Periodic Reporting for period 3 - OPTOACOUSTOGENETICS (Hybrid Volumetric Optoacoustic-Ultrasound Tomography for Noninvasive Large-Scale Recording of Brain Activity with High Spatiotemporal Resolution)
Reporting period: 2019-01-01 to 2020-06-30
and metabolism. In the OPTOACOUSTOGENETICS project we embarked on a new technological development aimed at revolutionizing the way brain signaling is studied. In particular, a new generation of volumetric hybrid optoacoustic-ultrasound imaging technology is developed that can perform rapid volumetric imaging of neural activation in whole brains of rodents with spatial resolution approaching dimension of single neurons.
view containing millions of neurons. Furthermore, we will develop and test optimal markers for deep brain optoacoustic monitoring of neural activity excitable in the far-red and near-infrared spectral regions. Finally, we will establish ultimate sensitivity limits of the functional optoacoustic neuro-tomography when monitoring responses due to various stimuli in healthy and diseased animal models.