Periodic Reporting for period 3 - MitoVin (Mechanism and Consequences of the Interplay between Mitosis and Human Papillomavirus Initial Infection)
Reporting period: 2019-10-01 to 2021-03-31
Since infections of human papillomaviruses pose a severe health risk through the development of anogenital and oropharyngeal cancers, our work may allow the development of better preventative and possibly personalised treatment options.
The overall objectives aim at understanding of these human papillomaviruses infect cells under a variety of conditions, but also to experimentally establish systems that allow to study how viruses in general are impacted by physiological and pathophysiological changes that arise during our life time. The latter implies that besides our genetic background, the way our lives have been influences our susceptibility to viral infections, a feature that has been observed in epidemiological studies, but that remains mostly inaccessible to experimentation. But as long as we cannot understand the underlying cause for different susceptibility, we may not be able to protect ourselves from infections depending on our personal history.