Protection of cardiometabolic inflammation by modulation of myeloid glutamine homeostasis

Project Information

PROGLUTASIS

Grant agreement ID: 724838

DOI

10.3030/724838

Project closed

EC signature date 13 March 2017

Start date 1 April 2017

End date 30 September 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 091 338,00

EU contribution

€ 2 091 338,00

Coordinated by

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (17)

Does metabolism protect our immune system?

Author(s): Laurent Yvan-Charvet, Béatrice Bailly-Maitre
Published in: médecine/sciences, Issue 38/6, 2022, ISSN 0767-0974
Publisher: Editions E D K
DOI: 10.1051/medsci/2022075

Metabolic Reprogramming of Macrophages in Atherosclerosis: Is It All about Cholesterol?

Author(s): Laurent Yvan-Charvet, Stoyan Ivanov
Published in: J Lipid Atheroscler, Issue 9/2, 2020, ISSN 2287-2892
Publisher: Korean Society of Lipid and Atherosclerosis
DOI: 10.12997/jla.2020.9.2.231

Cholesterol efflux pathways hinder KRAS-driven lung tumor progenitor cell expansion

Author(s): Emma Guilbaud, Thibault Barouillet, Marius Ilie, Coraline Borowczyk, Stoyan Ivanov, Vincent Sarrazy, Nathalie Vaillant, Marion Ayrault, Alexia Castiglione, Guylène Rignol, Patrick Brest, Venetia Bazioti, Konstantin Zaitsev, Kevin Lebrigand, Sébastien Dussaud, Virginie Magnone, Corine Bertolotto, Sandrine Marchetti, Marie Irondelle, Ira Goldberg, Thierry Huby, Marit Westerterp, Emmanuel L Gautier
Published in: Cell Stem Cell, Issue 30/6, 2023, Page(s) 800-817, ISSN 1875-9777
Publisher: Cell press
DOI: 10.1016/j.stem.2023.05.005

Macrophage ontogeny and functional diversity in cardiometabolic diseases

Author(s): Emmanuel L. Gautier, Haoussa Askia, Florent Murcy, Laurent Yvan-Charvet
Published in: Seminars in Cell & Developmental Biology, Issue 119, 2021, Page(s) 119-129, ISSN 1084-9521
Publisher: Academic Press
DOI: 10.1016/j.semcdb.2021.06.023

Mitochondria orchestrate macrophage effector functions in atherosclerosis

Author(s): Adélie Dumont, ManKS. Lee, Thibault Barouillet, Andrew Murphy, Laurent Yvan-Charvet
Published in: Molecular Aspects of Medicine, Issue 77, 2021, Page(s) 100922, ISSN 0098-2997
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.mam.2020.100922

Metabolic Inflammation in Obesity—At the Crossroads between Fatty Acid and Cholesterol Metabolism

Author(s): Sean Curley, Julie Gall, Rachel Byrne, Laurent Yvan‐Charvet, Fiona C. McGillicuddy
Published in: Molecular Nutrition & Food Research, Issue 65/1, 2021, Page(s) 1900482, ISSN 1613-4125
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/mnfr.201900482

Is defective cholesterol efflux an integral inflammatory component in myelopoiesis-driven cardiovascular diseases?

Author(s): Laurent Yvan-Charvet, Filip K Swirski
Published in: European Heart Journal, Issue 39/23, 2018, Page(s) 2168-2171, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehy269

Poststatin era in atherosclerosis management

Author(s): Laurent Yvan-Charvet, Bertrand Cariou
Published in: Current Opinion in Lipidology, 2018, Page(s) 1, ISSN 0957-9672
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/MOL.0000000000000505

Granulopoiesis and Neutrophil Homeostasis: A Metabolic, Daily Balancing Act

Author(s): Laurent Yvan-Charvet, Lai Guan Ng
Published in: Trends in Immunology, Issue 40/7, 2019, Page(s) 598-612, ISSN 1471-4906
Publisher: Elsevier BV
DOI: 10.1016/j.it.2019.05.004

Le sommeil protège-t-il nos vaisseaux sanguins ?

