Mechanisms and functional significance of diffusion barriers for asymmetric segregation of age in neural stem cells

Project Information

STEMBAR

Grant agreement ID: 682256

DOI 10.3030/682256

Project closed

EC signature date 24 February 2016

Start date 1 September 2016

End date 28 February 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 000 000,00

EU contribution € 2 000 000,00

Coordinated by

UNIVERSITAT ZURICH
Switzerland

Publications

Peer reviewed articles (18)

Visualization of individual cell division history in complex tissues using iCOUNT Cell

Author(s): Denoth-Lippuner A, Jaeger BN, Liang T, Royall LN, Chie SE, Buthey K, Machado D, Korobeynyk VI, Kruse M, Munz CM, Gerbaulet A, Simons BD, Jessberger S
Published in: Cell Stem Cell, 2021, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2021.08.012

Formation and integration of new neurons in the adult hippocampus

Author(s): Denoth-Lippuner A, Jessberger S
Published in: Nature Reviews Neuroscience, 2021, ISSN 1471-003X
Publisher: Nature Publishing Group
DOI: 10.1038/s41583-021-00433-z

Palmitoylation of BMPR1a regulates neural stem cell fate

Author(s): Wegleiter T, Buthey K, Gonzalez-Bohorquez D, Hruzova M, Bin Imtiaz MK, Abegg A, Mebert I, Molteni A, Kollegger D, Pelczar P, Jessberger
Published in: PNAS, 2019, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1912671116

Human neural progenitors establish a diffusion barrier in the endoplasmic reticulum mebrane during cell division

Author(s): Bin Imtiaz MK, Gonzalez-Bohorquez D, Jessberger S
Published in: Development in press, 2022, ISSN 0950-1991
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dev.200613

Long-term self-renewing stem cells in the adult mouse hippocampus identified by intravital imaging

Author(s): Bottes S, Jaeger BN, Pilz GA, Jörg DJ, Cole JD, Kruse M, Harris L, Korobeynyk VI, Mallona I, Guillemot F, Helmchen F, Simons BD, Jessberger S
Published in: Nature Neuroscience, 2021, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-020-00759-4

FASN-dependent de novo lipogenesis is required for brain development

Author(s): Gonzalez-Bohorquez D, Gallego Lopez IM, Jaeger BN, Pfammatter S, Bowers M, Semenkovich CF, Jessberger S
Published in: PNAS, 2022, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2112040119

FASN-dependent metabolism links neural stem/progenitor cell activity to learning and memory deficits

Author(s): Bowers M, Liang T, Gonzalez-Bohorquez D, Zocher S, Jaeger BN, Kovacs W, Röhrl C, Cramb K, Winterer J, Kruse M, Dimitrieva S, Overall RW, Wegleiter T, Najmabadi H, Semenkovich CF, Kempermann G, Földy C, Jessberger S
Published in: Cell Stem Cell, 2020, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2020.04.002

Mechanisms of cellular rejuvenation

Author(s): Denoth-Lippuner A, Jessberger S
Published in: FEBS Lett, 2019, ISSN 0014-5793
Publisher: Elsevier BV
DOI: 10.1002/1873-3468.13483

A Single Metabolite which Modulates Lipid Metabolism Alters Hematopoietic Stem/Progenitor Cell Behavior and Promotes Lymphoid Reconstitution

Author(s): Giger S, Kovtonyuk LV, Utz SG, Ramosaj M, Kovacs WJ, Schmid E, Ioannidis V, Greter M, Manz MG, Lutolf MP, Jessberger S*, Knobloch M*
Published in: Stem Cell Reports, 2020, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2020.07.021

Live imaging of remyelination in the adult mouse corpus callosum

Author(s): Bottes S, Jessberger S
Published in: PNAS, 2021, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2025795118

Characterization of the neurogenic niche in the aging dentate gyrus using iterative immunofluorescence imaging

Author(s): Cole JD, Sarabia Del Castillo J, Gut G, Gonzalez-Bohorquez D, Pelkmans L, Jessberger S
Published in: eLife, 2022, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.68000

Creating Age Asymmetry: Consequences of Inheriting Damaged Goods in Mammalian Cells

Author(s): Darcie L. Moore, Sebastian Jessberger
Published in: Trends in Cell Biology, Issue 27/1, 2017, Page(s) 82-92, ISSN 0962-8924
Publisher: Elsevier BV
DOI: 10.1016/j.tcb.2016.09.007

Live imaging of neurogenesis in the adult mouse hippocampus

Author(s): Gregor-Alexander Pilz, Sara Bottes, Marion Betizeau, David J. Jörg, Stefano Carta, Benjamin D. Simons, Fritjof Helmchen, Sebastian Jessberger
Published in: Science, Issue 359/6376, 2018, Page(s) 658-662, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aao5056

A mechanism for the segregation of age in mammalian neural stem cells

Author(s): D. L. Moore, G. A. Pilz, M. J. Arauzo-Bravo, Y. Barral, S. Jessberger
Published in: Science, Issue 349/6254, 2015, Page(s) 1334-1338, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aac9868

A Fatty Acid Oxidation-Dependent Metabolic Shift Regulates Adult Neural Stem Cell Activity

Author(s): Marlen Knobloch, Gregor-Alexander Pilz, Bart Ghesquière, Werner J. Kovacs, Thomas Wegleiter, Darcie L. Moore, Martina Hruzova, Nicola Zamboni, Peter Carmeliet, Sebastian Jessberger
Published in: Cell Reports, Issue 20/9, 2017, Page(s) 2144-2155, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2017.08.029

Human Adult Neurogenesis: Evidence and Remaining Questions

Author(s): Gerd Kempermann, Fred H. Gage, Ludwig Aigner, Hongjun Song, Maurice A. Curtis, Sandrine Thuret, H. Georg Kuhn, Sebastian Jessberger, Paul W. Frankland, Heather A. Cameron, Elizabeth Gould, Rene Hen, D. Nora Abrous, Nicolas Toni, Alejandro F. Schinder, Xinyu Zhao, Paul J. Lucassen, Jonas Frisén
Published in: Cell Stem Cell, Issue 23/1, 2018, Page(s) 25-30, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2018.04.004

How stem cells remember their past

Author(s): Royall LN, Jessberger S
Published in: Current Opinion in Cell Biol, 2020, ISSN 0955-0674
Publisher: Elsevier BV
DOI: 10.1016/j.ceb.2020.12.008

Decline of Lamin B1 expression mediate age-dependent decreases of hippocampal stem cell activity

Author(s): Bin Imtiaz MK, Jaeger BN, Bottes S, Machado RAC, Vidmar M, Moore DL, Jessberger S
Published in: Cell Stem Cell, 2021, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.xpro.2021.100695