Deformable vascular registration for co-mapping altered hemodynamics with vascular responses, and for introducing a new measure for aneurysm rupture risk assessment: the local surface growth

Project Information

VASCFORM

Grant agreement ID: 747094

DOI 10.3030/747094

Project terminated on 10 August 2018

Start date 1 September 2018

End date 31 August 2020

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 187 419,60

EU contribution € 187 419,60

Coordinated by

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland

Objective

Growth rate of ascending aortic aneurysm (AsAA) is a rupture risk marker as it potentially reflects a wall remodeling that leads to fast growth. It is measured as the maximum diameter change over time. However, expansion is not uniform but presents localized growth. We propose to develop a methodology based on deformable surface registration tools that will provide correspondence between aortic surface meshes obtained at consecutive time points and quantify vascular surface growth distribution. The direct application of this methodology in animal and clinical research will answer some long debated questions about AsAA pathology. While a cause and effect relationship between hemodynamics and lesion development is long suspected, exact quantification of the responsible hemodynamic factors has not been performed so far. This is because the geometry changes between baseline (measurement of initiating hemodynamics with computational fluid mechanics) and end stage (lesion development), making it difficult to identify corresponding regions at the microscopic level of lesion size. We will use angiotensin II-infused ApoE-/- mice, a model for AsAA, and apply the developed registration methodology to obtain a detailed correspondence between the 3D images, and co-map the complex initiating hemodynamic microenvironment and the histological findings at sacrifice for the identification of disturbed hemodynamics. Furthermore, the local wall expansion can indirectly provide information about aneurysm state. We will associate maximum local growth with the degree of aneurysm initiation (size of media tear) which will be used as a groundwork and pre-clinical justification to introduce the regional growth measurement in clinical risk assessment. Lastly, clinical data from AsAA patients will be used in order to correlate the maximum regional growth with clinical outcome, which will establish a new metric for a more sensitive aneurysm growth quantification.

Fields of science

• medical and health sciences › clinical medicine › angiology › vascular diseases
• medical and health sciences › basic medicine › pathology
• natural sciences › mathematics › pure mathematics › geometry

Keywords

• Non-rigid registration
• computational fluid dynamics
• ascending aortic aneurysm
• ApoE-
• mouse
• model

Programme(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2016 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2016

Funding Scheme

MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)

Coordinator

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE

• Net EU contribution: € 187 419,60
• Address: Batiment ce 3316 station 1 ; 1015 Lausanne ; Switzerland
• Region: Schweiz/Suisse/Svizzera › Région lémanique › Vaud
• Activity type: Higher or Secondary Education Establishments
• Other funding: € 0,00