Skip to main content

Visual and vestibular processing in secondary visual cortex

Objective

Spatial navigation requires the integration of visual and vestibular inputs to build a representation of space. Connectivity studies have shown that the secondary visual cortex (V2) of mice receives bottom-up inputs from primary visual cortex and anterior thalamus, conveying respectively visual and vestibular information, and feedback top-down inputs from the retrosplenial cortex.
The aims of this project are to determine the visual and vestibular tuning of layer 5 pyramidal neurons in V2, how these inputs are recruited and interact when the mouse is engaged in a spatial navigation task, and how they are modulated by retrosplenial inputs. This will be accomplished using a combination of population calcium imaging or whole-cell patch-clamp recordings of layer 5 neurons, coupled with sensory stimulation and optogenetic activation or inhibition of sensory or top-down inputs and behavioural experiments.

Coordinator

THE FRANCIS CRICK INSTITUTE LIMITED
Net EU contribution
€ 183 454,80
Address
1 Midland Road
NW1 1AT London
United Kingdom

See on map

Region
London Inner London — West Camden and City of London
Activity type
Research Organisations
Non-EU contribution
€ 0,00