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Metabolic characterization of ILCs under homeostatic or stress conditions.

Objective

Innate lymphoid cells (ILCs) are the most recently identified components of the innate immune system. ILCs colonize mainly mucosa-associated tissues and they have a crucial role in metabolic homeostasis, and defense against infections and cancer. ILCs are highly plastic and they rapidly shape their functional output in response to local environmental cues. Two ILC subsets (ILC2 and NK cells) have been respectively implicated in the maintenance of adipose tissue homeostasis and in the development of chronic inflammation in obese patients. It has been shown that cellular metabolism affects the development and function of adaptive lymphocytes. In contrast, very little is known about innate lymphocytes metabolic requirements under homeostatic conditions and how they metabolically adapt to environmental perturbations.
This project will study metabolic profiles in human ILC subsets isolated from the bloodstream, lymphoid and non-lymphoid tissues under healthy conditions and inflammatory disease states. Whole-genome transcriptomes, proteomes and metabolomes will be compared in order to decipher the pathways that regulate ILCs. A better understanding of the metabolic network that govern ILCs in steady state and how these cells “switch” their metabolism to exert their function, may ultimately reveal novel targets for the treatment of chronic inflammatory diseases and metabolic disorders, like obesity.

Field of science

  • /medical and health sciences/basic medicine/pathology
  • /medical and health sciences/basic medicine/physiology/homeostasis
  • /medical and health sciences/health sciences/public and environmental health/epidemics prevention/immunisation
  • /natural sciences/chemical sciences/analytical chemistry/mass spectrometry
  • /natural sciences/biological sciences/cell biology/cell metabolism
  • /medical and health sciences/health sciences/inflammatory diseases
  • /medical and health sciences/basic medicine/immunology
  • /medical and health sciences/medical biotechnology/cells technologies

Call for proposal

H2020-MSCA-IF-2016
See other projects for this call

Funding Scheme

MSCA-IF-EF-ST - Standard EF

Coordinator

INSTITUT PASTEUR
Address
Rue Du Docteur Roux 25-28
75724 Paris Cedex 15
France
Activity type
Research Organisations
EU contribution
€ 173 076