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Unravelling PIM kinase signal integration in the T cell response

Objective

Understanding how T cells integrate alternative signal combinations to determine immune response strength and functionality is of critical importance for rational design of immunomodulatory therapies. The PIM kinase family have been identified as important regulators of cell division, survival and protein synthesis independent of, but in parallel to the key signalling molecule mTOR. I propose to use cutting-edge quantitative proteomic technology to identify substrates and downstream protein networks regulated by PIM kinase in activated T cells. I will investigate where these downstream targets qualitatively diverge from, or quantitatively interact with, the mTOR signalling pathway (Objective 1 and 2). Using advanced cell culture and mathematical modelling I will quantify how this co-ordinated activity regulates T cell division, survival and differentiation outcomes (Objective 3). This comprehensive exploration of PIM kinase and mTOR signalling pathway integration will provide important fundamental insight into how these signals combine to regulate T cell fate and may be manipulated in the context of immunotherapy or cancer.

Field of science

  • /medical and health sciences/basic medicine/immunology/autoimmune diseases
  • /medical and health sciences/health sciences/public and environmental health/epidemics prevention/immunisation
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins
  • /natural sciences/chemical sciences/analytical chemistry/mass spectrometry
  • /medical and health sciences/clinical medicine/transplantation

Call for proposal

H2020-MSCA-IF-2015
See other projects for this call

Funding Scheme

MSCA-IF-EF-ST - Standard EF

Coordinator

UNIVERSITY OF DUNDEE
Address
Nethergate
DD1 4HN Dundee
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 183 454,80