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European Human Biomonitoring Initiative

Deliverables

Revised set of key indicators (DOMG)

We will revise the set of indicators following the first 2.5 years of the initiative and add, delete or modify the previous indicators taking into account societal, scientific, policy and stakeholder perspectives. DOMG is an LTP to VITO and is responsible for this deliverable.

Report on risk characterisation ratios and evaluation of new regulatory thresholds for 1st set of priority substances (ANSES)

This report will provide estimates of the risk characterization ratios for the 1st set of priority substances based on the results of the quantitative estimates of exposure derived in task 12.2.a. In this context, any new regulatory thresholds discussed at the policy level for the 1st set of priority substances will be evaluated vis-à-vis the exposure estimates generated using the exposure reconstruction algorithms developed in HBM4EU. ANSES is an LTP to INSERM and is responsible for this deliverable.

Prioritized list of known emerging chemicals (IRAS)

List of known chemicals parent compounds or metabolites to be considered as exposure markers of emerging concernIRAS is an LTP to RIVM and is responsible for this deliverable

Databases of candidate laboratories for the 2nd prioritization round of substances (ULPGC)

Database of the laboratories considered as candidate to perform the analysis of samples, to develop new methods and to support the QA/QC Program considering the substances included in the first round of prioritization. ULPGC is an LTP to ISCIII and is responsible for this deliverable.

Report on generated HBM data (INRA)

Report dealing with the generated human data related to known and unknown emerging substancesINRA is an LTP to INSERM and is responsible for this deliverable

List of criteria for selecting cohort studies

This deliverable will report on the criteria that will have be used to select data and samples needed for determining exposureresponse associations for all priority substances

2019 Programme of training activities, materials and capacity building mechanisms (RUMC)

The 2019 programme of training activities, materials and capacity building mechanisms will provide a time schedule for the activities planned for 2019. For each activity it will identify objectives linked to the AWP, partner/s responsible for delivering training, available training materials and the likely location of training (expect for online training). Links to any existing training activities at international level will also be identified, together with contact names. RUMC is an LTP to RIVM and is responsible for this deliverable.

1st update on the report on opportunities and obstacles of combining HBM and health studies, availability of health studies and administrative registers and guidelines

Update of the report under D11.1 adding new information about on-going/planned studies and updates to the SOPs based on the 2nd prioritization round.

Databases of candidate laboratories for the 1st prioritization round of substances (ULPGC)

Database of the laboratories considered as candidate to perform the analysis of samples to develop new methods and to support the QAQC Program considering the substances included in the first round of prioritizationULPGC is an LTP to ISCIII and is responsible for this deliverable

3rd substance specific derivation of HBM guidance values

3rd substance-group specific derivation of HBM guidance values based on data collected through HBM4EU.

Prioritised list of biomarkers, matrices and analytical methods for the 2nd prioritization round of substances

A list with the selected biomarkers matrices and analytical methods selected according to the criteria defined in task 91 and considering the substances included in the second round of prioritization

2nd-priorisation-Report on survey design: Study protocols, SOPs and Guidelines, tailored and transferred questionnaires for recruitment and sampling

Detailed working documents are provided for recruitment and sampling for the study conduct for the second prioritized substances to close identified data gaps.

Final evaluation report from the feasibility studies

Report including information about conducted feasibility studies in which countries by whom when and how and their final outcome about feasibility

Report on approaches to identify mixture health effects (UBRUN)

This report provides a description of viable approaches to describe and assess mixture health effects for relevant mixtures identified under tasks 15.1 and 15.2 and proposes topical cases studies as proof of concept. UBRUN is an LTP to DH and is responsible for this deliverable.

Final report on exposure-response associations based on pre-existing cohort data for the 1st and 2nd list of priority substances

This deliverable will report on the final robust associations between population exposure to the HBM4EU priority substances and observed adverse health effects or markers thereof

Report on ongoing activities and existing data and data gaps for the 2nd prioritised substances including a list of metadata that can be uploaded in IPCheM (FMUL)

The existing information about the substances prioritised in the second prioritisation round M18 on ongoing or within the next five years initiated or planned studies in the field of HBM general population and occupational exposure and health will be reported and data gaps identified Metadata that can be uploaded in IPCheM will be compiled FMUL is an LTP to FCT and is responsible for this deliverableFMUL is an LTP to FCT and is responsible for this deliverable

Initial report on occupational studies

Initial proposals and research plan for targeted occupational studies with EU added value on priority substances

Template for AOP update report for selected priority substances

This deliverable will provide the comprehensive template that will have to be used to collect data on AOPs for the priority substances dealt with in HBM4EU This will be fully compatible with the AOP KB of the OECD in order to ensure high level of coordination of the work done in WP13 with major international efforts in this domain

First report on biobank activities (KI)

Report on progress made to access biobanked samples from across Europe and how these samples will be used to address data gapsKI is an LTP to SEPA and is responsible for this deliverable

1st Phased Action Plan for translation of HBM results into policy advise, measures and suggestions for further research at general level (UAntwerpen)

A generic canvas for policy interpretation of the HBM findings based on the input from EU policy board members policy makers and stakeholdersUAntwerpen is LTP to VITO and is responsible for this deliverable

2nd material for communication to participants, including informed consent

Necessary material to communicate with the participants are compiled and examples for the second prioritised substances provided.

2nd Report on stakeholder consultation and mapping of needs

The report will summarise the outcomes of the 2019-2020 consultation on the prioritisation process, and will include a list of users of HBM4EU outputs and an inventory of gaps and needs, as well as the list of key terms and definitions. The report will be presented to the Governing Board and the Stakeholder Forum in support of the third list of priority substances.

Initial report on strategies adopted to align studies across Europe and preliminary results

Report on the national studies which will align the processes to integrate the requiremns from HBM4EU to these national structures and any obstacles

Description of national programmes

Description of national HBM programmes which may align to form a network for HBM4EU EJP

2020 Strategy for the communication and dissemination of HBM4EU results

An update of the Strategy for the communication and dissemination of HBM4EU results to reflect the activities and outputs foreseen in the 2020 AWP.

Report on AOPs of priority substances

This deliverable will report on the preliminary AOPs derived for the 1st list of priority substances. The complete results of the AOP development work for the 1st list of priority substances will be included in the final report on AOPs (D13.5).

2nd substance-group specific risk assessment

2nd substance-group specific risk assessment based on HBM data of first round priority substances collected in HBM4EU.

Sustainability of HBM4EU in the future and related operational architecture concept: first report

This initial report will provide specific proposals for the future of the initiative based on our initial interactions with a large number of bodies. It will include the mechanisms of cooperation with DG RTD, the financial plans for 2021-2030, a governance structure and an institutional anchor at EU level.

3rd-priorisation-Report on survey design: Study protocols, SOPs and Guidelines, tailored and transferred questionnaires for recruitment and sampling for the 3rd prioritised substances

Working documents are drafted for recruitment and sampling for the study conduct for the third prioritized substances to prepare for closing identified data gaps.

Scoping documents for 2020

The scoping document will outline targeted research activities proposed for 2020 and designed to address policy questions regarding a specific substance or group of substances. The descriptions will include goals, activities to be undertaken, methods, expected output and results, assumptions, constraints and budget estimates, as well as addressing ethical issues for each of the prioritized substances.

1st substance-group specific derivation of EU-wide health based guidance values

Derivation of health based guidance value for first round priority substances based on existing data

Scoping documents for 2019

The scoping document will outline targeted research activities proposed for 2019 and designed to address policy questions regarding a specific substance or group of substances The descriptions will include goals activities to be undertaken methods expected output and results assumptions constraints and budget estimates as well as addressing ethical issues for each of the prioritized substances

Criteria for prioritisation of biomarkers of effect (UGR)

List of criteria to select biomarkers of effect according to the type of study the biological matrices where they have been developed and to the analytical methods used in coordination to task 91UGR is an LTP to ISCIII and is responsible for this deliverable

Report on available biomarkers of effect of proven utility in human epidemiological studies for the 1st set of prioritised substances (UGR)

A list of biomarkers based on the human health effects the quality of the assay and its usefulness for large population studies which provide the most significant added value to HBM4EU by linking exposure data to measures of biological effects This deliverable will also report on the outcome of the workshop organised in M18 as well as the metaanalysis on existing data if appropriateUGR is an LTP to ISCIII and is responsible for this deliverable

Report on estimation of relevant tissue and biological fluid doses of 1st set of priority compounds in the EU population using refined PBTK modeling

This report will provide estimates of the risk characterization ratios for the 1st set of priority substances based on the results of the quantitative estimates of exposure derived in task 12.2.a. In this context, any new regulatory thresholds discussed at the policy level for the 1st set of priority substances will be evaluated vis-à-vis the exposure estimates generated using the exposure reconstruction algorithms developed in HBM4EU.

2nd annual list of exposure distributions and/or EU-wide reference values

List of European reference values derived by analysis of consolidated data in IPCheM.

Derivation of HBM guidance values for Bisphenol A

"Derivation of HBM guidance value for first round priority substances based on data collected through HBM4EU. The former deliverable with the title ""2nd substance-group specific derivation of HBM guidance values"" was split into 3 separate deliverables in order to ensure a high dissemination of information regarding the different HBM guidance values it is useful to have the derivation of different substances in separate documents: D5.6 – “Derivation of HBM guidance values for selected phthalates” (M28) D5.14 – “Derivation of HBM guidance values for Bisphenol A” (M28) D5.15 – “Derivation of HBM guidance values for Cadmium” (M28)"

Report on estimation of relevant tissue and biological fluid doses of 2nd set of priority compounds in the EU population using refined PBTK modeling

This report will provide the values of the internal dose of the 2nd set of priority compounds at the compoundspecific target tissues and biological fluids of interest The quantitative estimates will be generated through the use of refined PBTK modeling coupled with external exposure modeling across the EU taking into account population variability in space gender and age group

2nd Phased Action Plan for policies, measures and suggestions for further research at domestic level, case studies (UAntwerpen)

2nd Phased Action Plan for translation of HBM findings into policy advise measures and suggestions for further research at domestic level country specific case studyUAntwerpen is LTP to VITO and is responsible for this deliverable

Inventory of available samples and data collected from existing cohorts and preliminary results on exposure-response associations for 1st list of priority substances

This deliverable will provide a comprehensive inventory of all previously collected samples and data including the inventory prepared in WP7 and WP8 that will be available and useful for the derivation of robust exposureresponse relationships for the 1st list of priority substances

1st Report on analytical results and new methods development (IPA)

Results obtained by the qualified laboratories and the achievements and problems encountered during the development of new methods. IPA is an LTP to UBA and is responsible for this deliverable.

