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Educational Network in Ocular Drug Delivery and Therapeutics

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Publications

Topical ocular pharmacokinetics and bioavailability for a cocktail of atenolol, timolol and betaxolol in rabbits

Author(s): Anam Fayyaz, Veli-Pekka Ranta, Elisa Toropainen, Kati-Sisko Vellonen, Annika Valtari, Jooseppi Puranen, Marika Ruponen, Iain Gardner, Arto Urtti, Masoud Jamei, Eva M. del Amo
Published in: European Journal of Pharmaceutical Sciences, Issue 155, 2020, Page(s) 105553, ISSN 0928-0987
DOI: 10.1016/j.ejps.2020.105553

Versatile Reversible Cross-Linking Strategy to Stabilize CCMV Virus Like Particles for Efficient siRNA Delivery

Author(s): Chiara Pretto, Jan C. M. van Hest
Published in: Bioconjugate Chemistry, Issue 30/12, 2019, Page(s) 3069-3077, ISSN 1043-1802
DOI: 10.1021/acs.bioconjchem.9b00731

Modulation of three key innate immune pathways for the most common retinal degenerative diseases

Author(s): Isha Akhtar‐Schäfer, Luping Wang, Tim U Krohne, Heping Xu, Thomas Langmann
Published in: EMBO Molecular Medicine, Issue 10/10, 2018, Page(s) e8259, ISSN 1757-4676
DOI: 10.15252/emmm.201708259

Dexamethasone Loaded Liposomes by Thin-Film Hydration and Microfluidic Procedures: Formulation Challenges

Author(s): MD Al-Amin, Federica Bellato, Francesca Mastrotto, Mariangela Garofalo, Alessio Malfanti, Stefano Salmaso, Paolo Caliceti
Published in: International Journal of Molecular Sciences, Issue 21/5, 2020, Page(s) 1611, ISSN 1422-0067
DOI: 10.3390/ijms21051611

Fatty acids and oxidized lipoproteins contribute to autophagy and innate immunity responses upon the degeneration of retinal pigment epithelium and development of age-related macular degeneration

Author(s): Kai Kaarniranta, Ali Koskela, Szabolcs Felszeghy, Niko Kivinen, Antero Salminen, Anu Kauppinen
Published in: Biochimie, Issue 159, 2019, Page(s) 49-54, ISSN 0300-9084
DOI: 10.1016/j.biochi.2018.07.010

Pharmacokinetics of intravitreal macromolecules: scaling between rats and rabbits

Author(s): Amir Sadeghi, Jooseppi Puranen, Marika Ruponen, Annika Valtari, Astrid Subrizi, Veli-Pekka Ranta, Elisa Toropainen, Arto Urtti
Published in: European Journal of Pharmaceutical Sciences, 2021, Page(s) 105720, ISSN 0928-0987
DOI: 10.1016/j.ejps.2021.105720

Advances in Drug Delivery and Biomaterials: Facts and Vision

Author(s): Paolo Caliceti, Pietro Matricardi
Published in: Pharmaceutics, Issue 11/1, 2019, Page(s) 48, ISSN 1999-4923
DOI: 10.3390/pharmaceutics11010048

Mechanistical retinal drug targets and challenges

Author(s): Kai Kaarniranta, Heping Xu, Anu Kauppinen
Published in: Advanced Drug Delivery Reviews, Issue 126, 2018, Page(s) 177-184, ISSN 0169-409X
DOI: 10.1016/j.addr.2018.04.016

Intravitreal hydrogels for sustained release of therapeutic proteins

Author(s): Blessing C. Ilochonwu, Arto Urtti, Wim E. Hennink, Tina Vermonden
Published in: Journal of Controlled Release, Issue 326, 2020, Page(s) 419-441, ISSN 0168-3659
DOI: 10.1016/j.jconrel.2020.07.031

Cytokine Signaling Protein 3 Deficiency in Myeloid Cells Promotes Retinal Degeneration and Angiogenesis through Arginase-1 Up-Regulation in Experimental Autoimmune Uveoretinitis

