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Optomechanics for Virology


Poxvirus MVA Expressing SARS-CoV-2 S Protein Induces Robust Immunity and Protects Rhesus Macaques From SARS-CoV-2

Author(s): Mooij, Petra; García-Arriaza, Juan; Pérez, Patricia; Lázaro-Frías, Adrián; Verstrepen, Babs E.; Böszörményi, Kinga P.; Mortier, Daniella; Fagrouch, Zahra; Kiemenyi-Kayere, Gwendoline; Niphuis, Henk; Acar, Roja Fidel; Meijer, Lisette; Stammes, Marieke A.; Kondova, Ivanela; Verschoor, Ernst J.; GeurtsvanKessel, Corine H.; Bruin, Erwin de; Sikkema, Reina S.; Luczkowiak, Joanna; Delgado, Rafae
Published in: Frontiers in Immunology, Issue 1, 2022, ISSN 1664-3224
Publisher: Frontiers in Immunology
DOI: 10.3389/fimmu.2022.845887

A Single Dose of an MVA Vaccine Expressing a Prefusion-Stabilized SARS-CoV-2 Spike Protein Neutralizes Variants of Concern and Protects Mice From a Lethal SARS-CoV-2 Infection

Author(s): Patricia Pérez; Patricia Pérez; Adrián Lázaro-Frías; Adrián Lázaro-Frías; Carmen Zamora; Pedro J. Sánchez-Cordón; David Astorgano; Joanna Luczkowiak; Rafael Delgado; Rafael Delgado; José M. Casasnovas; Mariano Esteban; Juan García-Arriaza; Juan García-Arriaza
Published in: Frontiers in Immunology, Vol 12 (2022), Issue 2, 2022, ISSN 1664-3224
Publisher: Frontiers in Immunology
DOI: 10.3389/fimmu.2021.824728

Genomic Epidemiology of SARS-CoV-2 in Madrid, Spain, during the First Wave of the Pandemic: Fast Spread and Early Dominance by D614G Variants.

Author(s): Esther Viedma; Elias Dahdouh; José María González-Alba; Sara González-Bodi; Laura Martínez-García; Fernando Lázaro-Perona; Raúl Recio; María Rodríguez-Tejedor; María Dolores Folgueira; Rafael Cantón; Rafael Delgado; Julio García-Rodríguez; Juan Carlos Galán; Jesús Mingorance; on behalf of the SARS-CoV-2 Working Groups
Published in: MDPI MICROORGANISMS, Issue 1, 2021, ISSN 2076-2607
DOI: 10.3390/microorganisms9020454

Prime-Boost Vaccination With BNT162b2 Induces High Neutralizing Activity Against SARS-CoV-2 variants in Naïve and COVID-19-Convalescent Individuals

Author(s): Joanna Luczkowiak, Nuria Labiod, Gonzalo Rivas, Marta Rolo, Fátima Lasala, Jaime Lora-Tamayo, Mikel Mancheno-Losa, David Rial, Alfredo Pérez-Rivilla, María D. Folgueira and Rafael Delgado
Published in: Open Forum Infectious Diseases, Issue Volume 8, 2021, ISSN 2328-8957
Publisher: OFID
DOI: 10.1093/ofid/ofab468

Force Sensing with an Optomechanical Self-Oscillator

Author(s): Biswarup Guha; Pierre Etienne Allain; Aristide Lemaître; Giuseppe Leo; Ivan Favero
Published in: Phys. Rev. Applied, Issue 1, 2020, ISSN 2331-7019
Publisher: American Physical Society
DOI: 10.1103/physrevapplied.14.024079

Potential pharmacological strategies targeting the Niemann-Pick C1 receptor and Ebola virus glycoprotein interaction.

Author(s): Marcos Morales-Tenorio; Tiziana Ginex; Miguel Ángel Cuesta-Geijo; Nuria E. Campillo; César Muñoz-Fontela; Covadonga Alonso; Rafael Delgado; Carmen Gil
Published in: European Journal of Medicinal Chemistry, Issue 1, 2021, ISSN 2772-6525
Publisher: Elsevier Masson SAS
DOI: 10.1016/j.ejmech.2021.113654

Identification of potential inhibitors of protein-protein interaction useful to fight against Ebola and other highly pathogenic viruses