Statistical Analysis Plan for each substance group for 1st set of substances (ISGlobal)

The statistical analysis plan describes the statistical analyses that will be performed to test the hypotheses that are formulated as part of the study protocol for each of prioritized substancesISGlobal is an LTP to ISCIII and is responsible for this deliverable

Report information needs from policy makers translated in terms of functionality of HBM mixture information

This report describes the results of the consultation of information needs policymakers and stakeholders with respect to mixtures and gap analysis. The report will further outline the challenges and direction of research activities in Task 15.1, 15.2 and 15.3 to serve the information needs.

First report on targeted new fieldwork study results

Report on the new planned studies the countries who will be involved and the material that has been prepared for these studies

Scoping documents for 2018

The scoping document will outline targeted research activities proposed for 2018 and designed to address policy questions regarding a specific substance or group of substances The descriptions will include goals activities to be undertaken methods expected output and results assumptions constraints and budget estimates as well as addressing ethical issues for each of the prioritized substances

Report Outline and workplan for the joint survey on HBM mixtures (IRAS)

This report describes the gaps in existing data as identified under 15.1, the outcome of the CGL and MS and EC institutions’ consultation, and outlines the workplan for a joint HBM survey on mixtures in 3-5 MS. IRAS is an LTP to RIVM and is responsible for this deliverable.

Derivation of HBM guidance values for Cadmium

"Derivation of HBM guidance value for first round priority substances based on data collected through HBM4EU. The former deliverable with the title ""2nd substance-group specific derivation of HBM guidance values"" was split into 3 separate deliverables in order to ensure a high dissemination of information regarding the different HBM guidance values it is useful to have the derivation of different substances in separate documents: D5.6 – “Derivation of HBM guidance values for selected phthalates” (M28) D5.14 – “Derivation of HBM guidance values for Bisphenol A” (M28) D5.15 – “Derivation of HBM guidance values for Cadmium” (M28) "

1st annual list of exposure distributions and/or EU-wide reference values

List of European reference values derived by analysis of consolidated data in IPCheM

Statistical analysis plan for the co-funded studies of WP8

The statistical working group (VITO, ANSP, UBA, ISGlobal) will elaborate a statistical analysis plan (SAP) for the co-funded studies of WP 8 by M39. The statistical analysis plan will be developed in close collaboration with researchers from the 1st and 2nd set substance group and CGLs as part of task 10.4.

Templates for the submission of urgent requests for new information, one for EU policy makers and one for national policy makers (ANSES)

The templates will provide a consistent approach to the submission of requests for action by HBM4EU under the rapid response mechanism Templates will be produced for two communities the EU policy community and the national policy makersANSES is LTP to INSERM and is responsible for this deliverable

Report on the optimal methodology for exposure reconstruction from HBM data

This report will lay out the tiered methodology for exposure reconstruction from HBM data the methodology will be structured in tiers on the basis of data availability and model estimation capacity for the compounds targeted in HBM4EU

Revised Data Management Plan

The delivered data management plan (D 10.1) will be revised based on acquired experiences.

3rd Phased Action Plan for policies, measures and suggestions for further research at domestic level, case studies (UAntwerpen)

3rd Phased Action Plan for translation of HBM findings into policy advise measures and suggestions for further research at domestic level country specific case study through a participatory approachUAntwerpen is an LTP to VITO and is responsible for this deliverable

1st substance-group specific risk assessment

The first risk assessment will make use of already existing HBM data and will develop draft protocols for use in specific policy domains eg food safety chemical safety occupational safety

Second report on biobank activities (KI)

Report on progress with Biobanks – the establishment of permanent networks and links with HBM4EU. KI is an LTP to SEPA and is responsible for this deliverable.

Final report on results from the new targeted studies

Final report on the results achieved lessons learnt as well as a draft proposals for future fieldwork

Legal and Ethics Policy document (UCPH)

A legal ethics and intellectual property rights framework in parallel and in coordination with the Data Management Plan under task 101 to ensure that procedures for the collection collation transfer and use of HBM data fully respect data management and privacy legislation both at EU and at national levelUCPH is an LTP to NRCWE and is responsible for this deliverable

Report real-life exposure profiles from re-analysis of existing HBM mixture data

The report describes available HBM mixture data and presents and discusses the results from the reanalysis of compiled database of existing HBM mixture data

Report on biological half-lives of 2nd set of priority compounds (LSMU)

This report will provide the values of the biological half-lives of the 2nd set of priority compounds targeted in HBM4EU on the basis of the PBTK modeling results. The PBTK models will have been parameterized and upgraded based on the experimental data obtained in task 12.3.b. LSMU is an LTP to NPHSL and is responsible for this deliverable.

2017 Strategy for the communication and dissemination of HBM4EU results

The Strategy for the communication and dissemination of HBM4EU results will frame our key messages and identifying target audiences and relevant communication tools The Strategy will include a publication plan establishing a policy for the publication of articles in scientific journals including such issues as authorship as well as proposing processes to ensure that policy makers have access to results without undue delays caused by journal publication timeframes

Report on progress targeted occupational studies

Report on strategies used to collate occupational data results achieved and further proposals with EU added value on priority substances

Summary report on helpdesk activities

A first report summarising the helpdesk activities set up under the various work packages (task 6.2, task 8.5, task 9.6 and task 10.2) (D 2.8).

2018 Strategy for the communication and dissemination of HBM4EU results

An update of the Strategy for the communication and dissemination of HBM4EU results to reflect the activities and outputs foreseen in the 2018 AWP

First set of key indicators (LNE Department)

We will develop a first set of indicators capturing societal scientific policy and stakeholder perspectives to measure the performance and impacts of the HBM4EULNE Department is an LTP to VITO and is responsible for this deliverable

Report on opportunities and obstacles of combining HBM and health studies, availability of health studies and administrative registers and guidelines

Report about what type of opportunities and obstacles were observed mainly in Germany France and Israel when combining HBM and health studies summary of the results to the questionnaires about ongoingplanned health studies and administrative registers SOPs for criteria for the use of existing biobanked samples for HBM analysis and guidelines for linking HBM and health studies

Report on biological half-lives of 1st set of priority compounds

This report will provide the values of the biological halflives of the 1st set of priority compounds targeted in HBM4EU on the basis of the PBTK modeling results The PBTK models will have been parameterized and upgraded based on the experimental data obtained in task 123b

Report on ongoing activities and existing data and data gaps for the 3rd prioritised substances including a list of metadata that can be uploaded in IPCheM (FMUL)

The existing information about the substances prioritized in the third prioritisation round (M42) on ongoing or within the next five years planned studies in the field of HBM (general population and occupational exposure) and health will be reported and data gaps identified. Metadata that can be uploaded in IPCheM will be compiled. FMUL is an LTP to FCT and is responsible for this deliverable.

1st Report on the content and use of the online library

The report will detail the structure functionalities and content of the online library It will also report on usage over the first 21 project months based on the number of online users and downloads from the library

Workflows for screening emerging chemicals (INRA)

Standardised workflows for broad suspect chemical screening of known emerging chemicals and for screening unknown emerging chemicalsINRA is an LTP to INSERM and is responsible for this deliverable

Revised report on national needs, objectives of a long-term HBM4EU, inventory of funding mechanisms and recommendations for a sustainable HBM initiative in Europe and its organisation

We will revise the report of D6.3 following our additional interactions with the partners and the initial 3.5 years of the initiative.

Report on results of the selected biomarker of effect (UGR)

Experimental work Report on results of the validation of specific biomarker of effect ie ex vivo cellbased functional assays in a set of available collected human samples from ongoingcurrent studiesUGR is an LTP to ISCIII and is responsible for this deliverable

Case study reports on mixture health effects (UBRUN)

This deliverable describes and discusses the outcomes of the topical case studies, as outlined in D15, in the light of success or failure as proof of concept. UBRUN is an LTP to DH and is responsible for this deliverable.

Report on ongoing activities and existing data and data gaps for the 1st prioritised substances including a list of metadata that can be uploaded in IPCheM (FMUL)

The existing information about the substances prioritised in the period of proposal preparation on ongoing or within the next five years initiated or planned studies in the field of HBM general population and occupational exposure and health will be reported and data gaps identified Metadata that can be uploaded in IPCheM will be compiled FMUL is an LTP to FCT and is responsible for this deliverableFMUL is an LTP to FCT and is responsible for this deliverable

2nd Report on the content and use of the online library

The report will detail the structure, functionalities and content of the online library. It will also report on usage over the project, based on the number of online users and downloads from the library.

Report on the results of exposure reconstruction algorithms on available HBM data in the EU for all priority compounds

This report will provide georefrenced quantitative estimates of external exposure to the HBM4EU priority compounds based on the HBM data made available andor generated in Pillar 2 This overall report will provide exposure values for all priority compounds taking into account general population occupational and hot spot exposure

3rd review of training methods (RUMC)

A third review of the training materials that have been produced and used under the HBM4EU training programme. This may include both materials developed by the HBM4EU teams, as well as materials developed under other relevant initiatives. RUMC is an LTP to RIVM and is responsible for this deliverable.

Update statistical analysis plan for the aligned studies including the strategy to connect to effect markers and health data

An update of the statistical analysis plan for the aligned studies including the strategy to connect to effect markers and health data will be elaborated by VITO ASNP UBA ISGlobal in close collaboration with WP11 WP13 and WP14 This updated SAP will be delivered by VITO by M47

Identified gaps for the establishment of AOPs and required studies

This deliverable will report on the knowledge gaps identified in order to complete the establishment of AOPs for the 1st and 2nd list of priority substances in HBM4EU. It will also include a description of the studies (-omics, functional assays, etc.) necessary to complete the identified AOP knowledge gaps.

3rd substance-group specific risk assessment

3rd substance-group specific risk assessment for priority substances collected in HBM4EU.

2020 Programme of training activities, materials and capacity building mechanisms (RUMC)

The 2020 programme of training activities, materials and capacity building mechanisms will provide a time schedule for the activities planned for 2020. For each activity it will identify objectives linked to the AWP, partner/s responsible for delivering training, available training materials and the likely location of training (expect for online training). Links to any existing training activities at international level will also be identified, together with contact names. RUMC is an LTP to RIVM and is responsible for this deliverable.

Statistical Analysis Plan for each substance group for 2nd set of substances (ISGlobal)

The statistical analysis plan describes the statistical analyses that will be performed to test the hypotheses that are formulated as part of the study protocol for each of prioritized substancesISGlobal is LTP to ISCIII and is responsible for this deliverable

List of biomarkers for the 1st set of prioritized substances (UGR)

Report of selected effect biomarkers selected for the 1st set of prioritised substances including those that can provide integrated information on delineating the modes of action MOA of the adverse response or toxicityUGR is an LTP to ISCIII and is responsible for this deliverable

Progress report on Report on strategies adopted to align studies across Europe and preliminary results

Report on which strategies have proved successful – and a set of preliminary reults will also include suggestion for improvement.

