Periodic Reporting for period 1 - EXOGENESIS (Syntenin-phosphatidic acid interaction in exosome biogenesis and cell-cell communication: a structure-function based approach)
Reporting period: 2018-12-01 to 2020-11-30
Our study indicates that PLD2 controls a large population of exosomes and the formation of secretory MVBs.
These results were presented at international conferences in 2019 such as the joint meeting of the Belgian Society for Extracellular Vesicles and the Belgian Society for Cell and Developmental Biology (Leuven, Belgium) and the Gordon Research Conference on Molecular Membrane Biology (Andover NH, United States).
These data are included in a manuscript entitled “PLD2-phosphatidic acid recruit ESCRT-I to late endosomes for exosome biogenesis” which is under review in EMBO Reports and a preprint is available bioRxiv 2020.11.25.398396; doi: https://doi.org/10.1101/2020.11.25.398396