Objective
The bacterial cell cycle is of fundamental importance and an important potential antibiotic target; however, many details of
the molecular mechanisms involved remain elusive. Sporulation in Bacillus subtilis is an important model system for cell
cycle studies. Here, I propose applying the ribosome profiling method, not only to identify novel factors involved in the of B.
subtilis cell cycle, but also to create a map of factors regulating this process. I will use advanced genetic methods and
microscopic techniques to characterize the functions of the novel factors, gaining insights into their role in the cell cycle. My
extensive experience in prokaryotic translation gained in the laboratory of Dr. Daniel Wilson in Munich, Germany, combined
with the exceptional genetics and cell biology expertise of the laboratory of Prof. Jeff Errington in Newcastle, England,
creates a great opportunity to study important fundamental aspects of bacteria, with potential implications for healthcare,
drug discovery and industrial biotechnology, as well as providing the foundation for a successful independent career in
science.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
- natural sciencesbiological sciencesmicrobiologybacteriology
- natural sciencesbiological sciencescell biology
- medical and health sciencesbasic medicinephysiology
- natural sciencesbiological sciencesgeneticschromosomes
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes
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Programme(s)
Funding Scheme
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)Coordinator
NE1 7RU Newcastle Upon Tyne
United Kingdom