Strategy and SOPs for human sample exchange, including ethical demands (IBMT)

A strategy for the pan-European exchange of biobanked human samples is developed and laid down and SOPs including technical, legal and ethical requirements for the safe and standardized exchange elaborated. IBMT is an LTP to UBA and is responsible for this deliverable.

Second list of prioritised substances and proposed CGLs for 2019-2021 (ANSES)

The second list of prioritised substances will results from the prioritisation round from 2017 to 2018 It will identify substances that have been prioritised for inclusion in HBM surveys analysis andor research under HBM4EU in the three year period from 2019 to 2021 ANSES is LTP to INSERM and is responsible for this deliverableANSES is an LTP to INSERM and is responsible for this deliverable

Prioritisation strategy and criteria (ANSES)

The prioritisation strategy will be transparent credible and accountable and will set out the procedures by which substances will be prioritised for inclusion in HBM surveys analysis andor research under HBM4EU Decisions regarding which substances to work on will be based on a set of criteria that capture both scientific evidence aspects regulatory demands societal concerns and take into account financial and technical feasibility With regards to human exposure the criteria will take into account environmental consumer and occupational exposure pathways ANSES is LTP to INSERM and is responsible for this deliverableANSES is LTP to INSERM and is responsible for this deliverable

2018 Programme of training activities, materials and capacity building mechanisms (RUMC)

The 2018 programme of training activities materials and capacity building mechanisms will provide a time schedule for the activities planned for 2018 For each activity it will identify objectives linked to the AWP partners responsible for delivering training available training materials and the likely location of training expect for online training Links to any existing training activities at international level will also be identified together with contact namesRUMC is LTP to RIVM and is responsible for this deliverable

2nd update on the report on opportunities and obstacles of combining HBM and health studies, availability of health studies and administrative registers and guidelines

Update on the report under D11.2 adding new information about on-going/planned studies and updates to the SOPs based on the 3rd prioritization round.

2021 Strategy for the communication and dissemination of HBM4EU results

An update of the Strategy for the communication and dissemination of HBM4EU results to reflect the activities and outputs foreseen in the 2021 AWP.

3rd annual list of exposure distributions and/or EU-wide reference values

List of European reference values derived by analysis of consolidated data in IPCheM

Final report on biobank activities completed (KI)

Report on the sampels accessed across Europe to fill data gaps the establishment of a network of biobanks and lessons learntKI is an LTP to SEPA and is responsible for this deliverable

Sustainability of HBM4EU in the future and related operational architecture concept: completed report

We will revise the report of D65 and provide our best proposals for the future of the initiative It will include the mechanisms of cooperation with DG RTD the financial plans for 20212030 a governance structure and an institutional anchor at EU level

2019 Strategy for the communication and dissemination of HBM4EU results

An update of the Strategy for the communication and dissemination of HBM4EU results to reflect the activities and outputs foreseen in the 2019 AWP

1st Report on stakeholder consultation and mapping of needs

The report will summarise the outcomes of the 20172018 consultation on the prioritisation process and will include a list of users of HBM4EU outputs and an inventory of gaps and needs as well as the list of key terms and definitions The report will be presented to the Governing Board and the Stakeholder Forum in support of the proposed list of priority substances and proposed CGLs

Derivation of HBM guidance values for selected phthalates

"Derivation of HBM guidance value for first round priority substances based on data collected through HBM4EU. The former deliverable with the title ""2nd substance-group specific derivation of HBM guidance values"" was split into 3 separate deliverables in order to ensure a high dissemination of information regarding the different HBM guidance values it is useful to have the derivation of different substances in separate documents: D5.6 – “Derivation of HBM guidance values for selected phthalates” (M28) D5.14 – “Derivation of HBM guidance values (EU HBM-HBGV) for Bisphenol A” (M28) D5.15 – “Derivation of HBM guidance values (EU HBM-HBGV) for Cadmium” (M28) "

Emerging exposure markers database (UAntwerpen)

Emerging exposure markers database (MS and MS/MS libraries) to be possibly further included in IPCheM. UAntwerpen is an LTP to VITO and is responsible for this deliverable.

Data management plan

The data management plan describes how existing and newly generated data are processed managed and quality controlled at the national level harmonized transferred and analysed at the European level and made available for different user communities

Third list of prioritised substances (ANSES)

The 3rd list of prioritised substances will results from the prioritisation round from 20202021 It will identify substances that have been prioritised for inclusion in HBM surveys analysis andor research under a post 2021 HBM initiative ANSES is LTP to INSERM and is responsible for this deliverableANSES is an LTP to INSERM and is responsible for this deliverable

1st material for communication to participants, including informed consent

Necessary material to communicate with the participants are compiled and examples for the first prioritised substances provided

Criteria for prioritisation of biomarkers, matrices and analytical methods (ANSP)

A list of the criteria that will be applied in the prioritization process of the biomarkers and matrices for the target substances They will be general criteria and therefore common for the all prioritization roundsANSP is an LTP to INSERM and is responsible for this deliverable

The Quality Assurance/Quality Control Scheme in HBM4EU project (IPASUM)

Overview of the different approaches to be implemented in the HBM4EU project to cover the necessities in the different prioritization roundsIPASUM is an LTP to UBA and is responsible for this deliverable

2nd review of training methods (RUMC)

A second review of the training materials that have been produced and used under the HBM4EU training programme. This may include both materials developed by the HBM4EU teams, as well as materials developed under other relevant initiatives. RUMC is LTP to RIVM and is responsible for this deliverable.

Second report on targeted new fieldwork and results

Report on the first fieldwork results and the proposal and progress with the second field work following the second prioritisation round.

1st-priorisation-Report on survey design: Study protocols, SOPs and Guidelines, tailored and transferred questionnaires for recruitment and sampling

Detailed working documents are provided for recruitment and sampling for the study conduct for the first prioritised substances to close identified data gaps.

List of qualified laboratories (IPASUM)

List of the laboratories that complete successfully the ICIEQUAS for the different prioritization rounds

Prioritised list of biomarkers, matrices and analytical methods for the 1st prioritization round of substances

A list with the selected biomarkers matrices and analytical methods selected according to the criteria defined in task 91 and considering the substances included in the first round of prioritization

2021 Programme of training activities, materials and capacity building mechanisms (RUMC)

The 2021 programme of training activities, materials and capacity building mechanisms will provide a time schedule for the activities planned for 2021. For each activity it will identify objectives linked to the AWP, partner/s responsible for delivering training, available training materials and the likely location of training (expect for online training). Links to any existing training activities at international level will also be identified, together with contact names. RUMC is an LTP to RIVM and is responsible for this deliverable.

2nd Report on analytical results and new methods developed (IPA)

Results obtained by the qualified laboratories and the achievements and problems encountered during the development of new methods. IPA is an LTP to UBA and is responsible for this deliverable.

Establishment of Stakeholder Forum and Advisory Board

Selection criteria and members of Stakeholder Forum SF and Advisory Board AB

Integrated exposure modelling platform

This computational platform will describe the integrated external and internal exposure modeling components for all priority compounds targeted in HBM4EU It will include beyond stateoftheart exposure models with generic and agedifferentiated PBTKD models that will be further refined to adapt to the specific priority compounds of HBM4EU The modelling framework will be applied on the HBM4EU priority compounds on compounds prioritized from the rapid response mechanisms

First report on the implementation of traditional and novel effect biomarkers for the 1st set of prioritized substances in the aligned studies (UGR)

The new D148 will include first data of traditional and novel effect biomarkers in the HBM4EU aligned studies for the 1st setUGR is an LTP to ISCIII and is responsible for this deliverable

Review paper on PBTK/D models for the 1st set of priority compounds

This is a review paper to be published in the peerreviewed literature on current state of the art in PBTKD modeling regarding the 1st set of priority compounds analysis of capabilities and limitations and need for further refinement

Establishment of Governing Board

Governing Board GB members and terms of reference for its meetings

Report on user experience in data exchange and data use in HBM4EU

Report on the HBM data included into IPCheM together with an assessment of the advantages and disadvantages as well as limitations of proactively sharing data for users and providers

Report policy recommendations and future research avenues on mixtures

This report presents the overall interpretation of the main achievements from the mixture results in the light of the information needs identified in task 151 and provides recommendations for the way ahead

Scoping documents for 2021

The scoping document will outline targeted research activities proposed for 2021 and designed to address policy questions regarding a specific substance or group of substances. The descriptions will include goals, activities to be undertaken, methods, expected output and results, assumptions, constraints and budget estimates, as well as addressing ethical issues for each of the prioritized substances.

Report on workshop about opportunities and obstracles for linking HBM and health studies

Report about feasibility workshop with agenda list of participants presenations of the workshop and summary of the outcome

Selection criteria and inventory of effect biomarkers for the 2nd set of substances (UGR)

Classification of the biomarkers of effect into 3 categories. Reports of selected effect biomarkers selected for the 2nd set of prioritised substances, including those that can provide integrated information on delineation of the mode(s) of action (MOA) of the adverse response or toxicity, as well as those of utility in large epidemiological population studies. UGR is an LTP to ISCIII and is responsible for this deliverable.

Scoping paper on the development of an indicator on chemical exposure in the European population

The indicator will use HBM data for follow up of chemical exposure of the EU population

1st review of training methods (RUMC)

A first review of the training materials that have been produced and used under the HBM4EU training programme This may include both materials developed by the HBM4EU teams as well as materials developed under other relevant initiatives RUMC is LTP to RIVM and is responsible for this deliverable

HBM4EU website

The HBM4EU website will promote the project and serve as an access point for results including a link to IPCheM as well as linking with other relevant projects It will features an online library including technical materials on protocols and analytical methods as well as training materials and guidance It will also serve as an internal communication tool featuring web pages for internal information sharing accessible via password Continuous updates will ensure that the website is dynamic and effective as an information hub for the initiative

Searching for OpenAIRE data...

