Extra-gonadal roles of Anti-Müllerian Hormone in the aetiology of polycystic ovary syndrome: the domino effect to reproductive neuroendocrine dysfunctions

Project Information

REPRODAMH

Grant agreement ID: 725149

DOI 10.3030/725149

Project closed

EC signature date 27 April 2017

Start date 1 May 2017

End date 28 February 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 999 740,00

EU contribution € 1 999 740,00

Coordinated by

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

Publications

Peer reviewed articles (17)

Animal Models to Understand the Etiology and Pathophysiology of Polycystic Ovary Syndrome

Author(s): Elisabet Stener-Victorin, Vasantha Padmanabhan, Kirsty A Walters, Rebecca E Campbell, Anna Benrick, Paolo Giacobini, Daniel A Dumesic, David H Abbott
Published in: Endocrine Reviews, Issue 41/4, 2020, Page(s) 538-576, ISSN 0163-769X
Publisher: The Endocrine Society
DOI: 10.1210/endrev/bnaa010

The proportion of cleaved anti-Müllerian hormone is higher in serum but not follicular fluid of obese women independently of polycystic ovary syndrome

Author(s): Maëliss Peigné, Pascal Pigny, Michaël W. Pankhurst, Elodie Drumez, Anne Loyens, Didier Dewailly, Sophie Catteau-Jonard, Paolo Giacobini
Published in: Reproductive BioMedicine Online, Issue 41/6, 2020, Page(s) 1112-1121, ISSN 1472-6483
Publisher: Reproductive Healthcare Ltd
DOI: 10.1016/j.rbmo.2020.07.020

Don’t Trust Your Gut: When Gut Microbiota Disrupt Fertility

Author(s): Mauro S.B. Silva, Paolo Giacobini
Published in: Cell Metabolism, Issue 30/4, 2019, Page(s) 616-618, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2019.09.005

The Versatile Tanycyte: A Hypothalamic Integrator of Reproduction and Energy Metabolism

Author(s): Vincent Prevot, Bénédicte Dehouck, Ariane Sharif, Philippe Ciofi, Paolo Giacobini, Jerome Clasadonte
Published in: Endocrine Reviews, Issue 39/3, 2018, Page(s) 333-368, ISSN 0163-769X
Publisher: The Endocrine Society
DOI: 10.1210/er.2017-00235

GnRH replacement rescues cognition in Down syndrome

Author(s): Maria Manfredi-Lozano, Valerie Leysen, Michela Adamo, Isabel Paiva, Renaud Rovera, Jean-Michel Pignat, Fatima Ezzahra Timzoura, Michael Candlish, Sabiha Eddarkaoui, Samuel A. Malone, Mauro S. B. Silva, Sara Trova, Monica Imbernon, Laurine Decoster, Ludovica Cotellessa, Manuel Tena-Sempere, Marc Claret, Ariane Paoloni-Giacobino, Damien Plassard, Emmanuelle Paccou, Nathalie Vionnet, James Acierno, A
Published in: Science, Issue Vol 377, Issue 6610, 2022, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abq4515

New insights into anti-Müllerian hormone role in the hypothalamic–pituitary–gonadal axis and neuroendocrine development

Author(s): Mauro S. B. Silva, Paolo Giacobini
Published in: Cellular and Molecular Life Sciences, Issue 78/1, 2021, Page(s) 1-16, ISSN 1420-682X
Publisher: Birkhauser Verlag
DOI: 10.1007/s00018-020-03576-x

Changes in circulating forms of anti-Müllerian hormone and androgens in women with and without PCOS: a systematic longitudinal study throughout pregnancy

Author(s): Peigne ́M, Simon S, Pigny P, Mimouni N.E.H., Martin C, Dewailly D, Catteau-Jonard S, Giacobini P
Published in: Human Reproduction, 2023, Page(s) 1-13, ISSN 0268-1161
Publisher: Oxford University Press
DOI: 10.1093/humrep/dead050

Defective AMH signaling disrupts GnRH neuron development and function and contributes to hypogonadotropic hypogonadism

Author(s): Samuel Andrew Malone, Georgios E Papadakis, Andrea Messina, Nour El Houda Mimouni, Sara Trova, Monica Imbernon, Cecile Allet, Irene Cimino, James Acierno, Daniele Cassatella, Cheng Xu, Richard Quinton, Gabor Szinnai, Pascal Pigny, Lur Alonso-Cotchico, Laura Masgrau, Jean-Didier Maréchal, Vincent Prevot, Nelly Pitteloud, Paolo Giacobini
Published in: eLife, Issue 8, 2019, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.47198

Emerging Roles of Anti-Müllerian Hormone in Hypothalamic-Pituitary Function

Author(s): Anne-Laure Barbotin, Maëliss Peigné, Samuel Andrew Malone, Paolo Giacobini
Published in: Neuroendocrinology, Issue 109/3, 2019, Page(s) 218-229, ISSN 0028-3835
Publisher: S. Karger AG
DOI: 10.1159/000500689

Elevated prenatal anti-Müllerian hormone reprograms the fetus and induces polycystic ovary syndrome in adulthood

