Ribosome inhibition by nascent or antimicrobial peptides

Project Information

NascenTomiX

Grant agreement ID: 724040

DOI

10.3030/724040

Project closed

EC signature date 14 March 2017

Start date 1 June 2017

End date 31 May 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 999 125,00

EU contribution

€ 1 999 125,00

Coordinated by

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (8)

Structural basis for the tryptophan sensitivity of TnaC-mediated ribosome stalling

Author(s): Anne-Xander van der Stel, Emily R Gordon, Arnab Sengupta, Allyson K Martínez, Dorota Klepacki, Thomas N Perry, Alba Herrero Del Valle, Nora Vázquez-Laslop, Matthew S Sachs, Luis R Cruz-Vera, C Axel Innis
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-25663-8

Tetracenomycin X sequesters peptidyl-tRNA during translation of QK motifs.

Author(s): Elodie C. Leroy, Thomas N. Perry, Thibaud T. Renault, C. Axel Innis
Published in: Nature Chemical Biology, 2023, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/s41589-023-01343-0

Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics

Author(s): Bertrand Beckert, Elodie C. Leroy, Shanmugapriya Sothiselvam, Lars V. Bock, Maxim S. Svetlov, Michael Graf, Stefan Arenz, Maha Abdelshahid, Britta Seip, Helmut Grubmüller, Alexander S. Mankin, C. Axel Innis, Nora Vázquez-Laslop, Daniel N. Wilson
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-24674-9

The Dolphin Proline-Rich Antimicrobial Peptide Tur1A Inhibits Protein Synthesis by Targeting the Bacterial Ribosome

Author(s): Mario Mardirossian, Natacha Pérébaskine, Monica Benincasa, Stefano Gambato, Sven Hofmann, Paul Huter, Claudia Müller, Kai Hilpert, C. Axel Innis, Alessandro Tossi, Daniel N. Wilson
Published in: Cell Chemical Biology, Issue 25/5, 2018, Page(s) 530-539.e7, ISSN 2451-9456
Publisher: Cell Press (Elsevier)
DOI: 10.1016/j.chembiol.2018.02.004

Ribosomal stalling landscapes revealed by high-throughput inverse toeprinting of mRNA libraries

Author(s): Britta Seip, Guénaël Sacheau, Denis Dupuy, C Axel Innis
Published in: Life Science Alliance, Issue 1/5, 2018, Page(s) e201800148, ISSN 2575-1077
Publisher: Life Science Alliance LLC
DOI: 10.26508/lsa.201800148

Ornithine capture by a translating ribosome controls bacterial polyamine synthesis

Author(s): Alba Herrero del Valle, Britta Seip, Iñaki Cervera-Marzal, Guénaël Sacheau, A. Carolin Seefeldt, C. Axel Innis
Published in: Nature Microbiology, Issue 5/4, 2020, Page(s) 554-561, ISSN 2058-5276
Publisher: Springer Nature
DOI: 10.1038/s41564-020-0669-1

Proline-Rich Antimicrobial Peptides in Medicinal Maggots of Lucilia sericata Interact With Bacterial DnaK But Do Not Inhibit Protein Synthesis

Author(s): Małgorzata Cytryńska, Mohammad Rahnamaeian, Agnieszka Zdybicka-Barabas, Kristin Dobslaff, Thole Züchner, Guénaël Sacheau, C. Axel Innis, Andreas Vilcinskas
Published in: Frontiers in Pharmacology, Issue 11, 2020, ISSN 1663-9812
Publisher: Frontiers Media S.A.
DOI: 10.3389/fphar.2020.00532

Regulation of the macrolide resistance ABC-F translation factor MsrD

Author(s): Corentin R. Fostier, Farès Ousalem, Elodie C. Leroy, Saravuth Ngo, Heddy Soufari, C. Axel Innis,Yaser Hashem, Grégory Boël
Published in: Nature Communications, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-39553-8

Other (3)

Prospects for antimicrobial development in the cryo-EM era - a focus on the ribosome.

Author(s): Alba Herrero del Valle; C. Axel Innis
Published in: FEMS Microbiology Reviews, 2020, ISSN 0168-6445
Publisher: Blackwell
DOI: 10.1093/femsre/fuaa032

Using the Bacterial Ribosome as a Discovery Platform for Peptide-Based Antibiotics

Author(s): Justine Charon, Aitor Manteca, C. Axel Innis
Published in: Biochemistry, Issue 58/2, 2018, Page(s) 75-84, ISSN 0006-2960
Publisher: American Chemical Society
DOI: 10.1021/acs.biochem.8b00927

Directed Evolution in Drops: Molecular Aspects and Applications

Author(s): Aitor Manteca, Alejandra Gadea, David Van Assche, Pauline Cossard, Mélanie Gillard-Bocquet, Thomas Beneyton, C. Axel Innis, Jean-Christophe Baret
Published in: ACS Synthetic Biology, 2021, ISSN 2161-5063
Publisher: American Chemical Society
DOI: 10.1021/acssynbio.1c00313