Periodic Reporting for period 1 - REGDAM (REGULATORY T CELLS AND TISSUE DAMAGE CONTROL)
Reporting period: 2017-04-01 to 2019-03-31
inflammatory diseases. This project will address mechanistically how TREG receive signals from tissues exposed to oxidative and hypoxic stress and migrate to those tissues to modulate oxidative and hypoxic stress responses as to dampen tissue damage.
REGDAM will support the development of basic/translational biological knowledge related the impact exerted by immunoregulatory mechanisms on homeostasis and in particular on the function of parenchyma tissues. This should reveal new therapeutic approaches against a broad range of diseases with major morbidity and mortality. These include autoimmunity, metabolic disorders, neurological conditions or infectious diseases, where deregulated inflammation and immunity are the underlying cause of disease. REGDAM addresses a “hot” topic in immunology research, namely the mechanism of action of TREG cells. The uniqueness and hence the competitive edge of REGDAM is to integrate TREG cells cells into the physiologic context of tissue damage control which to the best of our knowledge has not been done before. REGDAM should reveal important knowledge for academia as well as for clinical research and practice, with concrete benefits for the European economy and society in general.
- Imaging analysis support a potential role of regualtory t cells in tissue regenration
- Postnatal kidney resembled damaged kidneys as they are also characterized by strong accumulation of these cells