Deliverables
How to analyze causality of environmental factors and epigenetics: In the first part of this course, the ESRs will learn which methods can be used to analyze whether associations between risk factors and mental health symptoms are causal. The second part will focus on the analyses of epigenetic data.
Wprkshop 6Data sharing and drug target validation: After this course, ESRs know which methods are available to jointly analyze data of several cohorts without the need to share all data. In the second part of this course, methods to identify potential targets for drug treatment, either via repurposing or via new drug development, based on results from genetic analyses will be discussed.
Workshop 1Statistical genetics – twin studies: The twin methodology will be explained and hands-on experience will be provided by practical’s with the commonly used software. This is an ongoing course.
Annual meeting 2During the meetings, research project findings will be exchanged, mainly by presentations of the ESRs. They will be open to a wider scientific audience. This will also teach the ESRs in presentation skillsin order optimize science divulgation to an attending audience.
workshop 3Childhood and adolescent psychopathology – description and course: This course will focus on the common childhood and adolescent psychiatric disorders and provide knowledge on the main symptoms and the prognosis.
International Open conferencein an open conference, open for a broad audience, the results of CAPICE will be presented.
Presentation of ESRsAll ESRs have presented their results at the annual meetings and at conferences.
workshop 4Longitudinal and multivariate modeling: The use of twin studies as well as polygenic analyses using SNPs for longitudinal and multivariate analyses will be discussed and practiced in the practical’s.
workshop 8Finding a job in Academia or Industry: This workshop will focus on planning research, research management, CV writing, finding a job in academia, how to get funded, grant writing, how to find a job in industry, management, setting up a company, and leadership.
Workshop 7Statistical genetics – latest developments: Given the rapid pace of development of statistical methods to analyze genetic data, at the end of the project a course will focus on these new developments. Obviously, the content will be based on these developments.
workshop 2Statistical genetics – genome-wide association studies: After the course, the ESRs will be able to perform a genome-wide association study. They know the methods to perform polygenic analyses and they have knowledge on GWA meta-analyses.
Annual meeting 3During the meetings, research project findings will be exchanged, mainly by presentations of the ESRs. They will be open to a wider scientific audience. This will also teach the ESRs in presentation skillsin order optimize science divulgation to an attending audience.
Annual meeting 1During the meetings, research project findings will be exchanged, mainly by presentations of the ESRs. They will be open to a wider scientific audience. This will also teach the ESRs in presentation skillsin order optimize science divulgation to an attending audience.
The results will be made available to scientists, clinicians and the general public. A dynamic and interactive website will be developed, supporting webcasting services. This website will also have a specific part dedicated for patients and their parents. The text for this part will be written in close collaboration with the patient organizations. The information will be translated in several languages so that it is also accessible to the general public of non-english speaking individuals.
Epigenomewide-association analyses will be conducted to identify DNA methylation signatures of both lifestyle behaviours during pregnancy and offspring outcomes, to identify potential epigenetic pathways through which lifestyle behaviours may influence offspring outcomes.
Mendelian randomization epigenetic analysesMendelian randomization techniques will be used to explore whether methylation of the child’s DNA at birth underlies the association between environmental exposures during pregnancy and psychopathology in childhood and adolescence.
Review paperReview paper on the latest achievements in genetics, epigenetics and transcriptomic research, that will also be translated from English to Dutch, Swedish and Italian so that they will be published in the national journals that are widely read by clinicians.
Drug target validation analysesThe genetic variants implicated in the WPs will be assessed using genetic circuit mapping technology to implicate molecular pathways relevant to the pathogenesis of mood disorders
Polygenic risk scoresPolygenic risk scores are available for each cohort
PHD Publications ESR2Multivariate analyses
Harmonized phenotypes in twins will be analyzed within age groups by genetic epidemiological multivariate analyses. Genetic correlations will be computed between the different types of mental health symptoms.
PhD Publications ESR6Publications for thesis of ESR6
PhD Publications ESR9Publications for thesis ESR9
Final ReportFinal report is sent to the EC summarizing all research, training, and impact.
Longitudinal analysesLongitudinal, multivariate epidemiological analyses will be performed on twin data to study to what extent different types of mental-health problems co-develop, with a particular focus to what extent the same genotypic variance underlies the stability in different mental-health problems.
Progress report 1Interim report is sent to the EC describing progress in research, training, and impact.
