Mechanisms and regulators coordinating replication integrity and DNA damage tolerance.

Project Information

REPSUMODDT

Grant agreement ID: 682190

DOI

10.3030/682190

Project closed

EC signature date 10 April 2016

Start date 1 July 2016

End date 31 December 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 991 250,00

EU contribution

€ 1 991 250,00

Coordinated by

IFOM-ISTITUTO FONDAZIONE DI ONCOLOGIA MOLECOLARE ETS
Italy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (16)

SMC 5/6 acts jointly with Fanconi anemia factors to support DNA repair and genome stability

Author(s): Francesco Rossi, Anne Helbling‐Leclerc, Ryotaro Kawasumi, Nanda Kumar Jegadesan, Xinlin Xu, Pierre Devulder, Takuya Abe, Minoru Takata, Dongyi Xu, Filippo Rosselli, Dana Branzei
Published in: EMBO reports, Issue 21/2, 2020, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.201948222

Mus81-Mms4 endonuclease is an Esc2-STUbL-Cullin8 mitotic substrate impacting on genome integrity

Author(s): Anja Waizenegger, Madhusoodanan Urulangodi, Carl P. Lehmann, Teresa Anne Clarisse Reyes, Irene Saugar, José Antonio Tercero, Barnabas Szakal, Dana Branzei
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-19503-4

SUMO-Chain-Regulated Proteasomal Degradation Timing Exemplified in DNA Replication Initiation

Author(s): Ivan Psakhye, Federica Castellucci, Dana Branzei
Published in: Molecular Cell, Issue 76/4, 2019, Page(s) 632-645.e6, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2019.08.003

SIRFing the replication fork: Assessing protein interactions with nascent DNA

Author(s): Dana Branzei, Michele Giannattasio
Published in: Journal of Cell Biology, Issue 217/4, 2018, Page(s) 1177-1179, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.201802083

ESCO1/2's roles in chromosome structure and interphase chromatin organization

Author(s): Ryotaro Kawasumi, Takuya Abe, Hiroshi Arakawa, Massimiliano Garre, Kouji Hirota, Dana Branzei
Published in: Genes & Development, Issue 31/21, 2017, Page(s) 2136-2150, ISSN 0890-9369
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.306084.117

Not all roads lead to Cdk1

Author(s): Dana Branzei, Andrea Ciliberto
Published in: Cell Cycle, Issue 16/5, 2016, Page(s) 395-396, ISSN 1538-4101
Publisher: Landes Bioscience
DOI: 10.1080/15384101.2016.1274585

Building up and breaking down: mechanisms controlling recombination during replication

Author(s): Dana Branzei, Barnabas Szakal
Published in: Critical Reviews in Biochemistry and Molecular Biology, Issue 52/4, 2017, Page(s) 381-394, ISSN 1040-9238
Publisher: Taylor & Francis
DOI: 10.1080/10409238.2017.1304355

S-phase checkpoint regulations that preserve replication and chromosome integrity upon dNTP depletion

Author(s): Michele Giannattasio, Dana Branzei
Published in: Cellular and Molecular Life Sciences, Issue 74/13, 2017, Page(s) 2361-2380, ISSN 1420-682X
Publisher: Birkhauser Verlag
DOI: 10.1007/s00018-017-2474-4

AND-1 fork protection function prevents fork resection and is essential for proliferation

Author(s): Takuya Abe, Ryotaro Kawasumi, Michele Giannattasio, Sabrina Dusi, Yui Yoshimoto, Keiji Miyata, Koyuki Umemura, Kouji Hirota, Dana Branzei
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-05586-7

Warsaw breakage syndrome DDX11 helicase acts jointly with RAD17 in the repair of bulky lesions and replication through abasic sites

Author(s): Takuya Abe, Masato Ooka, Ryotaro Kawasumi, Keiji Miyata, Minoru Takata, Kouji Hirota, Dana Branzei
Published in: Proceedings of the National Academy of Sciences, Issue 115/33, 2018, Page(s) 8412-8417, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1803110115

Error‐free DNA damage tolerance pathway is facilitated by the Irc5 translocase through cohesin

Author(s): Ireneusz Litwin, Tomasz Bakowski, Barnabas Szakal, Ewa Pilarczyk, Ewa Maciaszczyk‐Dziubinska, Dana Branzei, Robert Wysocki
Published in: The EMBO Journal, Issue 37/18, 2018, Page(s) e98732, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.201798732

The Swr1 chromatin-remodeling complex prevents genome instability induced by replication fork progression defects

Author(s): Anjana Srivatsan, Bin-Zhong Li, Barnabas Szakal, Dana Branzei, Christopher D. Putnam, Richard D. Kolodner
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-06131-2

Integrating Rio1 activities discloses its nutrient-activated network in Saccharomyces cerevisiae

Author(s): Maria G Iacovella, Michael Bremang, Omer Basha, Luciano Giacò, Walter Carotenuto, Cristina Golfieri, Barnabas Szakal, Marianna Dal Maschio, Valentina Infantino, Galina V Beznoussenko, Chinnu R Joseph, Clara Visintin, Alexander A Mironov, Rosella Visintin, Dana Branzei, Sébastien Ferreira-Cerca, Esti Yeger-Lotem, Peter De Wulf
Published in: Nucleic Acids Research, Issue 46/15, 2018, Page(s) 7586-7611, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gky618

DNA Replication Through Strand Displacement During Lagging Strand DNA Synthesis in Saccharomyces cerevisiae

Author(s): Michele Giannattasio, Dana Branzei
Published in: Genes, Issue 10/2, 2019, Page(s) 167, ISSN 2073-4425
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes10020167

The Mgs1/WRNIP1 ATPase is required to prevent a recombination salvage pathway at damaged replication forks

Author(s): Alberto Jiménez-Martín, Irene Saugar, Chinnu Rose Joseph, Alexandra Mayer, Carl P. Lehmann, Barnabas Szakal, Dana Branzei, José Antonio Tercero
Published in: Science Advances, Issue 6/15, 2020, Page(s) eaaz3327, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.aaz3327

Prevention of unwanted recombination at damaged replication forks

Author(s): Carl P. Lehmann, Alberto Jiménez-Martín, Dana Branzei, José Antonio Tercero
Published in: Current Genetics, Issue 66/6, 2020, Page(s) 1045-1051, ISSN 0172-8083
Publisher: Springer Verlag
DOI: 10.1007/s00294-020-01095-7