Objective Nitrogen-containing molecules are among the most important class of compounds due to their relevance as medicines, agrochemicals, organic materials and dyes. Nitrogen-centered-radicals are a class of very versatile synthetic intermediates with great potential in the synthesis of N-containing molecules. However, to date, difficulties associated to their generation have severely limited their use and exploitation. Here we propose the development of two conceptually novel and general ways to prepare Nitrogen-centered radicals using visible light as sustainable and inexpensive source of energy. These processes will capitalize on recent developments in the host group that has disclosed the use of easy-to-make aryl oximes for the organocatalytic generation of iminyl radicals. This proposal seeks to substantially expand this visible light chemistry through the development of methods for the generation and use of any known Nitrogen-centered radical. The power of this approach will be demonstrated by the short synthesis of the complex molecule legionaminic acid, responsible for the spread of hospital-acquired infections. Furthermore, these methods will be integrated with other reaction platforms that, taking advantage of visible light as source of energy, will engage the Nitrogen-centered radical in new reactivity modes, to allow novel and powerful multicomponent reactions.Through the use of this strategy, the rapid construction of many relevant and complex N-containing molecules will be possible.The development of such an innovative and ambitious project at the University of Manchester will be facilitated by generating, transferring, sharing and disseminating knowledge, and will enhance my career development following the training plan envisioned. Fields of science natural scienceschemical sciencescatalysisphotocatalysismedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsnatural scienceschemical sciencesphysical chemistryphotochemistrynatural scienceschemical sciencesorganic chemistryhydrocarbonsnatural scienceschemical sciencesorganic chemistryamines Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Topic(s) MSCA-IF-2015-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Call for proposal H2020-MSCA-IF-2015 See other projects for this call Funding Scheme MSCA-IF-EF-ST - Standard EF Coordinator THE UNIVERSITY OF MANCHESTER Net EU contribution € 183 454,80 Address OXFORD ROAD M13 9PL Manchester United Kingdom See on map Region North West (England) Greater Manchester Manchester Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 183 454,80
