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Advanced Spectroscopy and Spectrometry for Imaging Metabolism using Isotopically-Labeled Endogenous Substrates


Thermal annihilation of photo-induced radicals following dynamic nuclear polarization to produce transportable frozen hyperpolarized 13C-substrates

Author(s): Andrea Capozzi, Tian Cheng, Giovanni Boero, Christophe Roussel, Arnaud Comment
Published in: Nature Communications, Issue 8, 2017, Page(s) 15757, ISSN 2041-1723
DOI: 10.1038/ncomms15757

Measuring glucose cerebral metabolism in the healthy mouse using hyperpolarized 13C magnetic resonance

Author(s): Mor Mishkovsky, Brian Anderson, Magnus Karlsson, Mathilde H. Lerche, A. Dean Sherry, Rolf Gruetter, Zoltan Kovacs, Arnaud Comment
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
DOI: 10.1038/s41598-017-12086-z

Photogenerated Radical in Phenylglyoxylic Acid for in Vivo Hyperpolarized 13 C MR with Photosensitive Metabolic Substrates

Author(s): Irene Marco-Rius, Tian Cheng, Adam P. Gaunt, Saket Patel, Felix Kreis, Andrea Capozzi, Alan J. Wright, Kevin M. Brindle, Olivier Ouari, Arnaud Comment
Published in: Journal of the American Chemical Society, Issue 140/43, 2018, Page(s) 14455-14463, ISSN 0002-7863
DOI: 10.1021/jacs.8b09326

Efficient Hyperpolarization of U- 13 C-Glucose Using Narrow-Line UV-Generated Labile Free Radicals

Author(s): Andrea Capozzi, Saket Patel, Christine Pepke Gunnarsson, Irene Marco-Rius, Arnaud Comment, Magnus Karlsson, Mathilde H. Lerche, Olivier Ouari, Jan Henrik Ardenkjaer-Larsen
Published in: Angewandte Chemie International Edition, Issue 58/5, 2019, Page(s) 1334-1339, ISSN 1433-7851
DOI: 10.1002/anie.201810522

Hyperpolarized 13 C Magnetic Resonance Spectroscopy Reveals the Rate-Limiting Role of the Blood–Brain Barrier in the Cerebral Uptake and Metabolism of l -Lactate in Vivo

Author(s): Yuhei Takado, Tian Cheng, Jessica A. M. Bastiaansen, Hikari A. I. Yoshihara, Bernard Lanz, Mor Mishkovsky, Sylvain Lengacher, Arnaud Comment
Published in: ACS Chemical Neuroscience, Issue 9/11, 2018, Page(s) 2554-2562, ISSN 1948-7193
DOI: 10.1021/acschemneuro.8b00066

Probing cardiac metabolism by hyperpolarized 13C MR using an exclusively endogenous substrate mixture and photo-induced nonpersistent radicals

Author(s): Jessica A. M. Bastiaansen, Hikari A. I. Yoshihara, Andrea Capozzi, Juerg Schwitter, Rolf Gruetter, Matthew E. Merritt, Arnaud Comment
Published in: Magnetic Resonance in Medicine, Issue 79/5, 2018, Page(s) 2451-2459, ISSN 0740-3194
DOI: 10.1002/mrm.27122

A multisample 7 T dynamic nuclear polarization polarizer for preclinical hyperpolarized MR

Author(s): Tian Cheng, Adam P. Gaunt, Irene Marco‐Rius, Marcel Gehrung, Albert P. Chen, Jacques J. Klink, Arnaud Comment
Published in: NMR in Biomedicine, Issue 33/5, 2020, Page(s) e4264, ISSN 0952-3480
DOI: 10.1002/nbm.4264

Noninvasive rapid detection of metabolic adaptation in activated human T lymphocytes by hyperpolarized 13C magnetic resonance

Author(s): Emine Can, Mor Mishkovsky, Hikari A. I. Yoshihara, Nicolas Kunz, Dominique-Laurent Couturier, Ulf Petrausch, Marie-Agnès Doucey, Arnaud Comment
Published in: Scientific Reports, Issue 10/1, 2020, Page(s) 200, ISSN 2045-2322
DOI: 10.1038/s41598-019-57026-1

In Vivo Hyperpolarized 13C MRS and MRI Applications

Author(s): Irene Marco‐Rius and Arnaud Comment
Published in: eMagRes, Issue Volume 7, 2018, Page(s) 167-177