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A novel fast test for antibiotic susceptibility testing for Gram positive and Gram negative bacteria

Objective

In this project, the consortium will develop FAST-bact kits, a breakthrough test method to rapidly determine antibiotic drug susceptibility (AST), which will improve treatment of patients with serious bacterial infections. The current methodology in AST has a turnaround time of at least 24 hours, and up to 48 hours in case of blood cultures, whereas this novel flow cytometry-based test delivers results within 1-2 h. This will enable clinicians to start optimal antibiotic treatment as soon as possible, with a major impact on health and quality of life of patients and on health care costs.
Resistance to antibiotic treatment leads to difficulties in the treatment of patients with bacterial infections. The FAST-bact project will have great impact on treatment of patients with (resistant) bacterial infections; a susceptibility report in useful time will reduce the use of broad spectrum or last line antibiotics. The FAST-bact tests will be marketed to clinical and microbiology diagnostic laboratories, in order to perform fast and accurate AST testing and optimize treatment for these patients. The tests will be marketed as a microplate-based kit, containing panels of antibiotics and compatible probes to determine the effect of the antibiotics, and including a software package for interpretation of results.
The consortium will perform clinical validation of the tests against European and US standard methods. The previously designed decision support software, which allows fast and convenient result delivery, will be finalised and implemented. The technical file for regulatory proceedings will be drafted and large-scale production will be started. A commercialisation and dissemination plan will be drafted for market launch of the FAST-bact tests, first in Europe with expansion to other regions. In addition to these first products, opportunities will be explored to utilize the FAST-bact method for other tests, which will be included in the exploitation plan.

Call for proposal

H2020-FTIPilot-2016

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Sub call

H2020-FTIPilot-2016-1

Coordinator

FASTINOV SA
Net EU contribution
€ 1 319 062,50
Address
Rua Dr. Francisco Sa Carneiro 312 Loja C
4450-676 Matosinhos
Portugal

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 565 312,50

Participants (6)

UROBOPTICS - TECHNICAL CONSULTING & RESEARCH, LDA
Portugal
Net EU contribution
€ 267 890,00
Address
Rua Luis Vaz De Camoes Edificio S Jose 9C
3400 129 Oliveira Do Hospital

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Continente Centro (PT) Região de Coimbra
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 114 810,00
SERVICIO MADRILENO DE SALUD
Spain
Net EU contribution
€ 276 250,00
Address
Plaza Carlos Trias Bertran 7
28020 Madrid

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Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 0,00
EUROCLONE DIAGNOSTICA SRL

Participation ended

Italy
Net EU contribution
€ 346 070,19
Address
Via Spezia 1
20142 Milano

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 148 315,80
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

EUROCLONE SPA

Participation ended

Italy
Net EU contribution
€ 24 676,43
Address
Via Spezia 1
20142 Milano

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 10 575,61
PROFESS MEDICAL CONSULTANCY BV
Netherlands
Net EU contribution
€ 181 125,00
Address
Paradijsvogel 31
1704 WP Heerhugowaard

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
West-Nederland Noord-Holland Alkmaar en omgeving
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 77 625,00
CLONIT SRL
Italy
Net EU contribution
€ 240 528,38
Address
Via Varese 20
20121 Milano

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 103 083,60