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Childhood and Adolescence Psychopathology: unravelling the complex etiology by a large Interdisciplinary Collaboration in Europe

Deliverables

Website

The results will be made available to scientists, clinicians and the general public. A dynamic and interactive website will be developed, supporting webcasting services. This website will also have a specific part dedicated for patients and their parents. The text for this part will be written in close collaboration with the patient organizations. The information will be translated in several languages so that it is also accessible to the general public of non-english speaking individuals.

Workshop 1

Statistical genetics – twin studies: The twin methodology will be explained and hands-on experience will be provided by practical’s with the commonly used software. This is an ongoing course.

Annual meeting 2

During the meetings, research project findings will be exchanged, mainly by presentations of the ESRs. They will be open to a wider scientific audience. This will also teach the ESRs in presentation skillsin order optimize science divulgation to an attending audience.

workshop 3

Childhood and adolescent psychopathology – description and course: This course will focus on the common childhood and adolescent psychiatric disorders and provide knowledge on the main symptoms and the prognosis.

workshop 4

Longitudinal and multivariate modeling: The use of twin studies as well as polygenic analyses using SNPs for longitudinal and multivariate analyses will be discussed and practiced in the practical’s.

workshop 2

Statistical genetics – genome-wide association studies: After the course, the ESRs will be able to perform a genome-wide association study. They know the methods to perform polygenic analyses and they have knowledge on GWA meta-analyses.

Annual meeting 1

During the meetings, research project findings will be exchanged, mainly by presentations of the ESRs. They will be open to a wider scientific audience. This will also teach the ESRs in presentation skillsin order optimize science divulgation to an attending audience.

Polygenic risk scores

Polygenic risk scores are available for each cohort

Progress report 1

Interim report is sent to the EC describing progress in research, training, and impact.

Mendelian randomization analyses

Mendelian randomization analyses will be conducted, using either single variants or polygenic risk scores robustly associated with lifestyle behaviours, to identify causal pathways between lifestyle behaviours during pregnancy and offspring outcomes.

Harmonized scores

Within each cohort and within each age group, phenotypic data from various measurement instruments will be harmonized in such a way that all subjects have scores on the same scale.

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Publications

Scale-free networks in metabolomics

Author(s): Hema Sekhar Reddy Rajula, Matteo Mauri, Vassilios Fanos
Published in: Bioinformation, Issue 14/03, 2018, Page(s) 140-144, ISSN 0973-8894
DOI: 10.6026/97320630014140

Genomic prediction of cognitive traits in childhood and adolescence

Author(s): A. G. Allegrini, S. Selzam, K. Rimfeld, S. von Stumm, J. B. Pingault, R. Plomin
Published in: Molecular Psychiatry, Issue 24/6, 2019, Page(s) 819-827, ISSN 1359-4184
DOI: 10.1038/s41380-019-0394-4

The p factor: genetic analyses support a general dimension of psychopathology in childhood and adolescence

Author(s): Andrea G. Allegrini, Rosa Cheesman, Kaili Rimfeld, Saskia Selzam, Jean‐Baptiste Pingault, Thalia C. Eley, Robert Plomin
Published in: Journal of Child Psychology and Psychiatry, Issue 61/1, 2019, Page(s) 30-39, ISSN 0021-9630
DOI: 10.1111/jcpp.13113