Precision Multi-Spectral Optoacoustic Tomography for Discovery Diagnosis and Intervention

Publications

Peer reviewed articles (36)

Optoacoustic mesoscopy shows potential to increase accuracy of allergy patch testing

Author(s): Benedikt Hindelang, Juan Aguirre, Andrei Berezhnoi, Hailong He, Kilian Eyerich, Vasilis Ntziachristos, Tilo Biedermann, Ulf Darsow
Published in: Contact Dermatitis, 83/3, 2020, Page(s) 206-214, ISSN 0105-1873
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/cod.13563

Spatial heterogeneity of oxygenation and haemodynamics in breast cancer resolved in vivo by conical multispectral optoacoustic mesoscopy

Author(s): Jiao Li, Andrei Chekkoury, Jaya Prakash, Sarah Glasl, Paul Vetschera, Benno Koberstein-Schwarz, Ivan Olefir, Vipul Gujrati, Murad Omar, Vasilis Ntziachristos
Published in: Light: Science & Applications, 9/1, 2020, ISSN 2047-7538
Publisher: Nature Publishing Group
DOI: 10.1038/s41377-020-0295-y

Deep Learning-Based Spectral Unmixing for Optoacoustic Imaging of Tissue Oxygen Saturation

Author(s): Ivan Olefir, Stratis Tzoumas, Courtney Restivo, Pouyan Mohajerani, Lei Xing, Vasilis Ntziachristos
Published in: IEEE Transactions on Medical Imaging, 39/11, 2020, Page(s) 3643-3654, ISSN 0278-0062
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tmi.2020.3001750

A submicrometre silicon-on-insulator resonator for ultrasound detection

Author(s): Rami Shnaiderman, Georg Wissmeyer, Okan Ülgen, Qutaiba Mustafa, Andriy Chmyrov, Vasilis Ntziachristos
Published in: Nature, 585/7825, 2020, Page(s) 372-378, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2685-y

Low-cost single-point optoacoustic sensor for spectroscopic measurement of local vascular oxygenation

Author(s): Antonios Stylogiannis, Lucas Riobo, Ludwig Prade, Sarah Glasl, Sabine Klein, Giulia Lucidi, Martin Fuchs, Dieter Saur, Vasilis Ntziachristos
Published in: Optics Letters, 45/24, 2020, Page(s) 6579, ISSN 0146-9592
Publisher: Optical Society of America
DOI: 10.1364/ol.412034

Silicon‐Photonics Point Sensor for High‐Resolution Optoacoustic Imaging

Author(s): Rami Shnaiderman, Qutaiba Mustafa, Okan Ülgen, Georg Wissmeyer, Héctor Estrada, Daniel Razansky, Andriy Chmyrov, Vasilis Ntziachristos
Published in: Advanced Optical Materials, 2021, Page(s) 2100256, ISSN 2195-1071
Publisher: John Wiley & Sons, Inc.
DOI: 10.1002/adom.202100256

A sparse deep learning approach for automatic segmentation of human vasculature in multispectral optoacoustic tomography

Author(s): Nikolaos-Kosmas Chlis, Angelos Karlas, Nikolina-Alexia Fasoula, Michael Kallmayer, Hans-Henning Eckstein, Fabian J. Theis, Vasilis Ntziachristos, Carsten Marr
Published in: Photoacoustics, 20, 2020, Page(s) 100203, ISSN 2213-5979
Publisher: Elsevier GmbH
DOI: 10.1016/j.pacs.2020.100203

Multicompartmental non-invasive sensing of postprandial lipemia in humans with multispectral optoacoustic tomography

Author(s): Nikolina-Alexia Fasoula, Angelos Karlas, Michael Kallmayer, Anamaria Beatrice Milik, Jaroslav Pelisek, Hans-Henning Eckstein, Martin Klingenspor, Vasilis Ntziachristos
Published in: Molecular Metabolism, 47, 2021, Page(s) 101184, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2021.101184

Multispectral optoacoustic tomography of peripheral arterial disease based on muscle hemoglobin gradients—a pilot clinical study

