Objective
Growth rate of ascending aortic aneurysm (AsAA) is a rupture risk marker as it potentially reflects a wall remodeling that leads to fast growth. It is measured as the maximum diameter change over time. However, expansion is not uniform but presents localized growth. We propose to develop a methodology based on deformable surface registration tools that will provide correspondence between aortic surface meshes obtained at consecutive time points and quantify vascular surface growth distribution. The direct application of this methodology in animal and clinical research will answer some long debated questions about AsAA pathology. While a cause and effect relationship between hemodynamics and lesion development is long suspected, exact quantification of the responsible hemodynamic factors has not been performed so far. This is because the geometry changes between baseline (measurement of initiating hemodynamics with computational fluid mechanics) and end stage (lesion development), making it difficult to identify corresponding regions at the microscopic level of lesion size. We will use angiotensin II-infused ApoE-/- mice, a model for AsAA, and apply the developed registration methodology to obtain a detailed correspondence between the 3D images, and co-map the complex initiating hemodynamic microenvironment and the histological findings at sacrifice for the identification of disturbed hemodynamics. Furthermore, the local wall expansion can indirectly provide information about aneurysm state. We will associate maximum local growth with the degree of aneurysm initiation (size of media tear) which will be used as a groundwork and pre-clinical justification to introduce the regional growth measurement in clinical risk assessment. Lastly, clinical data from AsAA patients will be used in order to correlate the maximum regional growth with clinical outcome, which will establish a new metric for a more sensitive aneurysm growth quantification.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine angiology vascular diseases
- medical and health sciences basic medicine pathology
- natural sciences mathematics pure mathematics geometry
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2016
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1015 LAUSANNE
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.