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PROTECTion against Endocrine Disruptors; Detection, mixtures, health effects, risk assessment and communication.


Final WP6 report

Final WP6 report.

Completion of network-wide events

Completion of network-wide events.

End of Project Meeting/Final Report

End of Project Meeting/Final Report.

Final WP2 report

Final WP2 report.

Final WP5 report

Final WP5 report.

Final WP7 report

Final WP7 report.

Final WP3 report

Final WP3 report.

Final WP4 report

Final WP4 report.


Targeting the aryl hydrocarbon receptor with a novel set of triarylmethanes.

Author(s): Elizabeth Goya-Jorge; Céline Rampal; Rafael Gozalbes; Maité Sylla-Iyarreta Veitía; Clotilde Ferroud; Nicolas Loones; Laureano E. Carpio; Rosa M. Giner; Stephen J. Barigye
Published in: European Journal of Medicinal Chemistry, 2020, ISSN 0223-5234
Publisher: Elsevier BV
DOI: 10.1016/j.ejmech.2020.112777

Public Awareness and Risk Perceptions of Endocrine Disrupting Chemicals: A Qualitative Study

Author(s): Melissa Kelly, Lisa Connolly, Moira Dean
Published in: International Journal of Environmental Research and Public Health, Issue 17/21, 2020, Page(s) 7778, ISSN 1660-4601
Publisher: MDPI
DOI: 10.3390/ijerph17217778

Discovery of 2-aryl and 2-pyridinylbenzothiazoles endowed with antimicrobial and aryl hydrocarbon receptor agonistic activities

Author(s): Elizabeth Goya-Jorge, Fatma Abdmouleh, Laureano E. Carpio, Rosa M. Giner, Maité Sylla-Iyarreta Veitía
Published in: European Journal of Pharmaceutical Sciences, Issue 151, 2020, Page(s) 105386, ISSN 0928-0987
Publisher: Elsevier BV
DOI: 10.1016/j.ejps.2020.105386

Plant Occurring Flavonoids as Modulators of the Aryl Hydrocarbon Receptor

Author(s): Elizabeth Goya-Jorge, María Elisa Jorge Rodríguez, Maité Sylla-Iyarreta Veitía, Rosa M. Giner
Published in: Molecules, Issue 26/8, 2021, Page(s) 2315, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26082315

PROTECTion against Endocrine Disruption through Quantitative Structure-Activity Relationship modelling [“Revisión de los modelos computacionales que relacionan la estructura química con la disrupción del sistema endocrino”]

Author(s): Elizabeth Goya-Jorge Jesús V. de Julián-Ortiz Rafael Gozalbes
Published in: Revista de Toxicología, Issue June 2020, 2020, Page(s) 55-68, ISSN 0212-7113
Publisher: Asociacion Espanola de Toxicologia

Human-Based Exposure Levels of Perfluoroalkyl Acids May Induce Harmful Effects to Health by Disrupting Major Components of Androgen Receptor Signalling In Vitro

Author(s): J. McComb, I. G. Mills, Hanne Friis Berntsen, E. Ropstad, S. Verhaegen, L. Connolly
Published in: Exposure and Health, Issue 12/3, 2020, Page(s) 527-538, ISSN 2451-9766
Publisher: Springer
DOI: 10.1007/s12403-019-00318-8

Induction of AhR transactivation by PBDD/Fs and PCDD/Fs using a novel human-relevant, high-throughput DRhuman CALUX reporter gene assay

Author(s): Clémence Budin, Harrie Besselink, Barbara M.A. van Vugt-Lussenburg, Hai-Yen Man, Bart van der Burg, Abraham Brouwer
Published in: Chemosphere, Issue 263, 2021, Page(s) 128086, ISSN 0045-6535
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.chemosphere.2020.128086

A human relevant mixture of persistent organic pollutants (POPs) and perfluorooctane sulfonic acid (PFOS) enhance nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells

Author(s): Ajay Yadav, Mazia Amber, Denis Zosen, Nils Anders Labba, Eva Henriette Willemijn Huiberts, Johanna Samulin Erdem, Fred Haugen, Hanne Friis Berntsen, Shanbeh Zienolddiny, Ragnhild Elisabeth Paulsen, Erik Ropstad, Lisa Connolly, Steven Verhaegen
Published in: Toxicology Letters, Issue 338, 2021, Page(s) 85-96, ISSN 0378-4274
Publisher: Elsevier BV
DOI: 10.1016/j.toxlet.2020.12.007

Investigation of In Vitro Endocrine Activities of Microcystis and Planktothrix Cyanobacterial Strains

Author(s): Vittoria Mallia, Lada Ivanova, Gunnar S. Eriksen, Emma Harper, Lisa Connolly, Silvio Uhlig
Published in: Toxins, Issue 12/4, 2020, Page(s) 228, ISSN 2072-6651
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/toxins12040228

Effects of Defined Mixtures of Persistent Organic Pollutants (POPs) on Pre-lethal Cytotoxicity in the Human A-498 Kidney Cell Line In Vitro