PhD Publications ESR5Publications for thesis ESR5
PhD Publications ESR12Publications for thesis ESR12
PhD Publications ESR10Publications for thesis ESR10
Progress report 2Interim report is sent to the EC describing progress in research, training, and impact.
PhD Publications ESR3Publications ready for thesis ESR3
Validated prediction model for internalizing problemsUsing results from the (epi)genetic and environmental risk factors identified in the other WPs a prediction model will be developed for internalizing problems that can be used in clinical practice.
Validated prediction model for ADHDUsing results from the (epi)genetic and environmental risk factors identified in the other WPs a prediction model that can be used in clinical practice will be developed for ADHD
PhD Publications ESR4Publications ready for thesis ESR4
Gene-environment interaction analysesOmnibus tests will be performed to test for the presence of environmental effects that are sensitive to and interact with genotypic effects. Next, specific genetic and environmental stressors will be used to test the negative effects of environmental factors that are exacerbated by having specific genetic variants. These analyses will be based on harmonized phenotypes.
Mendelian randomization analysesMendelian randomization analyses will be conducted, using either single variants or polygenic risk scores robustly associated with lifestyle behaviours, to identify causal pathways between lifestyle behaviours during pregnancy and offspring outcomes.
PhD Publications ESR11PhD Publications ESR7
Publications for thesis of ESR7
Polygenic analysesAnalyze how the joint effect of all SNPs is of influence on co-morbidity, overlap in effects between ages and the genetic associations with other phenotypes. Methods that will be used are polygenic risk score analyses and GREML.
Progress report 3Interim report is sent to the EC describing progress in research, training, and impact.
PhD Publications ESR8Publications for thesis ESR8
PHD Publications ESR1Publications ready for thesis ESR1
Genome-wide association meta-analysesFor each phenotype, meta-analyses will be performed for the data available at childhood and at adolescence. This will first be done using linear regression. At a later stage, more advanced analyses will be performed using co-morbidity and longitudinal models. Meta-analyses will also be performed on the harmonized phenotypes for age 10
Harmonized scoresWithin each cohort and within each age group, phenotypic data from various measurement instruments will be harmonized in such a way that all subjects have scores on the same scale.
Publications
Author(s):
G. C. Sharp, L. Schellhas, S. S. Richardson, D. A. Lawlor
Published in:
Journal of Developmental Origins of Health and Disease, Issue 10/5, 2019, Page(s) 509-512, ISSN 2040-1744
Publisher:
Cambridge University Press
DOI:
10.1017/s2040174419000072
Author(s):
Marica Leone, Ralf Kuja-Halkola, Amy Leval, Brian M. D’Onofrio, Henrik Larsson, Paul Lichtenstein, Sarah E. Bergen
Published in:
JAMA Psychiatry, Issue 78/3, 2021, Page(s) 302, ISSN 2168-622X
Publisher:
American Medical Association
DOI:
10.1001/jamapsychiatry.2020.3786
Author(s):
Kayleigh E. Easey, Robyn E. Wootton, Hannah M. Sallis, Elis Haan, Laura Schellhas, Marcus R. Munafò, Nicholas J. Timpson, Luisa Zuccolo
Published in:
