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Decoding dynamic chromatin signaling by single-molecule multiplex detection

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Publications

BAF restricts cGAS on nuclear DNA to prevent innate immune activation

Author(s): Guey B, Wischnewski M, Decout A, Makasheva K, Kaynak M, Sakar MS, Fierz B, Ablasser A
Published in: Science, 2020, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aaw6421

Structural mechanism of cGAS inhibition by the nucleosome

Author(s): Pathare GR, Decout A, Glück S, Cavadini S, Makasheva K, Hovius R, Kempf G, Weiss J, Kozicka Z, Guey B, Melenec P, Fierz B, Thomä NH, Ablasser A.
Published in: Nature, 2020, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2750-6

Single-molecule FRET reveals multiscale chromatin dynamics modulated by HP1α

Author(s): Sinan Kilic, Suren Felekyan, Olga Doroshenko, Iuliia Boichenko, Mykola Dimura, Hayk Vardanyan, Louise C. Bryan, Gaurav Arya, Claus A. M. Seidel, Beat Fierz
Published in: Nature Communications, 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-017-02619-5

A bi-terminal protein ligation strategy to probe chromatin structure during DNA damage

Author(s): Sinan Kilic, Iuliia Boichenko, Carolin C. Lechner, Beat Fierz
Published in: Chemical Science, 9/15, 2018, Page(s) 3704-3709, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8sc00681d

Chromatin Fiber Invasion and Nucleosome Displacement by the Rap1 Transcription Factor

Author(s): Maxime Mivelaz, Anne-Marinette Cao, Slawomir Kubik, Sevil Zencir, Ruud Hovius, Iuliia Boichenko, Anna Maria Stachowicz, Christoph F. Kurat, David Shore, Beat Fierz
Published in: Molecular Cell, 2019, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2019.10.025

Multiplexed Single-Molecule Experiments Reveal Nucleosome Invasion Dynamics of the Cas9 Genome Editor

Author(s): Makasheva K, Bryan LC, Anders C, Panikulam S, Jinek M, Fierz B
Published in: JACS, 2021, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.1c06195

Nucleosome Binding by the Lysine Specific Demethylase 1 (LSD1) Enzyme Enables Histone H3 Demethylation.

Author(s): Abhinav Dhall; Patrick M. M. Shelton; Aurore Marie-France Delachat; Calvin Jon Antolin Leonen; Beat Fierz; Champak Chatterjee
Published in: Biochemistry, 1, 2020, Page(s) Vol 59, 2479-2483
Publisher: American Chemical Society
DOI: 10.1021/acs.biochem.0c00412

Chemical and biophysical methods to explore dynamic mechanisms of chromatin silencing

Author(s): Iuliia Boichenko, Beat Fierz
Published in: Current Opinion in Chemical Biology, 51, 2019, Page(s) 1-10, ISSN 1367-5931
Publisher: Elsevier BV
DOI: 10.1016/j.cbpa.2019.01.022

Re-evaluating the role of nucleosomal bivalency in early development

Author(s): Rohan N. Shah, Adrian T. Grzybowski, Jimmy Elias, Zhonglei Chen, Takamitsu Hattori, Carolin C. Lechner, Peter W. Lewis, Shohei Koide, Beat Fierz, Alexander J. Ruthenburg
Published in: BioRxiv, 2021
Publisher: CSH
DOI: 10.1101/2021.09.09.458948