Single-molecule spectroscopy of coordinated motions in allosteric proteins

Project Information

SMALLOSTERY

Grant agreement ID: 742637

DOI 10.3030/742637

Project closed

EC signature date 24 April 2017

Start date 1 May 2017

End date 31 October 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 484 722,00

EU contribution € 2 484 722,00

Coordinated by

WEIZMANN INSTITUTE OF SCIENCE
Israel

Publications

Peer reviewed articles (9)

The Effect of Time Resolution on Apparent Transition Path Times Observed in Single-Molecule Studies of Biomolecules

Author(s): Dmitrii E. Makarov; Alexander Berezhkovskii; Gilad Haran; Eli Pollak
Published in: Crossref, Issue 1, 2022, ISSN 1520-6106
Publisher: American Chemical Society
DOI: 10.1021/acs.jpcb.2c05550

Control of protein activity by photoinduced spin polarized charge reorganization

Author(s): Shirsendu Ghosh, Koyel Banerjee Ghosh, Dorit Levy, David Scheerer, Inbal Riven, Jieun Shin, Harry B. Gray, Ron Naaman and Gilad Haran
Published in: Proceedings of the National Academy of Sciences, 2022, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2204735119

Entropic Inhibition: How the Activity of a AAA+ Machine Is Modulated by Its Substrate-Binding Domain

Author(s): Marija Iljina, Hisham Mazal, Pierre Goloubinoff, Inbal Riven, Gilad Haran
Published in: ACS Chemical Biology, Issue 16/4, 2021, Page(s) 775-785, ISSN 1554-8929
Publisher: American Chemical Society
DOI: 10.1021/acschembio.1c00156

Direct observation of ultrafast large-scale dynamics of an enzyme under turnover conditions

Author(s): Haim Yuval Aviram, Menahem Pirchi, Hisham Mazal, Yoav Barak, Inbal Riven, Gilad Haran
Published in: Proceedings of the National Academy of Sciences, Issue 115/13, 2018, Page(s) 3243-3248, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1720448115

Tunable microsecond dynamics of an allosteric switch regulate the activity of a AAA+ disaggregation machine

Author(s): Hisham Mazal, Marija Iljina, Yoav Barak, Nadav Elad, Rina Rosenzweig, Pierre Goloubinoff, Inbal Riven, Gilad Haran
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-09474-6

Single-molecule FRET methods to study the dynamics of proteins at work

Author(s): Hisham Mazal, Gilad Haran
Published in: Current Opinion in Biomedical Engineering, Issue 12, 2019, Page(s) 8-17, ISSN 2468-4511
Publisher: Curr Opin Biomed Eng
DOI: 10.1016/j.cobme.2019.08.007

Role of Repeated Conformational Transitions in Substrate Binding of Adenylate Kinase

Author(s): Jiajun Lu; David Scheerer; Gilad Haran; Wenfei Li; Wei Wang
Published in: Crossref, Issue 1, 2022, ISSN 1520-6106
Publisher: American Chemical Society
DOI: 10.1021/acs.jpcb.2c05497

Fast dynamics shape the function of the <scp>AAA</scp> + machine <scp>ClpB</scp> : lessons from single‐molecule <scp>FRET</scp> spectroscopy

Author(s): Inbal Riven; Hisham Mazal; Marija Iljina; Gilad Haran
Published in: Crossref, Issue 1, 2022, ISSN 1742-464X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/febs.16539

How fast are the motions of tertiary-structure elements in proteins?

Author(s): Gilad Haran, Hisham Mazal
Published in: The Journal of Chemical Physics, Issue 153/13, 2020, Page(s) 130902, ISSN 0021-9606
Publisher: American Institute of Physics
DOI: 10.1063/5.0024972