Author(s): Laurent Yvan-Charvet, Johanna Merlin
Published in: médecine/sciences, Issue 35/10, 2019, Page(s) 743-746, ISSN 0767-0974
Publisher: Editions E D K
DOI: 10.1051/medsci/2019147

Mesothelial cell CSF1 sustains peritoneal macrophage proliferation

Author(s): Stoyan Ivanov, Alexandre Gallerand, Marilyn Gros, Marion I. Stunault, Johanna Merlin, Nathalie Vaillant, Laurent Yvan‐Charvet, Rodolphe R. Guinamard
Published in: European Journal of Immunology, Issue 49/11, 2019, Page(s) 2012-2018, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201948164

Immunometabolic function of cholesterol in cardiovascular disease and beyond

Author(s): Laurent Yvan-Charvet, Fabrizia Bonacina, Rodolphe Renè Guinamard, Giuseppe Danilo Norata
Published in: Cardiovascular Research, Issue 115/9, 2019, Page(s) 1393-1407, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvz127

LDL-cholesterol drives reversible myelomonocytic skewing in human bone marrow

Author(s): Laurent Yvan-Charvet, Marit Westerterp
Published in: European Heart Journal, 2021, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehab630

Non-canonical glutamine transamination sustains efferocytosis by coupling redox buffering to oxidative phosphorylation

Author(s): Johanna Merlin, Stoyan Ivanov, Adélie Dumont, Alexey Sergushichev, Julie Gall, Marion Stunault, Marion Ayrault, Nathalie Vaillant, Alexia Castiglione, Amanda Swain, Francois Orange, Alexandre Gallerand, Thierry Berton, Jean-Charles Martin, Stefania Carobbio, Justine Masson, Inna Gaisler-Salomon, Pierre Maechler, Stephen Rayport, Judith C. Sluimer, Erik A. L. Biessen, Rodolphe R. Guinamard, Emmanu
Published in: Nature Metabolism, Issue 3/10, 2021, Page(s) 1313-1326, ISSN 2522-5812
Publisher: nature publishing group
DOI: 10.1038/s42255-021-00471-y

Brown adipose tissue monocytes support tissue expansion

Author(s): Alexandre Gallerand, Marion I. Stunault, Johanna Merlin, Hannah P. Luehmann, Deborah H. Sultan, Maria M. Firulyova, Virginie Magnone, Narges Khedher, Antoine Jalil, Bastien Dolfi, Alexia Castiglione, Adelie Dumont, Marion Ayrault, Nathalie Vaillant, Jérôme Gilleron, Pascal Barbry, David Dombrowicz, Matthias Mack, David Masson, Thomas Bertero, Burkhard Becher, Jesse W. Williams, Konstantin Zaitse
Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-25616-1

Unravelling the sex-specific diversity and functions of adrenal gland macrophages

Author(s): Bastien Dolfi, Alexandre Gallerand, Maria M. Firulyova, Yingzheng Xu, Johanna Merlin, Adélie Dumont, Alexia Castiglione, Nathalie Vaillant, Sandrine Quemener, Heidi Gerke, Marion I. Stunault, Patricia R. Schrank, Seung-Hyeon Kim, Alisha Zhu, Jie Ding, Jerome Gilleron, Virginie Magnone, Pascal Barbry, David Dombrowicz, Christophe Duranton, Abdelilah Wakkach, Claudine Blin-Wakkach, Burkhard Becher,
Published in: Cell Rep, Issue 39/11, 2022, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2022.110949

Inflamed macrophages sans mitochondrial pyruvate carrier?

Author(s): Laurent Yvan-Charvet, Edward Benjamin Thorp
Published in: Nature Metabolism, Issue 5/5, 2023, ISSN 2522-5812
Publisher: nature publishing group
DOI: 10.1038/s42255-023-00789-9