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Big Data and models for personalized Head and Neck Cancer Decision support

Objective

"Cancers of the Head and Neck Region (HNC) are the 6th more deadly cancers worldwide: in Europe ~150.000 new cases are detected and ~70.000 patients die every year. The main reasons for high mortality are the fact that the majority of cases are diagnosed in advanced Stage and the intrinsic heterogeneity of such tumors. At present the only adopted treatment decision method is based on TNM (Tumor-lymph-Nodes-Metastasis) prognostic system, that considers only a few risk factors such as smoking, alcohol abuse and more recently HPV. The TNM system is therefore inadequate to capture the patient-specific biomolecular characteristics of the tumor. HNC treatments can have hard impact on patient’s aesthetics and functionalities and, due to their toxicity, can cause severe morbidity and greatly deteriorate patient’s quality of life. A more precise prognostic prediction than the current TNM system is needed that allows implementing the first-line treatment that maximizes the therapeutic result and minimizes the impacts of therapy.
BD2Decide DSS provides clinicians with the ""means"" and all the necessary information to tailor treatment and care delivery pathway to each and any HNC patient during their usual practice, in contrast to current “one-size-fits-all approach”. BD2Decide realizes and validates an Integrated Decision Support System that links population-specific epidemiology and behavioral data, patient-specific genomic, pathology, clinical and imaging data with big data techniques, multiscale prognostic models. Advanced graphical visualization tools are developed for prognostic data disclosure and patient co-participation to the selected treatment. BD2Decide will improve the clinical decision process, uncover new patient-specific patterns that can improve care, and create a virtuous circle of learning. A multicentric clinical study with more than 1.000 patients will be used to validate the system.
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Call for proposal

H2020-PHC-2014-2015

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Sub call

H2020-PHC-2015-single-stage

Coordinator

AZIENDA OSPEDALIERO-UNIVERSITARIA DI PARMA
Net EU contribution
€ 464 375,00
Address
Via Gramsci 14
43100 Parma
Italy

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Region
Nord-Est Emilia-Romagna Parma
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Other funding
€ 464 375,00

Participants (12)

STICHTING VU

Participation ended

Netherlands
Net EU contribution
€ 0,00
Address
De Boelelaan 1105
1081 HV Amsterdam
Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
HEINRICH-HEINE-UNIVERSITAET DUESSELDORF
Germany
Net EU contribution
€ 338 750,00
Address
Universitaetsstrasse 1
40225 Dusseldorf

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Region
Nordrhein-Westfalen Düsseldorf Düsseldorf, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 338 750,00
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI
Italy
Net EU contribution
€ 815 000,00
Address
Via Venezian 1
20133 Milan

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Region
Nord-Ovest Lombardia Milano
Activity type
Research Organisations
Other funding
€ 815 000,00
UNIVERSIDAD POLITECNICA DE MADRID
Spain
Net EU contribution
€ 415 000,00
Address
Calle Ramiro De Maeztu 7 Edificio Rectorado
28040 Madrid

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Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Higher or Secondary Education Establishments
Other funding
€ 415 000,00
FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV
Germany
Net EU contribution
€ 321 375,00
Address
Hansastrasse 27c
80686 Munchen

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Research Organisations
Other funding
€ 321 375,00
ATHENS TECHNOLOGY CENTER ANONYMI VIOMICHANIKI EMPORIKI KAI TECHNIKI ETAIREIA EFARMOGON YPSILIS TECHNOLOGIAS
Greece
Net EU contribution
€ 342 000,00
Address
Rizareiou 10
15233 Athina

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Βόρειος Τομέας Αθηνών Aττική Αττική
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 342 000,00
ALL-IN-IMAGE LTD
Israel
Net EU contribution
€ 495 750,00
Address
Maskit 32
46733 Hertzelia

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 495 750,00
STICHTING MAASTRICHT RADIATION ONCOLOGY MAASTRO CLINIC
Netherlands
Net EU contribution
€ 373 062,50
Address
Dr. Tanslaan 12
6229 ET Maastricht

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Region
Limburg (NL) Zuid-Limburg
Activity type
Research Organisations
Other funding
€ 373 062,50
POLITECNICO DI MILANO
Italy
Net EU contribution
€ 308 750,00
Address
Piazza Leonardo Da Vinci 32
20133 Milano

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Region
Nord-Ovest Lombardia Milano
Activity type
Higher or Secondary Education Establishments
Other funding
€ 308 750,00
MULTIMED ENGINEERS SRL
Italy
Net EU contribution
€ 150 000,00
Address
Strada Felice Cavallotti 11
43121 Parma

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Nord-Est Emilia-Romagna Parma
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 150 000,00
UNIVERSITA DEGLI STUDI DI PARMA
Italy
Net EU contribution
€ 60 000,00
Address
Via Universita 12
43100 Parma

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Region
Nord-Est Emilia-Romagna Parma
Activity type
Higher or Secondary Education Establishments
Other funding
€ 60 000,00
STICHTING VUMC
Netherlands
Net EU contribution
€ 760 937,50
Address
De Boelelaan 1117
1081 HV Amsterdam

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Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Research Organisations
Other funding
€ 760 937,50