrich, Annette Draeger
Published in: Biomaterials Science, 7/9, 2019, Page(s) 3693-3705, ISSN 2047-4830
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9bm00134d

Observations of Membrane Domain Reorganization in Mechanically Compressed Artificial Cells

Author(s): Tom Robinson, Petra S. Dittrich
Published in: ChemBioChem, 20/20, 2019, Page(s) 2666-2673, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201900167

Microbial factories: monitoring vitamin B2 production by Escherichia coli in microfluidic cultivation chambers

Author(s): Petra Jusková; Steven Schmitt; Lucas Armbrecht; Petra S. Dittrich
Published in: Lab on a Chip, 21, 2021, Page(s) 4071-4080, ISSN 1473-0197
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1lc00621e

Single-cell protein profiling in microchambers with barcoded beads

Author(s): Lucas Armbrecht, Rafael Sebastian Müller, Jonas Nikoloff, Petra Stephanie Dittrich
Published in: Microsystems & Nanoengineering, 5/1, 2019, ISSN 2055-7434
Publisher: Nature Publishing Group
DOI: 10.1038/s41378-019-0099-5

Permeation Studies across Symmetric and Asymmetric Membranes in Microdroplet Arrays

Author(s): Simon Bachler; Marion Ort; Stefanie D. Krämer; Petra S. Dittrich
Published in: Analytical Chemistry, 2, 2021, Page(s) 5137-5144, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.0c04939

Cell-Derived Vesicles as TRPC1 Channel Delivery Systems for the Recovery of Cellular Respiratory and Proliferative Capacities

Author(s): Felix Kurth; Yee Kit Tai; Dinesh Parate; Marc van Oostrum; Yannick R. F. Schmid; Shi Jie Toh; Jasmine Lye Yee Yap; Bernd Wollscheid; Alaa Othman; Alaa Othman; Petra S. Dittrich; Alfredo Franco-Obregón
Published in: Advanced Biosystems, 12, 2020, ISSN 2366-7478
Publisher: Wiley-VCH
DOI: 10.3929/ethz-b-000454082

Real-time respiration changes as a viability indicator for rapid antibiotic susceptibility testing in a microfluidic chamber array

Author(s): Petra Jusková; Steven Schmitt; André Kling; Darius G. Rackus; Martin Held; Adrian Egli; Petra S. Dittrich
Published in: ACS Sensors, 11, 2021, Page(s) 2202-2210, ISSN 2379-3694
Publisher: ACS
DOI: 10.1021/acssensors.1c00020

The iron chelator Deferasirox causes severe mitochondrial swelling without depolarization due to a specific effect on inner membrane permeability

Author(s): Esther M. Gottwald, Claus D. Schuh, Patrick Drücker, Dominik Haenni, Adam Pearson, Susan Ghazi, Milica Bugarski, Marcello Polesel, Michael Duss, Ehud M. Landau, Andres Kaech, Urs Ziegler, Anne K. M. Lundby, Carsten Lundby, Petra S. Dittrich, Andrew M. Hall
Published in: Scientific Reports, 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-58386-9

Droplet Microfluidics and Directed Evolution of Enzymes: an Intertwined Journey

Author(s): Ariane Stucki, Jaicy Vallapurackal, Thomas R. Ward Petra S. Dittrich
Published in: Angewandte Chemie Int. Ed., 2021, ISSN 1521-3773
Publisher: Wiley
DOI: 10.1002/anie.202016154

Calcium-Mediated Liposome Fusion to Engineer Giant Lipid Vesicles with Cytosolic Proteins and Reconstituted Mammalian Proteins.

Author(s): Yannick R. F. Schmid; Leo Scheller; Sebastian Buchmann; Petra S. Dittrich
Published in: Andvanced Biosystems, 2, 2020, ISSN 2366-7478
Publisher: Wiley-VCH
DOI: 10.1002/adbi.202000153

Quantification of Protein Secretion from Circulating Tumor Cells in Microfluidic Chambers

Author(s): Lucas Armbrecht, Ophélie Rutschmann, Barbara Maria Szczerba, Jonas Nikoloff, Nicola Aceto, Petra S. Dittrich
Published in: Advanced Science, 7/11, 2020, Page(s) 1903237, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/advs.201903237

Identifying extracellular vesicle populations from single cells

Author(s): Jonas M. Nikoloff; Mario A. Saucedo-Espinosa; André Kling; Petra S. Dittrich
Published in: Proceedings of the National Academy of Sciences of the United States of America, 118 (38), 4, 2021, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2106630118