Author(s): Angelos Karlas, Max Masthoff, Michael Kallmayer, Anne Helfen, Michail Bariotakis, Nikolina Alexia Fasoula, Michael Schäfers, Max Seidensticker, Hans-Henning Eckstein, Vasilis Ntziachristos, Moritz Wildgruber
Published in: Annals of Translational Medicine, 9/1, 2021, Page(s) 36-36, ISSN 2305-5839
Publisher: AME Publishing Company
DOI: 10.21037/atm-20-3321

Three-dimensional optoacoustic imaging of nailfold capillaries in systemic sclerosis and its potential for disease differentiation using deep learning

Author(s): Suhanyaa Nitkunanantharajah, Katja Haedicke, Tonia B. Moore, Joanne B. Manning, Graham Dinsdale, Michael Berks, Christopher Taylor, Mark R. Dickinson, Dominik Jüstel, Vasilis Ntziachristos, Ariane L. Herrick, Andrea K. Murray
Published in: Scientific Reports, 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-73319-2

Multispectral optoacoustic tomography of muscle perfusion and oxygenation under arterial and venous occlusion: A human pilot study

Author(s): Angelos Karlas, Michael Kallmayer, Nikolina‐Alexia Fasoula, Evangelos Liapis, Michail Bariotakis, Markus Krönke, Maria Anastasopoulou, Josefine Reber, Hans‐Henning Eckstein, Vasilis Ntziachristos
Published in: Journal of Biophotonics, 13/6, 2020, ISSN 1864-063X
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/jbio.201960169

Croconaine-based nanoparticles enable efficient optoacoustic imaging of murine brain tumors

Author(s): Nian Liu, Vipul Gujrati, Jaber Malekzadeh-Najafabadi, Juan Pablo Fuenzalida Werner, Uwe Klemm, Longguang Tang, Zhenyue Chen, Jaya Prakash, Yuanhui Huang, Andre Stiel, Gabriele Mettenleiter, Michaela Aichler, Andreas Blutke, Axel Walch, Karin Kleigrewe, Daniel Razansky, Michael Sattler, Vasilis Ntziachristos
Published in: Photoacoustics, 22, 2021, Page(s) 100263, ISSN 2213-5979
Publisher: Elsevier GmbH
DOI: 10.1016/j.pacs.2021.100263

Optoacoustic imaging in endocrinology and metabolism

Author(s): Angelos Karlas, Miguel A. Pleitez, Juan Aguirre, Vasilis Ntziachristos
Published in: Nature Reviews Endocrinology, 17/6, 2021, Page(s) 323-335, ISSN 1759-5029
Publisher: Nature Publishing Group
DOI: 10.1038/s41574-021-00482-5

Soft ultrasound priors in optoacoustic reconstruction: Improving clinical vascular imaging

Author(s): Hong Yang, Dominik Jüstel, Jaya Prakash, Angelos Karlas, Anne Helfen, Max Masthoff, Moritz Wildgruber, Vasilis Ntziachristos
Published in: Photoacoustics, 19, 2020, Page(s) 100172, ISSN 2213-5979
Publisher: Elsevier GmbH
DOI: 10.1016/j.pacs.2020.100172

Individual transducer impulse response characterization method to improve image quality of array-based handheld optoacoustic tomography

Author(s): Kaushik Basak Chowdhury, Maximilian Bader, Christoph Dehner, Dominik Jüstel, Vasilis Ntziachristos
Published in: Optics Letters, 46/1, 2021, Page(s) 1, ISSN 0146-9592
Publisher: Optical Society of America
DOI: 10.1364/ol.412661

Spectral unmixing techniques for optoacoustic imaging of tissue pathophysiology

Author(s): Stratis Tzoumas, Vasilis Ntziachristos
Published in: Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 375/2107, 2017, Page(s) 20170262, ISSN 1364-503X
Publisher: Royal Society of London
DOI: 10.1098/rsta.2017.0262

Flow-mediated dilatation test using optoacoustic imaging: a proof-of-concept

Author(s): Angelos Karlas, Josefine Reber, Gael Diot, Dmitry Bozhko, Maria Anastasopoulou, Tareq Ibrahim, Markus Schwaiger, Fabien Hyafil, Vasilis Ntziachristos
Published in: Biomedical Optics Express, 8/7, 2017, Page(s) 3395, ISSN 2156-7085
Publisher: The Optical Society
DOI: 10.1364/boe.8.003395