Author(s): Fátima Lasala, Alfonso García-Rubia, Carlos Requena, Inmaculada Galindo, Miguel Angel Cuesta-Geijo, Isabel García-Dorival, Paula Bueno, Nuria Labiod, Joanna Luczkowiak, Ana Martinez, Nuria E. Campillo, Covadonga Alonso, Rafael Delgado, Carmen Gil
Published in: Antiviral Research, 2021, Page(s) 105011, ISSN 0166-3542
Publisher: Elsevier BV
DOI: 10.1016/j.antiviral.2021.105011

A multiphysics model for high frequency optomechanical sensors optically actuated and detected in the oscillating mode

Author(s): Sbarra, Samantha; Allain, Pierre Etienne; Lemaître, Aristide; Favero, Ivan
Published in: APL Photonics, Issue 1, 2021, ISSN 2378-0967
Publisher: APL Photonics
DOI: 10.1063/5.0050061

N-Terminal VP1 Truncations Favor T = 1 Norovirus-Like Particles

Author(s): Ronja Pogan, Victor U. Weiss, Kevin Bond, Jasmin Dülfer, Christoph Krisp, Nicholas Lyktey, Jürgen Müller-Guhl, Samuele Zoratto, Günter Allmaier, Martin F. Jarrold, Cesar Muñoz-Fontela, Hartmut Schlüter and Charlotte Uetrecht
Published in: Vaccines, 2020, ISSN 2076-393X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines9010008

A Review on Theory and Modelling of Nanomechanical Sensors for Biological Applications

Author(s): J. J. Ruz; Óscar Malvar; Eduardo Gil-Santos; Daniel Ramos; Montserrat Calleja; Javier Tamayo
Published in: Processes, Vol 9, Iss 164, p 164 (2021), Issue 1, 2021, ISSN 2227-9717
Publisher: MDPI Processes
DOI: 10.3390/pr9010164

Effects of energy metabolism on the mechanical properties of breast cancer cells

Author(s): Marina L. Yubero; Priscila M. Kosaka; Álvaro San Paulo; Marcos Malumbres; Montserrat Calleja; Javier Tamayo
Published in: Communications Biology, Issue 1, 2020, ISSN 2399-3642
Publisher: Communications Biology
DOI: 10.1038/s42003-020-01330-4

Development of a methodology for reversible chemical modification of silicon surfaces with application in nanomechanical biosensors.

Author(s): Roseli Hiromi Sato; Priscila M. Kosaka; Álvaro T. Omori; Edgard A. Ferreira; Denise Freitas Siqueira Petri; Óscar Malvar; Carmen Domínguez; Valerio Pini; O. Ahumada; Javier Tamayo; Montserrat Calleja; Rodrigo L. O. R. Cunha; Pablo A. Fiorito
Published in: Biosensors and Bioelectronics, Issue 1, 2019, ISSN 0956-5663
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.bios.2019.04.028

Biosensing extracellular vesicles: contribution of biomolecules in affinity-based methods for detection and isolation

Author(s): Gaillard, M.; Thuaire, A.; Nonglaton, G.; Agache, V.; Roupioz, Y.; Raillon, C.
Published in: Analyst, Issue 1, 2022, ISSN 1364-5528
Publisher: Analyst
DOI: 10.1039/c9an01949a

Full efficacy and long-term immunogenicity induced by the SARS-CoV-2 vaccine candidate MVA-CoV2-S in mice

Author(s): Adrián Lázaro-Frías; Patricia Pérez; Carmen Zamora; Pedro J. Sánchez-Cordón; María Guzmán; Joanna Luczkowiak; Rafael Delgado; José M. Casasnovas; Mariano Esteban; Juan García-Arriaza
Published in: npj Vaccines, Vol 7, Iss 1, Pp 1-15 (2022), Issue 3, 2022, ISSN 2059-0105
Publisher: Springer Nature
DOI: 10.1038/s41541-022-00440-w

Multimode Optomechanical Weighting of a Single Nanoparticle

Author(s): Samantha Sbarra, Louis Waquier, Stephan Suffit, Aristide Lemaître, and Ivan Favero
Published in: ACS publications, 2022, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/acs.nanolett.1c03890

Prolonged SARS-CoV-2 cell culture replication in respiratory samplesfrom patients with severe COVID-19

Author(s): Maria Dolores Folgueira, Joanna Luczkowiak, Fátima Lasala, Alfredo Pérez-Rivilla, Rafael Delgado
Published in: Clinical Microbiology and Infection, 2021, Page(s) 886-891, ISSN 2398-8096
Publisher: Elsevier
DOI: 10.1016/j.cmi.2021.02.014

Effect of particle adsorption on the eigenfrequencies of nano-mechanical resonators