Publications

Metabolic Syndrome and Endocrine Disrupting Chemicals: An Overview of Exposure and Health Effects

Author(s): Elsi Haverinen, Mariana F. Fernandez, Vicente Mustieles, Hanna Tolonen
Published in: International Journal of Environmental Research and Public Health, Volume 18, 2021, Page(s) Issue 24, ISSN 1660-4601
Publisher: MDPI
DOI: 10.3390/ijerph182413047

Providing Biological Plausibility for Exposure–Health Relationships for the Mycotoxins Deoxynivalenol (DON) and Fumonisin B1 (FB1) in Humans Using the AOP Framework

Author(s): Annick D. van den Brand, Lola Bajard, Inger-Lise Steffensen, Anne Lise Brantsæter, Hubert A. A. M. Dirven, Jochem Louisse, Ad Peijnenburg, Sophie Ndaw, Alberto Mantovani, Barbara De Santis, Marcel J. B. Mengelers
Published in: "Toxins - Special Issue ""Human Biomonitoring and Risk Assessment of Mycotoxins""", Volume 14 (Issue 4), 279, 2022, ISSN 2072-6651
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/toxins14040279

Towards harmonised criteria in quality assurance and quality control of suspect and non-target LC-HRMS analytical workflows for screening of emerging contaminants in human biomonitoring

Author(s): Noelia Caballero-Casero, Lidia Belova, Philippe Vervliet, Jean-Philippe Antignac, Argelia Castaño, Laurent Debrauwer, Marta Esteban López, Carolin Huber, Jana Klanova, Martin Krauss, Arjen Lommen, Hans G.J. Mol, Herbert Oberacher, Olga Pardo, Elliott J. Price, Vera Reinstadler, Chiara Maria Vitale, Alexander L.N. van Nuijs, Adrian Covaci
Published in: TrAC Trends in Analytical Chemistry, 136, 2021, Page(s) 116201, ISSN 0165-9936
Publisher: Elsevier BV
DOI: 10.1016/j.trac.2021.116201

A human biomonitoring (HBM) Global Registry Framework: Further advancement of HBM research following the FAIR principles

Author(s): Zare Jeddi M, Virgolino A, Fantke P, Hopf NB, Galea KS, Remy S, Viegas S, Mustieles V, Fernandez MF, von Goetz N, Vicente JL, Slobodnik J, Rambaud L, Denys S, St-Amand A, Nakayama SF, Santonen T, Barouki R, Pasanen-Kase R, Mol HGJ, Vermeire T, Jones K, Silva MJ, Louro H, van der Voet H, Duca RC, Verhagen H, Canova C, van Klaveren J, Kolossa-Gehring M, Bessems J.
Published in: International Journal of Hygiene and Environmental Health, Volume 238, 2021, ISSN 1438-4639
Publisher: Elsevier BV
DOI: 10.1016/j.ijheh.2021.113826

Burden of osteoporosis and costs associated with human biomonitored cadmium exposure in three European countries: France, Spain and Belgium

Author(s): Eva Ougier; Karine Fiore; Christophe Rousselle; Ricardo Assunção; Carla Martins; Jurgen Buekers
Published in: International Journal of Hygiene and Environmental Health, 234 (2021), 2021, ISSN 1438-4639
Publisher: Elsevier BV
DOI: 10.1016/j.ijheh.2021.113747

Biomonitoring of co-exposure to bisphenols by consumers of canned foodstuffs

Author(s): Neus González, Montse Marquès, Sara C. Cunha, José O. Fernandes, José L. Domingo, Martí Nadal
Published in: Environment International, 140, 2020, Page(s) 105760, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2020.105760

Exploring the relationship between metal exposure, BDNF, and behavior in adolescent males

Author(s): Andrea Rodríguez-Carrillo, Vicente Mustieles, Shereen Cynthia D'Cruze, Louis Legoff, Fernando Gil, Pablo Olmedo, Iris Reina-Pérez, Antonio Mundo, Marina Molina, Fatima Smagulova, Arthur David, Carmen Freire, Mariana F. Fernández
Published in: International Journal of Hygiene and Environmental Health, 239, 2022, Page(s) Article 113877, ISSN 1438-4639
Publisher: Elsevier BV
DOI: 10.1016/j.ijheh.2021.113877

Receptor-based in vitro activities to assess human exposure to chemical mixtures and related health impacts

Author(s): Anne Marie Vinggaard, Eva Cecilie Bonefeld-Jørgensen, Tina Kold Jensen, Mariana F. Fernandez, Anna Kjerstine Rosenmai, Camilla Taxvig, Andrea Rodriguez-Carrillo, Maria Wielsøe, Manhai Long, Nicolas Olea, Jean-Philippe Antignac, Timo Hamers, Marja Lamoree
Published in: Environment International, 146, 2021, Page(s) 106191, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2020.106191

Testing for thyroid hormone disruptors, a review of non-mammalian in vivo models

Author(s): Stephan Couderq, Michelle Leemans, Jean-Baptiste Fini
Published in: Molecular and Cellular Endocrinology, 508, 2020, Page(s) 110779, ISSN 0303-7207
Publisher: Elsevier BV
DOI: 10.1016/j.mce.2020.110779

Systemic PFOS and PFOA exposure and disturbed lipid homeostasis in humans: what do we know and what not?

Author(s): Fragki S, Dirven H, Fletcher T, Grasl-Kraupp B, Bjerve Gützkow K, Hoogenboom R, Kersten S, Lindeman B, Louisse J, Peijnenburg A, Piersma AH, Princen HMG, Uhl M, Westerhout J, Zeilmaker MJ, Luijten M.
Published in: Critical Reviews in Toxicology, Volume 51 No. 2, 2021, ISSN 1547-6898
Publisher: Informa UK Limited
DOI: 10.1080/10408444.2021.1888073

Learning from previous work and finding synergies in the domains of public and environmental health: EU-funded projects BRIDGE Health and HBM4EU

Author(s): Madlen David, Gerda Schwedler, Lena Reiber, Hanna Tolonen, Anna-Maria Andersson, Marta Esteban López, Anke Joas, Miriam Schöpel, Alexandra Polcher, Marike Kolossa-Gehring
Published in: Archives of Public Health, 78/1, 2020, ISSN 2049-3258
Publisher: Springer Nature
DOI: 10.1186/s13690-020-00460-9

Using Human Biomonitoring Data to Support Risk Assessment of Cosmetic Ingredients — A Case Study of Benzophenone-3

Author(s): Christophe Rousselle, Matthieu Meslin, Tamar Berman, Marjolijn Woutersen, Wieneke Bil, Jenna Wildeman, Qasim Chaudhry
Published in: "Toxics - Special Issue ""Human Biomonitoring in Health Risk Assessment: Current Practices and Recommendations for the Future""", Volume 10 (Issue 2), 2022, ISSN 2305-6304
Publisher: MDPI
DOI: 10.3390/toxics10020096

Environmental Substances Associated with Chronic Obstructive Pulmonary Disease—A Scoping Review

Author(s): Hanna Maria Elonheimo, Tiina Mattila, Helle Raun Andersen, Beatrice Bocca, Flavia Ruggieri, Elsi Haverinen, Hanna Tolonen
Published in: International Journal of Environmental Research and Public Health, Volume 19 (Issue 7), 2022, ISSN 1660-4601
Publisher: MDPI
DOI: 10.3390/ijerph19073945

Radia Bousoumah, Veruscka Leso, Ivo Iavicoli, Pasi Huuskonen, Susana Viegas, Simo P. Porras,Tiina Santonen, Nadine Frery, Alain Robert, Sophie Ndaw

Author(s): Biomonitoring of occupational exposure to bisphenol A, bisphenol S and bisphenol F: A systematic review
Published in: Science of the Total Environment, Volume 783, 2021, ISSN 0048-9697
Publisher: Elsevier BV
DOI: 10.1016/j.scitotenv.2021.146905

HBM4EU Occupational Biomonitoring Study on e-Waste—Study Protocol

Author(s): Paul T. J. Scheepers, Radu Corneliu Duca, Karen S. Galea, Lode Godderis, Emilie Hardy, Lisbeth E. Knudsen, Elizabeth Leese, Henriqueta Louro, Selma Mahiout, Sophie Ndaw, Katrien Poels, Simo P. Porras, Maria J. Silva, Ana Maria Tavares, Jelle Verdonck, Susana Viegas, Tiina Santonen, HBM4EU e-Waste Study Team
Published in: International Journal of Environmental Research and Public Health, Volume 18, 2021, Page(s) Issue 24, ISSN 1660-4601
Publisher: MDPI
DOI: 10.3390/ijerph182412987

Children exposure to inorganic and organic arsenic metabolites: A cohort study in Northeast Italy.

Author(s): Beatrice Bocca; Anna Pino; Liza Vecchi Brumatti; Valentina Rosolen; Luca Ronfani; Jenny D’Aversa; Flavia Ruggieri; Francesco Petrucci; Gemma Calamandrei; Fabio Barbone; Alessandro Alimonti
Published in: Environmental Pollution, 265 (2020), 2020, ISSN 0269-7491
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2020.114826

Biomonitoring of occupational exposure to phthalates: A systematic review

Author(s): Nadine Fréry, Tiina Santonen, Simo P. Porras, Aleksandra Fucic, Veruscka Leso, Radia Bousoumah, Radu Corneliu Duca, Mounia El Yamani, Marike Kolossa-Gehring, Sophie Ndaw, Susana Viegas, Ivo Iavicoli
Published in: International Journal of Hygiene and Environmental Health, 229, 2020, Page(s) 113548, ISSN 1438-4639
Publisher: Elsevier BV
DOI: 10.1016/j.ijheh.2020.113548

Assessment of chemical mixtures using biomarkers of combined biological activity: A screening study in human placentas

Author(s): Andrea Rodríguez-Carrillo, Anna Kjerstine Rosenmai, Vicente Mustieles, Stephan Couderq, Jean-Baptiste Fini, Fernando Vela-Soria, Jose Manuel Molina-Molina, Patricia Ferrando-Marco, Maria Wielsøe, Manhai Long, Eva Cecilie Bonefeld-Jorgensen, Nicolás Olea, Anne Marie Vinggaard, Mariana F. Fernández
Published in: Reproductive Toxicology, 100, 2021, Page(s) 143-154, ISSN 0890-6238
Publisher: Elsevier BV
DOI: 10.1016/j.reprotox.2021.01.002

What is required to combine human biomonitoring and health surveys?

