Optomechanics for Virology

Project Information

VIRUSCAN

Grant agreement ID: 731868

DOI

10.3030/731868

Project closed

EC signature date 13 October 2016

Start date 1 November 2016

End date 30 April 2022

Funded under

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Total cost

€ 7 148 586,25

EU contribution

€ 7 148 586,25

Coordinated by

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (31)

Poxvirus MVA Expressing SARS-CoV-2 S Protein Induces Robust Immunity and Protects Rhesus Macaques From SARS-CoV-2

Author(s): Mooij, Petra; García-Arriaza, Juan; Pérez, Patricia; Lázaro-Frías, Adrián; Verstrepen, Babs E.; Böszörményi, Kinga P.; Mortier, Daniella; Fagrouch, Zahra; Kiemenyi-Kayere, Gwendoline; Niphuis, Henk; Acar, Roja Fidel; Meijer, Lisette; Stammes, Marieke A.; Kondova, Ivanela; Verschoor, Ernst J.; GeurtsvanKessel, Corine H.; Bruin, Erwin de; Sikkema, Reina S.; Luczkowiak, Joanna; Delgado, Rafae
Published in: Frontiers in Immunology, Issue 1, 2022, ISSN 1664-3224
Publisher: Frontiers in Immunology
DOI: 10.3389/fimmu.2022.845887

A Single Dose of an MVA Vaccine Expressing a Prefusion-Stabilized SARS-CoV-2 Spike Protein Neutralizes Variants of Concern and Protects Mice From a Lethal SARS-CoV-2 Infection

Author(s): Patricia Pérez; Patricia Pérez; Adrián Lázaro-Frías; Adrián Lázaro-Frías; Carmen Zamora; Pedro J. Sánchez-Cordón; David Astorgano; Joanna Luczkowiak; Rafael Delgado; Rafael Delgado; José M. Casasnovas; Mariano Esteban; Juan García-Arriaza; Juan García-Arriaza
Published in: Frontiers in Immunology, Vol 12 (2022), Issue 2, 2022, ISSN 1664-3224
Publisher: Frontiers in Immunology
DOI: 10.3389/fimmu.2021.824728

Genomic Epidemiology of SARS-CoV-2 in Madrid, Spain, during the First Wave of the Pandemic: Fast Spread and Early Dominance by D614G Variants.

Author(s): Esther Viedma; Elias Dahdouh; José María González-Alba; Sara González-Bodi; Laura Martínez-García; Fernando Lázaro-Perona; Raúl Recio; María Rodríguez-Tejedor; María Dolores Folgueira; Rafael Cantón; Rafael Delgado; Julio García-Rodríguez; Juan Carlos Galán; Jesús Mingorance; on behalf of the SARS-CoV-2 Working Groups
Published in: MDPI MICROORGANISMS, Issue 1, 2021, ISSN 2076-2607
Publisher: MDPI MICROORGANISMS
DOI: 10.3390/microorganisms9020454

Prime-Boost Vaccination With BNT162b2 Induces High Neutralizing Activity Against SARS-CoV-2 variants in Naïve and COVID-19-Convalescent Individuals

Author(s): Joanna Luczkowiak, Nuria Labiod, Gonzalo Rivas, Marta Rolo, Fátima Lasala, Jaime Lora-Tamayo, Mikel Mancheno-Losa, David Rial, Alfredo Pérez-Rivilla, María D. Folgueira and Rafael Delgado
Published in: Open Forum Infectious Diseases, Issue Volume 8, 2021, ISSN 2328-8957
Publisher: OFID
DOI: 10.1093/ofid/ofab468

Force Sensing with an Optomechanical Self-Oscillator

Author(s): Biswarup Guha; Pierre Etienne Allain; Aristide Lemaître; Giuseppe Leo; Ivan Favero
Published in: Phys. Rev. Applied, Issue 1, 2020, ISSN 2331-7019
Publisher: American Physical Society
DOI: 10.1103/physrevapplied.14.024079

Potential pharmacological strategies targeting the Niemann-Pick C1 receptor and Ebola virus glycoprotein interaction.