Author(s): Mazia Amber, Yuling Xie, Hanne Friis Berntsen, Karin Elizabeth Zimmer, Erik Ropstad, Steven Verhaegen, Lisa Connolly
Published in: Exposure and Health, 2021, ISSN 2451-9766
Publisher: Springer nature
DOI: 10.1007/s12403-021-00396-7

In vitro profiling of the potential endocrine disrupting activities affecting steroid and aryl hydrocarbon receptors of compounds and mixtures prevalent in human drinking water resources

Author(s): Doan TQ, Connolly L, Igout A, Nott K, Muller M, Scippo ML
Published in: Chemosphere, Issue 258, 2020, Page(s) 127332, ISSN 0045-6535
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.chemosphere.2020.127332

Predictive modeling of aryl hydrocarbon receptor (AhR) agonism

Author(s): Elizabeth Goya-Jorge, Rosa M. Giner, Maité Sylla-Iyarreta Veitía, Rafael Gozalbes, Stephen J. Barigye
Published in: Chemosphere, Issue 256, 2020, Page(s) 127068, ISSN 0045-6535
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.chemosphere.2020.127068

Assessing the chemical-induced estrogenicity using in silico and in vitro methods

Author(s): Elizabeth Goya-Jorge, Mazia Amber, Rafael Gozalbes, Lisa Connolly, Stephen J. Barigye
Published in: Environmental Toxicology and Pharmacology, 2021, Page(s) 103688, ISSN 1382-6689
Publisher: Elsevier BV
DOI: 10.1016/j.etap.2021.103688

Versicolorin A enhances the genotoxicity of aflatoxin B1 in human liver cells by inducing the transactivation of the Ah-receptor

Author(s): Clémence Budin, Hai-Yen Man, Carine Al-Ayoubi, Sylvie Puel, Barbara M.A. van Vugt-Lussenburg, Abraham Brouwer, Isabelle P. Oswald, Bart van der Burg, Laura Soler
Published in: Food and Chemical Toxicology, Issue 153, 2021, Page(s) 112258, ISSN 0278-6915
Publisher: Elsevier BV
DOI: 10.1016/j.fct.2021.112258

The insulin-like growth factor system: A target for endocrine disruptors?

Author(s): Chiara Talia, Lisa Connolly, Paul A. Fowler
Published in: Environment International, Issue 147, 2021, Page(s) 106311, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2020.106311

Testing the twin testosterone transfer hypothesis—intergenerational analysis of 317 dizygotic twins born in Aberdeen, Scotland

Author(s): Chiara Talia, Edwin-Amalraj Raja, Sohinee Bhattacharya, Paul A Fowler
Published in: Human Reproduction, Issue 35/7, 2020, Page(s) 1702-1711, ISSN 0268-1161
Publisher: Oxford University Press
DOI: 10.1093/humrep/deaa091

Microcystins and Microcystis aeruginosa PCC7806 extracts modulate steroidogenesis differentially in the human H295R adrenal model

Author(s): Vittoria Mallia, Steven Verhaegen, Bjarne Styrishave, Gunnar Sundstøl Eriksen, Malene Louise Johannsen, Erik Ropstad, Silvio Uhlig
Published in: PLOS ONE, Issue 15/12, 2020, Page(s) e0244000, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0244000

A mixture of persistent organic pollutants relevant for human exposure inhibits the transactivation activity of the aryl hydrocarbon receptor in vitro

Author(s): T.Q. Doan, H.F. Berntsen, S. Verhaegen, E. Ropstad, L. Connolly, A. Igout, M. Muller, M.L. Scippo
Published in: Environmental Pollution, Issue 254, 2019, Page(s) 113098, ISSN 0269-7491
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2019.113098

Elucidating the aryl hydrocarbon receptor antagonism from a chemical-structural perspective

Author(s): E. Goya-Jorge, T.Q. Doan, M.L. Scippo, M. Muller, R.M. Giner, S.J. Barigye, R. Gozalbes
Published in: SAR and QSAR in Environmental Research, Issue 31/3, 2020, Page(s) 209-226, ISSN 1062-936X
Publisher: Taylor & Francis
DOI: 10.1080/1062936x.2019.1708460

Detection of high PBDD/Fs levels and dioxin-like activity in toys using a combination of GC-HRMS, rat-based and human-based DR CALUX® reporter gene assays

Author(s): Clémence Budin, Jindrich Petrlik, Jitka Strakova, Stephan Hamm, Bjorn Beeler, Peter Behnisch, Harrie Besselink, Bart van der Burg, Abraham Brouwer
Published in: Chemosphere, Issue 251, 2020, Page(s) 126579, ISSN 0045-6535
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.chemosphere.2020.126579

Potential adverse effects on animal health and performance caused by the addition of mineral adsorbents to feeds to reduce mycotoxin exposure

Author(s): Christopher T. Elliott, Lisa Connolly, Oluwatobi Kolawole
Published in: Mycotoxin Research, Issue 36/1, 2020, Page(s) 115-126, ISSN 0178-7888
Publisher: Hans W. Schmidt
DOI: 10.1007/s12550-019-00375-7