Author(s): Hanna Tolonen, Sonja Moore, Dominik Lermen, Ana Virgolino, Lisbeth E. Knudsen, Anna-Maria Andersson, Loïc Rambaud, Carla Ancona, Marike Kolossa-Gehring
Published in: International Journal of Hygiene and Environmental Health, Volume 242 (2022), 2022, ISSN 1438-4639
Publisher: Elsevier BV
DOI: 10.1016/j.ijheh.2022.113964

Concentrations and determinants of lead, mercury, cadmium, and arsenic in pooled donor breast milk in Spain

Author(s): Freire C, Iribarne-Durán LM, Gil F, Olmedo P, Serrano-Lopez L, Peña-Caballero M, Hurtado JA, Alvarado-González NE, Fernández MF, Peinado FM, Artacho-Cordón F, Olea N.
Published in: International Journal of Hygiene and Environmental Health, Volume 240 (2022), 2021, ISSN 1438-4639
Publisher: Elsevier BV
DOI: 10.1016/j.ijheh.2021.113914

The questionnaire design process in the European Human Biomonitoring Initiative (HBM4EU)

Author(s): Beatriz Gonzalez-Alzaga, Antonio F. Hernandez, L. Kim Pack, Ivo Iavicoli, Hanna Tolonen, Tiina Santonen, Marco Vinceti, Tommaso Filippini, Hanns Moshammer, Nicole Probst-Hensch, Marike Kolossa-Gehring, Marina Lacasana
Published in: Environment International, Volume 160 (2022) 107071, 2021, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2021.107071

Human biomonitoring initiative (HBM4EU): Human biomonitoring guidance values (HBM-GVs) derived for bisphenol A

Author(s): Eva Ougier, Florence Zeman, Jean-Philippe Antignac, Christophe Rousselle, Rosa Lange, Marike Kolossa-Gehring, Petra Apel
Published in: Environment International, 154, 2021, Page(s) 106563, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2021.106563

Lead (Pb) and neurodevelopment: A review on exposure and biomarkers of effect (BDNF, HDL) and susceptibility

Author(s): Claudia Gundacker, Martin Forsthuber, Tamás Szigeti, Réka Kakucs, Vicente Mustieles, Mariana F. Fernandez, Elizabeth Bengtsen, Ulla Vogel, Karin Sørig Hougaard, Anne Thoustrup Saber
Published in: International Journal of Hygiene and Environmental Health, 238, 2021, Page(s) 113855, ISSN 1438-4639
Publisher: Elsevier BV
DOI: 10.1016/j.ijheh.2021.113855

Reproductive Health Risks Associated with Occupational and Environmental Exposure to Pesticides

Author(s): Aleksandra Fucic, Radu C. Duca, Karen S. Galea, Tihana Maric, Kelly Garcia, Michael S. Bloom, Helle R. Andersen, John E. Vena
Published in: International Journal of Environmental Research and Public Health, 18/12, 2021, Page(s) 6576, ISSN 1660-4601
Publisher: MDPI
DOI: 10.3390/ijerph18126576

Network Analysis to Identify Communities Among Multiple Exposure Biomarkers Measured at Birth in Three Flemish General Population Samples

Author(s): Ilse Ottenbros, Eva Govarts, Erik Lebret, Roel Vermeulen, Greet Schoeters, Jelle Vlaanderen
Published in: Frontiers in Public Health, 9, 2021, ISSN 2296-2565
Publisher: Frontiers Media S.A.
DOI: 10.3389/fpubh.2021.590038

The European Human Biomonitoring Initiative (HBM4EU): Human biomonitoring guidance values for selected phthalates and a substitute plasticizer

Author(s): Rosa Lange, Petra Apel, Christophe Rousselle, Sandrine Charles, Fatoumata Sissoko, Marike Kolossa-Gehring, Eva Ougier
Published in: International Journal of Hygiene and Environmental Health, 234, 2021, Page(s) 113722, ISSN 1438-4639
Publisher: Elsevier BV
DOI: 10.1016/j.ijheh.2021.113722

Environmental Substances Associated with Alzheimer’s Disease—A Scoping Review

Author(s): Hanna Maria Elonheimo, Helle Raun Andersen, Andromachi Katsonouri, Hanna Tolonen
Published in: International Journal of Environmental Research and Public Health, Volume 18, 2021, Page(s) Issue 22, ISSN 1660-4601
Publisher: MDPI
DOI: 10.3390/ijerph182211839

Suspect and non-targeted screening of chemicals of emerging concern for human biomonitoring, environmental health studies and support to risk assessment: From promises to challenges and harmonisation issues

Author(s): Mariane Pourchet, Laurent Debrauwer, Jana Klanova, Elliott J. Price, Adrian Covaci, Noelia Caballero-Casero, Herbert Oberacher, Marja Lamoree, Annelaure Damont, François Fenaille, Jelle Vlaanderen, Jeroen Meijer, Martin Krauss, Denis Sarigiannis, Robert Barouki, Bruno Le Bizec, Jean-Philippe Antignac
Published in: Environment International, 139, 2020, Page(s) 105545, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2020.105545

Biomarkers, matrices and analytical methods targeting human exposure to chemicals selected for a European human biomonitoring initiative

Author(s): Katrin Vorkamp, Argelia Castaño, Jean-Philippe Antignac, Luis D. Boada, Enrique Cequier, Adrian Covaci, Marta Esteban López, Line S. Haug, Monika Kasper-Sonnenberg, Holger M. Koch, Octavio Pérez Luzardo, Agnese Osīte, Loïc Rambaud, Maria-Teresa Pinorini, Gabriele Sabbioni, Cathrine Thomsen
Published in: Environment International, 146, 2021, Page(s) 106082, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2020.106082

Assessment of perfluoroalkyl substances in placenta by coupling salt assisted liquid-liquid extraction with dispersive liquid-liquid microextraction prior to liquid chromatography-tandem mass spectrometry

Author(s): F. Vela-Soria, J. García-Villanova, V. Mustieles, T. de Haro, J.P. Antignac, M.F. Fernandez
Published in: Talanta, 221, 2021, ISSN 0039-9140
Publisher: Elsevier BV
DOI: 10.1016/j.talanta.2020.121577

Scoping Review—The Association between Asthma and Environmental Chemicals

Author(s): Tiina Mattila, Tiina Santonen, Helle Raun Andersen, Andromachi Katsonouri, Tamás Szigeti, Maria Uhl, Wojciech Wąsowicz, Rosa Lange, Beatrice Bocca, Flavia Ruggieri, Marike Kolossa-Gehring, Denis A. Sarigiannis, Hanna Tolonen
Published in: International Journal of Environmental Research and Public Health, Volume 18, 2021, Page(s) Issue 3, ISSN 1660-4601
Publisher: MDPI
DOI: 10.3390/ijerph18031323

Non-targeted screening methodology to characterise human internal chemical exposure: Application to halogenated compounds in human milk

Author(s): Mariane Pourchet, Luca Narduzzi, Annabelle Jean, Ingrid Guiffard, Emmanuelle Bichon, Ronan Cariou, Yann Guitton, Sébastien Hutinet, Jelle Vlaanderen, Jeroen Meijer, Bruno Le Bizec, Jean-Philippe Antignac
Published in: Talanta, 225, 2021, Page(s) 121979, ISSN 0039-9140
Publisher: Elsevier BV
DOI: 10.1016/j.talanta.2020.121979

Bisphenol A and its analogues: A comprehensive review to identify and prioritize effect biomarkers for human biomonitoring

Author(s): Vicente Mustieles, Shereen Cynthia D'Cruz, Stephan Couderq, Andrea Rodríguez-Carrillo, Jean-Baptiste Fini, Tim Hofer, Inger-Lise Steffensen, Hubert Dirven, Robert Barouki, Nicolás Olea, Mariana F. Fernández, Arthur David
Published in: Environment International, 144, 2020, Page(s) 105811, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2020.105811

HBM4EU combines and harmonises human biomonitoring data across the EU, building on existing capacity – The HBM4EU survey

Author(s): Liese Gilles, Eva Govarts, Loïc Rambaud, Nina Vogel, Argelia Castaño, Marta Esteban López, Laura Rodriguez Martin, Gudrun Koppen, Sylvie Remy, Martine Vrijheid, Parisa Montazeri, Laura Birks, Ovnair Sepai, Lorraine Stewart, Ulrike Fiddicke, Ilse Loots, Lisbeth E. Knudsen, Marike Kolossa-Gehring, Greet Schoeters
Published in: International Journal of Hygiene and Environmental Health, 237, 2021, Page(s) 113809, ISSN 1438-4639
Publisher: Elsevier BV
DOI: 10.1016/j.ijheh.2021.113809

The European human biomonitoring platform - Design and implementation of a laboratory quality assurance/quality control (QA/QC) programme for selected priority chemicals

Author(s): Marta Esteban López; Thomas Göen; Hans Mol; Stefanie Nübler; Karin Haji-Abbas-Zarrabi; Holger M. Koch; Monika Kasper-Sonnenberg; Darina Dvorakova; Jana Hajslova; Jean-Philippe Antignac; Vincent Vaccher; Ingrid Elbers; Cathrine Thomsen; Katrin Vorkamp; Susana Pedraza – Díaz; Marike Kolossa-Gehring; Argelia Castaño
Published in: International Journal of Hygiene and Environmental Health, 234 (2021), 2021, ISSN 1438-4639
Publisher: Elsevier BV
DOI: 10.1016/j.ijheh.2021.113740

Improving the screening annotation level of pesticide metabolites with combined high-throughput in-vitro incubation and automated LC-HRMS data processing

Author(s): Huber C, Müller E, Schulze T, Brack W, Krauss M.
Published in: Analytical Chemistry, 93 (Article 26), 2021, ISSN 1520-6882
Publisher: ACS Publications
DOI: 10.1021/acs.analchem.1c00972

Comparison of polycyclic aromatic hydrocarbon metabolite concentrations in urine of mothers and their newborns

Author(s): Katerina Urbancova, Darina Dvorakova, Tomas Gramblicka, Radim J. Sram, Jana Hajslova, Jana Pulkrabova
Published in: Science of The Total Environment, 723, 2020, Page(s) 138116, ISSN 0048-9697
Publisher: Elsevier BV
DOI: 10.1016/j.scitotenv.2020.138116

Linking past uses of legacy SVOCs with today's indoor levels and human exposure

Author(s): Hale Demirtepe, Lisa Melymuk, Miriam L. Diamond, Lola Bajard, Šimon Vojta, Roman Prokeš, Ondřej Sáňka, Jana Klánová, Ľubica Palkovičová Murínová, Denisa Richterová, Vladimíra Rašplová, Tomáš Trnovec
Published in: Environment International, 127, 2019, Page(s) 653-663, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2019.04.001

Proficiency and Interlaboratory Variability in the Determination of Phthalate and DINCH Biomarkers in Human Urine: Results from the HBM4EU Project

Author(s): Hans G. J. Mol, Ingrid Elbers, Claudia Pälmke, Daniel Bury, Thomas Göen, Marta Esteban López, Stefanie Nübler, Vincent Vaccher, Jean-Philippe Antignac, Darina Dvoráková, Jana Hajšlová, Amrit Kaur Sakhi, Cathrine Thomsen, Katrin Vorkamp, Argelia Castaño, Holger M. Koch
Published in: "Toxics - Special Issue ""Phthalate Exposure: From Quantification to Risk Assessment""", Volume 10 (Issue 2), 2022, ISSN 2305-6304
Publisher: MDPI
DOI: 10.3390/toxics10020057

An annotation database for chemicals of emerging concern in exposome research

Author(s): Jeroen Meijer, Marja Lamoree, Timo Hamers, Jean-Philippe Antignac, Sébastien Hutinet, Laurent Debrauwer, Adrian Covaci, Carolin Huber, Martin Krauss, Douglas I. Walker, Emma L. Schymanski, Roel Vermeulen, Jelle Vlaanderen
Published in: Environment International, 152, 2021, Page(s) 106511, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2021.106511

