Objective Endometriosis (the presence of endometrial-like tissue or ‘lesions’ outside the uterus) is a chronic inflammatory disease affecting 6-10% of reproductive age women. It is associated with pelvic pain, painful periods, pain with sexual intercourse, and subfertility. The socioeconomic impacts of endometriosis are considerable. The recent WERF EndoCost study (a worldwide cost-of-illness study) reported that endometriosis reduced work productivity in 51% and negatively affected relationships in 50% of women with endometriosis. Current treatment options include invasive and repeated surgeries, or hormonal suppression with significant side effects analogous to a premature menopause. While several general concepts of the etiology of the disease such as retrograde menstruation, coelomic metaplasia, lymphovascular metastasis or the embryonic rest theory have been developed, the molecular mechanisms underlying the disease are currently still incompletely understood, hampering the development of efficient targeted therapies with limited side effects. MOMENDO utilizes the potential of an interdisciplinary consortium of leading world endometriosis experts to provide a deeper understanding of key molecular processes contributing to disease etiology and progression. By employing a wide range of experimental methods (biomarker and epigenetic studies on patient tissues, advanced animal models of the disease, proprietary atomic force microscopy for marker-free diagnostics) and novel and innovative conceptual approaches (adult stem cells, microRNAs, iron-induced inflammatory responses, novel endocrine concepts), MOMENDO will substantially contribute to a deeper understanding of the molecular mechanisms that explain the inflammatory pain associated with endometriosis and the persistent growth of endometriosis lesions. By combining the respective strengths of non-academic and clinical partners, MOMENDO expect to successfully translate these findings into novel therapeutic approaches. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverymedical and health scienceshealth sciencespublic healthmedical and health sciencesclinical medicinesurgerymedical and health scienceshealth sciencesinflammatory diseasesmedical and health sciencesmedical biotechnologycells technologiesstem cells Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.3. - Stimulating innovation by means of cross-fertilisation of knowledge Topic(s) MSCA-RISE-2015 - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) Call for proposal H2020-MSCA-RISE-2015 See other projects for this call Funding Scheme MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) Coordinator WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER Net EU contribution € 63 000,00 Address Schlossplatz 2 48149 Muenster Germany See on map Region Nordrhein-Westfalen Münster Münster, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (6) Sort alphabetically Sort by Net EU contribution Expand all Collapse all THE UNIVERSITY OF EDINBURGH United Kingdom Net EU contribution € 40 500,00 Address Old college, south bridge EH8 9YL Edinburgh See on map Region Scotland Eastern Scotland Edinburgh Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 KAROLINSKA INSTITUTET Sweden Net EU contribution € 81 000,00 Address Nobels vag 5 17177 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 CHARITE - UNIVERSITAETSMEDIZIN BERLIN Germany Net EU contribution € 54 000,00 Address Chariteplatz 1 10117 Berlin See on map Region Berlin Berlin Berlin Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 SEREND-IP GMBH Germany Net EU contribution € 13 500,00 Address Rostockweg 25 48147 Muenster See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Nordrhein-Westfalen Münster Münster, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 AQUILA BIOMEDICAL LIMITED United Kingdom Net EU contribution € 0,00 Address Nine the bioquarter EH16 4UX Edinburgh See on map Region Scotland Eastern Scotland Edinburgh Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 TERVISETEHNOLOOGIATE ARENDUSKESKUS AS Estonia Net EU contribution € 94 500,00 Address Teaduspargi tn 13 50411 Tartu See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Eesti Eesti Lõuna-Eesti Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Partners (2) Sort alphabetically Sort by Net EU contribution Expand all Collapse all Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (CONICET) Argentina Net EU contribution € 0,00 Address Godoy cruz 2290 C1425FQB Buenos aires See on map Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 58 500,00 Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. UNIVERSIDAD DE CHILE Chile Net EU contribution € 0,00 Address Av. libertador bernardo o'higgins 1058 10 Santiago See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 13 500,00
