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Healthy minds from 0-100 years: Optimising the use of European brain imaging cohorts

Deliverables

Lifebrain gender equity report (R)

The management in coordination with the Safety Board (SB) team will ensure and monitor that the consortium’s policy regarding gender issues is correctly implemented, including the awareness and sensitisation programmes.

Communication management routines and infrastructure implemented

Establish routines for communication amongst consortium partners including the exchange of information and materials, while ensuring maintenance the EC Grant Agreement and Consortium Agreement. Provide assistance and advice to partners regarding administrative matters, and to ensure compliance with EC rules including the communication with and reporting to the EC on behalf of the consortium

Multi-modal MRI-data processing stream which allows for a state-of-the art central integration of data across sites

A standardized analysis stream will be developed that all data can be run through, with special focus put on neuroimaging.

Enrichment of existing cohorts by home collection of DBS to be analysed across WP4 tasks 2-6

Kits for home collection of DBS will be sent to participants in all samples, which will send them back to Vitas for analyses, with the aim of getting 2000 samples

Lifebrain conference in Berlin

Organization and completion of conference

Risk and protective factors for cognitive and mental health in broader epidemiological samples

Divided into two parts: A) Using multivariate regression analysis and multilevel/hierarchical models, existing European Research Infrastructure Consortia (ERICs, SHARE) will be leveraged to analyze i) how cognitive performance and risks of depression and anxiety differ by socioeconomic status (SES), gender and age, ii) how these patterns differ across regions/countries, and iii) the extent to which the cognitive outcomes are associated with differences in health and everyday functioning. B) Based on results from task A, population-covering administrative register data from Scandinavian countries will be used to corroborate the real-world relevance of these findings

Online/mobile tools for stakeholder engagement conceptualized and developed

Prepare tools and platform for stakeholder engagement. Social media, like twitter, will be one area of interest. Also web-based questionnaires, tests and engagement tools will be considered, and possibly developed

Tool for post hoc harmonization of MRI data across sites, to allow integration of data from different scanners/sites

Implement and test a novel procedure to correct images for scanner-specific differences in tissue contrast and intensity non-uniformity.

Enrichment of existing cohorts by administration of buccal swabs for epigenetic analyses across WP4 tasks 2-6

Coordination of the sample collection, laboratory experiments and bioinformatic processing of the data for analysis in WP4

Input to the Dissemination, Exploitation and Communication(DEC) plan (T5.1)

Prepare tools and platform for stakeholder engagement, ensure that WP1 is fully aligned with WP5s DEC plan

DBS assays for relevant biomarkers for data enrichment

Develop and validate new additional biomarkers on DBS tailored for the Lifebrain project

DEC Strategy, Operative Plan and SOPs for the Lifebrain project

Details the communication and dissemination strategy including stakeholder engagement practices for targeting different audiences and resulting in the definition of a detailed activity plan for phase one (M1-30). The operative part of the DEC Plan will be updated based on project activities and experiences. Standard operating procedures (SOPs) for publications, participation in conferences and exploitation will be annexed to this plan

Data storage and processing system to share data, manage data access and integrated analysis

Establish an international image sharing, storage and processing platform for management of neuroimaging and harmonized target variables

Online platform for collection of questionnaire and test data for data enrichment

The implementation will include three major steps: (a) identifying and operationalizing (e.g., selecting standard and custom questionnaires, or neuropsychological tests) the variables to be assessed; (b) translating the instructions, questionnaires/test items or identifying language-specific version for standard questionnaires/tests); (c) implementing a OS independent internet browser-based platform which allows for data collection and transfer of data using secure file transfer protocol.

Exploitation and IP management strategy - I

An integrated IP and exploitation strategy will be defined and implemented along with innovative communication channels developed

List of relevant stakeholders for project engagement

Identify and invite research participant groups, patient groups, clinicians and policy makers that will have an interest in the project and that should be taken into consideration

Enrichment of existing cohorts by online data collection

Develop and apply a tool for online collection of data to enrich available database, allowing Lifebrain databases to attain data which not all sites have available and data on new variables, and by doing so optimize the utilization of the existing data

DEC strategy and Operative plan – Update

Update strategy report conducted under D5.1

Financial and legal management routines implemented

To establish a robust management structure to ensure that the objectives of the project are met within agreed budget and timeframe, granting that the administrative, legal and ethical aspects are fulfilled by each partner and ensuring that allocated finances are appropriately managed and reported, carrying out adequate quality control of the work performed and of the deliverables;

Data harmonization guidelines and standardized data management/processing protocol across sites

We will develop and implement harmonization protocols, i.e. develop technical and semantic data standards, and quality protocols to unify and bridge the different coding standards of target variables between sites

GWAS data and harmonization of genetic data across samples for genetic analyses across WP4 tasks 2-6

This will include re-calling of genotypes, from existing genome-wide SNP genotype data, quality checking, imputation, determination of population substructure, and producing of analysis-ready genotypes maximally harmonized across the different Lifebrain centres.