Assessing nailfold microvascular structure with ultra-wideband raster-scan optoacoustic mesoscopy

Author(s): J. Aguirre, B. Hindelang, Andrei Berezhnoi, U. Darsow, F. Lauffer, K. Eyerich, T. Biedermann, V. Ntziachristos
Published in: Photoacoustics, 10, 2018, Page(s) 31-37, ISSN 2213-5979
Publisher: Elsevier GmbH
DOI: 10.1016/j.pacs.2018.02.002

Assessing hyperthermia-induced vasodilation in human skin in vivo using optoacoustic mesoscopy

Author(s): Andrei Berezhnoi, Mathias Schwarz, Andreas Buehler, Saak V. Ovsepian, Juan Aguirre, Vasilis Ntziachristos
Published in: Journal of Biophotonics, 2018, Page(s) e201700359, ISSN 1864-063X
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/jbio.201700359

Maximum Entropy Based Non-Negative Optoacoustic Tomographic Image Reconstruction

Author(s): Jaya Prakash, Subhamoy Mandal, Daniel Razansky, Vasilis Ntziachristos
Published in: IEEE Transactions on Biomedical Engineering, 66/9, 2019, Page(s) 2604-2616, ISSN 0018-9294
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tbme.2019.2892842

Motion Quantification and Automated Correction in Clinical RSOM

Author(s): Juan Aguirre, Andrei Berezhnoi, Hailong He, Mathias Schwarz, Benedikt Hindelang, Murad Omar, Vasilis Ntziachristos
Published in: IEEE Transactions on Medical Imaging, 38/6, 2019, Page(s) 1340-1346, ISSN 0278-0062
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tmi.2018.2883154

Cardiovascular optoacoustics: From mice to men – A review

Author(s): Angelos Karlas, Nikolina-Alexia Fasoula, Korbinian Paul-Yuan, Josefine Reber, Michael Kallmayer, Dmitry Bozhko, Markus Seeger, Hans-Henning Eckstein, Moritz Wildgruber, Vasilis Ntziachristos
Published in: Photoacoustics, 14, 2019, Page(s) 19-30, ISSN 2213-5979
Publisher: Elsevier GmbH
DOI: 10.1016/j.pacs.2019.03.001

Skin surface detection in 3D optoacoustic mesoscopy based on dynamic programming

Author(s): Suhanyaa Nitkunanantharajah, Guillaume Zahnd, Malini Olivo, Nassir Navab, Pouyan Mohajerani, Vasilis Ntziachristos
Published in: IEEE Transactions on Medical Imaging, 2019, Page(s) 1-1, ISSN 0278-0062
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tmi.2019.2928393

Fully automated identification of skin morphology in raster‐scan optoacoustic mesoscopy using artificial intelligence

Author(s): Serafeim Moustakidis, Murad Omar, Juan Aguirre, Pouyan Mohajerani, Vasilis Ntziachristos
Published in: Medical Physics, 2019, ISSN 0094-2405
Publisher: American Association of Physicists in Medicine
DOI: 10.1002/mp.13725

Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes

Author(s): Christoffer Clemmensen, Sigrid Jall, Maximilian Kleinert, Carmelo Quarta, Tim Gruber, Josefine Reber, Stephan Sachs, Katrin Fischer, Annette Feuchtinger, Angelos Karlas, Stephanie E. Simonds, Gerald Grandl, Daniela Loher, Eva Sanchez-Quant, Susanne Keipert, Martin Jastroch, Susanna M. Hofmann, Emmani B. M. Nascimento, Patrick Schrauwen, Vasilis Ntziachristos, Michael A. Cowley, Brian Finan, Timo D
Published in: Nature Communications, 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-06769-y

Bioengineered bacterial vesicles as biological nano-heaters for optoacoustic imaging

