Oogenesis spotlighted: making mature human oocytes

Project Information

OVO-GROWTH

Grant agreement ID: 725722

DOI 10.3030/725722

Project closed

EC signature date 16 June 2017

Start date 1 July 2017

End date 28 February 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 000 000,00

EU contribution € 2 000 000,00

Coordinated by

ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands

Publications

Peer reviewed articles (24)

Two decades of embryonic stem cells: a historical overview

Author(s): Eguizabal C, Aran B, Chuva de Sousa Lopes SM, Geens M, Heindryckx B, Panula S, Popovic M, Vassena R, Veiga A
Published in: Hum Reprod Open, Issue 4, 2019, Page(s) hoy024, ISSN 2399-3529
Publisher: Oxford University Pres
DOI: 10.1093/hropen/hoy024

X chromosome inactivation in human pluripotent stem cells as a model for human development: back to the drawing board?

Author(s): Mieke Geens; Susana M. Chuva de Sousa Lopes; Susana M. Chuva de Sousa Lopes
Published in: Human Reproduction Update, Issue 2, 2017, ISSN 1355-4786
Publisher: Oxford University Press
DOI: 10.1093/humupd/dmx015

Ligand-receptor interactions elucidate sex-specificpathways in the trajectory from primordial germ cells to gonia during human development

Author(s): Overeem AW, Chang YW, Spruit J, Roelse CM, Chuva De Sousa Lopes SM
Published in: Front Cell Dev Biol, Issue 12, 2021, ISSN 2296-634X
Publisher: Frontiers Media S.A.
DOI: 10.3389/fcell.2021.661243

Improving In Vitro Culture of Human Male Fetal Germ Cells.

Author(s): Myriam Martin-Inaraja; Monica Ferreira; Jasin Taelman; Cristina Eguizabal; Susana M. Chuva de Sousa Lopes
Published in: Cells, Issue 12, 2021, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10082033

Transcriptional progression during meiotic prophase I reveals sex-specific features and X chromosome dynamics in human fetal female germline.

Author(s): Xueying Fan; Ioannis Moustakas; Vanessa Torrens-Juaneda; Qijing Lei; Geert Hamer; Leoni A. Louwe; Gonneke S. K. Pilgram; Karoly Szuhai; Roberto Matorras; Cristina Eguizabal; Lucette A. J. van der Westerlaken; Hailiang Mei; Susana M. Chuva de Sousa Lopes; Susana M. Chuva de Sousa Lopes
Published in: Plos Genetics, Issue 12, 2021, ISSN 1553-7390
Publisher: Public Library of Science
DOI: 10.1371/journal.pgen.1009773

Fetal germ cell development in humans, a link with infertility.

Author(s): Czukiewska, S.M.; Lopes, S.M.C.D.
Published in: Seminars in Cell and Developmental Biology, Issue 1, 2022, ISSN 1096-3634
Publisher: Elsevier
DOI: 10.1016/j.semcdb.2022.03.035

Rethinking organoid technology through bioengineering

Author(s): Elena Garreta; Roger D. Kamm; Susana M. Chuva de Sousa Lopes; Madeline A. Lancaster; Ron Weiss; Xavier Trepat; Insoo Hyun; Insoo Hyun; Nuria Montserrat; Nuria Montserrat
Published in: Nature Materials, Issue 12, 2021, ISSN 1476-1122
Publisher: Nature Publishing Group
DOI: 10.1038/s41563-020-00804-4

Cell–cell interactions during the formation of primordial follicles in humans

Author(s): Sylwia M Czukiewska; Xueying Fan; Adriaan A Mulder; Talia Van Der Helm; Sanne Hillenius; Lotte Van Der Meeren; Roberto Matorras; Cristina Eguizabal; Lei Lei; Roman I Koning; Susana M Chuva De Sousa Lopes
Published in: Life Science Alliance, Issue 12, 2023, ISSN 2575-1077
Publisher: Life Science Alliance, LLC
DOI: 10.26508/lsa.202301926

Molecular makeup of the human adult ovary

Author(s): Xueying Fan, Susana M. Chuva de Sousa Lopes
Published in: Current Opinion in Endocrine and Metabolic Research, Issue 18, 2021, Page(s) 187-193, ISSN 2451-9650
Publisher: Elsevier
DOI: 10.1016/j.coemr.2021.03.016

The development of the amnion in mice and other amniotes

Author(s): Chuva de Sousa Lopes SM, Roelen BAJ, Lawson KA, Zwijsen A
Published in: Philosophical Transactions of the Royal Society B: Biological Sciences, 2022, ISSN 1471-2970
Publisher: Royal Society
DOI: 10.1098/rstb.2021.0258

Emerging in vitro platforms and omics technologies for studying the endometrium and early embryo-maternal interface in humans

Author(s): Mina Popovic; Susana M. Chuva de Sousa Lopes
Published in: Placenta, Issue 1, 2022, ISSN 1532-3102
Publisher: Elsevier
DOI: 10.1016/j.placenta.2022.01.006

One-third of amenorrheic transmasculine people on testosterone ovulate

Author(s): Asseler, Joyce D; Del Valle, Julieta S; Chuva de Sousa Lopes, Susana M; Verhoeven, Marieke O; Goddijn, Mariette; Huirne, Judith A F; van Mello, Norah M
Published in: Cell reports medicine, Issue 12, 2024, ISSN 2666-3791
Publisher: cell press
DOI: 10.1016/j.xcrm.2024.101440

