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Targeting TGF-β activation, likely the core mechanism of immunosuppression by human regulatory T cells.

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Publications

Cutting Edge: Active TGF-β1 Released from GARP/TGF-β1 Complexes on the Surface of Stimulated Human B Lymphocytes Increases Class-Switch Recombination and Production of IgA

Author(s): Olivier Dedobbeleer, Julie Stockis, Bas van der Woning, Pierre G. Coulie, Sophie Lucas
Published in: The Journal of Immunology, Issue 199/2, 2017, Page(s) 391-396, ISSN 0022-1767
DOI: 10.4049/jimmunol.1601882

Blocking immunosuppression by human Tregs in vivo with antibodies targeting integrin αVβ8

Author(s): Julie Stockis, Stéphanie Liénart, Didier Colau, Amandine Collignon, Stephen L. Nishimura, Dean Sheppard, Pierre G. Coulie, Sophie Lucas
Published in: Proceedings of the National Academy of Sciences, Issue 114/47, 2017, Page(s) E10161-E10168, ISSN 0027-8424
DOI: 10.1073/pnas.1710680114

Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cells

Author(s): Stéphanie Liénart, Romain Merceron, Christophe Vanderaa, Fanny Lambert, Didier Colau, Julie Stockis, Bas van der Woning, Hans De Haard, Michael Saunders, Pierre G. Coulie, Savvas N. Savvides, Sophie Lucas
Published in: Science, Issue 362/6417, 2018, Page(s) 952-956, ISSN 0036-8075
DOI: 10.1126/science.aau2909