Author(s): Vipul Gujrati, Jaya Prakash, Jaber Malekzadeh-Najafabadi, Andre Stiel, Uwe Klemm, Gabriele Mettenleiter, Michaela Aichler, Axel Walch, Vasilis Ntziachristos
Published in: Nature Communications, 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-09034-y

Emerging Technologies to Image Tissue Metabolism

Author(s): Vasilis Ntziachristos, Miguel A. Pleitez, Silvio Aime, Kevin M. Brindle
Published in: Cell Metabolism, 29/3, 2019, Page(s) 518-538, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2018.09.004

Characterization of Brown Adipose Tissue in a Diabetic Mouse Model with Spiral Volumetric Optoacoustic Tomography

Author(s): Avihai Ron, Xosé Luís Deán-Ben, Josephine Reber, Vasilis Ntziachristos, Daniel Razansky
Published in: Molecular Imaging and Biology, 21/4, 2019, Page(s) 620-625, ISSN 1536-1632
Publisher: Elsevier BV
DOI: 10.1007/s11307-018-1291-y

Non‐invasive imaging in dermatology and the unique potential of raster‐scan optoacoustic mesoscopy

Author(s): B. Hindelang, J. Aguirre, M. Schwarz, A. Berezhnoi, K. Eyerich, V. Ntziachristos, T. Biedermann, U. Darsow
Published in: Journal of the European Academy of Dermatology and Venereology, 33/6, 2019, Page(s) 1051-1061, ISSN 0926-9959
Publisher: Elsevier BV
DOI: 10.1111/jdv.15342

Label-free metabolic imaging by mid-infrared optoacoustic microscopy in living cells

Author(s): Miguel A. Pleitez, Asrar Ali Khan, Alice Soldà, Andriy Chmyrov, Josefine Reber, Francesca Gasparin, Markus R. Seeger, Benedikt Schätz, Stephan Herzig, Marcel Scheideler, Vasilis Ntziachristos
Published in: Nature Biotechnology, 2019, ISSN 1087-0156
Publisher: Nature Publishing Group
DOI: 10.1038/s41587-019-0359-9

Fluorescence imaging reversion using spatially variant deconvolution

Author(s): Maria Anastasopoulou, Dimitris Gorpas, Maximilian Koch, Evangelos Liapis, Sarah Glasl, Uwe Klemm, Angelos Karlas, Tobias Lasser, Vasilis Ntziachristos
Published in: Scientific Reports, 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-54578-0

Assessment of hessian-based Frangi vesselness filter in optoacoustic imaging

Author(s): Antonia Longo, Stefan Morscher, Jaber Malekzadeh Najafababdi, Dominik Jüstel, Christian Zakian, Vasilis Ntziachristos
Published in: Photoacoustics, 20, 2020, Page(s) 100200, ISSN 2213-5979
Publisher: Elsevier GmbH
DOI: 10.1016/j.pacs.2020.100200

A Synthetic Total Impulse Response Characterization Method for Correction of Hand-Held Optoacoustic Images

Author(s): Kaushik Basak Chowdhury, Jaya Prakash, Angelos Karlas, Dominik Justel, Vasilis Ntziachristos
Published in: IEEE Transactions on Medical Imaging, 39/10, 2020, Page(s) 3218-3230, ISSN 0278-0062
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tmi.2020.2989236

Chemotherapeutic effects on breast tumor hemodynamics revealed by eigenspectra multispectral optoacoustic tomography (eMSOT)

Author(s): Evangelos Liapis, Angelos Karlas, Uwe Klemm, Vasilis Ntziachristos
Published in: Theranostics, 11/16, 2021, Page(s) 7813-7828, ISSN 1838-7640
Publisher: Ivyspring International Publisher
DOI: 10.7150/thno.56173

Multispectral optoacoustic tomography of lipid and hemoglobin contrast in human carotid atherosclerosis

Author(s): Angelos Karlas, Michael Kallmayer, Michael Bariotakis, Nikolina-Alexia Fasoula, Evangelos Liapis, Fabien Hyafil, Jaroslav Pelisek, Moritz Wildgruber, Hans-Henning Eckstein, Vasilis Ntziachristos
Published in: Photoacoustics, 23, 2021, Page(s) 100283, ISSN 2213-5979
Publisher: Elsevier GmbH
DOI: 10.1016/j.pacs.2021.100283