“Basicles”: Microbial Growth and Production Monitoring in Giant Lipid Vesicles

Author(s): Petra Jusková, Yannick R. F. Schmid, Ariane Stucki, Steven Schmitt, Martin Held, Petra S. Dittrich
Published in: ACS Applied Materials & Interfaces, 11/38, 2019, Page(s) 34698-34706, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.9b12169

A Multiplexed Cell-Free Assay to Screen for Antimicrobial Peptides in Double Emulsion Droplets

Author(s): Nicola Nuti, Philipp Rottmann, Ariane Stucki, Philipp Koch, Sven Panke, Petra S. Dittrich
Published in: Angewandte Chemie International Edition, 2022, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202114632

Synchronized Reagent Delivery in Double Emulsions for Triggering Chemical Reactions and Gene Expression

Author(s): Ariane Stucki; Petra Jusková; Nicola Nuti; Steven Schmitt; Petra Dittrich
Published in: Small Methods, 5 (8), 2, 2021, ISSN 2366-9608
Publisher: Wiley-VCH
DOI: 10.1002/smtd.202100331

In-Droplet Electrophoretic Separation and Enrichment of Biomolecules

Author(s): Mario A. Saucedo-Espinosa, Petra S. Dittrich
Published in: Analytical Chemistry, 92/12, 2020, Page(s) 8414-8421, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.0c01044

Multiplexed Point-of-Care Testing – xPOCT

Author(s): Can Dincer, Richard Bruch, André Kling, Petra S. Dittrich, Gerald A. Urban
Published in: Trends in Biotechnology, 35/8, 2017, Page(s) 728-742, ISSN 0167-7799
Publisher: Elsevier BV
DOI: 10.1016/j.tibtech.2017.03.013

Multivesicular droplets: a cell model system to study compartmentalised biochemical reactions

Author(s): N. Nuti, P. E. Verboket, P. S. Dittrich
Published in: Lab on a Chip, 17/18, 2017, Page(s) 3112-3119, ISSN 1473-0197
Publisher: Royal Society of Chemistry
DOI: 10.1039/c7lc00710h

Characterisation of anticancer peptides at the single-cell level

Author(s): L. Armbrecht, G. Gabernet, F. Kurth, J. A. Hiss, G. Schneider, P. S. Dittrich
Published in: Lab on a Chip, 17/17, 2017, Page(s) 2933-2940, ISSN 1473-0197
Publisher: Royal Society of Chemistry
DOI: 10.1039/c7lc00505a

A microfluidic device for the delivery of enzymes into cells by liposome fusion

Author(s): Phillip Kuhn, Klaus Eyer, Petra S. Dittrich
Published in: Engineering in Life Sciences, 18/2, 2018, Page(s) 149-156, ISSN 1618-0240
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/elsc.201600150

Recent Advances in the Analysis of Single Cells

Author(s): Lucas Armbrecht, Petra S. Dittrich
Published in: Analytical Chemistry, 89/1, 2016, Page(s) 2-21, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.6b04255

The Effects of Shear Force Transmission Across Vesicle Membranes

Author(s): Bernhard Sebastian, Tobias Favero, Petra S. Dittrich
Published in: The Journal of Physical Chemistry Letters, 8/24, 2017, Page(s) 6128-6134, ISSN 1948-7185
Publisher: American Chemical Society
DOI: 10.1021/acs.jpclett.7b02676

Spectrophotometric Quantification of Peroxidase with p -Phenylene-diamine for Analyzing Peroxidase-Encapsulating Lipid Vesicles

Author(s): Ya Zhang, Yannick R. F. Schmid, Sandra Luginbühl, Qiang Wang, Petra S. Dittrich, Peter Walde
Published in: Analytical Chemistry, 89/10, 2017, Page(s) 5484-5493, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.7b00423

Rational Design of Membrane-Pore-Forming Peptides

Author(s): Max Pillong, Jan A. Hiss, Petra Schneider, Yen-Chu Lin, Gernot Posselt, Bernhard Pfeiffer, Markus Blatter, Alex T. Müller, Simon Bachler, Claudia S. Neuhaus, Petra S. Dittrich, Karl-Heinz Altmann, Silja Wessler, Gisbert Schneider
Published in: Small, 13/40, 2017, Page(s) 1701316, ISSN 1613-6810
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.201701316

Microfluidics to Mimic Blood Flow in Health and Disease

Author(s): Bernhard Sebastian, Petra S. Dittrich
Published in: Annual Review of Fluid Mechanics, 50/1, 2018, Page(s) 483-504, ISSN 0066-4189
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-fluid-010816-060246

