Objective EFSA recently prohibited 75% of insecticides to account for their toxicity and ecotoxicity. Moreover, the spread of insecticide resistance and invasion of Europe by new tropical vectors and pests require the development of alternative biological techniques.Recently, we hypothesized that shifting the vision of the sterile male from a sexual competitor only to a specific transporter of active biocides to the targeted female might boost the impact of the sterile insect technique (SIT). Here we want to demonstrate this concept using three biocides: Pyriproxifen, Bacillus thuringiensis and a Densovirus against the Tiger mosquito (Aedes albopictus). Pyriproxifen will also be tested against tsetse and fruit flies.We will test the technology both in the laboratory and at an operational scale and model the relative impacts of SIT and boosted-SIT on the dynamics of the targeted population. Moreover, we will compare the evolutionary response of the target population to these different control pressures (multiple lethal mutations, multiple lethal mutations + biocides), for three different biocides and three demographic strategies. This will generate breakthrough knowledge on the transmission of biocides and pathogens in insects and the sustainability of genetic control, provide a new control technique for mosquitoes, and improve the cost-effectiveness of SIT in tsetse and fruit flies.We will have to address technical issues associated to mass rearing, sterilization, sex separation and aerial release of mosquitoes as well as regulatory issues required for releasing sterile males coated with bioicides. Fields of science medical and health scienceshealth sciencesinfectious diseasesmalariaagricultural sciencesagriculture, forestry, and fisheriesagriculturehorticulturefruit growingsocial sciencessociologydemographyfertilitynatural sciencesbiological scienceszoologyentomologynatural sciencesbiological scienceszoologyinvertebrate zoology Programme(s) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Topic(s) ERC-CoG-2015 - ERC Consolidator Grant Call for proposal ERC-2015-CoG See other projects for this call Funding Scheme ERC-COG - Consolidator Grant Coordinator CENTRE DE COOPERATION INTERNATIONALE EN RECHERCHE AGRONOMIQUE POUR LEDEVELOPPEMENT - C.I.R.A.D. EPIC Net EU contribution € 1 355 109,75 Address Rue scheffer 42 75016 Paris France See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Beneficiaries (4) Sort alphabetically Sort by Net EU contribution Expand all Collapse all CENTRE DE COOPERATION INTERNATIONALE EN RECHERCHE AGRONOMIQUE POUR LEDEVELOPPEMENT - C.I.R.A.D. EPIC France Net EU contribution € 1 355 109,75 Address Rue scheffer 42 75016 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT France Net EU contribution € 495 371,25 Address Boulevard de dunkerque 44 cs 90009 13572 Marseille See on map Region Provence-Alpes-Côte d’Azur Provence-Alpes-Côte d’Azur Bouches-du-Rhône Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. UNIVERSITE DE MONTPELLIER France Net EU contribution € 142 800,00 Address 163 rue auguste broussonnet 34090 Montpellier See on map Region Occitanie Languedoc-Roussillon Hérault Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 THE FOOD AND AGRICULTURE ORGANIZATION OF THE UNITED NATIONS Italy Net EU contribution € 0,00 Address Viale delle terme di caracalla 00153 Roma See on map Region Centro (IT) Lazio Roma Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