Human biomonitoring initiative (HBM4EU): Human biomonitoring guidance values (HBM-GVs) derived for cadmium and its compounds

Author(s): Farida Lamkarkach, Eva Ougier, Robert Garnier, Claude Viau, Marike Kolossa-Gehring, Rosa Lange, Petra Apel
Published in: Environment International, 147, 2021, Page(s) 106337, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2020.106337

Urinary metabolites of non-persistent pesticides and serum hormones in Spanish adolescent males

Author(s): Carmen Freire, Beatriz Suárez, Fernando Vela-Soria, Francesca Castiello, Iris Reina-Pérez, Helle R. Andersen, Nicolás Olea, Mariana F. Fernández
Published in: Environmental Research, 197, 2021, Page(s) 111016, ISSN 0013-9351
Publisher: Academic Press
DOI: 10.1016/j.envres.2021.111016

Chemical prioritisation strategy in the European Human Biomonitoring Initiative (HBM4EU) – Development and results

Author(s): Eva Ougier, Catherine Ganzleben, Pierre Lecoq, Jos Bessems, Madlen David, Greet Schoeters, Rosa Lange, Matthieu Meslin, Maria Uhl, Marike Kolossa-Gehring, Christophe Rousselle, Joana Lobo Vicente
Published in: International Journal of Hygiene and Environmental Health, 236, 2021, Page(s) 113778, ISSN 1438-4639
Publisher: Elsevier BV
DOI: 10.1016/j.ijheh.2021.113778

Estimating human exposure to pyrethroids' mixtures from biomonitoring data using physiologically based pharmacokinetic modeling.

Author(s): Paul Quindroit; Amélie Crépet; Céline Brochot
Published in: Environmental Research, 192 (2021), 2020, ISSN 0013-9351
Publisher: Academic Press
DOI: 10.1016/j.envres.2020.110281

The European Human Biomonitoring Initiative (HBM4EU): Human biomonitoring guidance values (HBM-GVs) for the aprotic solvents N-methyl-2-pyrrolidone (NMP) and N-ethyl-2-pyrrolidone (NEP)

Author(s): Madlen David, Antje Gerofke, Rosa Lange, Marike Kolossa-Gehring, Petra Apel
Published in: International Journal of Hygiene and Environmental Health, 238, 2021, Page(s) 113856, ISSN 1438-4639
Publisher: Elsevier BV
DOI: 10.1016/j.ijheh.2021.113856

Exposure to non-persistent pesticides, BDNF, and behavioral function in adolescent males: Exploring a novel effect biomarker approach

Author(s): Andrea Rodríguez-Carrillo, Shereen C. D’Cruz, Vicente Mustieles, Beatriz Suarez, Fatima Smagulova, Arthur David, Francisco Peinado, Francisco Artacho-Cordon, Luis C. Lopez, Juan P. Arrebola, Nicolas Olea, Mariana F. Fernandez, Carmen Freire
Published in: Environmental Research, Volume 211 (2022), 2022, ISSN 0013-9351
Publisher: Academic Press
DOI: 10.1016/j.envres.2022.113115

The Association between ADHD and Environmental Chemicals — A Scoping Review

Author(s): Sonja Moore, Laura Paalanen, Lisa Melymuk, Andromachi Katsonouri, Marike Kolossa-Gehring, Hanna Tolonen
Published in: International Journal of Environmental Research and Public Health, Volume 19, Issue 5, 2022, ISSN 1660-4601
Publisher: MDPI
DOI: 10.3390/ijerph19052849

Dietary Intake of Acrylamide and Risk of Breast, Endometrial, and Ovarian Cancers: A Systematic Review and Dose–Response Meta-analysis

Author(s): Giorgia Adani, Tommaso Filippini, Lauren A. Wise, Thorhallur I. Halldorsson, Ludek Blaha, Marco Vinceti
Published in: Cancer Epidemiology Biomarkers & Prevention, 29/6, 2020, Page(s) 1095-1106, ISSN 1055-9965
Publisher: American Association for Cancer Research
DOI: 10.1158/1055-9965.epi-19-1628

A Phased Approach for preparation and organization of human biomonitoring studies

Author(s): Ulrike Fiddicke, L. Kim Pack, Hanna Tolonen, Ovnair Sepai, Marta Esteban López, Argelia Castaño, Greet Schoeters, Marike Kolossa-Gehring
Published in: International Journal of Hygiene and Environmental Health, 232, 2021, Page(s) 113684, ISSN 1438-4639
Publisher: Elsevier BV
DOI: 10.1016/j.ijheh.2020.113684

Environmental Substances Associated with Osteoporosis–A Scoping Review

Author(s): Hanna Elonheimo, Rosa Lange, Hanna Tolonen, Marike Kolossa-Gehring
Published in: International Journal of Environmental Research and Public Health, 18/2, 2021, Page(s) 738, ISSN 1660-4601
Publisher: MDPI
DOI: 10.3390/ijerph18020738

HBM4EU chromates study - Overall results and recommendations for the biomonitoring of occupational exposure to hexavalent chromium

Author(s): Tiina Santonen, Simo P. Porras, Beatrice Bocca, Radia Bousoumah, Radu Corneliu Duca, Karen S. Galea, Lode Godderis, Thomas Göen, Emilie Hardy, Ivo Iavicoli, Beata Janasik, Kate Jones, Elizabeth Leese, Veruscka Leso, Henriqueta Louro, Nicole Majery, Sophie Ndaw, Hermínia Pinhal, Flavia Ruggieri, Maria J. Silva, An van Nieuwenhuyse, Jelle Verdonck, Susana Viegas, Wojciech Wasowicz, Ovnair Sepai, P
Published in: Environmental Research, 204, 2022, Page(s) 111984, ISSN 0013-9351
Publisher: Academic Press
DOI: 10.1016/j.envres.2021.111984

Bisphenol A shapes children's brain and behavior: towards an integrated neurotoxicity assessment including human data

Author(s): Mustieles V, Fernández MF
Published in: Environmental Health, 19.66, 2020, ISSN 1476-069X
Publisher: BioMed Central
DOI: 10.1186/s12940-020-00620-y

Towards Harmonized Biobanking for Biomonitoring: A Comparison of Human Biomonitoring-Related and Clinical Biorepositories

Author(s): Dominik Lermen, Frederik Gwinner, Martina Bartel-Steinbach, Sabine C. Mueller, Jens K. Habermann, Matharoo-Ball Balwir, Elke Smits, Ana Virgolino, Ulrike Fiddicke, Marika Berglund, Agneta Åkesson, Anna Bergstrom, Karin Leander, Milena Horvat, Janja Snoj Tratnik, Manuel Posada de la Paz, Argelia Castaño Calvo, Marta Esteban López, Hagen von Briesen, Heiko Zimmermann, Marike Kolossa-Gehring
Published in: Biopreservation and Biobanking, 18/2, 2020, Page(s) 122-135, ISSN 1947-5535
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/bio.2019.0092

Human biomonitoring as a tool to support chemicals regulation in the European Union

Author(s): Catherine Ganzleben, Jean-Philippe Antignac, Robert Barouki, Argelia Castaño, Ulrike Fiddicke, Jana Klánová, Erik Lebret, Nicolas Olea, Dimosthenis Sarigiannis, Greet R. Schoeters, Ovnair Sepai, Hanna Tolonen, Marike Kolossa-Gehring
Published in: International Journal of Hygiene and Environmental Health, 220/2, 2017, Page(s) 94-97, ISSN 1438-4639
Publisher: Elsevier BV
DOI: 10.1016/j.ijheh.2017.01.007

Prioritization of hazards of novel flame retardants using the mechanistic toxicology information from ToxCast and Adverse Outcome Pathways

Author(s): Lola Bajard, Lisa Melymuk, Ludek Blaha
Published in: Environmental Sciences Europe, 31/1, 2019, ISSN 2190-4707
Publisher: Springer Verlag
DOI: 10.1186/s12302-019-0195-z

Development of Policy Relevant Human Biomonitoring Indicators for Chemical Exposure in the European Population

Author(s): Jurgen Buekers, Madlen David, Gudrun Koppen, Jos Bessems, Martin Scheringer, Erik Lebret, Denis Sarigiannis, Marike Kolossa-Gehring, Marika Berglund, Greet Schoeters, Xenia Trier
Published in: International Journal of Environmental Research and Public Health, 15/10, 2018, Page(s) 2085, ISSN 1660-4601
Publisher: Int. J. Environ. Res. Public Health 2018
DOI: 10.3390/ijerph15102085

Physiology-based toxicokinetic modelling in the frame of the European Human Biomonitoring Initiative

Author(s): Dimosthenis A. Sarigiannis, Spyros Karakitsios, Elena Dominguez-Romero, Krystalia Papadaki, Celine Brochot, Vikas Kumar, Marta Schumacher, Moustapha Sy, Hans Mielke, Mathias Greiner, Marcel Mengelers, Martin Scheringer
Published in: Environmental Research, 172, 2019, Page(s) 216-230, ISSN 0013-9351
Publisher: Academic Press
DOI: 10.1016/j.envres.2019.01.045

Current EU research activities on combined exposure to multiple chemicals

Author(s): Stephanie K. Bopp, Robert Barouki, Werner Brack, Silvia Dalla Costa, Jean-Lou C.M. Dorne, Paula E. Drakvik, Michael Faust, Tuomo K. Karjalainen, Stylianos Kephalopoulos, Jacob van Klaveren, Marike Kolossa-Gehring, Andreas Kortenkamp, Erik Lebret, Teresa Lettieri, Sofie Nørager, Joëlle Rüegg, Jose V. Tarazona, Xenia Trier, Bob van de Water, Jos van Gils, Åke Bergman
Published in: Environment International, 120, 2018, Page(s) 544-562, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2018.07.037

A strategy to validate a selection of human effect biomarkers using adverse outcome pathways: Proof of concept for phthalates and reproductive effects

Author(s): Kirsten A. Baken, Nathalie Lambrechts, Sylvie Remy, Vicente Mustieles, Andrea Rodríguez-Carrillo, Christiana M. Neophytou, Nicolas Olea, Greet Schoeters
Published in: Environmental Research, 175, 2019, Page(s) 235-256, ISSN 0013-9351
Publisher: Academic Press
DOI: 10.1016/j.envres.2019.05.013

Human biomonitoring in health risk assessment in Europe: Current practices and recommendations for the future

