Targeting TGF-β activation, likely the core mechanism of immunosuppression by human regulatory T cells.

Project Information

TARG-SUP

Grant agreement ID: 682818

DOI 10.3030/682818

Project closed

EC signature date 21 March 2016

Start date 1 April 2016

End date 31 March 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 993 125,00

EU contribution € 1 993 125,00

Coordinated by

UNIVERSITE CATHOLIQUE DE LOUVAIN
Belgium

Publications

Peer reviewed articles (4)

Cutting Edge: Active TGF-β1 Released from GARP/TGF-β1 Complexes on the Surface of Stimulated Human B Lymphocytes Increases Class-Switch Recombination and Production of IgA

Author(s): Olivier Dedobbeleer, Julie Stockis, Bas van der Woning, Pierre G. Coulie, Sophie Lucas
Published in: The Journal of Immunology, Issue 199/2, 2017, Page(s) 391-396, ISSN 0022-1767
Publisher: American Association of Immunologists
DOI: 10.4049/jimmunol.1601882

Blocking immunosuppression by human Tregs in vivo with antibodies targeting integrin αVβ8

Author(s): Julie Stockis, Stéphanie Liénart, Didier Colau, Amandine Collignon, Stephen L. Nishimura, Dean Sheppard, Pierre G. Coulie, Sophie Lucas
Published in: Proceedings of the National Academy of Sciences, Issue 114/47, 2017, Page(s) E10161-E10168, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1710680114

Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cells

Author(s): Stéphanie Liénart, Romain Merceron, Christophe Vanderaa, Fanny Lambert, Didier Colau, Julie Stockis, Bas van der Woning, Hans De Haard, Michael Saunders, Pierre G. Coulie, Savvas N. Savvides, Sophie Lucas
Published in: Science, Issue 362/6417, 2018, Page(s) 952-956, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aau2909

Selective inhibition of TGF-β1 produced by GARP-expressing Tregs overcomes resistance to PD-1/PD-L1 blockade in cancer

Author(s): Grégoire de Streel, Charlotte Bertrand, Nicolas Chalon, Stéphanie Liénart, Orian Bricard, Sara Lecomte, Julien Devreux, Mélanie Gaignage, Gitte De Boeck, Lore Mariën, Inge Van De Walle, Bas van der Woning, Michael Saunders, Hans de Haard, Elien Vermeersch, Wim Maes, Hans Deckmyn, Pierre G. Coulie, Nicolas van Baren, Sophie Lucas
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-17811-3