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Big Data and models for personalized Head and Neck Cancer Decision support

Objective

"Cancers of the Head and Neck Region (HNC) are the 6th more deadly cancers worldwide: in Europe ~150.000 new cases are detected and ~70.000 patients die every year. The main reasons for high mortality are the fact that the majority of cases are diagnosed in advanced Stage and the intrinsic heterogeneity of such tumors. At present the only adopted treatment decision method is based on TNM (Tumor-lymph-Nodes-Metastasis) prognostic system, that considers only a few risk factors such as smoking, alcohol abuse and more recently HPV. The TNM system is therefore inadequate to capture the patient-specific biomolecular characteristics of the tumor. HNC treatments can have hard impact on patient’s aesthetics and functionalities and, due to their toxicity, can cause severe morbidity and greatly deteriorate patient’s quality of life. A more precise prognostic prediction than the current TNM system is needed that allows implementing the first-line treatment that maximizes the therapeutic result and minimizes the impacts of therapy.
BD2Decide DSS provides clinicians with the ""means"" and all the necessary information to tailor treatment and care delivery pathway to each and any HNC patient during their usual practice, in contrast to current “one-size-fits-all approach”. BD2Decide realizes and validates an Integrated Decision Support System that links population-specific epidemiology and behavioral data, patient-specific genomic, pathology, clinical and imaging data with big data techniques, multiscale prognostic models. Advanced graphical visualization tools are developed for prognostic data disclosure and patient co-participation to the selected treatment. BD2Decide will improve the clinical decision process, uncover new patient-specific patterns that can improve care, and create a virtuous circle of learning. A multicentric clinical study with more than 1.000 patients will be used to validate the system.
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Field of science

  • /medical and health sciences/health sciences/epidemiology
  • /medical and health sciences/basic medicine/pathology
  • /natural sciences/computer and information sciences/data science/data analysis
  • /humanities/languages and literature/general language studies
  • /natural sciences/computer and information sciences/computer security/data protection
  • /humanities/philosophy, ethics and religion/philosophy/metaphysics/ontology
  • /medical and health sciences/clinical medicine/cancer/head and neck cancer
  • /social sciences/sociology/demography/mortality
  • /natural sciences/mathematics/applied mathematics/statistics and probability
  • /natural sciences/computer and information sciences/data science/big data
  • /social sciences/political science/political policy/civil society

Call for proposal

H2020-PHC-2015-single-stage
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

AZIENDA OSPEDALIERO-UNIVERSITARIA DI PARMA
Address
Via Gramsci 14
43100 Parma
Italy
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
EU contribution
€ 464 375

Participants (12)

STICHTING VU

Participation ended

Netherlands
EU contribution
€ 0
Address
De Boelelaan 1105
1081 HV Amsterdam
Activity type
Higher or Secondary Education Establishments
HEINRICH-HEINE-UNIVERSITAET DUESSELDORF
Germany
EU contribution
€ 338 750
Address
Universitaetsstrasse 1
40225 Dusseldorf
Activity type
Higher or Secondary Education Establishments
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI
Italy
EU contribution
€ 815 000
Address
Via Venezian 1
20133 Milan
Activity type
Research Organisations
UNIVERSIDAD POLITECNICA DE MADRID
Spain
EU contribution
€ 415 000
Address
Calle Ramiro De Maeztu 7 Edificio Rectorado
28040 Madrid
Activity type
Higher or Secondary Education Establishments
FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Germany
EU contribution
€ 321 375
Address
Hansastrasse 27C
80686 Munchen
Activity type
Research Organisations
ATHENS TECHNOLOGY CENTER ANONYMI BIOMICHANIKI EMPORIKI KAI TECHNIKI ETAIREIA EFARMOGON YPSILIS TECHNOLOGIAS
Greece
EU contribution
€ 342 000
Address
Rizareiou 10
152 33 Athina
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ALL-IN-IMAGE LTD
Israel
EU contribution
€ 495 750
Address
Maskit 32
46733 Hertzelia
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
STICHTING MAASTRICHT RADIATION ONCOLOGY MAASTRO CLINIC
Netherlands
EU contribution
€ 373 062,50
Address
Dr. Tanslaan 12
6229 ET Maastricht
Activity type
Research Organisations
POLITECNICO DI MILANO
Italy
EU contribution
€ 308 750
Address
Piazza Leonardo Da Vinci 32
20133 Milano
Activity type
Higher or Secondary Education Establishments
MULTIMED ENGINEERS SRL
Italy
EU contribution
€ 150 000
Address
Strada Felice Cavallotti 11
43121 Parma
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITA DEGLI STUDI DI PARMA
Italy
EU contribution
€ 60 000
Address
Via Universita 12
43100 Parma
Activity type
Higher or Secondary Education Establishments
STICHTING VUMC
Netherlands
EU contribution
€ 760 937,50
Address
De Boelelaan 1117
1081 HV Amsterdam
Activity type
Research Organisations