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Epigenomic Reprogramming of Adipose Tissue Function and Energy Metabolism in Type 2 Diabetes

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The corepressors GPS2 and SMRT control enhancer and silencer remodeling via eRNA transcription during inflammatory activation of macrophages

Author(s): Zhiqiang Huang, Ning Liang, Saioa Goñi, Anastasios Damdimopoulos, Cheng Wang, Raphaelle Ballaire, Jennifer Jager, Henri Niskanen, Hongya Han, Tomas Jakobsson, Adrian P. Bracken, Myriam Aouadi, Nicolas Venteclef, Minna U. Kaikkonen, Rongrong Fan, Eckardt Treuter
Published in: Molecular Cell, 81/5, 2021, Page(s) 953-968.e9, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2020.12.040

Monocytopenia, monocyte morphological anomalies and hyperinflammation characterise severe COVID ‐19 in type 2 diabetes

Author(s): Fawaz Alzaid, Jean‐Baptiste Julla, Marc Diedisheim, Charline Potier, Louis Potier, Gilberto Velho, Bénédicte Gaborit, Philippe Manivet, Stéphane Germain, Tiphaine Vidal‐Trecan, Ronan Roussel, Jean‐Pierre Riveline, Elise Dalmas, Nicolas Venteclef, Jean‐François Gautier
Published in: EMBO Molecular Medicine, 12/10, 2020, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202013038

Loss of G protein pathway suppressor 2 in human adipocytes triggers lipid remodeling by upregulating ATP binding cassette subfamily G member 1.

Author(s): Wilfried Le Goff; Antoine Soprani; Enrichetta Mileti; Ning Liang; Sophie Lemoine; Eckardt Treuter; Jean-François Gautier; Raphaëlle Ballaire; Marie Lhomme; Nicolas Venteclef; Serena Barilla; Maharajah Ponnaiah; Ez-Zoubir Amri
Published in: ISSN: 2212-8778, 1, 2020, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2020.101066

GPS2 Deficiency Triggers Maladaptive White Adipose Tissue Expansion in Obesity via HIF1A Activation

Author(s): Karima Drareni, Raphaëlle Ballaire, Serena Barilla, Mano J. Mathew, Amine Toubal, Rongrong Fan, Ning Liang, Catherine Chollet, Zhiqiang Huang, Maria Kondili, Fabienne Foufelle, Antoine Soprani, Ronan Roussel, Jean-François Gautier, Fawaz Alzaid, Eckardt Treuter, Nicolas Venteclef
Published in: Cell Reports, 24/11, 2018, Page(s) 2957-2971.e6, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2018.08.032

Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health

Author(s): Ludivine Laurans, Nicolas Venteclef, Yacine Haddad, Mouna Chajadine, Fawaz Alzaid, Sarvenaz Metghalchi, Bruno Sovran, Raphael G. P. Denis, Julien Dairou, Marina Cardellini, Jose-Maria Moreno-Navarrete, Marjolene Straub, Sarah Jegou, Claire McQuitty, Thomas Viel, Bruno Esposito, Bertrand Tavitian, Jacques Callebert, Serge H. Luquet, Massimo Federici, José Manuel Fernandez-Real, Remy Burcelin, Jean
Published in: Nature Medicine, 24/8, 2018, Page(s) 1113-1120, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-018-0060-4

Rab4b Deficiency in T Cells Promotes Adipose Treg/Th17 Imbalance, Adipose Tissue Dysfunction, and Insulin Resistance

Author(s): Jérôme Gilleron, Gwennaëlle Bouget, Stoyan Ivanov, Cindy Meziat, Franck Ceppo, Bastien Vergoni, Mansour Djedaini, Antoine Soprani, Karine Dumas, Arnaud Jacquel, Laurent Yvan-Charvet, Nicolas Venteclef, Jean-François Tanti, Mireille Cormont
Published in: Cell Reports, 25/12, 2018, Page(s) 3329-3341.e5, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2018.11.083

Transcriptional control of macrophage polarisation in type 2 diabetes

Author(s): Karima Drareni, Jean-François Gautier, Nicolas Venteclef, Fawaz Alzaid
Published in: Seminars in Immunopathology, 2019, ISSN 1863-2297
Publisher: Springer Verlag
DOI: 10.1007/s00281-019-00748-1

Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα

Author(s): Ning Liang, Anastasius Damdimopoulos, Saioa Goñi, Zhiqiang Huang, Lise-Lotte Vedin, Tomas Jakobsson, Marco Giudici, Osman Ahmed, Matteo Pedrelli, Serena Barilla, Fawaz Alzaid, Arturo Mendoza, Tarja Schröder, Raoul Kuiper, Paolo Parini, Anthony Hollenberg, Philippe Lefebvre, Sven Francque, Luc Van Gaal, Bart Staels, Nicolas Venteclef, Eckardt Treuter, Rongrong Fan
Published in: Nature Communications, 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-09524-z

Glucagon-like peptide 1 receptor agonists, diabetic retinopathy and angiogenesis: The AngioSafe type 2 diabetes study

Author(s): Bénédicte Gaborit, Jean-Baptiste Julla, Samaher Besbes, Matthieu Proust, Clara Vincentelli, Benjamin Alos, Patricia Ancel, Fawaz Alzaid, Rodrigue Garcia, Philippe Mailly, Florence Sabatier, Maud Righini, Pierre Gascon, Frédéric Matonti, Marie Houssays, Louisa Goumidi, Lucile Vignaud, Xavier Guillonneau, Ali Erginay, Bénédicte Dupas, Marie-Louise Jennifer, Marianne Autié, Tiphaine Vidal-Trec
Published in: The Journal of Clinical Endocrinology & Metabolism, 2019, ISSN 0021-972X
Publisher: The Endocrine Society
DOI: 10.1210/clinem/dgz069

Plasma Copeptin and Risk of Lower-Extremity Amputation in Type 1 and Type 2 Diabetes

Author(s): Louis Potier, Ronan Roussel, Michel Marre, Petter Bjornstad, David Z. Cherney, Ray El Boustany, Frédéric Fumeron, Nicolas Venteclef, Jean-François Gautier, Samy Hadjadj, Kamel Mohammedi, Gilberto Velho
Published in: Diabetes Care, 42/12, 2019, Page(s) 2290-2297, ISSN 0149-5992
Publisher: American Diabetes Association
DOI: 10.2337/dc19-1062

Regulation of inflammation in diabetes: From genetics to epigenomics evidence

Author(s): Marc Diedisheim, Elena Carcarino, Claire Vandiedonck, Ronan Roussel, Jean-François Gautier, Nicolas Venteclef
Published in: Molecular Metabolism, 41, 2020, Page(s) 101041, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2020.101041