DEVELOPMENT OF HEALTHY HOST-MICROBIAL MUTUALISM IN EARLY LIFE

Project Information

HHMM-Neonates

Grant agreement ID: 742195

DOI 10.3030/742195

Project closed

EC signature date 24 April 2017

Start date 1 September 2017

End date 31 August 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 500 000,00

EU contribution € 2 500 000,00

Coordinated by

UNIVERSITAET BERN
Switzerland

Publications

Peer reviewed articles (14)

“‘ELO, world!”—Early-life origins of B cells

Author(s): Rollenske, Tim; Macpherson, Andrew J
Published in: Immunity, Issue 3, 2022, Page(s) 1753-1755, ISSN 1097-4180
Publisher: Cell Press
DOI: 10.1016/j.immuni.2022.09.012

Long-term evolution and short-term adaptation of microbiota strains and sub-strains in mice

Author(s): Bahtiyar Yilmaz, Catherine Mooser, Irene Keller, Hai Li, Jakob Zimmermann, Lars Bosshard, Tobias Fuhrer, Mercedes Gomez de Agüero, Nerea Fernandez Trigo, Heidi Tschanz-Lischer, Julien P Limenitakis, Wolf-Dietrich Hardt, Kathy D McCoy, Bärbel Stecher, Laurent Excoffier, Uwe Sauer, Stephanie C Ganal-Vonarburg, Andrew J Macpherson
Published in: Cell Host&Microbe, 2021, ISSN 1931-3128
Publisher: Cell Press
DOI: 10.1016/j.chom.2021.02.001

Boundaries and integration between microbiota, the nervous system, and immunity

Author(s): Macpherson, Andrew J; Pachnis, Vassilis; Prinz, Marco
Published in: Immunity, Issue 56(8), 2023, Page(s) 1712-1726, ISSN 1097-4180
Publisher: Cell Press
DOI: 10.1016/j.immuni.2023.07.011

Noninvasive assessment of gut function using transcriptional recording sentinel cells

Author(s): Schmidt, Florian; Jakob Zimmermann, Jakob; Tanna, Tanmay; Farouni, Rick; Conway, Tyrrell; Macpherson, Andrew J*; Platt, Randall J* (*Joint senior authors)
Published in: Science, Issue 376(6594), 2021, Page(s) eabm6038, ISSN 1095-9203
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abm6038

Mucosal or systemic microbiota exposures shape the B cell repertoire

Author(s): Hai Li, Julien P. Limenitakis, Victor Greiff, Bahtiyar Yilmaz, Olivier Schären, Camilla Urbaniak, Mirjam Zünd, Melissa A. E. Lawson, Ian D. Young, Sandra Rupp, Mathias Heikenwälder, Kathy D. McCoy, Siegfried Hapfelmeier, Stephanie C. Ganal-Vonarburg, Andrew J. Macpherson
Published in: Nature, 2020, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2564-6

Parallelism of intestinal secretory IgA shapes functional microbial fitness

Author(s): Rollenske, Tim; Burkhalter, Sophie; Muerner, Lukas; von Gunten, Stephan; Lukasiewicz, Jolanta; Wardemann, Hedda; Macpherson, Andrew J.
Published in: Nature, Issue 598(7882), 2022, Page(s) 657-661, ISSN 1476-4687
Publisher: Springer Nature
DOI: 10.1038/s41586-021-03973-7

Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies

Author(s): Katherine M. Kennedy, Marcus C. de Goffau, Maria Elisa Perez-Muñoz, Marie-Claire Arrieta, Fredrik Bäckhed, Peer Bork, Thorsten Braun, Frederic D. Bushman, Joel Dore, Willem M. de Vos, Ashlee M. Earl, Jonathan A. Eisen, Michal A. Elovitz, Stephanie C. Ganal-Vonarburg, Michael G. Gänzle, Wendy S. Garrett, Lindsay J. Hall, Mathias W. Hornef, Curtis Huttenhower, Liza Konnikova, Sarah Lebeer, Andrew
Published in: Nature, Issue 613(7945), 2023, Page(s) 639-649, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-05546-8

Checkpoint for gut microbes after birth

Author(s): Andrew J. Macpherson, Stephanie C. Ganal-Vonarburg
Published in: Nature, Issue 560/7719, 2018, Page(s) 436-438, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/d41586-018-05861-z

How nutrition and the maternal microbiota shape the neonatal immune system

Author(s): Andrew J. Macpherson, Mercedes Gomez de Agüero, Stephanie C. Ganal-Vonarburg
Published in: Nature Reviews Immunology, Issue 17/8, 2017, Page(s) 508-517, ISSN 1474-1733
Publisher: Nature Publishing Group
DOI: 10.1038/nri.2017.58

Microbial network disturbances in relapsing refractory Crohn’s disease

Author(s): Bahtiyar Yilmaz, Pascal Juillerat, Ove Øyås, Charlotte Ramon, Francisco Damian Bravo, Yannick Franc, Nicolas Fournier, Pierre Michetti, Christoph Mueller, Markus Geuking, Valerie E. H. Pittet, Michel H. Maillard, Gerhard Rogler, Reiner Wiest, Jörg Stelling, Andrew J. Macpherson
Published in: Nature Medicine, Issue 25/2, 2019, Page(s) 323-336, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-018-0308-z

Microbial–host molecular exchange and its functional consequences in early mammalian life

Author(s): Stephanie C. Ganal-Vonarburg, Mathias W. Hornef, Andrew J. Macpherson
Published in: Science, Issue 368/6491, 2020, Page(s) 604-607, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aba0478

Neuronal programming by microbiota regulates intestinal physiology

Author(s): Yuuki Obata, Álvaro Castaño, Stefan Boeing, Ana Carina Bon-Frauches, Candice Fung, Todd Fallesen, Mercedes Gomez de Agüero, Bahtiyar Yilmaz, Rita Lopes, Almaz Huseynova, Stuart Horswell, Muralidhara Rao Maradana, Werend Boesmans, Pieter Vanden Berghe, Andrew J. Murray, Brigitta Stockinger, Andrew J. Macpherson, Vassilis Pachnis
Published in: Nature, Issue 578/7794, 2020, Page(s) 284-289, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-1975-8

Breast Milk Modulates Transgenerational Immune Inheritance

Author(s): Jakob Zimmermann, Andrew J. Macpherson
Published in: Cell, Issue 181/6, 2020, Page(s) 1202-1204, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2020.05.030

Maternal Microbiota, Early Life Colonization and Breast Milk Drive Immune Development in the Newborn

Author(s): Cristina Kalbermatter, Nerea Fernandez Trigo, Sandro Christensen, Stephanie C. Ganal-Vonarburg
Published in: Frontiers in Immunology, 2021, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2021.683022