Objective Target-specific and controlled drug delivery are nowadays integral and extremely promising parts of research and practice in modern medicine. It gives an option to reduce drug toxicity and increase bioavailability by delivering a drug to a specific site with defined concentration. During the last decade highly efficient non-viral gene delivery has been achieved by encapsulation of nucleic acids into complexes of liposomes and polycations - lipopolyplexes (LPP) - new generation gene delivery systems. The main challenge in liposome-based gene delivery is to achieve high level of control over gene release. The main aim of this project is to develop a new approach for non-invasive gene delivery while gene release is highly controlled in space and time. This will be achieved by the design of infra-red light sensitive LPPs. The project includes engineering of the tailor-made LPPs, detailed investigation of the light triggered release mechanism, and will eventually result in intracellular light triggered gene delivery. Expert knowledge of the researcher together with the knowledge to be contributed by the hosting institution and from collaborations established by the researcher worldwide will allow successful project implementation. Mutual knowledge transfer will strengthen scientific contacts within and outside the EU as well as will let the researcher to develop her own independent research career. Attraction of interest from industrial partners is expected in case of success. Collaboration with industrial partners will profit from an exceptional record of the host with successful industrial projects. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesnucleic acids Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Topic(s) MSCA-IF-2016 - Individual Fellowships Call for proposal H2020-MSCA-IF-2016 See other projects for this call Funding Scheme MSCA-IF-EF-ST - Standard EF Coordinator FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV Net EU contribution € 171 460,80 Address Hansastrasse 27c 80686 Munchen Germany See on map Region Bayern Oberbayern München, Kreisfreie Stadt Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
