CORDIS - EU research results

Characterisation of DNA Double-Strand Break Repair by Alternative End-Joining: Potential Targets for Cancer Therapy


A first-in-class Polymerase Theta Inhibitor selectively targets Homologous-Recombination-Deficient Tumors

Author(s): Jia Zhou, Camille Gelot , Constantia Pantelidou, Adam Li, Hatice Yücel, Rachel E Davis, Anniina Farkkila, Bose Kochupurakkal, Aleem Syed, Geoffrey I Shapiro, John A Tainer, Brian S J Blagg, Raphael Ceccaldi, Alan D D'Andrea
Published in: Nature Cancer, 2021, Page(s) 598–610., ISSN 2662-1347
Publisher: Springer Nature
DOI: 10.1038/s43018-021-00203-x

DNA damage induces nuclear envelope rupture through ATR-mediated phosphorylation of Lamin A/C

Author(s): Kovacs M.T, Vallette M, Wiertsema P, Dingli F, Loew D, Nader G.P, Piel M, Ceccaldi R
Published in: Molecular Cell, 2023, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2023.09.023

Polθ is phosphorylated by PLK1 to repair double-strand breaks in mitosis

Author(s): Gelot C, Kovacs M.T, Miron S, Mylne E, Ghouil R, Popova T, Dingli F, Loew D, Guirouilh-Barbat J, Del Nery E, Zinn S and Ceccaldi R
Published in: Nature, 2023, Page(s) Sept 6. 621, 415–422, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-023-06506-6

FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair

Author(s): Zeina Kais, Beatrice Rondinelli, Amie Holmes, Colin O’Leary, David Kozono, Alan D. D’Andrea, Raphael Ceccaldi
Published in: Cell Reports, Issue 15/11, 2016, Page(s) 2488-2499, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2016.05.031

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