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Characterisation of DNA Double-Strand Break Repair by Alternative End-Joining: Potential Targets for Cancer Therapy

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A first-in-class Polymerase Theta Inhibitor selectively targets Homologous-Recombination-Deficient Tumors

Author(s): Jia Zhou, Camille Gelot , Constantia Pantelidou, Adam Li, Hatice Yücel, Rachel E Davis, Anniina Farkkila, Bose Kochupurakkal, Aleem Syed, Geoffrey I Shapiro, John A Tainer, Brian S J Blagg, Raphael Ceccaldi, Alan D D'Andrea
Published in: Nature Cancer, 2021, Page(s) 598–610., ISSN 2662-1347
Publisher: Springer Nature
DOI: 10.1038/s43018-021-00203-x

FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair

Author(s): Zeina Kais, Beatrice Rondinelli, Amie Holmes, Colin O’Leary, David Kozono, Alan D. D’Andrea, Raphael Ceccaldi
Published in: Cell Reports, 15/11, 2016, Page(s) 2488-2499, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2016.05.031