Spatial navigation requires the integration of visual and vestibular inputs to build a representation of space. Connectivity studies have shown that the secondary visual cortex (V2) of mice receives bottom-up inputs from primary visual cortex and anterior thalamus, conveying respectively visual and vestibular information, and feedback top-down inputs from the retrosplenial cortex.
The aims of this project are to determine the visual and vestibular tuning of layer 5 pyramidal neurons in V2, how these inputs are recruited and interact when the mouse is engaged in a spatial navigation task, and how they are modulated by retrosplenial inputs. This will be accomplished using a combination of population calcium imaging or whole-cell patch-clamp recordings of layer 5 neurons, coupled with sensory stimulation and optogenetic activation or inhibition of sensory or top-down inputs and behavioural experiments.
Fields of science
- natural sciencesbiological scienceszoologymammalogyprimatology
- medical and health sciencesbasic medicineneurologydementiaalzheimer
- natural scienceschemical sciencesinorganic chemistryalkaline earth metals
- medical and health sciencesbasic medicineneurologystroke
- natural sciencescomputer and information sciencessoftwaresoftware applicationsvirtual reality
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