Objective
Molecular mechanisms that determine survival, differentiation and movement in multicellular organisms depend on extracellular matrix (ECM) integrity and cells interacting with the ECM. Collagens are the most abundant proteins in the ECM. Their primary function is to provide structural support to cells and to maintain biomechanical integrity of tissues. However, collagens are not just structural proteins. They act as extracellular modulators of signaling events and serve critical regulatory roles in various cell functions during embryonic development and adult homeostasis. It’s increasingly important to understand these mechanisms in cancer biology. Disruption or imbalance in collagen dynamics is associated to tumor formation and progression by directly acting on the development of tumoral stroma, cancer-associated fibroblasts and angiogenesis. Hence, targeting aberrant ECM may provide an effective avenue to combat cancer. Fibrillar collagens are among the first components to be compromised in cancers. This research proposal focuses on the role of the regulatory fibril forming collagen V whose upregulation has been reported in several types of human tumors. Combining my skills in cancer biology with the expertise of the host lab in ECM biology, I will investigate the versatile regulatory roles of collagens in ECM dynamics. I will focus in particular on the formation of the tumoral microenvironment and the complex mechanisms by which the properties of ECM instruct the development of cancer.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology prostate cancer
- medical and health sciences clinical medicine oncology lung cancer
- medical and health sciences clinical medicine oncology colorectal cancer
- medical and health sciences clinical medicine oncology pancreatic cancer
- medical and health sciences basic medicine physiology homeostasis
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2015
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75794 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.