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Imaging and detection of tumor-associated glycan structures on tumor cells

Deliverables

Produce a project poster and a presentation

Produce a project poster and a presentation

Produce a minimum of 2 press releases

Produce a minimum of 2 press releases

Project website launched

Project website launched

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Publications

Installation of O-glycan sulfation capacities in human HEK293 cells for display of sulfated mucins

Author(s): Lingbo Sun; Andriana Konstantinidi; Zilu Ye; Rebecca Nason; Yuecheng Zhang; Christian Büll; Barbro Kahl-Knutson; Lars Hansen; Hakon Leffler; Sergey Y. Vakhrushev; Zhang Yang; Henrik Clausen; Yoshiki Narimatsu
Published in: Journal of biological chemistry, Dec 24;298(2), 2021, Page(s) 1-14, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.101382

Molecularly imprinted polymers in biological applications

Author(s): Zahra El-Schich, Yuecheng Zhang, Marek Feith, Sarah Beyer, Louise Sternbæk, Lars Ohlsson, Maria Stollenwerk, Anette Gjörloff Wingren
Published in: BioTechniques, 69/6, 2020, Page(s) 406-419, ISSN 0736-6205
Publisher: Eaton Publishing Co.
DOI: 10.2144/btn-2020-0091

Sialic Acid as a Biomarker Studied in Breast Cancer Cell Lines In Vitro Using Fluorescent Molecularly Imprinted Polymers

Author(s): Zahra El-Schich, Yuecheng Zhang, Tommy Göransson, Nishtman Dizeyi, Jenny L. Persson, Emil Johansson, Remi Caraballo, Mikael Elofsson, Sudhirkumar Shinde, Börje Sellergren, Anette Gjörloff Wingren
Published in: Applied Sciences, 11/7, 2021, Page(s) 3256, ISSN 2076-3417
Publisher: MDPI
DOI: 10.3390/app11073256

Targeted inhibition of ERα signaling and PIP5K1α/Akt pathways in castration‐resistant prostate cancer

Author(s): Julius Semenas, Tianyan Wang, Azharuddin Sajid Syed Khaja, AKM Firoj Mahmud, Athanasios Simoulis, Thomas Grundström, Maria Fällman, Jenny L. Persson
Published in: Molecular Oncology, 15/4, 2021, Page(s) 968-986, ISSN 1574-7891
Publisher: Elsevier BV
DOI: 10.1002/1878-0261.12873

Establishment of Prostate Tumor Growth and Metastasis Is Supported by Bone Marrow Cells and Is Mediated by PIP5K1α Lipid Kinase

Author(s): Richard Karlsson, Per Larsson, Regina Miftakhova, Azharuddin Sajid Syed Khaja, Martuza Sarwar, Julius Semenas, Sa Chen, Andreas Hedblom, Tianyan Wang, Kristina Ekström-Holka, Athanasios Simoulis, Anjani Kumar, Niels Ødum, Thomas Grundström, Jenny L. Persson
Published in: Cancers, 12/9, 2020, Page(s) 2719, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12092719

Primary breast cancer biomarkers based on glycosylation and extracellular vesicles detected from human serum

Author(s): Joonas Terävä, Alejandra Verhassel, Orsola Botti, Md. Khirul Islam, Janne Leivo, Saara Wittfooth, Pirkko Härkönen, Kim Pettersson, Kamlesh Gidwani
Published in: Cancer Reports, 2021, ISSN 2573-8348
Publisher: Wiley Online Library
DOI: 10.1002/cnr2.1540

Imprinted Particles for Direct Fluorescence Detection of Sialic Acid in Polar Media and on Cancer Cells with Enhanced Control of Nonspecific Binding

Author(s): Martha Kimani, Sarah Beyer, Zahra El-Schich, Kornelia Gawlitza, Anette Gjörloff-Wingren, Knut Rurack
Published in: ACS Applied Polymer Materials, 3/5, 2021, Page(s) 2363-2373, ISSN 2637-6105
Publisher: ACS Publications
DOI: 10.1021/acsapm.0c01353

Quantitative characterization of O-GalNAc glycosylation

Author(s): Tomislav Čaval, Noortje de Haan, Andriana Konstantinidi, Sergey Y Vakhrushev
Published in: Current Opinion in Structural Biology, 68, 2021, Page(s) 135-141, ISSN 0959-440X
Publisher: Elsevier BV
DOI: 10.1016/j.sbi.2020.12.010

The GAGOme: a cell-based library of displayed glycosaminoglycans

Author(s): Yen-Hsi Chen, Yoshiki Narimatsu, Thomas M. Clausen, Catarina Gomes, Richard Karlsson, Catharina Steentoft, Charlotte B. Spliid, Tobias Gustavsson, Ali Salanti, Andrea Persson, Anders Malmström, Daniel Willén, Ulf Ellervik, Eric P. Bennett, Yang Mao, Henrik Clausen, Zhang Yang
Published in: Nature Methods, 15/11, 2018, Page(s) 881-888, ISSN 1548-7091
Publisher: Nature Publishing Group
DOI: 10.1038/s41592-018-0086-z