Author(s): Marcos Morales-Tenorio; Tiziana Ginex; Miguel Ángel Cuesta-Geijo; Nuria E. Campillo; César Muñoz-Fontela; Covadonga Alonso; Rafael Delgado; Carmen Gil
Published in: European Journal of Medicinal Chemistry, Issue 1, 2021, ISSN 0223-5234
Publisher: Elsevier BV
DOI: 10.1016/j.ejmech.2021.113654

Identification of potential inhibitors of protein-protein interaction useful to fight against Ebola and other highly pathogenic viruses

Author(s): Fátima Lasala, Alfonso García-Rubia, Carlos Requena, Inmaculada Galindo, Miguel Angel Cuesta-Geijo, Isabel García-Dorival, Paula Bueno, Nuria Labiod, Joanna Luczkowiak, Ana Martinez, Nuria E. Campillo, Covadonga Alonso, Rafael Delgado, Carmen Gil
Published in: Antiviral Research, 2021, Page(s) 105011, ISSN 0166-3542
Publisher: Elsevier BV
DOI: 10.1016/j.antiviral.2021.105011

A multiphysics model for high frequency optomechanical sensors optically actuated and detected in the oscillating mode

Author(s): Sbarra, Samantha; Allain, Pierre Etienne; Lemaître, Aristide; Favero, Ivan
Published in: APL Photonics, Issue 1, 2021, ISSN 2378-0967
Publisher: APL Photonics
DOI: 10.1063/5.0050061

N-Terminal VP1 Truncations Favor T = 1 Norovirus-Like Particles

Author(s): Ronja Pogan, Victor U. Weiss, Kevin Bond, Jasmin Dülfer, Christoph Krisp, Nicholas Lyktey, Jürgen Müller-Guhl, Samuele Zoratto, Günter Allmaier, Martin F. Jarrold, Cesar Muñoz-Fontela, Hartmut Schlüter and Charlotte Uetrecht
Published in: Vaccines, 2020, ISSN 2076-393X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines9010008

A Review on Theory and Modelling of Nanomechanical Sensors for Biological Applications

Author(s): J. J. Ruz; Óscar Malvar; Eduardo Gil-Santos; Daniel Ramos; Montserrat Calleja; Javier Tamayo
Published in: Processes, Vol 9, Iss 164, p 164 (2021), Issue 1, 2021, ISSN 2227-9717
Publisher: MDPI Processes
DOI: 10.3390/pr9010164

Effects of energy metabolism on the mechanical properties of breast cancer cells

Author(s): Marina L. Yubero; Priscila M. Kosaka; Álvaro San Paulo; Marcos Malumbres; Montserrat Calleja; Javier Tamayo
Published in: Communications Biology, Issue 1, 2020, ISSN 2399-3642
Publisher: Communications Biology
DOI: 10.1038/s42003-020-01330-4

Development of a methodology for reversible chemical modification of silicon surfaces with application in nanomechanical biosensors.

Author(s): Roseli Hiromi Sato; Priscila M. Kosaka; Álvaro T. Omori; Edgard A. Ferreira; Denise Freitas Siqueira Petri; Óscar Malvar; Carmen Domínguez; Valerio Pini; O. Ahumada; Javier Tamayo; Montserrat Calleja; Rodrigo L. O. R. Cunha; Pablo A. Fiorito
Published in: Biosensors and Bioelectronics, Issue 1, 2019, ISSN 0956-5663
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.bios.2019.04.028

Biosensing extracellular vesicles: contribution of biomolecules in affinity-based methods for detection and isolation

Author(s): Gaillard, M.; Thuaire, A.; Nonglaton, G.; Agache, V.; Roupioz, Y.; Raillon, C.
Published in: Analyst, Issue 1, 2022, ISSN 1364-5528
Publisher: Analyst
DOI: 10.1039/c9an01949a

Full efficacy and long-term immunogenicity induced by the SARS-CoV-2 vaccine candidate MVA-CoV2-S in mice

Author(s): Adrián Lázaro-Frías; Patricia Pérez; Carmen Zamora; Pedro J. Sánchez-Cordón; María Guzmán; Joanna Luczkowiak; Rafael Delgado; José M. Casasnovas; Mariano Esteban; Juan García-Arriaza
Published in: npj Vaccines, Vol 7, Iss 1, Pp 1-15 (2022), Issue 3, 2022, ISSN 2059-0105
Publisher: Springer Nature
DOI: 10.1038/s41541-022-00440-w

Multimode Optomechanical Weighting of a Single Nanoparticle

Author(s): Samantha Sbarra, Louis Waquier, Stephan Suffit, Aristide Lemaître, and Ivan Favero
Published in: ACS publications, 2022, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/acs.nanolett.1c03890

Prolonged SARS-CoV-2 cell culture replication in respiratory samplesfrom patients with severe COVID-19

Author(s): Maria Dolores Folgueira, Joanna Luczkowiak, Fátima Lasala, Alfredo Pérez-Rivilla, Rafael Delgado
Published in: Clinical Microbiology and Infection, 2021, Page(s) 886-891, ISSN 2398-8096
Publisher: Elsevier
DOI: 10.1016/j.cmi.2021.02.014