Novel longitudinal statistical tools, allowing to tackle challenges associated with multi-side mixed model lifespan data

Develop tools where goal is to identify models that optimally represent the consolidated findings of the consortium, and hence contribute to theory development and generalizability.

Dissemination tools and communication strategies - I

Tools include both printed material (flyers, flyer inlays, posters and factsheets etc.) as well as online / digital tools - website, social media accounts, newsletters and power point presentations. Project partners will be actively involved in determining appropriate tools, content generation and dissemination & communication opportunities associated with agreed DEC activities.

Kick-off meeting completed; advisory board, safety board, executive board instantiated

Organization of meeting and establishment of relevant boards

Dissemination tools and communication strategies II

Update strategy report conducted under D5.2

Data obtained from national registries; incl standardization, integration, quality control and pooling with existing data across sites

Coupling of existing data with national health, conscription and population registries. This will be done for the Nordic countries (Norway, Sweden, Denmark) as well as the Netherlands and Spain.

Policy reviews on cognitive & mental well-being across all age groups - I

Selected National/European policies will be reviewed and policy-makers engaged to determine the appropriateness and relevance of project results and how these results can lead to promotion of policies on ‘personalised health’ opportunities for European citizens

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Publications

Healthy minds 0–100 years: Optimising the use of European brain imaging cohorts (“Lifebrain”)

Author(s): Kristine B. Walhovd, Anders M. Fjell, René Westerhausen, Lars Nyberg, Klaus P. Ebmeier, Ulman Lindenberger, David Bartrés-Faz, William F.C. Baaré, Hartwig R. Siebner, Richard Henson, Christian A. Drevon, Gun Peggy Strømstad Knudsen, Isabelle Budin Ljøsne, Brenda W.J.H. Penninx, Paolo Ghisletta, Ole Rogeberg, Lorraine Tyler, Lars Bertram
Published in: European Psychiatry, Issue 50, 2018, Page(s) 47-56, ISSN 0924-9338
DOI: 10.1016/j.eurpsy.2017.12.006

Assessing reliability in neuroimaging research through intra-class effect decomposition (ICED)

Author(s): Andreas M Brandmaier , Elisabeth Wenger, Nils C Bodammer, Simone Kühn, Naftali Raz, Ulman Lindenberger
Published in: eLife, Issue eLife 2018;7:e35718, 2018, ISSN 2050-084X
DOI: 10.7554/eLife.35718.001

A systematic review and meta-analysis of structural magnetic resonance imaging studies investigating cognitive and social activity levels in older adults

Author(s): M. Anatürk, N. Demnitz, K.P. Ebmeier, C.E. Sexton
Published in: Neuroscience & Biobehavioral Reviews, Issue 93, 2018, Page(s) 71-84, ISSN 0149-7634
DOI: 10.1016/j.neubiorev.2018.06.012

Developmental cognitive neuroscience using latent change score models: A tutorial and applications

Author(s): Rogier A. Kievit, Andreas M. Brandmaier, Gabriel Ziegler, Anne-Laura van Harmelen, Susanne M.M. de Mooij, Michael Moutoussis, Ian M. Goodyer, Ed Bullmore, Peter B. Jones, Peter Fonagy, Ulman Lindenberger, Raymond J. Dolan
Published in: Developmental Cognitive Neuroscience, 2017, ISSN 1878-9293
DOI: 10.1016/j.dcn.2017.11.007

Lifestyle activities in mid-life contribute to cognitive reserve in late-life, independent of education, occupation, and late-life activities

Author(s): Dennis Chan, Meredith Shafto, Rogier Kievit, Fiona Matthews, Molly Spink, Michael Valenzuela, Rik N. Henson
Published in: Neurobiology of Aging, Issue 70, 2018, Page(s) 180-183, ISSN 0197-4580
DOI: 10.1016/j.neurobiolaging.2018.06.012

Age Differentiation within Gray Matter, White Matter, and between Memory and White Matter in an Adult Life Span Cohort

Author(s): Susanne M.M. de Mooij, Richard N.A. Henson, Lourens J. Waldorp, Rogier A. Kievit
Published in: The Journal of Neuroscience, Issue 38/25, 2018, Page(s) 5826-5836, ISSN 0270-6474
DOI: 10.1523/jneurosci.1627-17.2018

Strong and specific associations between cardiovascular risk factors and white matter micro- and macrostructure in healthy aging

Author(s): Delia Fuhrmann, David Nesbitt, Meredith Shafto, James B. Rowe, Darren Price, Andrew Gadie, Rogier A. Kievit, Lorraine K. Tyler, Carol Brayne, Edward T. Bullmore, Andrew C. Calder, Rhodri Cusack, Tim Dalgleish, John Duncan, Richard N. Henson, Fiona E. Matthews, William D. Marslen-Wilson, James B. Rowe, Meredith A. Shafto, Karen Campbell, Teresa Cheung, Simon Davis, Linda Geerligs, Rogier Kievit, An
Published in: Neurobiology of Aging, Issue 74, 2019, Page(s) 46-55, ISSN 0197-4580
DOI: 10.1016/j.neurobiolaging.2018.10.005

