INTEGRATION AND PROPAGATION OF IMMUNOLOGICAL SIGNALS DURING CANCER AND INFECTION

Project Information

ENLIGHTEN

Grant agreement ID: 741167

DOI

10.3030/741167

Project closed

EC signature date 30 May 2017

Start date 1 January 2018

End date 31 December 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 499 994,00

EU contribution

€ 2 499 994,00

Coordinated by

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (11)

Anti-PD-1 therapy triggers Tfh cell–dependent IL-4 release to boost CD8 T cell responses in tumor-draining lymph nodes

Author(s): Mathilde Ruggiu, Marion V. Guérin, Béatrice Corre, Margot Bardou, Ruby Alonso, Erica Russo, Zacarias Garcia, Lea Feldmann, Fabrice Lemaître, Mathilde Dusseaux, Capucine L. Grandjean, Philippe Bousso
Published in: Journal of Experimental Medicine, Issue 221, 2024, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20232104

Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN-γ is a major determinant of CD4+ CAR T-cell antitumor activity.

Author(s): Boulch M, Cazaux M, Cuffel A, Guerin MV, Garcia Z, Alonso R, Lemaître F, Beer A, Corre B, Menger L, Grandjean CL, Morin F, Thieblemont C, Caillat-Zucman S, Bousso P.
Published in: Nature Cancer, 2023, ISSN 2662-1347
Publisher: Nature publishing group
DOI: 10.1038/s43018-023-00570-7

SPICE-Met: profiling and imaging energy metabolism at the single-cell level using a fluorescent reporter mouse.

Author(s): Russo E, Lemaître F, Corre B, Chikina AS, Langa-Vives F, Bousso P.
Published in: EMBO Journal, 2022, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2022111528

Single-cell imaging of CAR T cell activity in vivo reveals extensive functional and anatomical heterogeneity

Author(s): Marine Cazaux, Capucine L. Grandjean, Fabrice Lemaître, Zacarias Garcia, Richard J. Beck, Idan Milo, Jérémy Postat, Joost B. Beltman, Eleanor J. Cheadle, Philippe Bousso
Published in: The Journal of Experimental Medicine, Issue 216/5, 2019, Page(s) 1038-1049, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20182375

The immune system profoundly restricts intratumor genetic heterogeneity

Author(s): Idan Milo, Marie Bedora-Faure, Zacarias Garcia, Ronan Thibaut, Leïla Périé, Guy Shakhar, Ludovic Deriano, Philippe Bousso
Published in: Science Immunology, Issue 3/29, 2018, Page(s) eaat1435, ISSN 2470-9468
Publisher: AAAS
DOI: 10.1126/sciimmunol.aat1435

A Metabolism-Based Quorum Sensing Mechanism Contributes to Termination of Inflammatory Responses

Author(s): Jérémy Postat, Romain Olekhnovitch, Fabrice Lemaître, Philippe Bousso
Published in: Immunity, Issue 49/4, 2018, Page(s) 654-665.e5, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2018.07.014

Termination of T cell priming relies on a phase of unresponsiveness promoting disengagement from APCs and T cell division

Author(s): Armelle Bohineust, Zacarias Garcia, Hélène Beuneu, Fabrice Lemaître, Philippe Bousso
Published in: The Journal of Experimental Medicine, Issue 215/5, 2018, Page(s) 1481-1492, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20171708

Bystander IFN-γ activity promotes widespread and sustained cytokine signaling altering the tumor microenvironment

Author(s): Ronan Thibaut, Pierre Bost, Idan Milo, Marine Cazaux, Fabrice Lemaître, Zacarias Garcia, Ido Amit, Béatrice Breart, Clémence Cornuot, Benno Schwikowski, Philippe Bousso
Published in: Nature Cancer, Issue 1/3, 2020, Page(s) 302-314, ISSN 2662-1347
Publisher: Nature Cancer
DOI: 10.1038/s43018-020-0038-2

Optogenetic manipulation of calcium signals in single T cells in vivo

Author(s): Armelle Bohineust, Zacarias Garcia, Béatrice Corre, Fabrice Lemaître, Philippe Bousso
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-14810-2

Quorum Sensing by Monocyte-Derived Populations

Author(s): Jérémy Postat, Philippe Bousso
Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224
Publisher: Frontiers in Immunology
DOI: 10.3389/fimmu.2019.02140

A cross-talk between CAR T cell subsets and the tumor microenvironment is essential for sustained cytotoxic activity.

Author(s): Boulch M, Cazaux M, Loe-Mie Y, Thibaut R, Corre B, Lemaître F, Grandjean CL, Garcia Z, Bousso P. A cross-talk between CAR T cell subsets and the tumor microenvironment is essential for sustained cytotoxic activity. Sci Immunol. 2021 Mar 26;6(57):eabd4344. doi: 10.1126/sciimmunol.abd4344. PMID: 33771887.
Published in: Science Immunology, 2021, ISSN 2470-9468
Publisher: AAAS
DOI: 10.1126/sciimmunol.abd4344