Author(s): Henriqueta Louro, Milla Heinälä, Jos Bessems, Jurgen Buekers, Theo Vermeire, Marjolijn Woutersen, Jacqueline van Engelen, Teresa Borges, Christophe Rousselle, Eva Ougier, Paula Alvito, Carla Martins, Ricardo Assunção, Maria João Silva, Anjoeka Pronk, Bernice Schaddelee-Scholten, Maria Del Carmen Gonzalez, Mercedes de Alba, Argelia Castaño, Susana Viegas, Tatjana Humar-Juric, Lijana Kononenko
Published in: International Journal of Hygiene and Environmental Health, 222/5, 2019, Page(s) 727-737, ISSN 1438-4639
Publisher: Elsevier BV
DOI: 10.1016/j.ijheh.2019.05.009

Deciphering Adverse Outcome Pathway Network Linked to Bisphenol F Using Text Mining and Systems Toxicology Approaches

Author(s): Marylène Rugard, Xavier Coumoul, Jean-Charles Carvaillo, Robert Barouki, Karine Audouze
Published in: Toxicological Sciences, 173/1, 2019, Page(s) 32-40, ISSN 1096-6080
Publisher: Oxford University Press
DOI: 10.1093/toxsci/kfz214

Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment

Author(s): Elina Drakvik, Rolf Altenburger, Yasunobu Aoki, Thomas Backhaus, Tina Bahadori, Robert Barouki, Werner Brack, Mark T.D. Cronin, Barbara Demeneix, Susanne Hougaard Bennekou, Jacob van Klaveren, Carsten Kneuer, Marike Kolossa-Gehring, Erik Lebret, Leo Posthuma, Lena Reiber, Cynthia Rider, Joëlle Rüegg, Giuseppe Testa, Bart van der Burg, Hilko van der Voet, A. Michael Warhurst, Bob van de Water, Ku
Published in: Environment International, 134, 2020, Page(s) 105267, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2019.105267

Cadmium Exposure and Risk of Breast Cancer by Histological and Tumor Receptor Subtype in White Caucasian Women: A Hospital-Based Case-Control Study

Author(s): Loreta Strumylaite, Rima Kregzdyte, Algirdas Bogusevicius, Lina Poskiene, Dale Baranauskiene, Darius Pranys
Published in: International Journal of Molecular Sciences, 20/12, 2019, Page(s) 3029, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20123029

Linking Bisphenol S to Adverse Outcome Pathways Using a Combined Text Mining and Systems Biology Approach

Author(s): Jean-Charles Carvaillo, Robert Barouki, Xavier Coumoul, Karine Audouze
Published in: Environmental Health Perspectives, 127/4, 2019, Page(s) 047005, ISSN 0091-6765
Publisher: US Department of Health and Human Services
DOI: 10.1289/ehp4200

Human biomonitoring in Israel: Recent results and lessons learned

Author(s): Tamar Berman, Rebecca Goldsmith, Hagai Levine, Itamar Grotto
Published in: International Journal of Hygiene and Environmental Health, 220/2, 2017, Page(s) 6-12, ISSN 1438-4639
Publisher: Elsevier BV
DOI: 10.1016/j.ijheh.2016.09.008

Setting up a collaborative European human biological monitoring study on occupational exposure to hexavalent chromium

Author(s): Tiina Santonen, Alessandro Alimonti, Beatrice Bocca, Radu Corneliu Duca, Karen S. Galea, Lode Godderis, Thomas Göen, Bruno Gomes, Ogier Hanser, Ivo Iavicoli, Beata Janasik, Kate Jones, Mirja Kiilunen, Holger M. Koch, Elizabeth Leese, Veruscka Leso, Henriqueta Louro, Sophie Ndaw, Simo P. Porras, Alain Robert, Flavia Ruggieri, Paul T.J. Scheepers, Maria J. Silva, Susana Viegas, Wojciech Wasowicz, A
Published in: Environmental Research, 177, 2019, Page(s) 108583, ISSN 0013-9351
Publisher: Academic Press
DOI: 10.1016/j.envres.2019.108583

Thyroid-disrupting chemicals and brain development: an update

Author(s): Bilal B Mughal, Jean-Baptiste Fini, Barbara A Demeneix
Published in: Endocrine Connections, 7/4, 2018, Page(s) R160-R186, ISSN 2049-3614
Publisher: BioScientifica Ltd.
DOI: 10.1530/EC-18-0029

Biomonitoring for Occupational Exposure to Diisocyanates: A Systematic Review

Author(s): Bernice Scholten, Laura Kenny, Radu-Corneliu Duca, Anjoeka Pronk, Tiina Santonen, Karen S Galea, Miranda Loh, Katriina Huumonen, Anne Sleeuwenhoek, Matteo Creta, Lode Godderis, Kate Jones
Published in: Annals of Work Exposures and Health, 2020, ISSN 2398-7308
Publisher: Oxford Academic
DOI: 10.1093/annweh/wxaa038

Bisphenols and Oxidative Stress Biomarkers—Associations Found in Human Studies, Evaluation of Methods Used, and Strengths and Weaknesses of the Biomarkers

Author(s): Inger-Lise Steffensen, Hubert Dirven, Stephan Couderq, Arthur David, Shereen Cynthia D’Cruz, Mariana F Fernández, Vicente Mustieles, Andrea Rodríguez-Carillo, Tim Hofer
Published in: International Journal of Environmental Research and Public Health, 17/10, 2020, Page(s) 3609, ISSN 1660-4601
Publisher: MDPI
DOI: 10.3390/ijerph17103609

Pesticides With Potential Thyroid Hormone-Disrupting Effects: A Review of Recent Data

Author(s): Michelle Leemans, Stephan Couderq, Barbara Demeneix, Jean-Baptiste Fini
Published in: Frontiers in Endocrinology, 10, 2019, ISSN 1664-2392
Publisher: Frontiers in Endocrinology
DOI: 10.3389/fendo.2019.00743

Transcriptomic effect marker patterns of genotoxins – a comparative study with literature data

Author(s): Katrin Kreuzer, Falko Frenzel, Alfonso Lampen, Albert Braeuning, Linda Böhmert
Published in: Journal of Applied Toxicology, 40/4, 2020, Page(s) 448-457, ISSN 0260-437X
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/jat.3928

A review of phthalate pharmacokinetics in human and rat: what factors drive phthalate distribution and partitioning?

Author(s): Elena Domínguez-Romero, Martin Scheringer
Published in: Drug Metabolism Reviews, 51/3, 2019, Page(s) 314-329, ISSN 0360-2532
Publisher: Marcel Dekker Inc.
DOI: 10.1080/03602532.2019.1620762

Time course of phthalate cumulative risks to male developmental health over a 27-year period: Biomonitoring samples of the German Environmental Specimen Bank

Author(s): Petra Apel, Andreas Kortenkamp, Holger M. Koch, Nina Vogel, Maria Rüther, Monika Kasper-Sonnenberg, Andre Conrad, Thomas Brüning, Marike Kolossa-Gehring
Published in: Environment International, 137, 2020, Page(s) 105467, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2020.105467

AOP-helpFinder webserver: a tool for comprehensive analysis of the literature to support adverse outcome pathways development

Author(s): Florence Jornod, Thomas Jaylet, Ludek Blaha, Denis Sarigiannis, Luc Tamisier, Karine Audouze
Published in: Oxford Academic - Bioinformatics, 2021, ISSN 1367-4803
Publisher: Oxford University Press
DOI: 10.1093/bioinformatics/btab750

Concentrations of perfluoroalkyl substances in donor breast milk in Southern Spain and their potential determinants

Author(s): Laura Serrano, Luz Mª Iribarne-Durán, Beatriz Suárez, Francisco Artacho-Cordón, Fernando Vela-Soria, Manuela Peña-Caballero, Jose A. Hurtado, Nicolás Olea, Mariana F. Fernández, Carmen Freire
Published in: International Journal of Hygiene and Environmental Health, 236, 2021, Page(s) 113796, ISSN 1438-4639
Publisher: Elsevier BV
DOI: 10.1016/j.ijheh.2021.113796

BDNF as a potential mediator between childhood BPA exposure and behavioral function in adolescent boys from the INMA-Granada cohort

Author(s): Vicente Mustieles, Andrea Rodríguez-Carrillo, Fernando Vela-Soria, Shereen Cynthia D'Cruz, Arthur David, Fatima Smagulova, Antonio Mundo-López, Alicia Olivas-Martínez, Iris Reina-Pérez, Nicolás Olea, Carmen Freire, Juan P. Arrebola, Mariana F. Fernández
Published in: Science of The Total Environment, 803, 2022, Page(s) 150014, ISSN 0048-9697
Publisher: Elsevier BV
DOI: 10.1016/j.scitotenv.2021.150014

Towards a systematic use of effect biomarkers in population and occupational biomonitoring

Author(s): Maryam Zare Jeddi, Nancy B. Hopf, Susana Viegas, Anna Bal Price, Alicia Paini, Christoph van Thriel, Emilio Benfenati, Sophie Ndaw, Jos Bessems, Peter A. Behnisch, Gabriele Leng, Radu-Corneliu Duca, Hans Verhagen, Francesco Cubadda, Lorraine Brennan, Imran Ali, Arthur David, Vicente Mustieles, Mariana F. Fernandez, Henriqueta Louro, Robert Pasanen-Kase
Published in: Environment International, 146, 2021, Page(s) 106257, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2020.106257

Interlaboratory comparison investigations (ICI) and external quality assurance schemes (EQUAS) for cadmium in urine and blood: Results from the HBM4EU project

Author(s): Stefanie Nübler, Marta Esteban López, Argelia Castaño, Hans Mol, Moritz Schäfer, Karin Haji-Abbas-Zarrabi, Daniel Bury, Holger M. Koch, Vincent Vaccher, Jean-Philippe Antignac, Darina Dvorakova, Jana Hajslova, Cathrine Thomsen, Katrin Vorkamp, Thomas Göen
Published in: International Journal of Hygiene and Environmental Health, 234, 2021, Page(s) 113711, ISSN 1438-4639
Publisher: Elsevier BV
DOI: 10.1016/j.ijheh.2021.113711

Risk Assessment of Dietary Exposure to Organophosphorus Flame Retardants in Children by Using HBM-Data

Author(s): Veronika Plichta, Johann Steinwider, Nina Vogel, Till Weber, Marike Kolossa-Gehring, Lubica Palkovičová Murínová, Soňa Wimmerová, Janja Snoj Tratnik, Milena Horvat, Gudrun Koppen, Eva Govarts, Liese Gilles, Laura Rodriguez Martin, Greet Schoeters, Adrian Covaci, Clémence Fillol, Loïc Rambaud, Tina Kold Jensen, Elke Rauscher-Gabernig
Published in: Toxics, Volume 10 (Issue 5), 2022, ISSN 2305-6304
Publisher: MDPI
DOI: 10.3390/toxics10050234

Chemical Exposure: European Citizens' Perspectives, Trust, and Concerns on Human Biomonitoring Initiatives, Information Needs, and Scientific Results.

