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Ribosome inhibition by nascent or antimicrobial peptides

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Publications

Structural basis for the tryptophan sensitivity of TnaC-mediated ribosome stalling

Author(s): Anne-Xander van der Stel, Emily R Gordon, Arnab Sengupta, Allyson K Martínez, Dorota Klepacki, Thomas N Perry, Alba Herrero Del Valle, Nora Vázquez-Laslop, Matthew S Sachs, Luis R Cruz-Vera, C Axel Innis
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-25663-8

Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics

Author(s): Beckert B, Leroy EC, Sothiselvam S, Bock LV, Svetlov MS, Graf M, Arenz S, Abdelshahid M, Seip B, Grubmüller H, Mankin AS, Innis CA, Vázquez-Laslop N, Wilson DN.
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-24674-9

The Dolphin Proline-Rich Antimicrobial Peptide Tur1A Inhibits Protein Synthesis by Targeting the Bacterial Ribosome

Author(s): Mario Mardirossian, Natacha Pérébaskine, Monica Benincasa, Stefano Gambato, Sven Hofmann, Paul Huter, Claudia Müller, Kai Hilpert, C. Axel Innis, Alessandro Tossi, Daniel N. Wilson
Published in: Cell Chemical Biology, 25/5, 2018, Page(s) 530-539.e7, ISSN 2451-9456
Publisher: Cell Press (Elsevier)
DOI: 10.1016/j.chembiol.2018.02.004

Ribosomal stalling landscapes revealed by high-throughput inverse toeprinting of mRNA libraries

Author(s): Britta Seip, Guénaël Sacheau, Denis Dupuy, C Axel Innis
Published in: Life Science Alliance, 1/5, 2018, Page(s) e201800148, ISSN 2575-1077
Publisher: Life Science Alliance LLC
DOI: 10.26508/lsa.201800148

Ornithine capture by a translating ribosome controls bacterial polyamine synthesis

Author(s): Alba Herrero del Valle, Britta Seip, Iñaki Cervera-Marzal, Guénaël Sacheau, A. Carolin Seefeldt, C. Axel Innis
Published in: Nature Microbiology, 5/4, 2020, Page(s) 554-561, ISSN 2058-5276
Publisher: Springer Nature
DOI: 10.1038/s41564-020-0669-1

Proline-Rich Antimicrobial Peptides in Medicinal Maggots of Lucilia sericata Interact With Bacterial DnaK But Do Not Inhibit Protein Synthesis

Author(s): Małgorzata Cytryńska, Mohammad Rahnamaeian, Agnieszka Zdybicka-Barabas, Kristin Dobslaff, Thole Züchner, Guénaël Sacheau, C. Axel Innis, Andreas Vilcinskas
Published in: Frontiers in Pharmacology, 11, 2020, ISSN 1663-9812
Publisher: Frontiers Media S.A.
DOI: 10.3389/fphar.2020.00532

Prospects for antimicrobial development in the cryo-EM era - a focus on the ribosome.

Author(s): Alba Herrero del Valle; C. Axel Innis
Published in: FEMS Microbiology Reviews, 2020, ISSN 0168-6445
Publisher: Blackwell
DOI: 10.1093/femsre/fuaa032

Using the Bacterial Ribosome as a Discovery Platform for Peptide-Based Antibiotics

Author(s): Justine Charon, Aitor Manteca, C. Axel Innis
Published in: Biochemistry, 58/2, 2018, Page(s) 75-84, ISSN 0006-2960
Publisher: American Chemical Society
DOI: 10.1021/acs.biochem.8b00927

Directed Evolution in Drops: Molecular Aspects and Applications

Author(s): Aitor Manteca, Alejandra Gadea, David Van Assche, Pauline Cossard, Mélanie Gillard-Bocquet, Thomas Beneyton, C. Axel Innis, Jean-Christophe Baret
Published in: ACS Synthetic Biology, 2021, ISSN 2161-5063
Publisher: American Chemical Society
DOI: 10.1021/acssynbio.1c00313