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Extra-gonadal roles of Anti-Müllerian Hormone in the aetiology of polycystic ovary syndrome: the domino effect to reproductive neuroendocrine dysfunctions

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Animal Models to Understand the Etiology and Pathophysiology of Polycystic Ovary Syndrome

Author(s): Elisabet Stener-Victorin, Vasantha Padmanabhan, Kirsty A Walters, Rebecca E Campbell, Anna Benrick, Paolo Giacobini, Daniel A Dumesic, David H Abbott
Published in: Endocrine Reviews, 41/4, 2020, Page(s) 538-576, ISSN 0163-769X
Publisher: The Endocrine Society
DOI: 10.1210/endrev/bnaa010

The proportion of cleaved anti-Müllerian hormone is higher in serum but not follicular fluid of obese women independently of polycystic ovary syndrome

Author(s): Maëliss Peigné, Pascal Pigny, Michaël W. Pankhurst, Elodie Drumez, Anne Loyens, Didier Dewailly, Sophie Catteau-Jonard, Paolo Giacobini
Published in: Reproductive BioMedicine Online, 41/6, 2020, Page(s) 1112-1121, ISSN 1472-6483
Publisher: Reproductive Healthcare Ltd
DOI: 10.1016/j.rbmo.2020.07.020

Don’t Trust Your Gut: When Gut Microbiota Disrupt Fertility

Author(s): Mauro S.B. Silva, Paolo Giacobini
Published in: Cell Metabolism, 30/4, 2019, Page(s) 616-618, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2019.09.005

The Versatile Tanycyte: A Hypothalamic Integrator of Reproduction and Energy Metabolism

Author(s): Vincent Prevot, Bénédicte Dehouck, Ariane Sharif, Philippe Ciofi, Paolo Giacobini, Jerome Clasadonte
Published in: Endocrine Reviews, 39/3, 2018, Page(s) 333-368, ISSN 0163-769X
Publisher: The Endocrine Society
DOI: 10.1210/er.2017-00235

New insights into anti-Müllerian hormone role in the hypothalamic–pituitary–gonadal axis and neuroendocrine development

Author(s): Mauro S. B. Silva, Paolo Giacobini
Published in: Cellular and Molecular Life Sciences, 78/1, 2021, Page(s) 1-16, ISSN 1420-682X
Publisher: Birkhauser Verlag
DOI: 10.1007/s00018-020-03576-x

Defective AMH signaling disrupts GnRH neuron development and function and contributes to hypogonadotropic hypogonadism

Author(s): Samuel Andrew Malone, Georgios E Papadakis, Andrea Messina, Nour El Houda Mimouni, Sara Trova, Monica Imbernon, Cecile Allet, Irene Cimino, James Acierno, Daniele Cassatella, Cheng Xu, Richard Quinton, Gabor Szinnai, Pascal Pigny, Lur Alonso-Cotchico, Laura Masgrau, Jean-Didier Maréchal, Vincent Prevot, Nelly Pitteloud, Paolo Giacobini
Published in: eLife, 8, 2019, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.47198

Emerging Roles of Anti-Müllerian Hormone in Hypothalamic-Pituitary Function

Author(s): Anne-Laure Barbotin, Maëliss Peigné, Samuel Andrew Malone, Paolo Giacobini
Published in: Neuroendocrinology, 109/3, 2019, Page(s) 218-229, ISSN 0028-3835
Publisher: S. Karger AG
DOI: 10.1159/000500689

Elevated prenatal anti-Müllerian hormone reprograms the fetus and induces polycystic ovary syndrome in adulthood

Author(s): Brooke Tata, Nour El Houda Mimouni, Anne-Laure Barbotin, Samuel A. Malone, Anne Loyens, Pascal Pigny, Didier Dewailly, Sophie Catteau-Jonard, Inger Sundström-Poromaa, Terhi T. Piltonen, Federica Dal Bello, Claudio Medana, Vincent Prevot, Jerome Clasadonte, Paolo Giacobini
Published in: Nature Medicine, 24/6, 2018, Page(s) 834-846, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-018-0035-5

Female sexual behavior is disrupted in a preclinical mouse model of PCOS via an attenuated hypothalamic nitric oxide pathway

Author(s): Silva MSB, Decoster L, Trova S, Mimouni NEH, Delli V, Chachlaki K, Yu Q, Boehm U, Prevot V, Giacobini P
Published in: Proc Natl Acad Sci U S A, 2022, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2203503119

Polycystic ovary syndrome is transmitted via a transgenerational epigenetic process

Author(s): Nour El Houda Mimouni, Isabel Paiva, Anne-Laure Barbotin, Fatima Ezzahra Timzoura, Damien Plassard, Stephanie Le Gras, Gaetan Ternier, Pascal Pigny, Sophie Catteau-Jonard, Virginie Simon, Vincent Prevot, Anne-Laurence Boutillier, Paolo Giacobini
Published in: Cell Metabolism, 33/3, 2021, Page(s) 513-530.e8, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2021.01.004

Loss-of-function variants in SEMA3F and PLXNA3 encoding semaphorin-3F and its receptor plexin-A3 respectively cause idiopathic hypogonadotropic hypogonadism

Author(s): Leman Damla Kotan, Gaetan Ternier, Aydilek Dagdeviren Cakir, Hamdi Cihan Emeksiz, Ihsan Turan, Gaspard Delpouve, Asli Derya Kardelen, Bahar Ozcabi, Emregul Isik, Eda Mengen, Esra Deniz P. Cakir, Aysegul Yuksel, Sebahat Yilmaz Agladioglu, Semine Ozdemir Dilek, Olcay Evliyaoglu, Feyza Darendeliler, Fatih Gurbuz, Gamze Akkus, Bilgin Yuksel, Paolo Giacobini, A. Kemal Topaloglu
Published in: Genetics in Medicine, 23/6, 2021, Page(s) 1008-1016, ISSN 1098-3600
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1038/s41436-020-01087-5

Polycystic ovary syndrome mouse model by prenatal exposure to high anti-Müllerian hormone

Author(s): Nour El Houda Mimouni, Paolo Giacobini
Published in: STAR Protocols, 2/3, 2021, Page(s) 100684, ISSN 2666-1667
Publisher: Cell Press
DOI: 10.1016/j.xpro.2021.100684

Development of the gonadotropin‐releasing hormone system

Author(s): Duittoz AH, Forni PE, Giacobini P, Golan M, Mollard P, Negrón AL, Radovick S, Wray S.
Published in: Journal of Neuroendocrinology, 2022, ISSN 1365-2826
Publisher: Wiley Online Library
DOI: 10.1111/jne.13087