Advanced Spectroscopy and Spectrometry for Imaging Metabolism using Isotopically-Labeled Endogenous Substrates

Project Information

ASSIMILES

Grant agreement ID: 682574

DOI

10.3030/682574

Project closed

EC signature date 10 August 2016

Start date 1 September 2016

End date 30 April 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 199 145,76

EU contribution

€ 2 199 145,76

Coordinated by

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Book chapters (4)

Design Considerations for Implementing a Hyperpolarizer

Author(s): Arnaud Comment
Published in: Dynamic Hyperpolarized Nuclear Magnetic Resonance., Issue Handbook of Modern Biophysics., 2021, Page(s) 27–49, ISBN 978-3-030-55043-1
Publisher: Springer
DOI: 10.1007/978-3-030-55043-1_2

Hyperpolarised 13C magnetic resonance spectroscopic imaging

Author(s): Kevin Brindle, Arnaud Comment, Felix Kreis and Adam Gaunt
Published in: Imaging Modalities for Biological and Preclinical Research: A Compendium, Volume 2 Parts II–IV: In vivo preclinical imaging, multimodality imaging and outlook, Issue Chapter 11, 2021, Page(s) II.7.c-1 to II.7.c-8, ISBN 978-0-7503-3747-2
Publisher: IOP Publishing
DOI: 10.1088/978-0-7503-3747-2ch11

In Vivo Hyperpolarized 13C MRS and MRI Applications

Author(s): Irene Marco‐Rius and Arnaud Comment
Published in: eMagRes, Issue Volume 7, 2018, Page(s) 167-177
Publisher: John Wiley & Sons, Ltd.

Hardware for preparing HP 13C-molecules: from polarizer to patient

Author(s): Adam P. Gaunt and Arnaud Comment
Published in: Advances in Magnetic Resonance Technology and Applications, Issue 3, 2021, Page(s) 29-48, ISSN 2666-9099
Publisher: Academic Press
DOI: 10.1016/b978-0-12-822269-0.00002-6

Peer reviewed articles (12)

Labile photo-induced free radical in alpha-ketoglutaric acid: a universal endogenous polarizing agent for in vivo hyperpolarized 13C magnetic resonance

Author(s): Adam P. Gaunt; Jennifer S Lewis; Friederike Hesse; Tian Cheng; Irene Marco-Rius; Kevin M. Brindle; Arnaud Comment
Published in: Angewandte Chemie International Edition, Issue 61, 2022, Page(s) e202112982, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202112982

Thermal annihilation of photo-induced radicals following dynamic nuclear polarization to produce transportable frozen hyperpolarized 13C-substrates

Author(s): Andrea Capozzi, Tian Cheng, Giovanni Boero, Christophe Roussel, Arnaud Comment
Published in: Nature Communications, Issue 8, 2017, Page(s) 15757, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms15757

Measuring glucose cerebral metabolism in the healthy mouse using hyperpolarized 13C magnetic resonance

Author(s): Mor Mishkovsky, Brian Anderson, Magnus Karlsson, Mathilde H. Lerche, A. Dean Sherry, Rolf Gruetter, Zoltan Kovacs, Arnaud Comment
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-017-12086-z

Photogenerated Radical in Phenylglyoxylic Acid for in Vivo Hyperpolarized 13 C MR with Photosensitive Metabolic Substrates

Author(s): Irene Marco-Rius, Tian Cheng, Adam P. Gaunt, Saket Patel, Felix Kreis, Andrea Capozzi, Alan J. Wright, Kevin M. Brindle, Olivier Ouari, Arnaud Comment
Published in: Journal of the American Chemical Society, Issue 140/43, 2018, Page(s) 14455-14463, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.8b09326

Efficient Hyperpolarization of U- 13 C-Glucose Using Narrow-Line UV-Generated Labile Free Radicals

Author(s): Andrea Capozzi, Saket Patel, Christine Pepke Gunnarsson, Irene Marco-Rius, Arnaud Comment, Magnus Karlsson, Mathilde H. Lerche, Olivier Ouari, Jan Henrik Ardenkjaer-Larsen
Published in: Angewandte Chemie International Edition, Issue 58/5, 2019, Page(s) 1334-1339, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201810522

Hyperpolarized 13 C Magnetic Resonance Spectroscopy Reveals the Rate-Limiting Role of the Blood–Brain Barrier in the Cerebral Uptake and Metabolism of l -Lactate in Vivo

Author(s): Yuhei Takado, Tian Cheng, Jessica A. M. Bastiaansen, Hikari A. I. Yoshihara, Bernard Lanz, Mor Mishkovsky, Sylvain Lengacher, Arnaud Comment
Published in: ACS Chemical Neuroscience, Issue 9/11, 2018, Page(s) 2554-2562, ISSN 1948-7193
Publisher: American Chemical Society
DOI: 10.1021/acschemneuro.8b00066

Probing cardiac metabolism by hyperpolarized 13C MR using an exclusively endogenous substrate mixture and photo-induced nonpersistent radicals

Author(s): Jessica A. M. Bastiaansen, Hikari A. I. Yoshihara, Andrea Capozzi, Juerg Schwitter, Rolf Gruetter, Matthew E. Merritt, Arnaud Comment
Published in: Magnetic Resonance in Medicine, Issue 79/5, 2018, Page(s) 2451-2459, ISSN 0740-3194
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/mrm.27122

A multisample 7 T dynamic nuclear polarization polarizer for preclinical hyperpolarized MR

Author(s): Tian Cheng, Adam P. Gaunt, Irene Marco‐Rius, Marcel Gehrung, Albert P. Chen, Jacques J. Klink, Arnaud Comment
Published in: NMR in Biomedicine, Issue 33/5, 2020, Page(s) e4264, ISSN 0952-3480
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/nbm.4264

Noninvasive rapid detection of metabolic adaptation in activated human T lymphocytes by hyperpolarized 13C magnetic resonance

Author(s): Emine Can, Mor Mishkovsky, Hikari A. I. Yoshihara, Nicolas Kunz, Dominique-Laurent Couturier, Ulf Petrausch, Marie-Agnès Doucey, Arnaud Comment
Published in: Scientific Reports, Issue 10/1, 2020, Page(s) 200, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-57026-1

Noninvasive rapid detection of metabolic adaptation in activated human T lymphocytes by hyperpolarized 13C magnetic resonance.

Author(s): Can, Emine; Mishkovsky, Mor; Yoshihara, Hikari AI; Kunz, Nicolas; Couturier, Dominique; Petrausch, Ulf; Doucey, Marie-Agnès; Comment, Arnaud
Published in: Communications Biology, Issue 5, 2022, Page(s) 10, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s42003-021-02978-2

Probing hepatic metabolism of [2-13C]dihydroxyacetone in vivo with 1H-decoupled hyperpolarized 13C-MR.

Author(s): Irene Marco-Rius; Alan J. Wright; De-en Hu; Dragana Savic; Jack J. Miller; Kerstin N. Timm; Damian Tyler; Kevin M. Brindle; Arnaud Comment
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine, Issue 34, 2021, Page(s) 49–56, ISSN 1352-8661
Publisher: Springer
DOI: 10.1007/s10334-020-00884-y

Photochemistry of pyruvic acid is governed by photo-induced intermolecular electron transfer through hydrogen bonds

Author(s): Jennifer S. Lewis, Adam P. Gaunt, Arnaud Comment
Published in: Chemical Science, Issue 20416520, 2022, Page(s) 11849-11855, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2sc03038a