Objective
Recently, it has emerged that early life exposure to commensal microbes is crucial to instruct our immune system and prevent later life autoimmune and metabolic diseases. The host lab now showed that this education begins even earlier – during gestation by signals from the maternal intestinal microbiota. Using the E. coli strain HA 107, genetically engineered to grow in vitro without the ability to persist in vivo, they demonstrated that transient intestinal colonisation of pregnant germ-free mouse dams drives neonatal innate immune maturation. However, the long-term consequences of maternal microbiota cues especially for the adaptive immune system of the adult offspring remain elusive.
The MEMORIS project (Maternal Enteric Microbiota for Offspring's Repertoire development & Illness Susceptibility) shall elucidate the long-term consequences of maternal microbial signals for the offspring’s adaptive immune system and disease susceptibility.
My specific aims are to reveal the consequences of gestational colonisation for the offspring’s (1) own intestinal microbiota composition and metabolism; (2) adaptive immune repertoire development; and (3) susceptibility to autoimmune and metabolic diseases. For this, I will colonise offspring of gestationally colonised versus germ-free mouse dams at birth and by (1) metagenomic, metatranscriptomic and metabolomic read-outs assess its dynamic microbiota development. (2) Flow cytometric and transcriptional profiling, immunglobulin gene sequencing and bacterial FACS will reveal adaptive immune repertoire maturation. Based on these results I will (3) elucidate the role of maternal microbiota signals for disease susceptibility using NOD mice modeling type 1 diabetes and high fat diet-induced non-alcoholic fatty liver disease.
I would like to establish the concept that our susceptibility to autoimmune and metabolic diseases is influenced during a “window of opportunity” that opens – not just at birth – but already during pregnancy.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences basic medicine immunology
- medical and health sciences clinical medicine obstetrics
- medical and health sciences clinical medicine hepatology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2016
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
3012 BERN
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.