Comparative In Vitro Assessment of a Range of Commercial Feed Additives with Multiple Mycotoxin Binding Claims

Author(s): Kolawole, Meneely, Greer, Chevallier, Jones, Connolly, Elliott
Published in: Toxins, Issue 11/11, 2019, Page(s) 659, ISSN 2072-6651
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/toxins11110659

Human blood-based exposure levels of persistent organic pollutant (POP) mixtures antagonise androgen receptor transactivation and translocation

Author(s): J. McComb, I.G. Mills, M. Muller, H.F. Berntsen, K.E. Zimmer, E. Ropstad, S. Verhaegen, L. Connolly
Published in: Environment International, Issue 132, 2019, Page(s) 105083, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2019.105083

DMSO effects larval zebrafish (Danio rerio) behavior, with additive and interaction effects when combined with positive controls

Author(s): Maria Christou, Arturas Kavaliauskis, Erik Ropstad, Thomas William Kenneth Fraser
Published in: Science of The Total Environment, Issue 709, 2020, Page(s) 134490, ISSN 0048-9697
Publisher: Elsevier BV
DOI: 10.1016/j.scitotenv.2019.134490

Antagonistic activity towards the androgen receptor independent from natural sex hormones in human milk samples from the Norwegian HUMIS cohort

Author(s): Bérénice Collet, Barbara M.A. van Vugt-Lussenburg, Kees Swart, Rick Helmus, Matthijs Naderman, Eva de Rijke, Merete Eggesbø, Abraham Brouwer, Bart van der Burg
Published in: Environment International, Issue 143, 2020, Page(s) 105948, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2020.105948

Calcium signaling as a possible mechanism behind increased locomotor response in zebrafish larvae exposed to a human relevant persistent organic pollutant mixture or PFOS

Author(s): Maria Christou, Thomas W.K. Fraser, Vidar Berg, Erik Ropstad, Jorke H. Kamstra
Published in: Environmental Research, Issue 187, 2020, Page(s) 109702, ISSN 0013-9351
Publisher: Academic Press
DOI: 10.1016/j.envres.2020.109702

Acute Exposure to Zearalenone Disturbs Intestinal Homeostasis by Modulating the Wnt/β-Catenin Signaling Pathway

Author(s): Tarek Lahjouji, Aurora Bertaccini, Manon Neves, Sylvie Puel, Isabelle P. Oswald, Laura Soler
Published in: Toxins, Issue 12/2, 2020, Page(s) 113, ISSN 2072-6651
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/toxins12020113

Novel Microcystins from Planktothrix prolifica NIVA-CYA 544 Identified by LC-MS/MS, Functional Group Derivatization and 15N-labeling

Author(s): Vittoria Mallia, Silvio Uhlig, Cheryl Rafuse, Juris Meija, Christopher O. Miles
Published in: Marine Drugs, Issue 17/11, 2019, Page(s) 643, ISSN 1660-3397
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/md17110643

A human relevant mixture of persistent organic pollutants (POPs) and perfluorooctane sulfonic acid (PFOS) differentially affect glutamate induced excitotoxic responses in chicken cerebellum granule neurons (CGNs) in vitro

Author(s): Ajay Yadav, Steven Verhaegen, Evelien Verbruggen, Marie Kerhoas, Eva Henriëtte Willemijn Huiberts, Mussie Ghezu Hadera, Hanne Friis Berntsen, Karin Elisabeth Zimmer, Erik Ropstad, Ragnhild Elisabeth Paulsen
Published in: Reproductive Toxicology, Issue 100, 2021, Page(s) 109-119, ISSN 0890-6238
Publisher: Elsevier BV
DOI: 10.1016/j.reprotox.2021.01.008

Developmental exposure to a POPs mixture or PFOS increased body weight and reduced swimming ability but had no effect on reproduction or behavior in zebrafish adults

Author(s): Maria Christou, Erik Ropstad, Stephen Brown, Jorke H. Kamstra, Thomas W.K. Fraser
Published in: Aquatic Toxicology, Issue 237, 2021, Page(s) 105882, ISSN 0166-445X
Publisher: Elsevier BV
DOI: 10.1016/j.aquatox.2021.105882

Low Doses of Mycotoxin Mixtures below EU Regulatory Limits Can Negatively Affect the Performance of Broiler Chickens: A Longitudinal Study

Author(s): Oluwatobi Kolawole, Abigail Graham, Caroline Donaldson, Bronagh Owens, Wilfred A. Abia, Julie Meneely, Michael J. Alcorn, Lisa Connolly, Christopher T. Elliott
Published in: Toxins, Issue 12/7, 2020, Page(s) 433, ISSN 2072-6651
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/toxins12070433

In vitro differential responses of rat and human aryl hydrocarbon receptor to two distinct ligands and to different polyphenols.

Author(s): Marc Muller; Ahmed Igout; Thi-Que Doan; Lisa Connolly; Marie-Louise Scippo
Published in: Environmental Pollution, Issue 6, 2020, ISSN 0269-7491
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2020.114966

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