Effect of particle adsorption on the eigenfrequencies of nano-mechanical resonators

Author(s): J. J. Ruz; Óscar Malvar; Eduardo Gil-Santos; Montserrat Calleja; Javier Tamayo
Published in: Journal of Applied Physics, Issue 2, 2020, ISSN 0021-8979
Publisher: American Institute of Physics
DOI: 10.1063/5.0021640

DC/L-SIGN recognition of spike glycoprotein promotes SARS-CoV-2 trans-infection and can be inhibited by a glycomimetic antagonist

Author(s): "Thé paut, M.; Luczkowiak, J.; Vivè s, C.; Labiod, N.; Bally, I.; Lasala, F.; Grimoire, Y.; Fenel, D.; Sattin, S.; Thielens, N.; Schoehn, G.; Bernardi, A.; Delgado, R.; Fieschi, F."
Published in: PLoS Pathogens, Issue 1, 2021, ISSN 1553-7366
Publisher: Public Library of Science
DOI: 10.1101/2020.08.09.242917

Optomechanical devices for deep plasma cancer proteomics

Author(s): Priscila M. Kosaka, Montserrat Calleja, Javier Tamayo
Published in: Seminars in Cancer Biology, 2017, ISSN 1044-579X
Publisher: Academic Press
DOI: 10.1016/j.semcancer.2017.08.011

Separation of Biological Particles in a Modular Platform of Cascaded Deterministic Lateral Displacement Modules

Author(s): Eloise Pariset, Charlotte Parent, Yves Fouillet, Boizot François, Nicolas Verplanck, Frédéric Revol-Cavalier, Aurélie Thuaire, Vincent Agache
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-34958-8

Purification of complex samples: Implementation of a modular and reconfigurable droplet-based microfluidic platform with cascaded deterministic lateral displacement separation modules

Author(s): Eloise Pariset, Catherine Pudda, François Boizot, Nicolas Verplanck, Frédéric Revol-Cavalier, Jean Berthier, Aurélie Thuaire, Vincent Agache
Published in: PLOS ONE, Issue 13/5, 2018, Page(s) e0197629, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0197629

Norovirus-like VP1 particles exhibit isolate dependent stability profiles

Author(s): Ronja Pogan, Carola Schneider, Rudolph Reimer, Grant Hansman, Charlotte Uetrecht
Published in: Journal of Physics: Condensed Matter, Issue 30/6, 2018, Page(s) 064006, ISSN 0953-8984
Publisher: Institute of Physics Publishing
DOI: 10.1088/1361-648x/aaa43b

Broad Neutralizing Activity Against Ebolaviruses Lacking the Mucin-Like Domain in Convalescent Plasma Specimens From Patients With Ebola Virus Disease

Author(s): Joanna Luczkowiak, Fatima Lasala, Marta Mora-Rillo, Jose R Arribas, Rafael Delgado
Published in: The Journal of Infectious Diseases, Issue 218/suppl_5, 2018, Page(s) S574-S581, ISSN 0022-1899
Publisher: University of Chicago Press
DOI: 10.1093/infdis/jiy302

Direct Detection of OXA-48 Carbapenemase Gene in Lysate Samples through Changes in Mechanical Properties of DNA Monolayers upon Hybridization

Author(s): Carmen M. Domínguez, Daniel Ramos, Jesús Mingorance, José L. G. Fierro, Javier Tamayo, Montserrat Calleja
Published in: Analytical Chemistry, Issue 90/1, 2017, Page(s) 968-973, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.7b04094

Optimization of the readout of microdrum optomechanical resonators

Author(s): Valerio Pini, Daniel Ramos, Carmen M. Dominguez, Jose Jaime Ruz, Oscar Malvar, Priscila M. Kosaka, Zachary J. Davis, Javier Tamayo, Montserrat Calleja
Published in: Microelectronic Engineering, Issue 183-184, 2017, Page(s) 37-41, ISSN 0167-9317
Publisher: Elsevier BV
DOI: 10.1016/j.mee.2017.10.008

Effect of surface stress induced curvature on the eigenfrequencies of microcantilever plates

Author(s): J. J. Ruz, V. Pini, O. Malvar, P. M. Kosaka, M. Calleja, J. Tamayo
Published in: AIP Advances, Issue 8/10, 2018, Page(s) 105213, ISSN 2158-3226
Publisher: American Institute of Physics Inc.
DOI: 10.1063/1.5053561

Virus-like particle size and molecular weight/mass determination applying gas-phase electrophoresis (native nES GEMMA)