Increased Prefrontal Activity with Aging Reflects Nonspecific Neural Responses Rather than Compensation

Author(s): Alexa M. Morcom, Richard N.A. Henson
Published in: The Journal of Neuroscience, Issue 38/33, 2018, Page(s) 7303-7313, ISSN 0270-6474
DOI: 10.1523/jneurosci.1701-17.2018

In vivo visualization of age-related differences in the locus coeruleus

Author(s): Kathy Y. Liu, Julio Acosta-Cabronero, Arturo Cardenas-Blanco, Clare Loane, Alex J. Berry, Matthew J. Betts, Rogier A. Kievit, Richard N. Henson, Emrah Düzel, Robert Howard, Dorothea Hämmerer
Published in: Neurobiology of Aging, Issue 74, 2019, Page(s) 101-111, ISSN 0197-4580
DOI: 10.1016/j.neurobiolaging.2018.10.014

Self-reported sleep relates to hippocampal atrophy across the adult lifespan – results from the Lifebrain consortium

Author(s): Anders M Fjell, Øystein Sørensen, Inge K Amlien, David Bartrés-Faz, Didac Maciá Bros, Nikolaus Buchmann, Ilja Demuth, Christian A Drevon, Sandra Düzel, Klaus P Ebmeier, Ane-Victoria Idland, Tim C Kietzmann, Rogier Kievit, Simone Kühn, Ulman Lindenberger, Athanasia M Mowinckel, Lars Nyberg, Darren Price, Claire E Sexton, Cristina Solé-Padullés, Sara Pudas, Donatas Sederevicius, Sana Suri, G
Published in: Sleep, 2019, ISSN 0161-8105
DOI: 10.1093/sleep/zsz280

Association of Midlife Cardiovascular Risk Profiles With Cerebral Perfusion at Older Ages

Author(s): Sana Suri, Anya Topiwala, Michael A. Chappell, Thomas W. Okell, Eniko Zsoldos, Archana Singh-Manoux, Mika Kivimäki, Clare E. Mackay, Klaus P. Ebmeier
Published in: JAMA Network Open, Issue 2/6, 2019, Page(s) e195776, ISSN 2574-3805
DOI: 10.1001/jamanetworkopen.2019.5776

A Practical Guide to Variable Selection in Structural Equation Modeling by Using Regularized Multiple-Indicators, Multiple-Causes Models

Author(s): Ross Jacobucci, Andreas M. Brandmaier, Rogier A. Kievit
Published in: Advances in Methods and Practices in Psychological Science, Issue 2/1, 2019, Page(s) 55-76, ISSN 2515-2459
DOI: 10.1177/2515245919826527

Are People Ready for Personalized Brain Health? Perspectives of Research Participants in the Lifebrain Consortium

Author(s): Barbara Bodorkos Friedman, Sana Suri, Cristina Solé-Padullés, Sandra Düzel, Christian A Drevon, William F C Baaré, David Bartrés-Faz, Anders M Fjell, Heidi Johansen-Berg, Kathrine S Madsen, Lars Nyberg, Brenda W J H Penninx, Claire Sexton, Kristine B Walhovd, Enikő Zsoldos, Isabelle Budin-Ljøsne
Published in: The Gerontologist, 2019, ISSN 0016-9013
DOI: 10.1093/geront/gnz155

On the use of growth models to study normal cognitive aging

Author(s): Paolo Ghisletta, Fabio Mason, Timo von Oertzen, Christopher Hertzog, Lars-Göran Nilsson, Ulman Lindenberger
Published in: International Journal of Behavioral Development, Issue 44/1, 2020, Page(s) 88-96, ISSN 0165-0254
DOI: 10.1177/0165025419851576

Optimal planned missing data design for linear latent growth curve models

Author(s): Andreas M. Brandmaier, Paolo Ghisletta, Timo von Oertzen
Published in: Behavior Research Methods, 2020, ISSN 1554-3528
DOI: 10.3758/s13428-019-01325-y

Association of midlife stroke risk with structural brain integrity and memory performance at older ages: a longitudinal cohort study

Author(s): Enikő Zsoldos, Abda Mahmood, Nicola Filippini, Sana Suri, Verena Heise, Ludovica Griffanti, Clare E Mackay, Archana Singh-Manoux, Mika Kivimäki, Klaus P Ebmeier
Published in: Brain Communications, Issue 2/1, 2020, ISSN 2632-1297
DOI: 10.1093/braincomms/fcaa026

Time, frequency, and time-varying Granger-causality measures in neuroscience

Author(s): Sezen Cekic, Didier Grandjean, Olivier Renaud
Published in: Statistics in Medicine, Issue 37/11, 2018, Page(s) 1910-1931, ISSN 0277-6715
DOI: 10.1002/sim.7621

Multiscale Bayesian state-space model for Granger causality analysis of brain signal

Author(s): Sezen Cekic, Didier Grandjean, Olivier Renaud
Published in: Journal of Applied Statistics, Issue 46/1, 2018, Page(s) 66-84, ISSN 0266-4763
DOI: 10.1080/02664763.2018.1455814