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High level Integrated SEnsor for NanoToxicity Screening

Objective

The HISENTS vision is to address the problem of the dearth of high-quality tools for nano-safety assessment by introducing an innovative multimodular high throughput screening (HTP) platform including a set of individual modules each representing a critical physiological function connected and integrated in a hierarchical vectorial manner by a microfluidic network. The increase of the capacity to perform nano-safety assessment will be realised by innovative instrumentation developments for HTP and high content analysis (HCA) approaches. Toxicogenomics on chip is also one embedded objective. Our interdisciplinary approach focuses on tools to maximise the read-across and to assess applicable endpoints for advanced risk assessment of nanomaterials (NM). The main goal is thus to establish individual chip-based microfluidic tools as devices for (nano)toxicity screening which can be combined as an on-line HTP platform. Seven different chip-based sensor elements will be developed and hierarchically combined via a flow system to characterise toxicity pathways of NM. The HISENTS platform allows the grouping and identifying of NM. Parallel to the screening, the pathway and interaction of NM in biological organisms will be simulated using the physiologically based pharmacokinetic (PBPK) model. Using the different sensor modules from the molecular to cell to organ level, HISENTS can input quantitative parameters into the PBPK model resulting in an effective pathway analysis for NM and other critical compounds. The developed platform is crucial for realistic nano-safety assessment and will also find extensive application in pharmaceutical screening due to the flexible modifications of the HTP platform. The specific objective is the development of a multimodular HTP platform as new a screening tool for enhancing the efficiency of hazard profiling. Currently, no such flexible, easy-to-use screening platform with flexibly combinable chip-based sensors is available on the market.

Call for proposal

H2020-NMP-2014-2015

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Sub call

H2020-NMP-2015-two-stage

Coordinator

UNIVERSITY OF LEEDS
Net EU contribution
€ 1 411 205,00
Address
Woodhouse Lane
LS2 9JT Leeds
United Kingdom

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Region
Yorkshire and the Humber West Yorkshire Leeds
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (10)

FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV
Germany
Net EU contribution
€ 899 990,00
Address
Hansastrasse 27c
80686 Munchen

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Research Organisations
Non-EU contribution
€ 0,00
TEL AVIV UNIVERSITY
Israel
Net EU contribution
€ 631 875,00
Non-EU contribution
€ 0,00
Blueprint Product Design Ltd
United Kingdom
Net EU contribution
€ 500 050,00
Address
38 Market Street
BD21 5AD Keighley

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Yorkshire and the Humber West Yorkshire Bradford
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
SLOVENSKA TECHNICKA UNIVERZITA V BRATISLAVE
Slovakia
Net EU contribution
€ 508 745,00
Address
Vazovova 5
81243 Bratislava

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Region
Slovensko Bratislavský kraj Bratislavský kraj
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
TECHNISCHE UNIVERSITAET WIEN
Austria
Net EU contribution
€ 368 750,00
Address
Karlsplatz 13
1040 Wien

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Region
Wien Wien
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
BIOMEDICINSKE CENTRUM SLOVENSKEJ AKADEMIE VIED, VEREJNA VYSKUMNA INSTITUCIA
Slovakia
Net EU contribution
€ 300 000,00
Address
Dubravska Cesta 9
845 05 Bratislava

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Region
Slovensko Bratislavský kraj Bratislavský kraj
Activity type
Research Organisations
Non-EU contribution
€ 0,00
FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA
Spain
Net EU contribution
€ 341 250,00
Address
Campus De La Uab Edifici Q Icn2
08193 Bellaterra (Barcelona)

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Non-EU contribution
€ 0,00
UNIVERSITAT DES SAARLANDES
Germany
Net EU contribution
€ 270 000,00
Address
Campus
66123 Saarbrucken

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Region
Saarland Saarland Regionalverband Saarbrücken
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK
Ireland
Net EU contribution
€ 800 960,00
Address
Western Road
T12 YN60 Cork

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Region
Ireland Eastern and Midland Dublin
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
NILU STIFTELSEN NORSK INSTITUTT FORLUFTFORSKNING
Norway
Net EU contribution
€ 300 000,00
Address
Instituttveien 18
2027 Kjeller

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Region
Norge Oslo og Viken Viken
Activity type
Research Organisations
Non-EU contribution
€ 0,00