Immune checkpoint blockade for fighting Alzheimer’s disease

Project Information

ImmuneCheckpointsAD

Grant agreement ID: 741744

DOI 10.3030/741744

Project closed

EC signature date 18 May 2017

Start date 1 June 2017

End date 30 November 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 287 500,00

EU contribution € 2 287 500,00

Coordinated by

WEIZMANN INSTITUTE OF SCIENCE
Israel

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (17)

Targeting the immune system towards novel therapeutic avenues to fight brain aging and neurodegeneration

Author(s): Peralta Ramos, J. M. Kviatcovsky, D. Schwartz, M.
Published in: Eur J Neurosci, Issue 56, 2022, Page(s) 5413-5427, ISSN 0953-816X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/ejn.15609

A shared disease-associated oligodendrocyte signature among multiple CNS pathologies

Author(s): Kenigsbuch, M. Bost, P. Halevi, S. Chang, Y. Chen, S. Ma, Q. Hajbi, R. Schwikowski, B. Bodenmiller, B. Fu, H. Schwartz, M. Amit, I.
Published in: Nat Neurosci, Issue 25, 2022, Page(s) 876-886, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-022-01104-7

Immunological Features of Non-neuronal Brain Cells: Implications for Alzheimer’s Disease Immunotherapy

Author(s): Giulia Castellani; Michal Schwartz; Michal Schwartz
Published in: Immunological Features of Non-neuronal Brain Cells: Implications for Alzheimer's Disease Immunotherapy, Issue 1, 2020, ISSN 1471-4906
Publisher: Elsevier BV
DOI: 10.1016/j.it.2020.07.005

Microglial immune checkpoint mechanisms

Author(s): Aleksandra Deczkowska, Ido Amit, Michal Schwartz
Published in: Nature Neuroscience, Issue 21/6, 2018, Page(s) 779-786, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-018-0145-x

Targeting neuro–immune communication in neurodegeneration: Challenges and opportunities

Author(s): Aleksandra Deczkowska, Michal Schwartz
Published in: The Journal of Experimental Medicine, Issue 215/11, 2018, Page(s) 2702-2704, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20181737

Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration

Author(s): Aleksandra Deczkowska, Hadas Keren-Shaul, Assaf Weiner, Marco Colonna, Michal Schwartz, Ido Amit
Published in: Cell, Issue 173/5, 2018, Page(s) 1073-1081, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2018.05.003

PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model

Author(s): Neta Rosenzweig, Raz Dvir-Szternfeld, Afroditi Tsitsou-Kampeli, Hadas Keren-Shaul, Hila Ben-Yehuda, Pierre Weill-Raynal, Liora Cahalon, Alex Kertser, Kuti Baruch, Ido Amit, Assaf Weiner, Michal Schwartz
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-08352-5

Corticosteroid signaling at the brain-immune interface impedes coping with severe psychological stress

Author(s): A. Kertser, K. Baruch, A. Deczkowska, A. Weiner, T. Croese, M. Kenigsbuch, I. Cooper, M. Tsoory, S. Ben-Hamo, I. Amit, M. Schwartz
Published in: Science Advances, Issue 5/5, 2019, Page(s) eaav4111, ISSN 2375-2548
Publisher: AAAS
DOI: 10.1126/sciadv.aav4111

A 20-Year Journey from Axonal Injury to Neurodegenerative Diseases and the Prospect of Immunotherapy for Combating Alzheimer’s Disease

Author(s): Michal Schwartz, Javier M. Peralta Ramos, Hila Ben-Yehuda
Published in: The Journal of Immunology, Issue 204/2, 2020, Page(s) 243-250, ISSN 0022-1767
Publisher: American Association of Immunologists
DOI: 10.4049/jimmunol.1900844

Disease-associated astrocytes in Alzheimer’s disease and aging

Author(s): Naomi Habib, Cristin McCabe, Sedi Medina, Miriam Varshavsky, Daniel Kitsberg, Raz Dvir-Szternfeld, Gilad Green, Danielle Dionne, Lan Nguyen, Jamie L. Marshall, Fei Chen, Feng Zhang, Tommy Kaplan, Aviv Regev, Michal Schwartz
Published in: Nature Neuroscience, Issue 23/6, 2020, Page(s) 701-706, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-020-0624-8

Potential immunotherapy for Alzheimer disease and age-related dementia

Author(s): . Schwartz M, Arad M, Ben-Yehuda H
Published in: Dialogues in Clinical Neuroscience, Issue 21/1, 2019, Page(s) 21-25, ISSN 1294-8322
Publisher: Les Laboratoires Servier
DOI: 10.31887/dcns.2019.21.1/mschwartz

Key role of the CCR2-CCL2 axis in disease modification in a mouse model of tauopathy

Author(s): "Hila Ben-Yehuda # 1, Michal Arad # 1, Javier María Peralta Ramos # 1, Efrat Sharon 1, Giulia Castellani 1, Shir Ferrera 1, Liora Cahalon 1, Sarah Phoebeluc Colaiuta 1, Tomer-Meir Salame 2, Michal Schwartz 3"
Published in: Mol Neurodegener, 2021, ISSN 1750-1326
Publisher: BioMed Central
DOI: 10.1186/s13024-021-00458-z

The brain-immune ecosystem: Implications for immunotherapy in defeating neurodegenerative diseases

Author(s): Schwartz, M. Abellanas, M. A. Tsitsou-Kampeli, A. Suzzi, S.
Published in: Neuron, Issue 110, 2022, Page(s) 3421-3424, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2022.09.007

The vicious cycle governing the brain-immune system relationship in neurodegenerative diseases

Author(s): Schwartz, M. Cahalon, L.
Published in: Curr Opin Immunol, Issue 76, 2022, Page(s) 102182, ISSN 0952-7915
Publisher: Elsevier BV
DOI: 10.1016/j.coi.2022.102182

Alzheimer’s disease modification mediated by bone marrow-derived macrophages via a TREM2-independent pathway in mouse model of amyloidosis

Author(s): Dvir-Szternfeld, R. Castellani, G. Arad, M. Cahalon, L. Colaiuta, S. P. Keren-Shaul, H. Croese, T. Burgaletto, C. Baruch, K. Ulland, T. Colonna, M. Weiner, A. Amit, I. Schwartz, M.
Published in: Nature Aging, Issue 2, 2022, Page(s) 60-73, ISSN 2662-8465
Publisher: Nature Aging is a new online-only research journal publishing monthly
DOI: 10.1038/s43587-021-00149-w

Transforming the understanding of brain immunity

Author(s): Castellani G, Croese T, Peralta Ramos JM, Schwartz M.
Published in: Science, 2023, ISSN 0036-8075
Publisher: American Association for the Advancement of Science

Immune cell compartmentalization for brain surveillance and protection

Author(s): "Tommaso Croese # 1, Giulia Castellani # 1, Michal Schwartz # 2"
Published in: Nat Immunol ., 2021, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-021-00994-2