Drug and Alcohol Dependence, Issue 221, 2021, Page(s) 108654, ISSN 0376-8716
Publisher:
Elsevier BV
DOI:
10.1016/j.drugalcdep.2021.108654
Author(s):
Hema Sekhar Reddy Rajula, Mirko Manchia, Kratika Agarwal, Wonuola A. Akingbuwa, Andrea G. Allegrini, Elizabeth Diemer, Sabrina Doering, Elis Haan, Eshim S. Jami, Ville Karhunen, Marica Leone, Laura Schellhas, Ashley Thompson, Stéphanie M. van den Berg, Sarah E. Bergen, Ralf Kuja-Halkola, Anke R. Hammerschlag, Marjo Riitta Järvelin, Amy Leval, Paul Lichtenstein, Sebastian Lundstrom, Matteo Mauri,
Published in:
European Child & Adolescent Psychiatry, 2021, ISSN 1018-8827
Publisher:
Dr. Dietrich Steinkopff Verlag
DOI:
10.1007/s00787-020-01713-2
Author(s):
Sabrina Doering, Paul Lichtenstein, Christopher Gillberg, Christel M. Middeldorp, Meike Bartels, Ralf Kuja-Halkola, Sebastian Lundström
Published in:
BMC Psychiatry, Issue 19/1, 2019, ISSN 1471-244X
Publisher:
BioMed Central
DOI:
10.1186/s12888-019-2349-3
Author(s):
Sebastian Rauschert, Phillip E. Melton, Anni Heiskala, Ville Karhunen, Graham Burdge, Jeffrey M. Craig, Keith M. Godfrey, Karen Lillycrop, Trevor A. Mori, Lawrence J. Beilin, Wendy H. Oddy, Craig Pennell, Marjo-Riitta Järvelin, Sylvain Sebert, Rae-Chi Huang
Published in:
Environmental Health Perspectives, Issue 128/9, 2020, Page(s) 097003, ISSN 0091-6765
Publisher:
US Department of Health and Human Services
DOI:
10.1289/ehp6076
Author(s):
Dipender Gill, Alan C. Cameron, Stephen Burgess, Xue Li, Daniel J. Doherty, Ville Karhunen, Azmil H. Abdul-Rahim, Martin Taylor-Rowan, Verena Zuber, Philip S. Tsao, Derek Klarin, Evangelos Evangelou, Paul Elliott, Scott M. Damrauer, Terence J. Quinn, Abbas Dehghan, Evropi Theodoratou, Jesse Dawson, Ioanna Tzoulaki
Published in:
Hypertension, Issue 77/2, 2021, Page(s) 383-392, ISSN 0194-911X
Publisher:
Lippincott Williams & Wilkins Ltd.
DOI:
10.1161/hypertensionaha.120.16547
Author(s):
Wonuola A. Akingbuwa, Anke R. Hammerschlag, Eshim S. Jami, Andrea G. Allegrini, Ville Karhunen, Hannah Sallis, Helga Ask, Ragna B. Askeland, Bart Baselmans, Elizabeth Diemer, Fiona A. Hagenbeek, Alexandra Havdahl, Jouke-Jan Hottenga, Hamdi Mbarek, Fernando Rivadeneira, Martin Tesli, Catharina van Beijsterveldt, Gerome Breen, Cathryn M. Lewis, Anita Thapar, Dorret I. Boomsma, Ralf Kuja-Halkola, Ted
Published in:
JAMA Psychiatry, Issue 77/7, 2020, Page(s) 715, ISSN 2168-622X
Publisher:
American Medical Association
DOI:
10.1001/jamapsychiatry.2020.0527
Author(s):
Hema Sekhar Reddy Rajula, Giuseppe Verlato, Mirko Manchia, Nadia Antonucci, Vassilios Fanos
Published in:
Medicina, Issue 56/9, 2020, Page(s) 455, ISSN 1648-9144
Publisher:
MDPI
DOI:
10.3390/medicina56090455
Author(s):
Hema Sekhar Reddy Rajula, Matteo Mauri, Vassilios Fanos
Published in:
Bioinformation, Issue 14/03, 2018, Page(s) 140-144, ISSN 0973-8894
Publisher:
Biomedical Informatics
DOI:
10.6026/97320630014140
Author(s):
A. G. Allegrini, S. Selzam, K. Rimfeld, S. von Stumm, J. B. Pingault, R. Plomin
Published in:
Molecular Psychiatry, Issue 24/6, 2019, Page(s) 819-827, ISSN 1359-4184
Publisher:
Nature Publishing Group
DOI:
10.1038/s41380-019-0394-4
Author(s):
Andrea G. Allegrini, Rosa Cheesman, Kaili Rimfeld, Saskia Selzam, Jean‐Baptiste Pingault, Thalia C. Eley, Robert Plomin
Published in:
Journal of Child Psychology and Psychiatry, Issue 61/1, 2019, Page(s) 30-39, ISSN 0021-9630
Publisher:
Blackwell Publishing Inc.