Author(s): J. J. Ruz; Óscar Malvar; Eduardo Gil-Santos; Montserrat Calleja; Javier Tamayo
Published in: Journal of Applied Physics, Issue 2, 2020, ISSN 0021-8979
Publisher: American Institute of Physics
DOI: 10.1063/5.0021640

DC/L-SIGN recognition of spike glycoprotein promotes SARS-CoV-2 trans-infection and can be inhibited by a glycomimetic antagonist

Author(s): "Thé paut, M.; Luczkowiak, J.; Vivè s, C.; Labiod, N.; Bally, I.; Lasala, F.; Grimoire, Y.; Fenel, D.; Sattin, S.; Thielens, N.; Schoehn, G.; Bernardi, A.; Delgado, R.; Fieschi, F."
Published in: PLoS Pathogens, Issue 1, 2021, ISSN 1553-7366
Publisher: Public Library of Science
DOI: 10.1101/2020.08.09.242917

Optomechanical devices for deep plasma cancer proteomics

Author(s): Priscila M. Kosaka, Montserrat Calleja, Javier Tamayo
Published in: Seminars in Cancer Biology, 2017, ISSN 1044-579X
Publisher: Academic Press
DOI: 10.1016/j.semcancer.2017.08.011

Separation of Biological Particles in a Modular Platform of Cascaded Deterministic Lateral Displacement Modules

Author(s): Eloise Pariset, Charlotte Parent, Yves Fouillet, Boizot François, Nicolas Verplanck, Frédéric Revol-Cavalier, Aurélie Thuaire, Vincent Agache
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-34958-8

Purification of complex samples: Implementation of a modular and reconfigurable droplet-based microfluidic platform with cascaded deterministic lateral displacement separation modules

Author(s): Eloise Pariset, Catherine Pudda, François Boizot, Nicolas Verplanck, Frédéric Revol-Cavalier, Jean Berthier, Aurélie Thuaire, Vincent Agache
Published in: PLOS ONE, Issue 13/5, 2018, Page(s) e0197629, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0197629

Norovirus-like VP1 particles exhibit isolate dependent stability profiles

Author(s): Ronja Pogan, Carola Schneider, Rudolph Reimer, Grant Hansman, Charlotte Uetrecht
Published in: Journal of Physics: Condensed Matter, Issue 30/6, 2018, Page(s) 064006, ISSN 0953-8984
Publisher: Institute of Physics Publishing
DOI: 10.1088/1361-648x/aaa43b

Broad Neutralizing Activity Against Ebolaviruses Lacking the Mucin-Like Domain in Convalescent Plasma Specimens From Patients With Ebola Virus Disease

Author(s): Joanna Luczkowiak, Fatima Lasala, Marta Mora-Rillo, Jose R Arribas, Rafael Delgado
Published in: The Journal of Infectious Diseases, Issue 218/suppl_5, 2018, Page(s) S574-S581, ISSN 0022-1899
Publisher: University of Chicago Press
DOI: 10.1093/infdis/jiy302

Direct Detection of OXA-48 Carbapenemase Gene in Lysate Samples through Changes in Mechanical Properties of DNA Monolayers upon Hybridization

Author(s): Carmen M. Domínguez, Daniel Ramos, Jesús Mingorance, José L. G. Fierro, Javier Tamayo, Montserrat Calleja
Published in: Analytical Chemistry, Issue 90/1, 2017, Page(s) 968-973, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.7b04094

Optimization of the readout of microdrum optomechanical resonators

Author(s): Valerio Pini, Daniel Ramos, Carmen M. Dominguez, Jose Jaime Ruz, Oscar Malvar, Priscila M. Kosaka, Zachary J. Davis, Javier Tamayo, Montserrat Calleja
Published in: Microelectronic Engineering, Issue 183-184, 2017, Page(s) 37-41, ISSN 0167-9317
Publisher: Elsevier BV
DOI: 10.1016/j.mee.2017.10.008

Effect of surface stress induced curvature on the eigenfrequencies of microcantilever plates

Author(s): J. J. Ruz, V. Pini, O. Malvar, P. M. Kosaka, M. Calleja, J. Tamayo
Published in: AIP Advances, Issue 8/10, 2018, Page(s) 105213, ISSN 2158-3226
Publisher: American Institute of Physics Inc.
DOI: 10.1063/1.5053561

Virus-like particle size and molecular weight/mass determination applying gas-phase electrophoresis (native nES GEMMA)

