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Understanding the balance between functional and deleterious interactions of alpha-synuclein with lipid bilayers


Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine

Author(s): Michele Perni, Patrick Flagmeier, Ryan Limbocker, Roberta Cascella, Francesco A. Aprile, Céline Galvagnion, Gabriella T. Heller, Georg Meisl, Serene W. Chen, Janet R. Kumita, Pavan K. Challa, Julius B. Kirkegaard, Samuel I. A. Cohen, Benedetta Mannini, Denise Barbut, Ellen A. A. Nollen, Cristina Cecchi, Nunilo Cremades, Tuomas P. J. Knowles, Fabrizio Chiti, Michael Zasloff, Michele Vendruscolo, C
Published in: ACS Chemical Biology, Issue 13/8, 2018, Page(s) 2308-2319, ISSN 1554-8929
Publisher: American Chemical Society
DOI: 10.1021/acschembio.8b00466

Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes

Author(s): Johnny Habchi, Sean Chia, Céline Galvagnion, Thomas C. T. Michaels, Mathias M. J. Bellaiche, Francesco Simone Ruggeri, Michele Sanguanini, Ilaria Idini, Janet R. Kumita, Emma Sparr, Sara Linse, Christopher M. Dobson, Tuomas P. J. Knowles, Michele Vendruscolo
Published in: Nature Chemistry, Issue 10/6, 2018, Page(s) 673-683, ISSN 1755-4330
Publisher: Nature Publishing Group
DOI: 10.1038/s41557-018-0031-x

C-terminal truncation of α-synuclein promotes amyloid fibril amplification at physiological pH

Author(s): Ingrid M. van der Wateren, Tuomas P. J. Knowles, Alexander K. Buell, Christopher M. Dobson, Céline Galvagnion
Published in: Chemical Science, Issue 9/25, 2018, Page(s) 5506-5516, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8sc01109e

Kinetic barriers to α-synuclein protofilament formation and conversion into mature fibrils

Author(s): James W. P. Brown, Georg Meisl, Tuomas P. J. Knowles, Alexander K. Buell, Christopher M. Dobson, Céline Galvagnion
Published in: Chemical Communications, Issue 54/56, 2018, Page(s) 7854-7857, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8cc03002b

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