Tunable Membrane Potential Reconstituted in Giant Vesicles Promotes Permeation of Cationic Peptides at Nanomolar Concentrations

Author(s): Chao-Chen Lin, Michael Bachmann, Simon Bachler, Koushik Venkatesan, Petra S. Dittrich
Published in: ACS Applied Materials & Interfaces, 10/49, 2018, Page(s) 41909-41916, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.8b12217

Influence of the Membrane Dye R18 and of DMSO on Cell Penetration of Guanidinium-Rich Peptides

Author(s): Felix Kurth, Petra S. Dittrich, Peter Walde, Dieter Seebach
Published in: Chemistry & Biodiversity, 15/10, 2018, Page(s) e1800302, ISSN 1612-1872
Publisher: Verlag Helvetica Chimica Acta
DOI: 10.1002/cbdv.201800302

Cell Penetration, Herbicidal Activity, and in-vivo -Toxicity of Oligo-Arginine Derivatives and of Novel Guanidinium-Rich Compounds Derived from the Biopolymer Cyanophycin

Author(s): Marcel Grogg, Donald Hilvert, Marc-Olivier Ebert, Albert K. Beck, Dieter Seebach, Felix Kurth, Petra S. Dittrich, Christof Sparr, Sergio Wittlin, Matthias Rottmann, Pascal Mäser
Published in: Helvetica Chimica Acta, 101/10, 2018, Page(s) e1800112, ISSN 0018-019X
Publisher: Verlag Helvetica Chimica Acta
DOI: 10.1002/hlca.201800112

Pneumolysin-damaged cells benefit from non-homogeneous toxin binding to cholesterol-rich membrane domains

Author(s): Patrick Drücker, Simon Bachler, Heidi Wolfmeier, Roman Schoenauer, René Köffel, Viktoria S. Babiychuk, Petra S. Dittrich, Annette Draeger, Eduard B. Babiychuk
Published in: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1863/8, 2018, Page(s) 795-805, ISSN 1388-1981
Publisher: Elsevier BV
DOI: 10.1016/j.bbalip.2018.04.010

Calcium‐Mediated Liposome Fusion to Engineer Giant Lipid Vesicles with Cytosolic Proteins and Reconstituted Mammalian Proteins

Author(s): Yannick R. F. Schmid, Leo Scheller, Sebastian Buchmann, Petra S. Dittrich
Published in: Advanced Biosystems, 4/11, 2020, Page(s) 2000153, ISSN 2366-7478
Publisher: Wiley
DOI: 10.1002/adbi.202000153

Cell‐Derived Vesicles as TRPC1 Channel Delivery Systems for the Recovery of Cellular Respiratory and Proliferative Capacities

Author(s): Felix Kurth, Yee Kit Tai, Dinesh Parate, Marc Oostrum, Yannick R. F. Schmid, Shi Jie Toh, Jasmine Lye Yee Yap, Bernd Wollscheid, Alaa Othman, Petra S. Dittrich, Alfredo Franco‐Obregón
Published in: Advanced Biosystems, 4/11, 2020, Page(s) 2000146, ISSN 2366-7478
Publisher: Wiley
DOI: 10.1002/adbi.202000146

In vitro quantification of botulinum neurotoxin type A1 using immobilized nerve cell-mimicking nanoreactors in a microfluidic platform

Author(s): Oliver G. Weingart, Klaus Eyer, Christian Lüchtenborg, Timo Sachsenheimer, Britta Brügger, Marc van Oostrum, Bernd Wollscheid, Petra S. Dittrich, Martin J. Loessner
Published in: The Analyst, 144/19, 2019, Page(s) 5755-5765, ISSN 0003-2654
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9an00817a

Microfluidic liposome biosensor for detecting botulinum neurotoxin physiological activity

Author(s): F. Kurth, O. G. Weingart, K. Eyer, M. J. Loessner, P. S. Dittrich
Published in: Proceedings of the microTAS conference, Annual, 2017, Page(s) 973-974
Publisher: CBMS

Combination of a microfluidic device and fluorescence correlation spectroscopy to study peptide translocation across model membranes

Author(s): S. Bachler, C.-Ch. Lin, C. Del Don, and P. S. Dittrich
Published in: Proceedings of the microTAS conference, Annual, 2017, Page(s) 967-968
Publisher: CBMS

Towards Artificial Cells: Electrofusion of Lipid Vesicles on-chip

Author(s): Yannick Schmid, Petra S. Dittrich
Published in: Proceedings of the microTAS conference, Annual, 2018, Page(s) 1390-1392
Publisher: CBMS