DOI:
10.1111/jcpp.13113
Author(s):
Ashley E. Tate, Ryan C. McCabe, Henrik Larsson, Sebastian Lundström, Paul Lichtenstein, Ralf Kuja-Halkola
Published in:
PLOS ONE, Issue 15/4, 2020, Page(s) e0230389, ISSN 1932-6203
Publisher:
Public Library of Science
DOI:
10.1371/journal.pone.0230389
Author(s):
Alexessander Couto Alves, N. Maneka G. De Silva, Ville Karhunen, Ulla Sovio, Shikta Das, H. Rob Taal, Nicole M. Warrington, Alexandra M. Lewin, Marika Kaakinen, Diana L. Cousminer, Elisabeth Thiering, Nicholas J. Timpson, Tom A. Bond, Estelle Lowry, Christopher D. Brown, Xavier Estivill, Virpi Lindi, Jonathan P. Bradfield, Frank Geller, Doug Speed, Lachlan J. M. Coin, Marie Loh, Sheila J. Barton,
Published in:
Science Advances, Issue 5/9, 2019, Page(s) eaaw3095, ISSN 2375-2548
Publisher:
AAAS
DOI:
10.1126/sciadv.aaw3095
Author(s):
Petri Wiklund, Ville Karhunen, Rebecca C. Richmond, Priyanka Parmar, Alina Rodriguez, Maneka De Silva, Matthias Wielscher, Faisal I. Rezwan, Tom G. Richardson, Juha Veijola, Karl-Heinz Herzig, John W. Holloway, Caroline L. Relton, Sylvain Sebert, Marjo-Riitta Järvelin
Published in:
Clinical Epigenetics, Issue 11/1, 2019, ISSN 1868-7075
Publisher:
Springer Verlag
DOI:
10.1186/s13148-019-0683-4
Author(s):
Tom A Bond, Ville Karhunen, Matthias Wielscher, Juha Auvinen, Minna Männikkö, Sirkka Keinänen-Kiukaanniemi, Marc J Gunter, Janine F Felix, Inga Prokopenko, Jian Yang, Peter M Visscher, David M Evans, Sylvain Sebert, Alex Lewin, Paul F O’Reilly, Debbie A Lawlor, Marjo-Riitta Jarvelin
Published in:
International Journal of Epidemiology, Issue 49/1, 2019, Page(s) 233-243, ISSN 0300-5771
Publisher:
Oxford University Press
DOI:
10.1093/ije/dyz095
Author(s):
Andrea G. Allegrini, Ville Karhunen, Jonathan R. I. Coleman, Saskia Selzam, Kaili Rimfeld, Sophie von Stumm, Jean-Baptiste Pingault, Robert Plomin
Published in:
PLOS Genetics, Issue 16/11, 2020, Page(s) e1009153, ISSN 1553-7404
Publisher:
PLOS
DOI:
10.1371/journal.pgen.1009153
Author(s):
Hema Sekhar Reddy Rajula, Veronika Odintsova, Mirko Manchia, Vassilios Fanos
Published in:
Applied Sciences, Issue 9/19, 2019, Page(s) 4103, ISSN 2076-3417
Publisher:
MDPI
DOI:
10.3390/app9194103
Author(s):
Oliver Robinson, Alice R Carter, Mika Ala-Korpela, Juan P Casas, Nishi Chaturvedi, Jorgen Engmann, Laura D Howe, Alun D Hughes, Marjo-Riitta Järvelin, Mika Kähönen, Ville Karhunen, Diana Kuh, Tina Shah, Yoav Ben-Shlomo, Reecha Sofat, Chung-Ho E Lau, Terho Lehtimäki, Usha Menon, Olli Raitakari, Andy Ryan, Rui Providencia, Stephanie Smith, Julie Taylor, Therese Tillin, Jorma Viikari, Andrew Wong
Published in:
International Journal of Epidemiology, 2020, ISSN 0300-5771
Publisher:
Oxford University Press
DOI:
10.1093/ije/dyaa188
Author(s):
Dipender Gill, Marios Arvanitis, Paul Carter, Ana I. Hernández Cordero, Brian Jo, Ville Karhunen, Susanna C. Larsson, Xuan Li, Sam M. Lockhart, Amy Mason, Evanthia Pashos, Ashis Saha, Vanessa Y. Tan, Verena Zuber, Yohan Bossé, Sarah Fahle, Ke Hao, Tao Jiang, Philippe Joubert, Alan C. Lunt, Willem Hendrik Ouwehand, David J. Roberts, Wim Timens, Maarten van den Berge, Nicholas A. Watkins, Alexis B
Published in:
Royal Society Open Science, Issue 7/11, 2020, Page(s) 200958, ISSN 2054-5703
Publisher:
The Royal Society
DOI:
10.1098/rsos.200958
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