Author(s): Weiss, Victor U.; Pogan, Ronja; Zoratto, Samuele; Bond, Kevin M.; Boulanger, Pascale; Jarrold, Martin F.; Lyktey, Nicholas; Pahl, Dominik; Puffler, Nicole; Schelhaas, Mario; Selivanovitch, Ekaterina; Uetrecht, Charlotte; Allmaier, Günter
Published in: Analytical and Bioanalytical Chemistry, Issue 1, 2019, ISSN 1618-2642
Publisher: Springer Verlag
DOI: 10.1007/s00216-019-01998-6

Optomechanical resonating probe for very high frequency sensing of atomic forces

Author(s): Allain, Pierre Etienne; Schwab, Lucien; Mismer, Colin; Gely, Marc; Mairiaux, Estelle; Hermouet, Maxime; Walter, Benjamin; Leo, Giuseppe; Hentz, Sébastien; Faucher, Marc; Jourdan, Guillaume; Legrand, Bernard; Favero, Ivan
Published in: Nanoscale, Issue 1, 2020, ISSN 2040-3372
Publisher: Nanoscale
DOI: 10.1039/c9nr09690f

New insights into the role of endosomal proteins for African swine fever virus infection

Author(s): Miguel Ángel Cuesta-Geijo; Isabel García-Dorival; Ana del Puerto; Jesús Urquiza; Inmaculada Galindo; Lucía Barrado-Gil; Fátima Lasala; Ana Cayuela; Carlos Oscar S. Sorzano; Carmen Gil; Rafael Delgado; Covadonga Alonso
Published in: PLoS Pathogens, Issue 1, 2022, ISSN 1553-7366
Publisher: Public Library of Science
DOI: 10.1371/journal.ppat.1009784

Neutralizing Response Against SARS-CoV-2 Variants 8 Months After BNT162b2 Vaccination in Naive and COVID-19–Convalescent Individuals

Author(s): Joanna Luczkowiak; Nuria Labiod; Gonzalo Rivas; Marta Rolo; Fátima Lasala; Jaime Lora-Tamayo; Mikel Mancheno-Losa; David Rial-Crestelo; Alfredo Pérez-Rivilla; María Dolores Folgueira; Rafael Delgado
Published in: The Journal of Infectious Diseases, Issue 2, 2022, ISSN 1537-6613
Publisher: Oxford University Press
DOI: 10.1093/infdis/jiab634

Optomechanical detection of vibration modes of a single bacterium.

Author(s): Gil-Santos, Eduardo; Ruz, Jose J.; Malvar, Oscar; Favero, Ivan; Lemaître, Aristide; Kosaka, Priscila. M.; García-López, Sergio; Calleja, Montserrat; Tamayo, Javier
Published in: "Nature Nanotechnology, Nature Publishing Group, 2020, 15 (6), pp.469-474. ⟨10.1038/s41565-020-0672-y⟩", Issue 1, 2020, ISSN 1748-3387
Publisher: Nature Publishing Group
DOI: 10.1038/s41565-020-0672-y

Deterministic lateral displacement for the sorting of extracellular vesicles from complex biological samples

Author(s): M. Gaillard, N. Sarrut-Rio, L.Virot, F. Boizot, N. Verplanck, C. Raillon, V. Agache, Y. Roupioz, A. Thuaire
Published in: 2020
Publisher: MicroTAS 2020

Integration of DLD modules on a microfluidic platform for the fractionation of viral particles

Author(s): N. Sarrut-Rio, M. Gaillard, F. Boizot, P. Laurent, M. Cubizolles and A.Thuaire
Published in: 2021
Publisher: MicroTAS 2021

Isolation of extracellular vesicles subpopulations by combination of capture by aptamer-coated bead microcarriers with microfluidic size-sorting

Author(s): M. Gaillard, C. Raillon, V. Agache, A. Thuaire and Y. Roupioz
Published in: MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, 2021
Publisher: MicroTAS 2021

Optomechanical measurement of single nanodroplet evaporation with millisecond time-resolution

Author(s): Samantha Sbarra, Louis Waquier, Stephan Suffit, Aristide Lemaître,and Ivan Favero
Published in: 2022, ISSN 2331-8422
Publisher: arxiv
DOI: 10.48550/arxiv.2205.05944

Norovirus assembly and stability

Author(s): Ronja Pogan, Jasmin Dülfer, Charlotte Uetrecht
Published in: Current Opinion in Virology, Issue 31, 2018, Page(s) 59-65, ISSN 1879-6257
Publisher: Elsevier BV
DOI: 10.1016/j.coviro.2018.05.003

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