Determination of cytokine regulated glycan expression by using molecularly imprinted polymers targeting sialic acid

Author(s): Yuecheng Zhang, Kushtrim Llapashtica, Sudhirkumar Shinde, Borje Sellergren, Zahra El-Schich, Anette Gjorloff Wingren
Published in: Journal of Cancer Metastasis and Treatment, 2019, 2019, ISSN 2454-2857
Publisher: OAE Publishing Inc.
DOI: 10.20517/2394-4722.2018.112

An Atlas of Human Glycosylation Pathways Enables Display of the Human Glycome by Gene Engineered Cells

Author(s): Yoshiki Narimatsu, Hiren J. Joshi, Rebecca Nason, Julie Van Coillie, Richard Karlsson, Lingbo Sun, Zilu Ye, Yen-Hsi Chen, Katrine T. Schjoldager, Catharina Steentoft, Sanae Furukawa, Barbara A. Bensing, Paul M. Sullam, Andrew J. Thompson, James C. Paulson, Christian Büll, Gosse J. Adema, Ulla Mandel, Lars Hansen, Eric Paul Bennett, Ajit Varki, Sergey Y. Vakhrushev, Zhang Yang, Henrik Clausen
Published in: Molecular Cell, 75/2, 2019, Page(s) 394-407.e5, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2019.05.017

γ‐(S)‐Guanidinylmethyl Modified Triplex‐Forming Peptide Nucleic Acids Increase Hoogsteen‐Face Affinity for a MicroRNA and Enhance Cellular Uptake

Author(s): Ville Tähtinen, Alejandra Verhassel, Johanna Tuomela, Pasi Markus Virta
Published in: ChemBioChem, 2019, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201900393

Engineering mammalian cells to produce plant-specific N-glycosylation on proteins

Author(s): Joachim Steen Larsen, Richard Torbjörn Gustav Karlsson, Weihua Tian, Morten Alder Schulz, Annemarie Matthes, Henrik Clausen, Bent Larsen Petersen, Zhang Yang
Published in: Glycobiology, 2020, ISSN 1460-2423
Publisher: Glycobiology
DOI: 10.1093/glycob/cwaa009

The functional interlink between AR and MMP9/VEGF signaling axis is mediated through PIP5K1α/pAKT in prostate cancer

Author(s): Per Larsson, Azharuddin Sajid Syed Khaja, Julius Semenas, Tianyan Wang, Martuza Sarwar, Nishtman Dizeyi, Athanasios Simoulis, Andreas Hedblom, Sun Nyunt Wai, Niels Ødum, Jenny L. Persson
Published in: International Journal of Cancer, 146/6, 2019, Page(s) 1686-1699, ISSN 0020-7136
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/ijc.32607

Different isolation approaches lead to diverse glycosylated extracellular vesicle populations

Author(s): Daniela Freitas, Meritxell Balmaña, Juliana Poças, Diana Campos, Hugo Osório, Andriana Konstantinidi, Sergey Y. Vakhrushev, Ana Magalhães, Celso A. Reis
Published in: Journal of Extracellular Vesicles, 8/1, 2019, Page(s) 1621131, ISSN 2001-3078
Publisher: Taylor & Francis
DOI: 10.1080/20013078.2019.1621131

Synthesis of an Alkyne-Modified Bleomycin Disaccharide Precursor, Conversion to a 18 F-Labeled Radiotracer, and Preliminary in vivo-PET Imaging Studies

Author(s): Sajal K. Maity, Cheng-Bin Yim, Satish Jadhav, Alejandra Verhassel, Johanna Tuomela, Olof Solin, Tove J. Grönroos, Pasi Virta
Published in: European Journal of Organic Chemistry, 2019/1, 2019, Page(s) 156-163, ISSN 1434-193X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ejoc.201801488

Demystifying 3O-sulfation of Heparan Sulfate through Genetic Engineering and Development of Methods for Structural Analysis

Author(s): Richard Karlsson
Published in: 2021
Publisher: Copenhagen University

Glycosylation in cancer and infection – the role of sialic acid

Author(s): Yuecheng Zhang
Published in: 2021
Publisher: Malmö University

Dissection of the mucin O-glycosylation landscape

Author(s): Andriana Konstandinidi
Published in: 2021
Publisher: Copenhagen University

Digital holographic cytometry - Macrophage uptake of nanoprobes

Author(s): Louise Sternbæk, Martha Wamaitha Kimani, Kornelia Gawlitza Birgit Janicke, Kersti Alm, and Anette Gjörloff Wingren
Published in: Imaging&Microscopy, 1, 2019, Page(s) 21-23
Publisher: Wiley

Dual-Fluorescent Nanoparticle Probes Consisting of a Carbon Nanodot Core and a Molecularly Imprinted Polymer Shell

Author(s): Shan Jiang, Kornelia Gawlitza, Knut Rurack
Published in: Molecularly Imprinted Polymers - Methods and Protocols, 2359, 2021, Page(s) 195-208, ISBN 978-1-0716-1628-4
Publisher: Springer US
DOI: 10.1007/978-1-0716-1629-1_17