Author(s): Brooke Tata, Nour El Houda Mimouni, Anne-Laure Barbotin, Samuel A. Malone, Anne Loyens, Pascal Pigny, Didier Dewailly, Sophie Catteau-Jonard, Inger Sundström-Poromaa, Terhi T. Piltonen, Federica Dal Bello, Claudio Medana, Vincent Prevot, Jerome Clasadonte, Paolo Giacobini
Published in: Nature Medicine, Issue 24/6, 2018, Page(s) 834-846, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-018-0035-5

Quantitation of endogenous GnRH by validated nano‑HPLC‑HRMSmethod: a pilot study on ewe plasma

Author(s): Enrica Mecarelli, Riccardo Aigotti, Alberto Asteggiano, Paolo Giacobini, Manon Chasles, Yves Tillet, Federica Dal Bello, Claudio Medana
Published in: Analytical and Bioanalytical Chemistry, 2022, ISSN 1618-2642
Publisher: Springer Verlag
DOI: 10.1007/s00216-022-04293-z

Female sexual behavior is disrupted in a preclinical mouse model of PCOS via an attenuated hypothalamic nitric oxide pathway

Author(s): Silva MSB, Decoster L, Trova S, Mimouni NEH, Delli V, Chachlaki K, Yu Q, Boehm U, Prevot V, Giacobini P
Published in: Proc Natl Acad Sci U S A, 2022, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2203503119

Polycystic ovary syndrome is transmitted via a transgenerational epigenetic process

Author(s): Nour El Houda Mimouni, Isabel Paiva, Anne-Laure Barbotin, Fatima Ezzahra Timzoura, Damien Plassard, Stephanie Le Gras, Gaetan Ternier, Pascal Pigny, Sophie Catteau-Jonard, Virginie Simon, Vincent Prevot, Anne-Laurence Boutillier, Paolo Giacobini
Published in: Cell Metabolism, Issue 33/3, 2021, Page(s) 513-530.e8, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2021.01.004

Loss-of-function variants in SEMA3F and PLXNA3 encoding semaphorin-3F and its receptor plexin-A3 respectively cause idiopathic hypogonadotropic hypogonadism

Author(s): Leman Damla Kotan, Gaetan Ternier, Aydilek Dagdeviren Cakir, Hamdi Cihan Emeksiz, Ihsan Turan, Gaspard Delpouve, Asli Derya Kardelen, Bahar Ozcabi, Emregul Isik, Eda Mengen, Esra Deniz P. Cakir, Aysegul Yuksel, Sebahat Yilmaz Agladioglu, Semine Ozdemir Dilek, Olcay Evliyaoglu, Feyza Darendeliler, Fatih Gurbuz, Gamze Akkus, Bilgin Yuksel, Paolo Giacobini, A. Kemal Topaloglu
Published in: Genetics in Medicine, Issue 23/6, 2021, Page(s) 1008-1016, ISSN 1098-3600
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1038/s41436-020-01087-5

Polycystic ovary syndrome mouse model by prenatal exposure to high anti-Müllerian hormone

Author(s): Nour El Houda Mimouni, Paolo Giacobini
Published in: STAR Protocols, Issue 2/3, 2021, Page(s) 100684, ISSN 2666-1667
Publisher: Cell Press
DOI: 10.1016/j.xpro.2021.100684

Development of the gonadotropin‐releasing hormone system

Author(s): Duittoz AH, Forni PE, Giacobini P, Golan M, Mollard P, Negrón AL, Radovick S, Wray S.
Published in: Journal of Neuroendocrinology, 2022, ISSN 1365-2826
Publisher: Wiley Online Library
DOI: 10.1111/jne.13087

Hypothalamic neuroglial plasticity is regulated by anti-Müllerian hormone and disrupted in polycystic ovary syndrome

Author(s): Anne-Laure Barbotin, Nour El Houda Mimouni, Grégory Kuchcinski, Renaud Lopes, Romain Viard, Sowmyalakshmi Rasika, Daniele Mazur, Mauro S.B. Silva, Virginie Simon, Angèle Boursier, Jean-Pierre Pruvo, Qiang Yu, Michael Candlish, Ulrich Boehm, Federica Dal Bello, Claudio Medana, Pascal Pigny, Didier Dewailly, Vincent Prevot, Sophie Catteau-Jonard, Paolo Giacobini
Published in: eBioMedicine, Issue VOLUME 90, 104535, APRIL 2023, 2023, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2023.104535

Intellectual Property Rights

Patent (3)

PULSATIVE GNRH ADMINISTRATION FOR TREATING COGNITIVE DISORDERS

Application/Publication number: 20 20061943
Date: 2020-04-29

METHODS FOR DIAGNOSIS AND TREATING POLYCYSTIC OVARY SYNDROME (PCOS)

Application/Publication number: 20 21080741
Date: 2021-11-05

A GNRH ANTAGONIST FOR USE IN THE TREATMENT OF A WOMEN AFFECTED WITH POLYCYSTIC OVARY SYNDROME

Application/Publication number: 20 18056330
Date: 2018-03-14