Stay on the road: from germ cell specification to gonadal colonization in mammals

Author(s): Roelen BAJ, Chuva de Sousa Lopes SM
Published in: Philosophical Transactions of the Royal Society B: Biological Sciences, 2022, ISSN 1471-2970
Publisher: Royal Society
DOI: 10.1098/rstb.2021.0259

Characterization of the human fetal gonad and reproductive tract by single-cell transcriptomics

Author(s): Taelman J, Czukiewska SM, Moustakas I, Chang YW, Hillenius S, van der Helm T, van der Meeren LE, Mei H, Fan X, Chuva de Sousa Lopes SM.
Published in: Developmental Cell, Issue 24, 2024, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2024.01.006

Bioengineered 3D Ovarian Models as Paramount Technology for Female Health Management and Reproduction

Author(s): Julieta S. Del Valle; Susana M. Chuva de Sousa Lopes
Published in: Bioengineering, Issue 5, 2023, ISSN 2306-5354
Publisher: MDPI
DOI: 10.3390/bioengineering10070832

The extended analogy of extraembryonic development in insects and amniotes

Author(s): Kristen A. Panfilio; Susana M. Chuva de Sousa Lopes
Published in: Philosophical Transactions of the Royal Society B: Biological Sciences, Issue 1, 2022, ISSN 1471-2970
Publisher: Royal Society
DOI: 10.1098/rstb.2021.0268

Characterization of migratory primordial germ cells in the aorta-gonad-mesonephros of a 4.5-week-old human embryo: a toolbox to evaluate in vitro early gametogenesis

Author(s): Maria Gomes Fernandes, Monika Bialecka, Daniela C F Salvatori, Susana M Chuva de Sousa Lopes
Published in: MHR: Basic science of reproductive medicine, Issue 24/5, 2018, Page(s) 233-243, ISSN 1460-2407
Publisher: Oxford Academic
DOI: 10.1093/molehr/gay011

Parental haplotype-specific single-cell transcriptomics reveal incomplete epigenetic reprogramming in human female germ cells

Author(s): Ábel Vértesy, Wibowo Arindrarto, Matthias S. Roost, Björn Reinius, Vanessa Torrens-Juaneda, Monika Bialecka, Ioannis Moustakas, Yavuz Ariyurek, Ewart Kuijk, Hailiang Mei, Rickard Sandberg, Alexander van Oudenaarden, Susana M. Chuva de Sousa Lopes
Published in: Nature Communications, Issue 9/1, 2018, Page(s) na, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-04215-7

Single-cell reconstruction of follicular remodeling in the human adult ovary

Author(s): X. Fan, M. Bialecka, I. Moustakas, E. Lam, V. Torrens-Juaneda, N. V. Borggreven, L. Trouw, L. A. Louwe, G. S. K. Pilgram, H. Mei, L. van der Westerlaken, S. M. Chuva de Sousa Lopes
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-11036-9

Classification of Atretic Small Antral Follicles in the Human Ovary

Author(s): Fu Wei; Xueying Fan; Julieta S. del Valle; Joyce D. Asseler; Lotte E. van der Meeren; Hui Cheng; Bernard A. J. Roelen; Leoni A. Louwe; Gonneke S. K. Pilgram; Lucette A. J. van der Westerlaken; Norah M. van Mello; Susana M. Chuva de Sousa Lopes
Published in: International Journal of Molecular Sciences, Issue 3, 2023, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms242316846

Dynamic in vitro culture of cryopreserved-thawed human ovarian cortical tissue using a microfluidics platform does not improve early folliculogenesis.

Author(s): Del Valle JS, Mancini V, Laverde Garay M, Asseler JD, Fan X, Metzemaekers J, Louwe LA, Pilgram GSK, van der Westerlaken LAJ, van Mello NM, Chuva de Sousa Lopes SM
Published in: Frontiers in Endocrinology, 2022, ISSN 1664-2392
Publisher: Frontiers Media
DOI: 10.3389/fendo.2022.936765

Single-cell transcriptomics reveals gene expression dynamics of human fetal kidney development.

Author(s): Hochane, Mazène; van den Berg, Patrick R.; Fan, Xueying; Bérenger-Currias, Noémie; Adegeest, Esmée; Bialecka, Monika; Nieveen, Maaike; Menschaart, Maarten; Chuva de Sousa Lopes, Susana M.; Semrau, Stefan
Published in: Plos Biol, Issue 12, 2019, ISSN 1544-9173
Publisher: Public Library of Science
DOI: 10.1371/journal.pbio.3000152

Phiclust: a clusterability measure for single-cell transcriptomics reveals phenotypic subpopulations

Author(s): Maria Mircea; Mazène Hochane; Xueying Fan; Susana M. Chuva de Sousa Lopes; Diego Garlaschelli; Stefan Semrau
Published in: Genome Biology, Issue 1, 2022, ISSN 1474-760X
Publisher: BioMed Central
DOI: 10.1186/s13059-021-02590-x

Single-Cell Transcriptomics Analysis of Human Small Antral Follicles.

Author(s): Xueying Fan; Ioannis Moustakas; Monika Bialecka; Julieta S. del Valle; Arend W. Overeem; Leoni A. Louwe; Gonneke S. K. Pilgram; Lucette A. J. van der Westerlaken; Hailiang Mei; Susana M. Chuva de Sousa Lopes
Published in: Int J Mol Sci, Issue 12, 2021, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms222111955