Objective
Genome-wide association studies (GWAS) for complex traits, including glycaemia, type 2 diabetes (T2D) and coronary heart disease (CHD) have been successful in identifying genetic variants associated with those phenotypes. However, they explained only a small proportion of the estimated heritability. Possible reasons include the interplay between genetics and lifestyle determinants, small-effect variants, structural variations and the difficult to characterize non-coding functional variants that interact with other genetic regions. This proposal, in a new era of precision medicine, englobes the systematic study of the interplay between genetic variants associated with glycaemia, T2D, CHD and dietary and lifestyle factors. We propose to conduct a comprehensive analysis of gene and gene-lifestyle interaction, including the existing international GWAS consortia of CARDIoGRAM, DIAGRAM, MAGIC, the U.S. based DPP clinical trial, and the European-wide networks of EPIC-InterAct and PREDIMED. We will test hypothesis about: 1) whether genetically driven hyperglycaemia increases risk of CHD, 2) the association between genetic determinants of CHD and intermediate metabolic phenotypes, and 3) whether dietary components and lifestyle changes influence these associations. Finally, we will extend and replicate these previous results in two independent populations, and to deploy a new method to identify implicated biological pathways. Information that will emerge from that project will provide valuable insights into missing heritability for T2D and CHD. Specifically we expect to uncover genetic determinants for faster CHD progression in T2D, identifying vulnerable individuals who are more likely to experience a differential response to current prevention strategies and to validate potential targets and avenues for intervention. The experienced researcher will emerged from the project with new skills, and the capability to launch his own research group in Europe.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences health sciences public health
- medical and health sciences basic medicine physiology pathophysiology
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences clinical medicine cardiology cardiovascular diseases
- medical and health sciences health sciences personalized medicine
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-GF - Global Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2015
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
43003 Tarragona
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.