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Immune checkpoint blockade for fighting Alzheimer’s disease


Targeting the immune system towards novel therapeutic avenues to fight brain aging and neurodegeneration

Author(s): Peralta Ramos, J. M. Kviatcovsky, D. Schwartz, M.
Published in: Eur J Neurosci, Issue 56, 2022, Page(s) 5413-5427, ISSN 0953-816X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/ejn.15609

A shared disease-associated oligodendrocyte signature among multiple CNS pathologies

Author(s): Kenigsbuch, M. Bost, P. Halevi, S. Chang, Y. Chen, S. Ma, Q. Hajbi, R. Schwikowski, B. Bodenmiller, B. Fu, H. Schwartz, M. Amit, I.
Published in: Nat Neurosci, Issue 25, 2022, Page(s) 876-886, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-022-01104-7

Immunological Features of Non-neuronal Brain Cells: Implications for Alzheimer’s Disease Immunotherapy

Author(s): Giulia Castellani; Michal Schwartz; Michal Schwartz
Published in: Immunological Features of Non-neuronal Brain Cells: Implications for Alzheimer's Disease Immunotherapy, Issue 1, 2020, ISSN 1471-4906
Publisher: Elsevier BV
DOI: 10.1016/

Microglial immune checkpoint mechanisms

Author(s): Aleksandra Deczkowska, Ido Amit, Michal Schwartz
Published in: Nature Neuroscience, Issue 21/6, 2018, Page(s) 779-786, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-018-0145-x

Targeting neuro–immune communication in neurodegeneration: Challenges and opportunities

Author(s): Aleksandra Deczkowska, Michal Schwartz
Published in: The Journal of Experimental Medicine, Issue 215/11, 2018, Page(s) 2702-2704, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20181737

Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration

Author(s): Aleksandra Deczkowska, Hadas Keren-Shaul, Assaf Weiner, Marco Colonna, Michal Schwartz, Ido Amit
Published in: Cell, Issue 173/5, 2018, Page(s) 1073-1081, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2018.05.003

PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model

Author(s): Neta Rosenzweig, Raz Dvir-Szternfeld, Afroditi Tsitsou-Kampeli, Hadas Keren-Shaul, Hila Ben-Yehuda, Pierre Weill-Raynal, Liora Cahalon, Alex Kertser, Kuti Baruch, Ido Amit, Assaf Weiner, Michal Schwartz
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-08352-5

Corticosteroid signaling at the brain-immune interface impedes coping with severe psychological stress

Author(s): A. Kertser, K. Baruch, A. Deczkowska, A. Weiner, T. Croese, M. Kenigsbuch, I. Cooper, M. Tsoory, S. Ben-Hamo, I. Amit, M. Schwartz
Published in: Science Advances, Issue 5/5, 2019, Page(s) eaav4111, ISSN 2375-2548
Publisher: AAAS
DOI: 10.1126/sciadv.aav4111

A 20-Year Journey from Axonal Injury to Neurodegenerative Diseases and the Prospect of Immunotherapy for Combating Alzheimer’s Disease

Author(s): Michal Schwartz, Javier M. Peralta Ramos, Hila Ben-Yehuda
Published in: The Journal of Immunology, Issue 204/2, 2020, Page(s) 243-250, ISSN 0022-1767
Publisher: American Association of Immunologists
DOI: 10.4049/jimmunol.1900844

Disease-associated astrocytes in Alzheimer’s disease and aging

Author(s): Naomi Habib, Cristin McCabe, Sedi Medina, Miriam Varshavsky, Daniel Kitsberg, Raz Dvir-Szternfeld, Gilad Green, Danielle Dionne, Lan Nguyen, Jamie L. Marshall, Fei Chen, Feng Zhang, Tommy Kaplan, Aviv Regev, Michal Schwartz
Published in: Nature Neuroscience, Issue 23/6, 2020, Page(s) 701-706, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-020-0624-8

Potential immunotherapy for Alzheimer disease and age-related dementia

Author(s): . Schwartz M, Arad M, Ben-Yehuda H
Published in: Dialogues in Clinical Neuroscience, Issue 21/1, 2019, Page(s) 21-25, ISSN 1294-8322
Publisher: Les Laboratoires Servier
DOI: 10.31887/dcns.2019.21.1/mschwartz

Key role of the CCR2-CCL2 axis in disease modification in a mouse model of tauopathy

Author(s): "Hila Ben-Yehuda # 1, Michal Arad # 1, Javier María Peralta Ramos # 1, Efrat Sharon 1, Giulia Castellani 1, Shir Ferrera 1, Liora Cahalon 1, Sarah Phoebeluc Colaiuta 1, Tomer-Meir Salame 2, Michal Schwartz 3"
Published in: Mol Neurodegener, 2021, ISSN 1750-1326
Publisher: BioMed Central
DOI: 10.1186/s13024-021-00458-z

The brain-immune ecosystem: Implications for immunotherapy in defeating neurodegenerative diseases

Author(s): Schwartz, M. Abellanas, M. A. Tsitsou-Kampeli, A. Suzzi, S.
Published in: Neuron, Issue 110, 2022, Page(s) 3421-3424, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2022.09.007

The vicious cycle governing the brain-immune system relationship in neurodegenerative diseases

Author(s): Schwartz, M. Cahalon, L.
Published in: Curr Opin Immunol, Issue 76, 2022, Page(s) 102182, ISSN 0952-7915
Publisher: Elsevier BV
DOI: 10.1016/j.coi.2022.102182

Alzheimer’s disease modification mediated by bone marrow-derived macrophages via a TREM2-independent pathway in mouse model of amyloidosis

Author(s): Dvir-Szternfeld, R. Castellani, G. Arad, M. Cahalon, L. Colaiuta, S. P. Keren-Shaul, H. Croese, T. Burgaletto, C. Baruch, K. Ulland, T. Colonna, M. Weiner, A. Amit, I. Schwartz, M.
Published in: Nature Aging, Issue 2, 2022, Page(s) 60-73, ISSN 2662-8465
Publisher: Nature Aging is a new online-only research journal publishing monthly
DOI: 10.1038/s43587-021-00149-w

Immune cell compartmentalization for brain surveillance and protection

Author(s): "Tommaso Croese # 1, Giulia Castellani # 1, Michal Schwartz # 2"
Published in: Nat Immunol ., 2021, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-021-00994-2

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