CORDIS - EU research results

Transcriptional control of plasma cell development and function


Limited access to antigen drives generation of early B cell memory while restraining the plasmablast response

Author(s): Vassilis Glaros; Vassilis Glaros; René Rauschmeier; Artem V. Artemov; Annika Reinhardt; Annika Reinhardt; Sebastian Ols; Sebastian Ols; Aikaterini Emmanouilidi; Charlotte Gustafsson; Yuanyuan You; Yuanyuan You; Claudio Mirabello; Åsa K. Björklund; Laurent Perez; Neil P. King; Robert Månsson; Robert Månsson; Davide Angeletti; Karin Loré; Karin Loré; Igor Adameyko; Igor Adameyko; Meinrad Buss
Published in: Immunity, Issue 14.09.2021, 2021, ISSN 1097-4180
Publisher: Cell Press
DOI: 10.1016/j.immuni.2021.08.017

Bhlhe40 function in activated B and TFH cells restrains the GC reaction and prevents lymphomagenesis

Author(s): René Rauschmeier; Annika Reinhardt; Charlotte Gustafsson; Vassilis Glaros; Artem V. Artemov; Josefine Dunst; Reshma Taneja; Igor Adameyko; Robert Månsson; Meinrad Busslinger; Taras Kreslavsky
Published in: Journal of Experimental Medicine, Issue 17.12.2021, 2021, ISSN 1540-9538
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20211406

Igh and Igk loci use different folding principles for V gene recombination due to distinct chromosomal architectures of pro-B and pre-B cells

Author(s): Louisa Hill, Gordana Wutz, Markus Jaritz, Hiromi Tagoh, Lesly Calderón, Jan-Michael Peters, Anton Goloborodko, Meinrad Busslinger
Published in: Nature Communications, Issue 21.04.2023, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-37994-9

Comprehensive CRISPR-Cas9 screen identifies factors which are important for plasmablast development

Author(s): Theresa Pinter, Maria Fischer, Markus Schäfer, Michaela Fellner, Julian Jude, Johannes Zuber, Meinrad Busslinger, Miriam Wöhner
Published in: Frontiers in Immunology, Issue 15.09.2022, 2022, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2022.979606

Repression of the B cell identity factor Pax5 is not required for plasma cell development

Author(s): Grace J. Liu, Markus Jaritz, Miriam Wöhner, Benedikt Agerer, Andreas Bergthaler, Stephen G. Malin, Meinrad Busslinger
Published in: Journal of Experimental Medicine, Issue 217/11, 2020, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20200147

The Xbp1-regulated transcription factor Mist1 restricts antibody secretion by restraining Blimp1 expression in plasma cells

Author(s): Miriam Wöhner; Theresa Pinter; Peter Bönelt; Astrid Hagelkruys; Daniela Kostanova-Poliakova; Johannes Stadlmann; Stephen F. Konieczny; Maria Fischer; Markus Jaritz; Meinrad Busslinger
Published in: Frontiers in Immunology, Issue 21.12.2021, 2022, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2022.859598

Pax5 regulates B cell immunity by promoting PI3K signaling via PTEN down-regulation.

Author(s): Lesly Calderón; Karina Schindler; Stephen Malin; Stephen Malin; Alexandra Schebesta; Qiong Sun; Tanja A. Schwickert; Chiara Alberti; Maria Fischer; Markus Jaritz; Hiromi Tagoh; Anja Ebert; Martina Minnich; Adrian Liston; Luisa Cochella; Meinrad Busslinger
Published in: Science Immunology, Issue 27.07.2021, 2021, ISSN 2470-9468
Publisher: AAAS
DOI: 10.1126/sciimmunol.abg5003

Wapl repression by Pax5 promotes V gene recombination by Igh loop extrusion

Author(s): Louisa Hill, Anja Ebert, Markus Jaritz, Gordana Wutz, Kota Nagasaka, Hiromi Tagoh, Daniela Kostanova-Poliakova, Karina Schindler, Qiong Sun, Peter Bönelt, Maria Fischer, Jan-Michael Peters, Meinrad Busslinger
Published in: Nature, Issue 01.07.2020, 2020, ISSN 1476-4687
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2454-y

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