Facile Synthesis of a Croconaine‐Based Nanoformulation for Optoacoustic Imaging and Photothermal Therapy

Author(s): Nian Liu, Patrick O'Connor, Vipul Gujrati, Dimitris Gorpas, Sarah Glasl, Andreas Blutke, Axel Walch, Karin Kleigrewe, Michael Sattler, Oliver Plettenburg, Vasilis Ntziachristos
Published in: Advanced Healthcare Materials, 10/9, 2021, Page(s) 2002115, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202002115

Other (8)

Machine-Learning Powered Optoacoustic Sensor for Diabetes Progression

Author(s): Pouyan Mohajerani, Juan Aguirre, Murad Omar, Hailong He, Angelos Karlas, Nikolina-Alexia Fasoula, Jessica Lutz, Michael Kallmayer, Hans-Henning Eckstein, Anette-Gabriele Ziegler, Martin Füchtenbusch, Vasilis Ntziachristos
Published in: medRxiv, 2021
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2021.03.17.21253779

Optoacoustic skin mesoscopy opens a window to systemic effects of diabetes

Author(s): Hailong He, Nikolina-Alexia Fasoula, Angelos Karlas, Murad Omar, Juan Aguirre, Jessica Lutz, Michael Kallmayer, Martin Füchtenbusch, Hans-Henning Eckstein, Anette-Gabriele Ziegler, Vasilis Ntziachristos
Published in: medXriv, 2020
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2020.06.29.20142273

Deep learning based electrical noise removal enables high spectral optoacoustic contrast in deep tissue

Author(s): Dehner, Christoph; Olefir, Ivan; Chowdhury, Kaushik Basak; Jüstel, Dominik; Ntziachristos, Vasilis
Published in: arXiv, 9, 2021
Publisher: Cornell Tech

Mid-infrared optoacoustic microscopy with label-free chemical contrast in living cells and tissues

Author(s): Miguel A. Pleitez, Asrar Ali Khan, Josefine Reber, Andriy Chmyrov, Markus R. Seeger, Stephan Herzig, Marcel Scheideler, Vasilis Ntziachristos
Published in: bioRxiv, February 22, 2018, 2018
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/270082

A Sparse Deep Learning Approach for Automatic Segmentation of Human Vasculature in Multispectral Optoacoustic Tomography

Author(s): Nikolaos-Kosmas Chlis, Angelos Karlas, Nikolina-Alexia Fasoula, Michael Kallmayer, Hans-Henning Eckstein, Fabian J Theis, Vasilis Ntziachristos, Carsten Marr
Published in: bioRxiv, doi: https://doi.org/10.1101/833251, 2019
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/833251

Disentangling the frequency content in optoacoustics

Author(s): Antonia Longo, Dominik Jüstel, Vasilis Ntziachristos
Published in: arXiv, arXiv:2104.14966, 2021
Publisher: Cornell University

Frequency Comb Optoacoustic Tomography

Author(s): Antonios Stylogiannis, Ludwig Prade, Sarah Glasl, Qutaiba Mustafa, Christian Zakian, Vasilis Ntziachristos
Published in: bioRxiv, 2021
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2021.05.12.443808

Functional multispectral optoacoustic tomography imaging of hepatic steatosis development in mice

Author(s): Shan Huang, Andreas Blutke, Annette Feuchtinger, Uwe Klemm, Robby Zachariah Tom, Susanna Hofmann, Andre C. Stiel, Vasilis Ntziachristos
Published in: bioRxiv, 2020
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2020.12.17.419531

Conference proceedings (1)

Non-invasive in-vivo sensing of metabolites with a novel optoacoustic spectroscope in the SWIR

Author(s): M. Mehdi Seyedebrahimi, Miguel Pleitez, Pouyan Mohajerani, Vasilis Ntziachristos
Published in: Opto-Acoustic Methods and Applications in Biophotonics IV, 2019, Page(s) 53, ISBN 9781-510628489
Publisher: SPIE
DOI: 10.1117/12.2531625