Author(s): Maria Uhl; Ricardo R. Santos; Joana Costa; Osvaldo Santos; Ana Virgolino; David S. Evans; Cora Murray; Maurice Mulcahy; Dorothy Ubong; Ovnair Sepai; Joana Lobo Vicente; Michaela Leitner; Silvia Benda-Kahri; Daniela Zanini-Freitag
Published in: International Journal of Environmental Research and Public Health, Volume 18 (Issue 4), 2021, ISSN 1660-4601
Publisher: MDPI
DOI: 10.3390/ijerph18041532

A European proposal for quality control and quality assurance of tandem mass spectral libraries

Author(s): Herbert Oberacher, Michael Sasse, Jean-Philippe Antignac, Yann Guitton, Laurent Debrauwer, Emilien L. Jamin, Tobias Schulze, Martin Krauss, Adrian Covaci, Noelia Caballero-Casero, Kathleen Rousseau, Annelaure Damont, François Fenaille, Marja Lamoree, Emma L. Schymanski
Published in: Environmental Sciences Europe, 32/1, 2020, ISSN 2190-4707
Publisher: Springer Verlag
DOI: 10.1186/s12302-020-00314-9

Systematic review of biomonitoring data on occupational exposure to hexavalent chromium.

Author(s): Jelle Verdonck; Radu-Corneliu Duca; Karen S. Galea; Ivo Iavicoli; Katrien Poels; Zehra Nur Töreyin; Jeroen Vanoirbeek; Lode Godderis
Published in: International Journal of Hygiene and Environmental Health, 236 (2021), 2021, ISSN 1438-4639
Publisher: Elsevier BV
DOI: 10.1016/j.ijheh.2021.113799

Interlaboratory comparison investigations (ICIs) and external quality assurance schemes (EQUASs) for flame retardant analysis in biological matrices: Results from the HBM4EU project

Author(s): Darina Dvorakova; Jana Pulkrabova; Tomas Gramblicka; Andrea Polachova; Martina Buresova; Marta Esteban López; Argelia Castaño; Stefanie Nübler; Karin Haji-Abbas-Zarrabi; Nadine Klausner; Thomas Göen; Hans Mol; Holger M. Koch; Vincent Vaccher; Jean-Philippe Antignac; Line Småstuen Haug; Katrin Vorkamp; Jana Hajslova
Published in: Environmental Research, 202 (2021), 2021, ISSN 0013-9351
Publisher: Academic Press
DOI: 10.1016/j.envres.2021.111705

Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells

Author(s): Katrin Kreuzer, Linda Böhmert, Deema Alhalabi, Thorsten Buhrke, Alfonso Lampen, Albert Braeuning
Published in: Food and Chemical Toxicology, 140, 2020, Page(s) 111297, ISSN 0278-6915
Publisher: Elsevier BV
DOI: 10.1016/j.fct.2020.111297

Critical review of analytical methods for the determination offlameretardants in human matrices

Author(s): Parvaneh Hajeb, Argelia Castaño, Enrique Cequier, Adrian Covaci, Marta Esteban López, Ana Gonzalez Antuña, Line Småstuen Haug, Luis Alberto Henríquez-Hernández, Lisa Melymuk, Octavio Pérez Luzardo, Cathrine Thomsen, Katrin Vorkamp
Published in: Analytica Chimica Acta, 2021, ISSN 0003-2670
Publisher: Elsevier BV
DOI: 10.1016/j.aca.2021.338828

Endocrine disrupting potential of replacement flame retardants - Review of current knowledge for nuclear receptors associated with reproductive outcomes

Author(s): Bajard L, Negi CK, Mustieles V, Melymuk L, Jomini S, Barthelemy-Berneron J, Fernandez MF, Blaha L.
Published in: Environment International, 153 (2021) 106550, 2021, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2021.106550

Low doses of Bisphenol S affect post-translational modifications of sperm proteins in male mice

Author(s): Hedvika Řimnáčová, Miriam Štiavnická, Jiří Moravec, Marouane Chemek, Yaroslav Kolinko, Olga García-Álvarez, Peter R. Mouton, Azalia Mariel Carranza Trejo, Tereza Fenclová, Nikola Eretová, Petr Hošek, Pavel Klein, Milena Králíčková, Jaroslav Petr & Jan Nevoral
Published in: Reproductive Biology and Endocrinology, 18 (Article 56), 2020, ISSN 1477-7827
Publisher: BioMed Central
DOI: 10.1186/s12958-020-00596-x

Oxidative stress of glyphosate, AMPA and metabolites of pyrethroids and chlorpyrifos pesticides among primary school children in Cyprus

Author(s): Konstantinos C. Makris, Nikolaos Efthymiou, Corina Konstantinou, Elena Anastasi, Greet Schoeters, Marike Kolossa-Gehring, Andromachi Katsonouri
Published in: Environmental Research, Volume 212, Part B (2022), 2022, ISSN 0013-9351
Publisher: Academic Press
DOI: 10.1016/j.envres.2022.113316

HBM4EU Chromates Study: Determinants of Exposure to Hexavalent Chromium in Plating, Welding and Other Occupational Settings

Author(s): Susana Viegas, Carla Martins, Beatrice Bocca, Radia Bousoumah, Radu Corneliu Duca, Karen S. Galea, Lode Godderis, Ivo Iavicoli, Beata Janasik, Kate Jones, Elizabeth Leese, Veruscka Leso, Sophie Ndaw, An van Nieuwenhuyse, Katrien Poels, Simo P. Porras, Flavia Ruggieri, Maria João Silva, Jelle Verdonck, Wojciech Wasowicz, Paul T. J. Scheepers, Tiina Santonen and HBM4EU Chromates Study Team
Published in: International Journal of Environmental Research and Public Health, Volume 19 (Issue 6), 2022, ISSN 1660-4601
Publisher: MDPI
DOI: 10.3390/ijerph19063683

Interlaboratory Comparison Investigations (ICIs) for human biomonitoring of chromium as part of the quality assurance programme under HBM4EU

Author(s): Stefanie Nübler, Moritz Schäfer, Karin Haji-Abbas-Zarrabi, Stefan Markovic, Katarina Markovic, Marta Esteban Lopez, Argelia Castano, Hans Mol, Holger M. Koch, Jean-Philippe Antignac, Jana Hajslova, Cathrine Thomsen, Katrin Vorkamp, Thomas Goen
Published in: Journal of Trace Elements in Medicine and Biology, Volume 70 (2022), 2021, ISSN 0946-672X
Publisher: Elsevier BV
DOI: 10.1016/j.jtemb.2021.126912

Annotating Nontargeted LC-HRMS/MS Data with Two Complementary Tandem Mass Spectral Libraries

Author(s): Herbert Oberacher, Vera Reinstadler, Marco Kreidl, Michael Stravs, Juliane Hollender, Emma Schymanski
Published in: Metabolites, 9/1, 2019, Page(s) 3, ISSN 2218-1989
Publisher: MDPI
DOI: 10.3390/metabo9010003

Bisphenol A and declining semen quality: A systematic review to support the derivation of a reference dose for mixture risk assessments

Author(s): Andreas Kortenkamp, Olwenn Martin, Sibylle Ermler, Asma Baig, Martin Scholze
Published in: International Journal of Hygiene and Environmental Health, Volume 241 (April 2022), 2022, ISSN 1438-4639
Publisher: Elsevier BV
DOI: 10.1016/j.ijheh.2022.113942

Exposure to Perflouroalkyl acids and foetal and maternal thyroid status: a review

Author(s): Sophie A. H. Boesen, Manhai Long, Maria Wielsøe, Vicente Mustieles, Mariana F. Fernandez, Eva C. Bonefeld-Jørgensen
Published in: Environmental Health, 19/1, 2020, ISSN 1476-069X
Publisher: BioMed Central
DOI: 10.1186/s12940-020-00647-1

Challenges to Evidence Synthesis and Identification of Data Gaps in Human Biomonitoring

Author(s): Ana Virgolino; Osvaldo Santos; Joana Costa; Mónica Fialho; Ivo Iavicoli; Tiina Santonen; Hanna Tolonen; Evangelia Samoli; Klea Katsouyanni; Georgios Baltatzis; Flavia Ruggieri; Annalisa Abballe; Ida Petrovičová; Branislav Kolena; Miroslava Šidlovská; Carla Ancona; Ivan Eržen; Ovnair Sepai; Argelia Castaño; Marike Kolossa-Gehring; Ulrike Fiddicke
Published in: International Journal of Environmental Research and Public Health, Volume 18 (Issue 6), 2021, Page(s) 2830, ISSN 1660-4601
Publisher: MDPI
DOI: 10.3390/ijerph18062830

HBM4EU chromates study - Reflection and lessons learnt from designing and undertaking a collaborative European biomonitoring study on occupational exposure to hexavalent chromium.

Author(s): Karen S. Galea; Simo P. Porras; Susana Viegas; Beatrice Bocca; Radia Bousoumah; Radu Corneliu Duca; Lode Godderis; Ivo Iavicoli; Beata Janasik; Kate Jones; Lisbeth E. Knudsen; Elizabeth Leese; Veruscka Leso; Henriqueta Louro; Sophie Ndaw; Flavia Ruggieri; Ovnair Sepai; Paul T.J. Scheepers; Maria João Silva; Wojciech Wasowicz; Tiina Santonen
Published in: International Journal of Hygiene and Environmental Health, Volume 234, 2021, ISSN 1438-4639
Publisher: Elsevier BV
DOI: 10.1016/j.ijheh.2021.113725

Biomarkers of effect as determined in human biomonitoring studies on hexavalent chromium and cadmium in the period 2008-2020.

Author(s): Célia Ventura; Bruno Costa Gomes; Axel Oberemm; Henriqueta Louro; Pasi Huuskonen; Vicente Mustieles; Mariana F. Fernández; Sophie Ndaw; Marcel Mengelers; Mirjam Luijten; Claudia Gundacker; Maria João Silva
Published in: Environmental Research, 197 (2021), 2021, ISSN 0013-9351
Publisher: Academic Press
DOI: 10.1016/j.envres.2021.110998

Human biomonitoring initiative (HBM4EU) - Strategy to derive human biomonitoring guidance values (HBM-GVs) for health risk assessment

Author(s): Petra Apel, Christophe Rousselle, Rosa Lange, Fatoumata Sissoko, Marike Kolossa-Gehring, Eva Ougier
Published in: International Journal of Hygiene and Environmental Health, 230, 2020, Page(s) 113622, ISSN 1438-4639
Publisher: Elsevier BV
DOI: 10.1016/j.ijheh.2020.113622