Periodic Reporting for period 3 - LEAPS (Light effected autonomous molecular pumps: Towards active transporters and actuating materials)
Reporting period: 2019-10-01 to 2021-03-31
In the past two decades, the progress in several areas of chemistry, together with an improved understanding of biomolecular machines, has led to the development of a large variety of wholly synthetic molecular machines. Although these systems have the potential to bring about radical innovations in several areas of technology and medicine, a significant research effort still needs to be done to make molecular devices that can effectively and continuously convert energy from a source into directed motion, and use such motion to carry out a useful task.
The goal of the LEAPS project is to make new prototypes of molecular motors powered by light energy, and to use them to perform functions that include controlled transport of molecules at the nanometer scale, and mechanical actuation at the macroscopic scale. These systems are rationally designed on the evolution of previously reported working prototypes, and are based on synthetically affordable compounds.
The demonstration of such functionalities would not only be a landmark accomplishment in chemistry and nanoscience, but also open up stimulating scenarios in nanotechnology, materials science, and nanomedicine. On the one hand, the development of artificial nanomotors that can use light energy to displace molecules can lead to radically new routes for solar energy conversion and medical phototherapies. On the other hand, devising novel photosensitive materials capable of macroscopic mechanical actuation has evident technological significance in fields such as robotics and prosthetics. Reaching these goals will constitute significant steps forward towards the real-world exploitation of chemical systems that, until just a few years ago, were considered no more than laboratory curiosities.
The LEAPS team has published 26 peer-reviewed publications, and a popular science book on molecular machines has been realized (open access). The project results have been presented in more than 85 lectures and poster presentations in national/international conferences, workshops, schools and public events. Renowned experts in the field have been invited to give seminars in our institute, and an international scientific workshop on “Light-activated nanostructures” (free registration) has been organized. Moreover, the "Molecular Machines Days" - a series of public events with the participation of the three Nobel Laureates in Chemistry 2016 - have been held in Bologna in November 2018. All the details are available in the LEAPS web site (https://site.unibo.it/leaps/en).
Another significant achievement of the project is its contribution to the setup of a joint research laboratory between the University of Bologna and the National Research Council of Italy. This lab, called Center for Light Activated Nanostructures (CLAN), aims at becoming a center of excellence for research in photochemical nanosciences in Europe. Visit https://centri.unibo.it/clan/en.
Another significant result of the project is the demonstration that the ring shuttling motion in rotaxanes can lead to new and potentially useful functions, such as the transfer of chemical information between two distant sites (PNAS 2018), the control of mechanical chirality and chiral anion recognition (JACS 2019), and frustrated ring-axle systems (JACS 2021). Possibilities emerge not only for the rational design of species with tailor-made functional and structural properties, but also for the development of model systems to understand some of Nature’s most effective regulatory mechanisms, namely, allostery, proton-coupled electron transfer and enantioselective molecular recognition.