Objective
The aim of the proposed research is to understand how Insulin/IGF signalling (IIS) interplays with other major hormone systems in Drosophila ageing. Ageing is a decline in survival probability and reproduction with advancing age. Reductions in IIS have bee n shown to extend lifespan and to reduce fecundity in invertebrates and mammals. I propose to use the power of molecular genetic manipulation and demographic measurements to determine how the cellular and systemic elements of IIS, ecdysone and juvenile hormone signalling regulate ageing and fecundity in Drosophila.
The insulin-like peptides of Drosophila (DILPs) are peptide hormone expressed in neurosecretory cells (NSCs) in the brain. Their expression is affected by nutrients, and regulates growth, glucose metabolism, reproduction and aging. The steroid hormone ecdysone and the sesquiterpenoid Juvenile hormone (JH) were discovered originally as molting hormones, but also influence reproduction and ageing in the adult. The mechanisms by which these hormonal systems interact, and how they regulate ageing and fecundity are not understood.
The proposed research project has two objectives:
1. To assess the interactions between IIS and ecdysone signalling in the determination of lifespan and fecundity in Drosophila:
(a) Does ECD signalling affects IIS or DILP-production and
(b) Does IIS affects the production of ECD in the ovary or elsewhere.
2. To assess regulation of juvenile hormone (JH) synthesis in the corpora allata (CA) by insulin/IGF-like signalling (IIS).
The results will be of direct relevance to human ageing, and could lead to the development of new drugs against obesity, diabetes and age-related decline in function.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology genetic engineering
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences clinical medicine cardiology cardiovascular diseases
- medical and health sciences basic medicine physiology homeostasis
- medical and health sciences health sciences nutrition obesity
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-7
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IIF - Marie Curie actions-Incoming International Fellowships
Coordinator
LONDON
United Kingdom
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