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4D analysis of heart development and regeneration using advanced light microscopy

Deliverables

Participation as Marie Curie Ambassadors in Researchers night and other actions

[1] Programs for Children: Visits to primary schools are planned as recurrent lab activities. The group of N. Mercader started in 2015 a one-day visit to school presenting the zebrafish model. The group of J. Vermot regularly opens the lab to the general public (3 to 4 days a year) from primary to high school level. These activities will continue. At CNIC, the program “Acércate” allows high school students to perform a short internship at the Centre to get insight into Cardiovascular Research. The program has revealed that many visitors have chosen to pursuit a scientific career path, perhaps through the motivation found in this short training. At the Institute of Anatomy of UBERN, researchers participate on the Annual Career Day for high school students to get them insight on scientists working environment. [2] General Public visits to the Research Centres will also take place. As an example, at CNIC there is an event related to the national scope of the institution and open to everyone interested in cardiovascular health. A seminar is foreseen for persons interested in zebrafish cardiovascular imaging and its impact on society. Outreach activities will be organized such as the one taking place during the CNIC conference 2016 on mechanobiology “May the force be with you” for children and adults. Visits to the General Public will also take place at the rest of host institutions during national events such as “Tag der Forschung” (Switzerland), the European Week for Scientific Culture and Institute Open door events. [3] Participation in Masters in Science and Summer students Teaching Programs: With this activity we expect to raise the awareness of the importance of in vivo imaging to understand developmental processes and exemplify some of the career options in this particular topic. Several of the participants are already actively involved in these programs. Generally, 1 Master student is mentored per year per academic beneficiaries. ESRs will supervise a Master or Summer student during their last PhD year. [4] Marie Curie Ambassadors: A number of different initiatives already running locally give ESRs the chance to present their personal experience and include the European Researchers Night, European Week for Scientific Culture, Institute Open door events, Madrid Science week, “Tag der Forschung” in Switzerland, “Strasbourg JOB WEEK”. These initiatives expose the results of this consortium to the general public. [5] Dedicated website: a website of the consortium presenting results and activities with public access to blogs and discussion forums will be published during the first 3 months of the EIDs activity. The website will be updated regularly by the project manager, who will collect input from all participants, particularly form ESRs. [6] Collaboration with the Press: The scientific output of this consortium is particularly visual, and thus easy to present to a general public. We envision the possibility of collaboration and preparing material for scientific TV programs. Members of 4D Heart have previously collaborated with the press “El Pais”, “El Mundo”, “TVE”, “Sonntagszeitung”. [7] Podcasts and articles for divulgation websites: We will continue to write small reports or reviews for websites such as the European Society of Cardiology and The Node (Company of Developmental Biologists Blog). Other examples are. [1] http://www.BITPLANE.com/learning/4d-particle-tracking-embryology by W. Supatto in 2011, [2] “Live 3D imaging of early-embryonic beating hearts in zebrafish” by J. Vermot in 2014 or, [3] the webinar published by Leica in 2015 (http://www.leica-microsystems.com/science-lab/webinar-light-sheet-imaging-new-solutions-and-their-applications-in-zebrafish-embryogenesis/. [8] Divulgation on Social Networks: likewise, the preparation of short videos is doable and the creation of a Youtube channel or equivalent for the consortium is foreseen. These mass media are essential chann

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Publications

Automated high-throughput heartbeat quantification in medaka and zebrafish embryos under physiological conditions

Author(s): Jakob Gierten, Christian Pylatiuk, Omar T. Hammouda, Christian Schock, Johannes Stegmaier, Joachim Wittbrodt, Jochen Gehrig, Felix Loosli
Published in: Scientific Reports, 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-58563-w

Model systems for regeneration: zebrafish

Author(s): Ines J. Marques, Eleonora Lupi, Nadia Mercader
Published in: Development, 146/18, 2019, Page(s) dev167692, ISSN 0950-1991
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dev.167692

Intraflagellar Transport Complex B Proteins Regulate the Hippo Effector Yap1 during Cardiogenesis

Author(s): Marina Peralta, Laia Ortiz Lopez, Katerina Jerabkova, Tommaso Lucchesi, Benjamin Vitre, Dong Han, Laurent Guillemot, Chaitanya Dingare, Izabela Sumara, Nadia Mercader, Virginie Lecaudey, Benedicte Delaval, Sigolène M. Meilhac, Julien Vermot
Published in: Cell Reports, 32/3, 2020, Page(s) 107932, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.107932

Single breath-hold saturation recovery 3D cardiac T1 mapping via compressed SENSE at 3T

Author(s): Tiago Ferreira da Silva, Carlos Galan-Arriola, Paula Montesinos, Gonzalo Javier López-Martín, Manuel Desco, Valentín Fuster, Borja Ibáñez, Javier Sanchez-Gonzalez
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine, 33/6, 2020, Page(s) 865-876, ISSN 0968-5243
Publisher: Springer Verlag
DOI: 10.1007/s10334-020-00848-2

How to define and optimize axial resolution in light-sheet microscopy: a simulation-based approach

Author(s): Elena Remacha, Lars Friedrich, Julien Vermot, Florian O. Fahrbach
Published in: Biomedical Optics Express, 11/1, 2020, Page(s) 8, ISSN 2156-7085
Publisher: The Optical Society
DOI: 10.1364/boe.11.000008

Intraflagellar transport complex B proteins regulate the Hippo effector Yap1 during cardiogenesis

Author(s): Marina Peralta1,2,3,4, Katerina Jerabkova1,2,3,4*, Tommaso Lucchesi5,6,7*, Laia Ortiz Lopez1,2,3,4, 5 Benjamin Vitre8, Dong Han5,6, Laurent Guillemot5,6, Chaitanya Dingare9, Izabela Sumara1,2,3,4, 6 Nadia Mercader10,11, Virginie Lecaudey9, Benedicte Delaval8, Sigolène M. Meilhac5,6 and 7 Julien Vermot1,2,3,4
Published in: https://doi.org/10.1101/777128, 2019
Publisher: https://doi.org/10.1101/777128
DOI: 10.1101/777128

How to define and optimize axial resolution in light-sheet microscopy: a simulation-based approach

Author(s): Elena Remacha, Lars Friedrich, Julien Vermot, Florian O. Fahrbach
Published in: https://www.biorxiv.org/content/10.1101/783589v1, 2019
Publisher: https://www.biorxiv.org/content/10.1101/783589v1
DOI: 10.1101/783589