Advanced Spectroscopy and Spectrometry for Imaging Metabolism using Isotopically-Labeled Endogenous Substrates

Project Information

ASSIMILES

Grant agreement ID: 682574

DOI 10.3030/682574

Project closed

EC signature date 10 August 2016

Start date 1 September 2016

End date 30 April 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 199 145,76

EU contribution € 2 199 145,76

Coordinated by

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

Publications

Book chapters (4)

Design Considerations for Implementing a Hyperpolarizer

Author(s): Arnaud Comment
Published in: Dynamic Hyperpolarized Nuclear Magnetic Resonance., Issue Handbook of Modern Biophysics., 2021, Page(s) 27–49, ISBN 978-3-030-55043-1
Publisher: Springer
DOI: 10.1007/978-3-030-55043-1_2

Hyperpolarised 13C magnetic resonance spectroscopic imaging

Author(s): Kevin Brindle, Arnaud Comment, Felix Kreis and Adam Gaunt
Published in: Imaging Modalities for Biological and Preclinical Research: A Compendium, Volume 2 Parts II–IV: In vivo preclinical imaging, multimodality imaging and outlook, Issue Chapter 11, 2021, Page(s) II.7.c-1 to II.7.c-8, ISBN 978-0-7503-3747-2
Publisher: IOP Publishing
DOI: 10.1088/978-0-7503-3747-2ch11

In Vivo Hyperpolarized 13C MRS and MRI Applications

Author(s): Irene Marco‐Rius and Arnaud Comment
Published in: eMagRes, Issue Volume 7, 2018, Page(s) 167-177
Publisher: John Wiley & Sons, Ltd.

Hardware for preparing HP 13C-molecules: from polarizer to patient

Author(s): Adam P. Gaunt and Arnaud Comment
Published in: Advances in Magnetic Resonance Technology and Applications, Issue 3, 2021, Page(s) 29-48, ISSN 2666-9099
Publisher: Academic Press
DOI: 10.1016/b978-0-12-822269-0.00002-6

Peer reviewed articles (12)

Labile photo-induced free radical in alpha-ketoglutaric acid: a universal endogenous polarizing agent for in vivo hyperpolarized 13C magnetic resonance

Author(s): Adam P. Gaunt; Jennifer S Lewis; Friederike Hesse; Tian Cheng; Irene Marco-Rius; Kevin M. Brindle; Arnaud Comment
Published in: Angewandte Chemie International Edition, Issue 61, 2022, Page(s) e202112982, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202112982

Thermal annihilation of photo-induced radicals following dynamic nuclear polarization to produce transportable frozen hyperpolarized 13C-substrates

Author(s): Andrea Capozzi, Tian Cheng, Giovanni Boero, Christophe Roussel, Arnaud Comment
Published in: Nature Communications, Issue 8, 2017, Page(s) 15757, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms15757

Measuring glucose cerebral metabolism in the healthy mouse using hyperpolarized 13C magnetic resonance

Author(s): Mor Mishkovsky, Brian Anderson, Magnus Karlsson, Mathilde H. Lerche, A. Dean Sherry, Rolf Gruetter, Zoltan Kovacs, Arnaud Comment
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-017-12086-z

Photogenerated Radical in Phenylglyoxylic Acid for in Vivo Hyperpolarized 13 C MR with Photosensitive Metabolic Substrates

Author(s): Irene Marco-Rius, Tian Cheng, Adam P. Gaunt, Saket Patel, Felix Kreis, Andrea Capozzi, Alan J. Wright, Kevin M. Brindle, Olivier Ouari, Arnaud Comment
Published in: Journal of the American Chemical Society, Issue 140/43, 2018, Page(s) 14455-14463, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.8b09326

Efficient Hyperpolarization of U- 13 C-Glucose Using Narrow-Line UV-Generated Labile Free Radicals

Author(s): Andrea Capozzi, Saket Patel, Christine Pepke Gunnarsson, Irene Marco-Rius, Arnaud Comment, Magnus Karlsson, Mathilde H. Lerche, Olivier Ouari, Jan Henrik Ardenkjaer-Larsen
Published in: Angewandte Chemie International Edition, Issue 58/5, 2019, Page(s) 1334-1339, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201810522

Hyperpolarized 13 C Magnetic Resonance Spectroscopy Reveals the Rate-Limiting Role of the Blood–Brain Barrier in the Cerebral Uptake and Metabolism of l -Lactate in Vivo

Author(s): Yuhei Takado, Tian Cheng, Jessica A. M. Bastiaansen, Hikari A. I. Yoshihara, Bernard Lanz, Mor Mishkovsky, Sylvain Lengacher, Arnaud Comment
Published in: ACS Chemical Neuroscience, Issue 9/11, 2018, Page(s) 2554-2562, ISSN 1948-7193
Publisher: American Chemical Society
DOI: 10.1021/acschemneuro.8b00066

Probing cardiac metabolism by hyperpolarized 13C MR using an exclusively endogenous substrate mixture and photo-induced nonpersistent radicals

Author(s): Jessica A. M. Bastiaansen, Hikari A. I. Yoshihara, Andrea Capozzi, Juerg Schwitter, Rolf Gruetter, Matthew E. Merritt, Arnaud Comment
Published in: Magnetic Resonance in Medicine, Issue 79/5, 2018, Page(s) 2451-2459, ISSN 0740-3194
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/mrm.27122

A multisample 7 T dynamic nuclear polarization polarizer for preclinical hyperpolarized MR

Author(s): Tian Cheng, Adam P. Gaunt, Irene Marco‐Rius, Marcel Gehrung, Albert P. Chen, Jacques J. Klink, Arnaud Comment
Published in: NMR in Biomedicine, Issue 33/5, 2020, Page(s) e4264, ISSN 0952-3480
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/nbm.4264

Noninvasive rapid detection of metabolic adaptation in activated human T lymphocytes by hyperpolarized 13C magnetic resonance

Author(s): Emine Can, Mor Mishkovsky, Hikari A. I. Yoshihara, Nicolas Kunz, Dominique-Laurent Couturier, Ulf Petrausch, Marie-Agnès Doucey, Arnaud Comment
Published in: Scientific Reports, Issue 10/1, 2020, Page(s) 200, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-57026-1

Noninvasive rapid detection of metabolic adaptation in activated human T lymphocytes by hyperpolarized 13C magnetic resonance.

Author(s): Can, Emine; Mishkovsky, Mor; Yoshihara, Hikari AI; Kunz, Nicolas; Couturier, Dominique; Petrausch, Ulf; Doucey, Marie-Agnès; Comment, Arnaud
Published in: Communications Biology, Issue 5, 2022, Page(s) 10, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s42003-021-02978-2

Probing hepatic metabolism of [2-13C]dihydroxyacetone in vivo with 1H-decoupled hyperpolarized 13C-MR.

Author(s): Irene Marco-Rius; Alan J. Wright; De-en Hu; Dragana Savic; Jack J. Miller; Kerstin N. Timm; Damian Tyler; Kevin M. Brindle; Arnaud Comment
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine, Issue 34, 2021, Page(s) 49–56, ISSN 1352-8661
Publisher: Springer
DOI: 10.1007/s10334-020-00884-y

Photochemistry of pyruvic acid is governed by photo-induced intermolecular electron transfer through hydrogen bonds

Author(s): Jennifer S. Lewis, Adam P. Gaunt, Arnaud Comment
Published in: Chemical Science, Issue 20416520, 2022, Page(s) 11849-11855, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2sc03038a