Author(s): Mei Chen, Jiawu Zhao, Imran H.A. Ali, Stephen Marry, Josy Augustine, Mohajeet Bhuckory, Aisling Lynch, Adrien Kissenpfennig, Heping Xu
Published in: The American Journal of Pathology, Issue 188/4, 2018, Page(s) 1007-1020, ISSN 0002-9440
DOI: 10.1016/j.ajpath.2017.12.021

Single‐cell RNA sequencing study of retinal immune regulators identified CD47 and CD59a expression in photoreceptors—Implications in subretinal immune regulation

Author(s): Jian Liu, Miao Tang, Kevin Harkin, Xuan Du, Chang Luo, Mei Chen, Heping Xu
Published in: Journal of Neuroscience Research, 2020, ISSN 0360-4012
DOI: 10.1002/jnr.24618

Microplasma assisted synthesis of gold nanoparticle/graphene oxide nanocomposites and their potential application in SERS sensing

Author(s): Daye Sun, Miao Tang, Li Zhang, Brian G Falzon, Dilli Babu Padmanaban, Davide Mariotti, Paul Maguire, Heping Xu, Mei Chen, Dan Sun
Published in: Nanotechnology, Issue 30/45, 2019, Page(s) 455603, ISSN 0957-4484
DOI: 10.1088/1361-6528/ab2a23

Dexamethasone Loaded Liposomes by Thin-Film Hydration and Microfluidic Procedures: Formulation Challenges

Author(s): MD Al-Amin, Federica Bellato, Francesca Mastrotto, Mariangela Garofalo, Alessio Malfanti, Stefano Salmaso, Paolo Caliceti
Published in: International Journal of Molecular Sciences, Issue 21/5, 2020, Page(s) 1611, ISSN 1422-0067
DOI: 10.3390/ijms21051611

Characterization, Stability, and In Vivo Efficacy Studies of Recombinant Human CNTF and Its Permeation into the Neural Retina in Ex Vivo Organotypic Retinal Explant Culture Models

Author(s): Jaakko Itkonen, Ada Annala, Shirin Tavakoli, Blanca Arango-Gonzalez, Marius Ueffing, Elisa Toropainen, Marika Ruponen, Marco G. Casteleijn, Arto Urtti
Published in: Pharmaceutics, Issue 12/7, 2020, Page(s) 611, ISSN 1999-4923
DOI: 10.3390/pharmaceutics12070611

Macrophage to myofibroblast transition contributes to subretinal fibrosis secondary to neovascular age-related macular degeneration

Author(s): Karis Little; Maria Llorián-Salvador; Miao Tang; Xuan Du; Stephen Marry; Mei Chen; Heping Xu
Published in: Journal of Neuroinflammation, Issue 17:355, 2020, ISSN 1742-2094
DOI: 10.1186/s12974-020-02033-7

Ocular Intracameral Pharmacokinetics for a Cocktail of Timolol, Betaxolol, and Atenolol in Rabbits

Author(s): Anam Fayyaz, Veli-Pekka Ranta, Elisa Toropainen, Kati-Sisko Vellonen, Giuseppe D’Amico Ricci, Mika Reinisalo, Emma M. Heikkinen, Iain Gardner, Arto Urtti, Masoud Jamei, Eva M. del Amo
Published in: Molecular Pharmaceutics, 2020, Page(s) 588–594, ISSN 1543-8384
DOI: 10.1021/acs.molpharmaceut.9b01024

Pharmacological interference in the VCP/ERAD/proteasome axis rescues photoreceptor degeneration in RhP23H

Author(s): Merve Sen; Oksana Kutsyr; Sylvia Bolz; Tsui-Fen Chou; Ray Deshaies; Blanca Arango-Gonzalez and Marius Ueffing
Published in: Investigative Ophthalmology & Visual Science, Issue 60,4881, 2019
DOI: 10.5281/zenodo.4485790