Author(s): Weiss, Victor U.; Pogan, Ronja; Zoratto, Samuele; Bond, Kevin M.; Boulanger, Pascale; Jarrold, Martin F.; Lyktey, Nicholas; Pahl, Dominik; Puffler, Nicole; Schelhaas, Mario; Selivanovitch, Ekaterina; Uetrecht, Charlotte; Allmaier, Günter
Published in: Analytical and Bioanalytical Chemistry, Issue 1, 2019, ISSN 1618-2642
Publisher: Springer Verlag
DOI: 10.1007/s00216-019-01998-6

Optomechanical resonating probe for very high frequency sensing of atomic forces

Author(s): Allain, Pierre Etienne; Schwab, Lucien; Mismer, Colin; Gely, Marc; Mairiaux, Estelle; Hermouet, Maxime; Walter, Benjamin; Leo, Giuseppe; Hentz, Sébastien; Faucher, Marc; Jourdan, Guillaume; Legrand, Bernard; Favero, Ivan
Published in: Nanoscale, Issue 1, 2020, ISSN 2040-3372
Publisher: Nanoscale
DOI: 10.1039/c9nr09690f

New insights into the role of endosomal proteins for African swine fever virus infection

Author(s): Miguel Ángel Cuesta-Geijo; Isabel García-Dorival; Ana del Puerto; Jesús Urquiza; Inmaculada Galindo; Lucía Barrado-Gil; Fátima Lasala; Ana Cayuela; Carlos Oscar S. Sorzano; Carmen Gil; Rafael Delgado; Covadonga Alonso
Published in: PLoS Pathogens, Issue 1, 2022, ISSN 1553-7366
Publisher: Public Library of Science
DOI: 10.1371/journal.ppat.1009784

Neutralizing Response Against SARS-CoV-2 Variants 8 Months After BNT162b2 Vaccination in Naive and COVID-19–Convalescent Individuals

Author(s): Joanna Luczkowiak; Nuria Labiod; Gonzalo Rivas; Marta Rolo; Fátima Lasala; Jaime Lora-Tamayo; Mikel Mancheno-Losa; David Rial-Crestelo; Alfredo Pérez-Rivilla; María Dolores Folgueira; Rafael Delgado
Published in: The Journal of Infectious Diseases, Issue 2, 2022, ISSN 1537-6613
Publisher: Oxford University Press
DOI: 10.1093/infdis/jiab634

Optomechanical detection of vibration modes of a single bacterium.

Author(s): Gil-Santos, Eduardo; Ruz, Jose J.; Malvar, Oscar; Favero, Ivan; Lemaître, Aristide; Kosaka, Priscila. M.; García-López, Sergio; Calleja, Montserrat; Tamayo, Javier
Published in: "Nature Nanotechnology, Nature Publishing Group, 2020, 15 (6), pp.469-474. ⟨10.1038/s41565-020-0672-y⟩", Issue 1, 2020, ISSN 1748-3387
Publisher: Nature Publishing Group
DOI: 10.1038/s41565-020-0672-y

Conference proceedings (3)

Deterministic lateral displacement for the sorting of extracellular vesicles from complex biological samples

Author(s): M. Gaillard, N. Sarrut-Rio, L.Virot, F. Boizot, N. Verplanck, C. Raillon, V. Agache, Y. Roupioz, A. Thuaire
Published in: 2020
Publisher: MicroTAS 2020

Integration of DLD modules on a microfluidic platform for the fractionation of viral particles

Author(s): N. Sarrut-Rio, M. Gaillard, F. Boizot, P. Laurent, M. Cubizolles and A.Thuaire
Published in: 2021
Publisher: MicroTAS 2021

Isolation of extracellular vesicles subpopulations by combination of capture by aptamer-coated bead microcarriers with microfluidic size-sorting

Author(s): M. Gaillard, C. Raillon, V. Agache, A. Thuaire and Y. Roupioz
Published in: MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, 2021
Publisher: MicroTAS 2021

Other (2)

Optomechanical measurement of single nanodroplet evaporation with millisecond time-resolution

Author(s): Samantha Sbarra, Louis Waquier, Stephan Suffit, Aristide Lemaître,and Ivan Favero
Published in: 2022, ISSN 2331-8422
Publisher: arxiv
DOI: 10.48550/arxiv.2205.05944

Norovirus assembly and stability

Author(s): Ronja Pogan, Jasmin Dülfer, Charlotte Uetrecht
Published in: Current Opinion in Virology, Issue 31, 2018, Page(s) 59-65, ISSN 1879-6257
Publisher: Elsevier BV
DOI: 10.1016/j.coviro.2018.05.003