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IN SITU IMAGING OF LIVING TISSUES WITH CELLULAR SPATIAL RESOLUTION

Objective

The main objective of HISTO-MRI project is to develop the technologies that will enable the non-invasive visualization of individual human cells in vivo and in real time, based on a radical new Magnetic Resonance Imaging concept: High Frequency Pulsed MRI. To accomplish this ambitious objective, several new challenging multidisciplinary technologies will have to be developed: 1) new method for the production of magnet coils, based on additive manufacturing technology, in order to stand very high currents at very high frequencies; 2) novel high frequency high voltage pulse power sources, based of semiconductor switches, to feed those magnet coils; and new pulse sequencing and computer algorithms to deal with and analyse the enormous amount of data. Therefore, this project has a foundational character, establishing the basis for a new field of research, pulsed MRI in the high frequency regime, which will radically advance MRI performance to micron resolution.
A Proof of Concept of the new technology will be accomplished through the visualization of a mouse brain at the neuron level. This new technology will enable transformative research in the fields of neurosciences, bioengineering, biophysics and experimental oncology

Field of science

  • /medical and health sciences/clinical medicine/radiology/medical imaging/magnetic resonance imaging
  • /engineering and technology/mechanical engineering/manufacturing engineering/additive manufacturing
  • /natural sciences/physical sciences/electromagnetism and electronics/electrical conductivity/semiconductor
  • /natural sciences/biological sciences/biophysics
  • /medical and health sciences/clinical medicine/oncology
  • /natural sciences/biological sciences/neurobiology
  • /natural sciences/biological sciences/neurobiology/neuroscience

Call for proposal

H2020-FETOPEN-1-2016-2017
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Address
Calle Serrano 117
28006 Madrid
Spain
Activity type
Research Organisations
EU contribution
€ 980 000

Participants (4)

DANFYSIK AS
Denmark
EU contribution
€ 693 750
Address
Gregersensvej 8
2630 Taastrup
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU contribution
€ 250 000
Address
Albinusdreef 2
2333 ZA Leiden
Activity type
Higher or Secondary Education Establishments
FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Germany
EU contribution
€ 812 500
Address
Hansastrasse 27C
80686 Munchen
Activity type
Research Organisations
TESORO IMAGING SL
Spain
EU contribution
€ 480 000
Address
Calle La Dorada 7-Bungalow 28
03540 Alicante
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)